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Identification of differentially expressed miRNAs associated with chronic kidney disease-mineral bone disorder

Frontiers of Medicine 2017年第3期11卷 378-385页

作者： kyung im kim Sohyun Jeong Nayoung Han Jung Mi Oh Kook-Hwan Oh In-Wha kim College of Pharmacy Korea University Sejong 30019 Republic of Korea College of Pharmacy and Research Institute of Pharmaceutical Sciences -Seoul National University Seoui 08826 Republic of Korea Divisionof-Nephrology Department of Internai Medicine Seoul National University Hospital Seoul 03080 Republic of Korea

The purpose of this study is to characterize a meta-signature of differentially expressed mRNA in chronic kidney disease （CKD） to predict putative microRNA （miRNA） in CKD-mineral bone disorder （CKD- MBD） and confirm the changes in these genes and miRNA expression under uremic conditions by using a cell culture system. PubMed searches using MeSH terms and keywords related to CKD, uremia, and mRNA arrays were conducted. Through a computational analysis, a meta-signature that characterizes the significant intersection of differentially expressed mRNA and expected miRNAs associated with CKD-MBD was determined. Additionally, changes in gene and miRNA expressions under uremic conditions were confirmed with human Saos-2 osteoblast-like cells. A statistically significant mRNA meta-signature of upregulated and downregulated mRNA levels was identified. Furthermore, miRNA expression profiles were inferred, and computational anaIyses were performed with the imputed mieroRNA regulation based on weighted ranked expression and putative microRNA targets （imRE） method to identify miRNAs associated with CKD occurrence. TLR4 and miR-146b levels were significantly associated with CKD-MBD. TLR4 levels were significantly downregulated, whereas pri- miR-146b and miR-146b were upregulated in the presence of uremic toxins in human Saos-2 osteoblast-like cells. Differentially expressed miRNAs associated with CKD-MBD were identified through a computational analysis, and changes in gene and miRNA expressions were confirmed with an in vitro cell culture system.

关键词： chronic kidney disease microRNA mineral bone disorder uremia

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Predicting the Rainfall-Triggered Landslides in a Forested Mountain Region Using TRIGRS Model

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Journal of Mountain Science 2010年第1期7卷 83-91页

作者： Dongyeob kim Sangjun im Sang Ho LEE Youngjoo HONG kyung-Sub CHA Dept. of Forest Sciences Seoul National University Dept. of Forest Sciences Research Institute for Agriculture & life sciences Seoul National University Civil Engineering Team DaeWoo E&C Suwon 440-210 Korea

Landslides are natural disasters which can pose a serious threat to human and property in many areas around the world. The Transient Rainfall Infiltration and Grid-based Regional Slope-stability (TRIGRS) model was used to investigate the rainfall-induced shallow landslides in a forested mountain region, Korea. Various input data for TRIGRS model include time-varying rainfall, topographic characteristics, soil depth, material strength, and hydraulic properties. A series of calculations were conducted in determining the slope stability over the Jangheung region in Korea during the storm occurred on August 6, 1998. The results show that TRIGRS model captured about 64.1% of landslides that were extracted from the IKONOS2 imageries. The model demonstrated how the factor of safety changed with time during a storm considering both the transient and spatial responses of pore water pressure in its slope stability calculation.

关键词： TRIGRS landslides IKONOS2 safetyfactor slope stability Korea

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Two-Terminal Lithium-Mediated Artificial Synapses with Enhanced Weight Modulation for Feasible Hardware Neural Networks

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Nano-Micro Letters 2023年第5期15卷 236-253页

作者： Ji Hyun Baek kyung Ju Kwak Seung Ju kim Jaehyun kim Jae Young kim In Hyuk im Sunyoung Lee Kisuk Kang Ho Won Jang Department of Materials Science and Engineering Research Institute of Advanced MaterialsSeoul National UniversitySeoul 08826Republic of Korea Advanced Institute of Convergence Technology Seoul National UniversitySuwon 16229Korea

Recently,artificial synapses involving an electrochemical reaction of Li-ion have been attributed to have remarkable synaptic ***-terminal synaptic transistors utilizing Li-ion intercalation exhibits reliable synaptic characteristics by exploiting the advantage of nondistributed weight updates owing to stable ion ***,the three-terminal configurations with large and complex structures impede the crossbar array implementation required for hardware neuromorphic ***,achieving adequate synaptic performances through effective Li-ion intercalation in vertical two-terminal synaptic devices for array integration remains ***,two-terminal Au/LixCoO_(2)/Pt artificial synapses are proposed with the potential for practical implementation of hardware neural *** Au/LixCoO_(2)/Pt devices demonstrated extraordinary neuromorphic behaviors based on a progressive dearth of Li in LixCoO_(2)*** intercalation and deintercalation of Li-ion inside the films are precisely controlled over the weight control spike,resulting in improved weight control *** types of synaptic plasticity were imitated and assessed in terms of key factors such as nonlinearity,symmetricity,and dynamic ***,the LixCoO_(2)-based neuromorphic system outperformed three-terminal synaptic transistors in simulations of convolutional neural networks and multilayer perceptrons due to the high linearity and low programming *** impressive performances suggest the vertical two-terminal Au/LixCoO_(2)/Pt artificial synapses as promising candidates for hardware neural networks.

关键词： Artificial synapse Neuromorphic Li-based Two-terminal Synaptic plasticity

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MICROMECHANICS OF ROUGH SURFACE ADHESION:A HOMOGENIZED PROJECTION METHOD

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Acta Mechanica Solida Sinica 2009年第5期22卷 377-390页

作者： kyung-Suk kim Division of Engineering Brown UniversityProvidenceRI 02912USA

A quasistatic homogenized projection is made to characterize the effective cohesive zone behavior for rough-surface adhesion. In the context of the homogenized projection, the traction versus separation relation for the homogenized cohesive zone （HCZ） of a rough interface can be highly oscillatory due to instabilities during microscopic adhesion and decohesion processes. The instabilities are found to occur not only individually but also collectively among the adhesive micro-asperity contacts, leading to extensive energy dissipation. Based on the behaviors of the HCZ relations, a framework for describing instability-induced energy dissipation in rough-surface adhesion is proposed to elucidate the effect of roughness on apparent interface adhesion. Two non- dimensional parameters, α related to roughness morphology and n related to flaw distribution, are identified to be most crucial for controlling the energy dissipation. For an interface with a shallow roughness and a strong intrinsic adhesive strength, the interface adhesion can be stronger if we make it rougher （reducing α） or lower its flaw density （increasing n）. The HCZ projection method can be potentially extended and employed to bridge the apparent adhesion from intrinsic adhesion properties for engineering surfaces with multi-scale shallow roughness.

关键词： homogenized cohesive zone interface adhesion roughness effect instability energy dissipation

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In situ synthesis of chemically bonded NaTi2（PO4）3/rGO 2D nanocomposite for high-rate sodium-ion batteries

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Nano Research 2016年第6期9卷 1844-1855页

作者： Ha-kyung Roh Hyun-kyung kim Myeong-Seong kim Dong-Hyun kim kyung Yoon Chung Kwang Chul Roh Kwang-Bum kim Department of Material Science & Engineering Yonsei University 50 Yonsei-ro Seodaemun-gu Seou103722 Republic of Korea Department of Materials Science and Metallurgy University of Cambridge 27 Charles Babbage Road Cambridge CB30FS UK Center for Energy Convergence Korea Institute of Science and Technology 5 Hwarang-ro 14-gil Seongbuk-gu Seou102792 Republic of Korea Energy & Environmental Division Korea Institute of Ceramic Engineering & Technology 101 Soho-ro Jinju-si Gyeongsangnam-do 52851 Republic of Korea

A phase-pure NaTi2（PO4）3/reduced graphene oxide （rGO） nanocomposite was prepared using a microwave-assisted one-pot method and subsequent heat treatment. The well-crystallized NaTi2（PO4）3 nanoparticles （30-40 nm） were uniformly precipitated on rGO templates through Ti-O-C bonds. The chemical interactions between the NaTi2（PO4）3 nanoparticles and rGO could immobilize the NaTi2（PO4）3 nanoparticles on the rGO sheets, which might be responsible for the excellent electrochemical performance of the nanocomposite. The NaTi2（PO4）B/rGO nanocomposite exhibited a specific capacity of 128.6 mA-h.g-1 approaching the theoretical value at a 0.1 C-rate with an excellent rate capability （72.9% capacity retention at 50 C-rate） and cycling performance （only 4.5% capacity loss after 1,000 cycles at a high rate of 10 C）. These properties were maintained even when the electrodes were prepared without the use of an additional conducting agent. The excellent sodium storage properties of the NaTi2（PO4）B/rGO nanocomposite could be attributed to the nano-sized NaTi2（PO4）3 particles, which significantly reduced the transport lengths for Na＋ ions, and an intimate contact between the NaTi2（PO4）3 particles and rGO due to chemical bonding.

关键词： NaTi2(PO4)dreducedgraphene oxide (rGO)nanocomposite chemical bonding energy-efficiency in situ synthesis high-rate sodium-ion batteries

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Efficacy of Saam acupuncture treatment on improvement of immune cell numbers in cancer patients:a pilot study

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Journal of Traditional Chinese Medicine 2014年第5期34卷 550-554页

作者： Dae-Joon kim Seong-Hoon Park Jung-Chul Seo kyung Soon kim Ki Cheul Sohn im Hee Shin Hun Mo Ryoo Department of Internal Medicine Oriental Medical HospitalDaegu Haany UniversityDaegu 730-090Korea Department of Research Comprehensive and Integrative Medicine InstituteDaegu 705-030Korea Department of Preventive Medicine Hospital of Catholic University of DaeguDaegu 705-718Korea Department of Medical Statistics School of MedicineCatholic University of DaeguDaegu 705-718Korea Department of Internal Medicine School of MedicineCatholic University of DaeguDaegu 705-718Korea

OBJECTIVE: To collect preliminary data on the effects of Saam acupuncture with regard to the immunity in cancer ***: Ten cancer patients were analyzed for improvements in immunity. Acupuncture was applied at the 5 acupuncture points, Jingqu(LU 8), Zutonggu(BL 66), Yanggu(SI 5), Yangchi(TE 4), and Zhongwan(CV 12) for 2 weeks with 4 sessions. We assessed the effect of Korean Saam acupuncture on the immune system in cancer patients by measuring particular blood cell subsets, including CD3 +,CD4+, CD8+, CD19+, and CD56+ cells, as well as total white blood cell count, absolute neutrophil count, and fatigue score. The measurement was performed before and after acupuncture and at a 2-week ***: There was a statistically significant increase in the number of CD3+(P=0.023) and CD8+ cells(Pimprove the immune system by increasing the counts of a few immune cells and relieve fatigue in cancer patients by decreasing FSS scores. Although this was a non-controlled study, it constitutes preliminary research investigating the potential effects of Saam acupuncture in increasing the counts of several immune cells in cancer patients.

关键词： Acupuncture Leukocyte count Neutro-phils Fatigue severity scale Pilot projects

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Silicon nanowire ratioed inverters on bendable substrates

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Nano Research 2018年第5期11卷 2586-2591页

作者： Jeongje Moon Yoonjoong kim Doohyeok Lim Kyeungmin im Sangsig kim Department of Electrical Engineering Korea University 145 Anam-ro Seongbuk-gu Seoul 02841 Republic of Korea LED PKG Development Group Samsung Electronics Co. Ltd. 1 Samsung-ro Yongin-si Gyeonggi-do 17113 Republic of Korea

In this study, we demonstrate the performance of silicon nanowire （SiNW） n-metal oxide semiconductor （MOS） and p-MOS ratioed inverters that are fabricated on bendable substrates. The electrical characteristics of the fabricated devices can be controlled by adjusting the load voltage. The logic swings of the n- and p-MOS ratioed inverters at a low supply voltage of 1V are 80% and 96%, respectively. The output voltage level of the p-MOS ratioed inverter is close to rail-to-rail operation. The device also exhibits stable characteristics with good fatigue properties. Our bendable SiNW ratioed inverters show promise as a candidate building block for future bendable electronics.

关键词： silicon nanowire ratioed inverter n-metal oxide semicon-ductor (MOS) inverter p-MOS inverter bendable substrate

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Maximizing biomass utilization: An integrated strategy for coproducing multiple chemicals

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Journal of Energy Chemistry 2025年第1期100卷 180-191页

作者： Byeongchan Ahn Sua Jo Jonggeol Na J.Jay Liu Young-Ju kim Wangyun Won Department of Chemical and Biological Engineering Korea University Department of Chemical Engineering (Integrated process) Kyung Hee University Department of Chemical Engineering and Materials Science Ewha Womans University Department of Chemical Engineering Pukyong National University Resources Engineering Plant Research Department Korea Institute of Geoscience and Mineral Resources

Lignocellulosic biomass is one of the viable solutions to alleviate the global warming. However, the limited utilization of biomass majorly focused on cellulose and hemicellulose restricts the economic and environmental feasibilities. To cope with this issue, we proposed an integrated process of co-producing 1,6-hexanediol（1,6-HDO） with tetrahydrofuran and adipic acid from biomass, referred to as Strategy A. To compare the impacts of lignin upgrading and feedstock, Strategy B, which co-produces tetrahydrofuran alone, and Strategy C, which is the traditional route to produce 1,6-HDO from fossil fuels, were used. Heat networks are also designed to reduce operating costs and indirect carbon emissions due to energy consumption, saving 87% and 83% of the heat and cooling requirements, respectively, in Strategy A. The market competitiveness of Strategy A was evaluated by determining the minimum selling price through techno-economic analysis, and sustainability was thoroughly investigated by quantifying the environmental impacts through both midpoint and endpoint life-cycle assessments（LCAs）.Strategy A was found to be the most favorable both economically（USRDSCHARDOLLAR3,402/ton） and environmentally（-26.9 kg CO2eq.）. This indicates that lignin valorization is not only economically but also environmentally preferred. Finally, changes in economic and environmental feasibilities depending on economic, process, and environmental parameters were investigated using sensitivity and uncertainty analyses. The results of these analyses provide valuable insight into bio-based chemical production.

关键词： Biorefinery Carbon mitigation Climate change Global warming Lignin utilization Bioeconomy

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Transmural penetration of sigmoid colon and rectum by retained surgical sponge after hysterectomy

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World Journal of Gastroenterology 2016年第10期22卷 3052-3055页

作者： Woo Young Shin Chan Hyuk im Sun Keun Choi Yun-Mee Choe kyung Rae kim Department of Surgery Inha University HospitalInha University College of Medicine

Gossypiboma is a surgical sponge that is retained in the body after the operation. A 39-year-old female presented with vague lower abdominal pain, fever, and rectal discharge 15 mo after hysterectomy. The sponge remaining in the abdomen had no radiopaque marker. Therefore a series of radiographic evaluations was fruitless. The surgical sponge was found in the rectosigmoid colon on colonoscopy. The sponge penetrated the sigmoid colon and rectum transmurally, forming an opening on both sides. The patient underwent low anterior resection and was discharged without postoperative complications.

关键词： Gossypiboma Textiloma Retained foreign object Surgical sponge Radiopaque marker

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Role of ERK/MAPK signalling pathway in anti-inflammatory effects of Ecklonia cava in activated human mast cell line-1 cells

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Asian Pacific Journal of Tropical Medicine 2014年第9期7卷 703-708页

作者： Hye kyung kim Department of Food and Biotechnology Hanseo UniversitySeosan 356-706Republic of Korea

Objective:The anti-inflammatory effects of Ecklonia cava(EC)and its mechanism of action were examined in phorbol-12 myristate 13-acetate(30 nmol/L)and A23187(1μmol/L)(PMACI)stimulated human mast cell line-1 ***:Nitric oxide content,inducible nitric oxide synthase and cyclooxygenase-2 protein expression,pro-inflammatory cytokines including IL-1β,TNF-α,and IL-6 mRNA and protein expressions were *** addition,extracellular regulated protein kinases/mitogen-activated protein kinase(ERK/MAPK)activation was ***:EC dose-dependently suppressed inducible nitric oxide synthase and cyclooxygenase-2 protein expression and subsequently it reduces nitric oxide content in PMACI stimulated human mast cell line-1 *** dose-dependently inhibited the mRNA as well as protein expression of TNF-α,IL—1β,and TL-6 in the PMACI stimulated human mast cell line-1 cells without any cytotoxic ***,EC significantly inhibited PMACI induced phosphorylation of ERK1/2 in a dose-dependent manner without affecting the total protein ***:EC exert its anti-inflammatory actions via inhibition of ERK/MAPK signalling pathway,suggesting that EC is a potent and efficacious anti-inflammatory agent for mast cellmediated inflammatory diseases.

关键词： Ecklonia cava Pro-inflammatory cytokine Inducible nitric oxide synthase Cyclooxygenase-2 Mitogen-activated protein kinase

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