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Differential diagnosis of left-sided abdominal pain:Primary epiploic appendagitis vs colonic diverticulitis

World Journal of Gastroenterology 2013年第40期19卷 6842-6848页

作者： Jeong Ah Hwang Sun moon Kim Hyun Jung Song Yu Mi Lee kyung min moon Chang Gi moon Hoon Sup Koo kyung Ho Song Yong Seok Kim Tae Hee Lee Kyu Chan Huh Young Woo Choi Young Woo Kang Woo Suk Chung Division of Gastroenterology and Hepatology Department of Internal MedicineKonyang University College of MedicineDaejeon 302-718South Korea Department of Diagnostic Radiology Konyang University College of MedicineDaejeon 302-718South Korea

AIM:To investigate the clinical characteristics of left primary epiploic appendagitis and to compare them with those of left colonic ***:We retrospectively reviewed the clinical records and radiologic images of the patients who presented with left-sided acute abdominal pain and had computer tomography(CT) performed at the time of presentation showing radiological signs of left primary epiploic appendagitis(PEA) or left acute colonic diverticulitis(ACD) between January 2001 and December 2011. A total of 53 consecutive patients were enrolled and evaluated. We also compared the clinical characteristics,laboratory findings,treatments,and clinical results of left PEA with those of left ***:Twenty-eight patients and twenty-five patients were diagnosed with symptomatic left PEA and ACD,respectively. The patients with left PEA had focal abdominal tenderness on the left lower quadrant(82.1%). On CT examination,most(89.3%) of the patients with left PEA were found to have an oval fatty mass with a hyperattenuated ring sign. In cases of left ACD,the patients presented with a more diffuse abdominal tenderness throughout the left side(52.0%vs 14.3%; P = 0.003). The patients with left ACD had fever and rebound tenderness more often than those with left PEA(40.0% vs 7.1%,P = 0.004; 52.0% vs14.3%,P = 0.003,respectively). Laboratory abnormalities such as leukocytosis were also more frequently observed in left ACD(52.0% vs 15.4%,P = 0.006).CONCLUSION:If patients have left-sided localized abdominal pain without associated symptoms or laboratory abnormalities,clinicians should suspect the diagnosis of PEA and consider a CT scan.

关键词： Acute abdomen Differential diagnosis Appendix epiploica Colonic diverticulitis Multidetector computed tomography

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Association between Tropical Convection and Boreal Wintertime Extratropical Circulation in 1982/83 and 1988/89

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Advances in Atmospheric Sciences 2003年第4期20卷 593-603页

作者： Ja-Yeon moon kyung-Ja HA Climate Research Laboratory Meteorological Research InstituteSeoul156-720KoreaDepartment of Atmospheric SciencesPusan National UniversityPusan609-735Korea

Boreal wintertime extratropical circulation is studied in relation to the tropical convection during the 1982/83 El Niño and 1988/89 La Niña. The anomaly structure of 1982/83 and 1988/89 over the extratropics reveals remarkably different features as the longitudinal tropical forcing region changes. The Rossby wave source (Positive) shows the largest maximum over East Asia in both years due to the persistent heating from the western Pacific warm pool area. However, the sink term shows contrasting features over the subtropics and extratropics between the two years. In the El Niño year, enhanced tropical convection over the eastern Pacific produces the Rossby wave sink at 10°N and shifted eastward over the North Pacific, while in the La Niña year, the sink area is shifted westward over the North Pacific. The contrasting features between the two events in mean-eddy interaction appears especially over the downstream area of the East Asian Jet. The extension (retraction) of the meanflow eastward (westward) to the east (west) of the dateline is related with the effect of the westward (eastward) E-vector and the strengthening (weakening) of the negative anomalies of the barotropic growth of kinetic energy. Hence, almost opposite characteristics between the two events can explain the close relationship of tropical convection and the extratropical internal variability.

关键词： tropical convection extratropical circulation rossby wave source mean-eddy interaction

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Fish bone migration to the urinary bladder after rectosigmoid colon perforation

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World Journal of Gastroenterology 2014年第22期20卷 7075-7078页

作者： min-kyung Cho moon-Soo Lee Hyun-Young Han Seung Hyo Woo Department of Surgery Eulji University HospitalDaejeon 302-799South Korea Department of Radiology Eulji University HospitalDaejeon 302-799South Korea Department of Urology Eulji University HospitalDaejeon 302-799South Korea

Fish bones are the most common foreign objects leading to bowel *** cases are confined to the extraluminal space without penetration of an adjacent ***,abscess formation due to the perforation of the rectosigmoid colon by a fish bone can lead to the penetration of the urinary bladder and may subsequently cause the fish bone to migrate into the urinary *** the presented case,a 42-yearold female was admitted for lower abdominal *** computed tomography(CT)demonstrated a 5cm pelvic abscess containing a thin and curvilinear foreign *** conservative management,the patient was *** 1 mo,the subject developed a mechanical *** had to be delayed due to her *** of the foreign body to the urinary bladder was shown on additional CT.A Yellowish fish bone 3.5 cm in size was removed through intraoperative *** patient was discharged 8 d after the operation without any unexpected event.

关键词： Fish bone Rectosigmoid colon perforation Urinary bladder Foreign body ingestion Foreign body induced bowel perforation

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Densification simulation of compacted Al powders using multi-particle finite element method

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中国有色金属学会会刊：英文版 2009年第B09期19卷 68-75页

作者： kyung-Hun LEE Jung-min LEE Byung-min KIM School of Mechanical Engineering Pu san National University

The powder compaction simulations were performed to demonstrate deformation behavior of particles and estimate the effect of different punch speeds and particle diameters on the relative density of powder by a multi-particle finite element model(MPFEM). Individual particle discretized with a finite element mesh allows for a full description of the contact mechanics. In order to verify the reliability of compaction simulation by MPFEM, the compaction tests of porous aluminum with average particle size of 20 μm and 3 μm were performed at different ram speeds of 5, 15, 30 and 60 mm/min by MTS servo-hydraulic tester. The results show that the slow ram speed is of great advantage for powder densification in low compaction force due to sufficient particle rearrangement and compaction force increases with decrease in average particle size of aluminum.

关键词：粉末压实粉末粒子多孔铝有限元法模拟致密化平均粒径有限元模型

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Effects of elastic-plastic properties of materials on residual indentation impressions in nano-indentation using sharp indenter

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中国有色金属学会会刊：英文版 2012年第S3期22卷 585-595页

作者： Jung-min LEE Chan-Joo LEE kyung-Hun LEE Byung-min KIM Dongnam Regional Division Korea Institute of Industrial Technology Precision Manufacturing Systems Division Pusan National University School of Mechanical Engineering Pusan National University

One of the primary features of nano-indentation technique is that the contact area induced by an indenter is indirectly measured by a relationship between the penetration depth and the known geometry of the ***,this indirect measurement occasionally leads to inaccurate properties of the indented *** objective of this study is to investigate the effects of E/σr and the strain hardening exponents n of materials on the behaviors of pile-up and sink-in in nano-indentation and to predict n values of materials from the residual indentation *** relations between the residual indentation profile and n value of the indented material were identified by dimensional ***,they were numerically formulated using FE analysis of nano-indentation for 140 different combinations of elastic-plastic parameters such as E,σy and *** parameters of hrp/hm,herp/hm,Rr/hm and HO&P/Hreal were introduced as various dimensionless parameters to represent and quantify the residual indentation profile after *** were subsequently characterized as dimensionless functions using n and E/σr ***,the validity of these functions was verified through 3D FE analysis of nano-indentation for Al 6061-T6 and AISI 1010 materials.

关键词： nano-indentation pile-up sink-in strain hardening exponent FE simulation

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miniaturized Twin-legged Robot with an Electromagnetic Oscillatory Actuator

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Journal of Bionic Engineering 2018年第1期15卷 106-113页

作者： Buhyun Shin Youngshik Kim Jamie Paik kyung-min Lee Department of Mechanical Engineering Hanbat National University 125 Dongseodaero Yuseong-gu Daejeon 34158 Republic of Korea The Institute of Mechanical Engineering EPFL BM 4118 Station 17 1015-Lausanne Switzerland School of Mechanical Engineering Yeungnam University 280 Daehak-Ro Gyeongsan Gyeongbuk 38541 Republic of Korea

There have been many studies on the moving mechanism of micro robots, such as stick-slip, inchworm like motion, and impact drive. Novel actuators like lead zirconate titanate （PZT）, Shape Memory Alloy （SMA）, magnetostrictive materials, electromagnetic actuators, electoractive polymers, ultrasonic linear motors, and dielectric elastomers are utilized to realize the moving mechanism. The use of a conventional electromagnetic actuator is unfavorable, because of a few drawbacks, such as generation of stray magnetic fields, hard to miniaturize to the millimeter scale because of 3D integration and a scaling law, and power consumption to maintain a certain position. This research presents a micro robot that uses an electromagnetic actuator customized and developed for micro robot. The electromagnetic actuator is designed from a Brushless Direct Current （BLDC） motor to overcome the drawbacks mentioned above. The developed robot is composed of two electromagnetic actuators. The overall size of the robot is 20 mm × 11 mm× 9 mm （length × height × width） and the weight is 3 g. The developed robot is able to move bidirectionally with a maximum moving speed of 15.76 mm·s︿-1 （0.79 body-length per second）. The optimal conditions of an input signal are calculated theoretically and verified with experiments.

关键词： electromagnetic actuator oscillatory actuator bionic micro robot stick-slip brushless DC motor

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A miniaturized Tadpole Robot Using an Electromagnetic Oscillatory Actuator

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Journal of Bionic Engineering 2015年第1期12卷 29-36页

作者： Bu Hyun Shin kyung-min Lee Seung-Yop Lee Department of Mechanical Engineering Hanbat National University Daejeon 305-719 Korea Convergence Technology Examination Division Korean Intellectual Property Office Daejeon 302-701 Korea Department of Mechanical Engineering Sogang University Seoul 121-742 Korea

In this paper, we propose a miniaturized tadpole-like robot using an electromagnetic oscillatory actuator. The electro- magnetic actuator has a simple structure with a moving-magnet type and the body size is 13 mm （length） × 11 mm （height） ×10 mm （width）. A tail has the thickness of 100 μm and the length of 20 mm which is twice of the body-length （BL）. The tail attached to the oscillatory actuator generates undulatory propulsion for the forward swimming. Moreover, the tadpole robot enables the change of the direction by controlling input signal pattems applied to the oscillatory actuator. Prototypes of the tadpole robot have been manufactured and the thrust force and swimming speed are measured to evaluate the performance of the biomimetic robot in water at various tail-beat frequencies. The maximum thrust force is 42 mN at the tail-beat frequency of 30 Hz with voltage of 3 V, enabling the tadpole robot to swim at the speed of 210 mm·s^-1 （6 BL·s^-1）. The tadpole robot can also change its moving direction with the angular velocity of 21 deg·s^-1 at the half pulse pattem of 30 Hz.

关键词： fish robot biomimetics tadpole robot electromagnetic actuator

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Single-atom Pd catalyst anchored on Zr-based metal-organic polyhedra for Suzuki-Miyaura cross coupling reactions in aqueous media

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Nano Research 2021年第2期14卷 486-492页

作者： Seongsoo Kim Seohyeon Jee kyung min Choi Dong-Sik Shin Division of Chemical and Bioengineering Kangwon National UniversityGangwon-do 24341Republic of Korea Department of Chemical and Biological Engineering Sookmyung Womens University100 Cheongpa-ro 47-gilYongsan-guSeoul 04310Republic of Korea

The challenge for single-atom catalysts in various C-C cross coupling reaction exists in the development of solid supporting *** has been desired tofind a supporting material designed in molecular level to anchor a single-atom catalyst and provide high degree of dispersion and substrate access in aqueous ***,we prepared discrete cages of metal-organic polyhedra anchoring single Pd atom(MOP-BPY(Pd))and successfully performed a Suzuki-Miyaura cross coupling reaction with various substrates in aqueous *** was revealed that each tetrahedral cage of MOP-BPY(Pd)has 4.5 Pd atoms on average and retained its high degree of dispersion up to 3 months in *** coupling efficiencies of the Suzuki-Miyaura cross coupling reaction exhibited more than 90.0%for various substrates we have tested in the aqueous media,which is superior to those of the molecular Pd complex and metal-organic framework(MOF)anchoring Pd ***,MOP-BPY(Pd)was successfully recovered and recycled without performance degradation.

关键词： metal-organic polyhedra Suzuki-Miyaura cross coupling reaction structure characterization aqueous phase reaction high-degree of dispersion

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Recent updates of precision therapy for gastric cancer: Towards optimal tailored management

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World Journal of Gastroenterology 2016年第19期22卷 4638-4650页

作者： moon kyung Joo Jong-Jae Park Hoon Jai Chun Division of Gastroenterology Department of Internal Medicine Korea University College of Medicine Guro Hospital Division of Gastroenterology and Hepatology Department of Internal Medicine Institute of Digestive Disease and Nutrition Korea University College of Medicine

Signaling pathways of gastric carcinogenesis and gastric cancer progression are being avidly studied to seek optimal treatment of gastric cancer. Among them, hepatocyte growth factor (HGF)/c-MET, phosphoinositide 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) and janus kinase 2/signal transducer and activator of transcription 3 (JAK2/STAT3) pathways have been widely investigated. Their aberrant expression or mutation has been significantly associated with advanced stage or poor prognosis of gastric cancer. Recently, aberrations of immune checkpoints including programmed cell death-1/programmed cell death ligand-1 (PD-1/PD-L1) have been suggested as an important step in the formation of a microenvironment favorable for gastric cancer. Accomplishments in basic research have led to the development of novel agents targeting these signaling pathways. However, phase III studies of selective anti-HGF/c-MET antibodies and mTOR inhibitor failed to show significant benefits in terms of overall survival and progression-free survival. Few agents directly targeting STAT3 have been developed. However, this target is still critical issue in terms of chemoresistance, and SH2-containing protein tyrosine phosphatase 1 might be a significant link to effectively inhibit STAT3 activity. Inhibition of PD-1/PD-L1 showed durable efficacy in phase I studies, and phase III evaluation is warranted. Therapeutic strategy to concurrently inhibit multiple tyrosine kinases is a reasonable option, however, lapatinib needs to be further evaluated to identify good responders. Regorafenib has shown promising effectiveness in prolonging progression-free survival in a phase II study. In this topic highlight, we review the biologic roles and outcomes of clinical studies targeting these signaling pathways.

关键词： Gastric cancer Hepatocyte growth factor Mammalian target of rapamycin Signal transducer and activator of transcription 3 Programmed cell death ligand-1

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Proton pump inhibitor: The dual role in gastric cancer

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World Journal of Gastroenterology 2019年第17期25卷 2058-2070页

作者： moon kyung Joo Jong-Jae Park Hoon Jai Chun Division of Gastroenterology Department of Internal MedicineKorea University College of Medicine Guro Hospital Division of Gastroenterology and Hepatology Department of Internal MedicineInstitute of Digestive Disease and NutritionKorea University College of Medicine

Proton pump inhibitors(PPIs) are one of the most frequently used medications for upper gastrointestinal diseases. However, a number of physicians have raised concern about the serious side effects of long-term use of PPIs, including the development of gastric cancer. Recent epidemiological studies have reported a significant association between long-term PPI intake and the risk of gastric cancer, even after successful Helicobacter pylori eradication. However, the effects of PPIs on the development of pre-malignant conditions such as atrophic gastritis or intestinal metaplasia are not fully known, suggesting the need for comprehensive and confirmative studies are needed in the future. Meanwhile,several experimental studies have demonstrated the effects of PPIs in reducing chemoresistance in gastric cancer cells by modulating the acidic microenvironment, cancer stemness and signal transducer and activator of transcription 3(STAT3) signaling pathway. The inhibitory effects of PPIs on STAT3 activity may overcome drug resistance and enhance the efficacy of conventional or targeted chemotherapeutic agents. Taken together, PPIs may"play dual role" in gastric carcinogenesis and treatment of gastric cancer.

关键词： Proton pump inhibitor Gastric cancer Drug resistance Signal transducer and activator of transcription 3

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