检索结果-南通市图书馆

Neuroprotective effects of tadalafil on gerbil dopaminergic neurons following cerebral ischemia

Neural Regeneration Research 2013年第8期8卷 693-701页

作者： Kwang Taek Kim kyung jin chung Han Sae Lee Il Gyu Ko Chang Ju Kim Yong Gil Na Khae Hawn Kim Department of Urology Gachon University Gil Medical CenterGachon University Department of Physiology College of MedicineKyung Hee University Department of Urology Chungnam National University HospitalChungnam National University School of Medicine

Impairment of dopamine function, which is known to have major effects on behaviors and cognition, is one of the main problems associated with cerebral ischemia. Tadalafil, a long-acting phosphodiesterase type-5 inhibitor, is known to ameliorate neurologic impairment induced by brain injury, but not in dopaminergic regions. We investigated the neuroprotective effects of treatment with tadalafil on cyclic guanosine monophosphate level and dopamine function following cerebral ischemia. Forty adult Mongolian gerbils were randomly and evenly divided into five groups （n = 8 in each group）： Sham-operation group, cerebral ischemia-induced and 0, 0.1, 1, and 10 mg/kg tadalafil-treated groups, respectively. Tadalafil dissolved in distilled water was administered orally for 7 consecutive days, starting 1 day after surgery. Cyclic guanosine monophosphate assay and immunohistochemistry were performed for thyrosine hydroxylase expression and western blot analysis for dopamine D2 receptor expression. A decrease in cyclic guanosine monophosphate level following cerebral ischemia was found with an increase in thyrosine hydroxylase activity and a decrease in dopamine D2 receptor expression in the striatum and substantia nigra region. However, treatment with tadalafil increased cyclic guanosine monophosphate expression, suppressed thyrosine hydroxylase expression and increased dopamine 92 receptor expression in the striatum and substantia nigra region in a dose-dependent manner. Tadalafil might ameliorate cerebral ischemia-induced dopaminergic neuron injury. Therefore, tadalafil has the potential as a new neuroprotective treatment strategy for cerebral ischemic injury.

关键词： neural regeneration brain injury cerebral ischemia Tadalafil phosphodiesterase type-5 inhibitor dopamine dopamine D2 receptor cyclic guanosine monophosphate grants-supported paper photographs-containing paper neuroregneration

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Effects of Ginkgo biloba extracts with mirodenafil on the relaxation of corpus cavernosal smooth muscle and the potassium channel activity of corporal smooth muscle cells

引用

Asian Journal of Andrology 2011年第5期13卷 742-746页

作者： Jung Jun Kim Deok Hyun Han Soo Hyun Lim Tae Hun Kim Mee Ree Chae kyung jin chung Sung Chul Kam Ju-Hong Jeon Jong Kwan Parks Sung Won Lee Department of Urology Samsung Medical Center Sungkyunkwan University School of Medicine Seou1135-710 Korea Department of Urology Gachon University Gil Hospital Incheon 405-760 Korea Department of Urology Gyeengsang National University College of Medicine Gyeongsangnam-do 660-702 Korea Department of Physiology and Biophysics Seeul National University College of Medicine Seeul 110-799 Korea Department of Urology Medical School Chonbuk National University and Institute for Medical Sciences Chonbuk National University and Research Institute and Clinical Trial Center of Medical Device of Chonbuk National University Hospital Jeonju-si 561-712 Korea

In this study, we investigated the effects of a combination of Ginkgo biloba extracts （GBE） and phosphodiesterase type 5 （PDE-5） inhibitors on the muscular tone of the corpus cavernosum and potassium channel activity of corporal smooth muscle cells. Strips of corpus cavernosum from male New Zealand white rabbits were mounted in organ baths for isometric tension studies. After contraction with 1 × 10^-5 mol I^-1 norepinephrine, GBE （0.01-1 mg ml^-1） and mirodenafil （0.01-100 nmol I^-1） were added together into the organ bath. In electrophysiological studies, whole-cell currents were recorded by the conventional patch-clamp technique in cultured smooth muscle cells of the human corpus cavernosum. The corpus cavemosum was relaxed in response to GBE in a dose-dependent manner （from 0.64%±8.35% at 0.01 mg ml^-1 to 52.28%±11.42% at 1 mg ml^-1）. After pre-treatment with 0.03 mg ml^-1 of GBE, the relaxant effects of mirodenafil were increased at all concentrations, After tetraethylammonium （TEA）（1 mmol I^-1） administration, the increased effects were inhibited （P〈0.01）. Extracellular administration of GBE increased the whole-cell K^＋ outward currents in a dose-dependent fashion. The increase of the outward current was inhibited by I mmol 1-1 TEA. These results suggest that GBE could increase the relaxant potency of mirodenafil even at a minimally effective dose. The K＋ flow through potassium channels might be one of the mechanisms involved in this synergistic relaxation.

关键词： calcium-activated potassium channels erectile dysfunction Ginkgo biloba phosphodiesterase inhibitors smooth muscles

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Delayed inflammatory response evoked in nasal alloplastic implants after COVID-19 vaccination: A case report

引用

World Journal of Clinical Cases 2022年第23期10卷 8298-8303页

作者： Min-Gi Seo Eun kyung Choi Kyu jin chung Department of Plastic and Reconstructive Surgery College of MedicineYeungnam UniversityDaegu 42415South Korea Department of Anesthesiology and Pain Medicine College of MedicineYeungnam UniversityDaegu 42415South Korea

BACKGROUND Delayed inflammatory reactions(DIRs)in alloplast rhinoplasty are a rare complication that may occur several months to years after *** exact causes and mechanisms are unclear,but several triggering factors,including infections,trauma,dental procedures,and vaccination,have been *** SUMMARY A 39-year-old male patient who had undergone augmentation rhinoplasty 8 years ago had DIRs after the administration of the first dose of the mRNA Pfizer coronavirus disease 2019(COVID-19)*** suddenly had tender,erythematous swelling on his face 6 d after *** there was no improvement in the patient’s condition after the conservative treatment,surgical removal of an alloplastic nasal implant was *** after the surgery,the DIRs and accompanying symptoms ameliorated rapidly.A histological study conducted during surgery was fibrosis and small fragments of the hyaline *** The correlation between DIRs and COVID-19 vaccination has not been reported yet and the exact mechanism is *** the uncontrolled inflammatory reactions on the nose leave serious sequelae,surgeons should be conscious of the correlation between COVID-19 vaccines and DIRs associated with nasal alloplastic *** further histological or microbiological studies should be performed to determine the cause of DIRs.

关键词： Delayed inflammatory reactions Alloplast rhinoplasty Silicone COVID-19 Vaccination Case report

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acoustic Nonlinearity of a Laser-Generated Surface Wave in a Plastically Deformed Aluminum Alloy

引用

Chinese Physics Letters 2012年第12期29卷 39-43页

作者： KIM chung-Seok JHANG kyung-Young Metallurgy and Materials Engineering Chosun UniversitySeosuk-dongGwangju501-759South Korea Mechanical Engineering Hanyang UniversityHangdang-dongSeongdong-guSeoul133-791South Korea

The acoustic nonlinearity of surface waves is studied to evaluate plastic deformation in aluminum alloys.A narrow-band surface wave is successfully generated by a pulsed Nd-YAG laser system consisting of a beam expander and a slit *** degrees of tensile deformation are induced by interrupting the tensile tests so as to obtain aluminum specimens with different degrees of plastic *** normalized acoustic nonlinearity increases as a function of tensile *** experimental results show that the acoustic nonlinearity of a laser-generated surface wave has a good correlation with the level of tensile deformation and has a potential to evaluate microdamage induced by dislocation microplasticity.

关键词： deformation nonlinearity Deform

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Fatigue-Induced Micro-damage Characterization of Austenitic Stainless Steel 316 Using Innovative Nonlinear Acoustics

引用

Chinese Physics Letters 2012年第6期29卷 82-85页

作者： chung-Seok KIM kyung-Young JHANG Automotive Engineering Hanyang UniversityHangdang-dongSeongdong-guSeoul133-791South Korea Mechanical Engineering Hanyang UniversityHangdang-dongSeongdong-guSeoul133-791South Korea

We present innovative nonlinear acoustics for characterizing fatigue-induced micro-damage of austenitic stainless steel 316 subjected to high-cycle *** fatigue-driven deformations are accumulated at several positions near the middle of hourglass-shaped specimens.A bell-shaped curve of acoustic nonlinearity as a function of position is observed,and the variation in acoustic nonlinearity is attributed to the evolution of a lattice defect (dislocation) and stress-induced martensite based on transmission electron microscopy (TEM) *** oblique incidence technique using a longitudinal waveform is a potentially viable method for characterizing the high-cycle fatigue deformation of austenitic stainless steel 316 alloys.

关键词： fatigue steel martensite

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Comparison of postoperative corneal changes between dry eye and non-dry eye in a murine cataract surgery model

引用

International Journal of Ophthalmology(English edition) 2016年第2期9卷 218-224页

作者： jin Woo Kwon Yeon Woong chung jin A Choi Tae Yoon La Dong Hyun Jee Yang kyung Cho Department of Ophthalmology St.Vincent's HospitalCollege of Medicine The Catholic University of Korea

AIM： To compare the effects of the surgical insult of cataract surgery on corneal inflammatory infiltration, neovascularization （NV） and lymphangiogenesis （LY） between the dry eye and non-dry eye in murine cataract surgery models.METHODS： We established two groups of animals, one with normal eyes （non-dry eye） and the second with induced dry eyes. In both groups, we used surgical insults to mimic human cataract surgery, which consisted of lens extraction, corneal incision and suture. After harvesting of corneas on the 9th postoperative day and immunohistochemical staining, we compared NV, LY and CD11b＋ cell infiltration in the corneas.RESULTS： Dry eye group had significantly more inflammatory infiltration （21.75%±7.17% r/s 3.65%±1.49%; P=0.049）. The dry eye group showed significantly more NV （48.21% ±4.02% ys 26.24% ±6.01% ; P =0.016） and greater levels of LY （9.27%±0.48% ys 4.84%±1.15%; P= 0.007）. In corneas on which no surgery was performed, there was no induction of NV in both the dry and non- dry group, but dry eye group demonstrated more CD11b＋ cells infiltration than the non-dry eye group （0.360%± 0.160% vs 0.023%±0.006%; P=0.068）. Dry eye group showed more NV than non-dry eye group in both topical PBS application and subconjunctival PBS injection （P= 0.020 and 0.000, respectively）.

关键词： angiogenesis cataract surgery dry eyedisease inflammation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Rapidly growing primary anal canal lymphoma:a case report and literature review

引用

Gastroenterology Report 2023年第1期11卷 582-584页

作者： Yu kyung chung Su Bum Park Department of Internal Medicine Pusan National University School of Medicine and Research Institute for Convergence of Biomedical Science and TechnologyPusan National University Yangsan HospitalYangsanRepublic of Korea

Introduction Anal cancer is a rare cancer accounting for2%of all gastrointestinal tract malignancies[1].Among anal cancers,squamous cell cancer(SCC)is the most common and lymphoma is one of the least *** gastrointestinal tract is the most common site for extranodal non-Hodgkin’s lymphoma(NHL),and diffuse large B-cell lymphoma(DLBCL)is the most common histologic ***,primary colorectal lymphoma accounts for only 0.3%of all large intestinal malignancies and3%of all gastrointestinal lymphomas[2].Anal canal SCC and lymphomas are treated differently;thus,accurate diagnosis is crucial.

关键词： lymphoma gastrointestinal diagnosis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Role of oxygen free radicals in patients with acute pancreatitis

引用

World Journal of Gastroenterology 2003年第10期9卷 2266-2269页

作者： Byung Kyu Park Jae Bock chung jin Heon Lee Jeong Hun Suh Seung Woo Park Si Young Song Hyeyoung Kim kyung Hwan Kim jin kyung Kang Department of Internal Medicine Institute of GastroenterologyCollege of MedicineYonsei UniversitySeoulKorea Department of Pharmacology College of MedicineYonsei UniversitySeoulKorea Departmentof Internal Medicine Institute of GastroenterologyCollege of MedicineYonsei UniversitySeoulKorea

AIM:The generation of oxygen free radicals has been implicated in the pathogenesis of experimental pancreatitis. The aim of this study was to determine the role of oxygen free radicals in patients with acute pancreatitis. METHODS:The plasma levels of C-reactive protein(CRP), lipid peroxide(LPO),myeloperoxidase(MPO)and superoxide dismutase(SOD)were measured in 13 patients with acute pancreatitis and 14 healthy volunteers. RESULTS:Among the patients with acute pancreatitis,there were higher plasma levels of LPO and MPO and lower SOD activity in patients with severe pancreatitis than in those with mild ***,there was no significant difference in the serum marker of oxidative stress no matter what the etiology *** LPO level was especially correlated with the concentration of serum CRP and CT severity index. CONCLUSION:The oxygen free radicals may be closely associated with inflammatory process and the severity of acute ***,the concentration of plasma LPO is a meaningful index for determining the severity of the disease.

关键词： Oxidative Stress Severity of Illness Index Acute Disease Adult Aged Female Humans Lipid Peroxides Male Middle Aged Pancreatitis Peroxidase Predictive Value of Tests Prognosis Reactive Oxygen Species Superoxide Dismutase

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Alpha-fetoprotein-targeted reporter gene expression imaging in hepatocellular carcinoma

引用

World Journal of Gastroenterology 2016年第27期22卷 6127-6134页

作者： Kwang Il Kim Hye kyung chung Ju Hui Park Yong jin Lee Joo Hyun Kang Molecular Imaging Research Center Korea Institute of Radiological and Medical Sciences Korea Drug Development Platform using Radio-Isotope Korea Institute of Radiological and Medical Sciences

Hepatocellular carcinoma (HCC) is one of the most common cancers in Eastern Asia, and its incidence is increasing globally. Numerous experimental models have been developed to better our understanding of the pathogenic mechanism of HCC and to evaluate novel therapeutic approaches. Molecular imaging is a convenient and up-to-date biomedical tool that enables the visualization, characterization and quantification of biologic processes in a living subject. Molecular imaging based on reporter gene expression, in particular, can elucidate tumor-specific events or processes by acquiring images of a reporter gene’s expression driven by tumor-specific enhancers/promoters. In this review, we discuss the advantages and disadvantages of various experimental HCC mouse models and we present in vivo images of tumor-specific reporter gene expression driven by an alpha-fetoprotein (AFP) enhancer/promoter system in a mouse model of HCC. The current mouse models of HCC development are established by xenograft, carcinogen induction and genetic engineering, representing the spectrum of tumor-inducing factors and tumor locations. The imaging analysis approach of reporter genes driven by AFP enhancer/promoter is presented for these different HCC mouse models. Such molecular imaging can provide longitudinal information about carcinogenesis and tumor progression. We expect that clinical application of AFP-targeted reporter gene expression imaging systems will be useful for the detection of AFP-expressing HCC tumors and screening of increased/decreased AFP levels due to disease or drug treatment.

关键词： Alpha-fetoprotein Hepatocellular carcinoma Molecular imaging Reporter gene Tumor-specific enhancer/promoter

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A study of influence of gravity on bulk behaviour of particulate solid

引用

Particuology 2008年第6期6卷 467-474页

作者： Yun-Chi chung jin Yeam Ooi Department of Civil and Environmental Engineering Nanya Institute of Technology Institute for Infrastructure & Environment School of Engineering & Electronics University of Edinburgh

This paper examines the influence of gravity on the bulk responses of a granular solid. The loading scenarios in this study include confined compression, rod penetration into a granular medium and discharging through an orifice. Similar loading and flow conditions are likely to be encountered in the stress and deformation regimes that regoliths are subjected to in extraterrestrial exploration activities including in situ resource utilisation processes. Both spherical and non-spherical particles were studied using the discrete element method （DEM）. Whilst DEM is increasingly used to model granular solids, careful validations of the simulation outcomes are rather rare. Thus in addition to exploring the effect of gravity, this paper also compares DEM simulations with experiments under terrestrial condition to verify whether DEM can produce satisfactory predictions. The terrestrial experiments were conducted with great care and simulated closely using DEM. The key mechanical and geometrical properties for the particles were measured in laboratory tests for use in the DEM simulations. A series of DEM computations were then performed under reduced gravity to simulate these experiments under extraterrestrial environment. It was found that gravity has no noticeable effect on the force transmission in the confined compression case; the loading gradient in the rod penetration is linearly proportional to the gravity; the mass flow rate in silo discharge is proportional to square root of the gravity and the angle of repose increases with reducing gravity. These findings are in agreement with expectation and existing scientific evidence.

关键词： Extraterrestrial Particulate assembly Confined compression Rod penetration Silo discharge Discrete element method Gravity effect

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：