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花拉阁,新加坡

城市建筑 2010年第10期 118-121页

作者： Edward Calver Bianca Cheung Dominiki Dadatsi Loreto Flores Helen Lee hee Seung Lee Jeonghoon Lee Feng Lin Jee Seon lim Ludovico Lombardi Clara Martins Kutbuddin Nadiadi Hoda Nobakhti Annarita Papeschi Line Rahbek Hala Sheikh Zhong Tian evil Yazici Effie Kuan Sandra Riess Eleni Pavlidou Federico Dunkelberg Evan Erlebacher Gorka Blas Bozana Komljenovic Sophie Le Bienvenu Kelly Lee Jose M.Monfa Selahattin Tuysuz TaKang Hsu Emily Chang Judith Wahle Zaha Hadid Architects Zaha Hadid with Patrik Schumacher GROSSMAX Edinburgh Engineering Acviron/Singapore

建筑基址花拉阁基址地处新加坡住宅区的关键地段,毗邻荷兰路(Holland Road)及未来规划中的MRT车站,与交通干道花拉路(Farrer Rd.)直接连通,基址周边无高层建筑。如此优越的地理及交通条件使该项目广受全城民众的关注。

关键词：基址规划长远计划新加坡直接连通花拉交通干道高层建筑

Clinical application of traditional herbal medicine in five countries and regions: Japan;South Korea;China's Mainland;Hong Kong, China;Taiwan, China

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Journal of Traditional Chinese Medical Sciences 2015年第3期2卷 140-149页

作者： liming Chen Yanling Fu Lin Zhang Sijia Zhao Qing Feng Yihua Cheng Tosha Yanai Daji Xu Mingyu Luo Sang Woo An Woong Seok Lee Seong Hoon Cho Byung Wook Lee Beijing University of Chinese Medicine Beijing 100029China Dongzhimen Hospital Beijing University of Chinese MedicineBeijing 100029China School of Chinese Medicine Hong Kong Baptist UniversityHong Kong SAR 999077China Chia-Ho Chinese Medicine Clinic Taipei 11271TaiwanROC Korean Institute of Oriental Medicine SeoulRepublic of Korea College of Oriental Medicine Kyung Hee UniversitySeoulRepublic of Korea School of Korean Medicine Pusan National UniversityYangsanRepublic of Korea

Objective:To study the characteristics of the clinical application of traditional herbal medicine in five countries and regions where traditional medicine(TM)is widely used:Japan;South Korea;China's Mainland;Hong Kong,China;Taiwan,*** to analyze,from multiple angles,the variations in the methods of TM used in each countries and ***:Fifty commonly used traditional herbs(TOP50)from classical formulae were selected,and descriptive statistics,correlation analyses,and Friedman test were used to compare methods of clinical application and dosages in the countries and regions of interest based on a retrospective review of randomly-selected medical ***:There were significant differences in sequencing TOP50 among the five countries and regions(P<.01).The adherence to the classical formulae,from strong to weak was Japan;China's Mainland;Taiwan,China;Hong Kong,China;South *** were also significant differences in TOP50 dosing regimens(P<.01).Overall dosages of TOP50 from high to low were:China's Mainland;Hong Kong,China;Taiwan,China;South Korea;***,there were significant differences in the dosage intervals(P<.01),with dosage intervals from maximum to minimum as follows:China's Mainland;Taiwan,China;Hong Kong,China;South Korea;***:The clinical dosages of traditional herbal medicine used in the China's Mainland are relatively large compared with those prescribed in the other four countries and regions,and the range of dosages in China's Mainland is more *** the other hand,clinical dosages of TOP50 are the lowest in Japan,where the dosage range is also the narrowest,supporting the idea that Doctors of Kampo medicine are highly cautious and are likely to adhere strictly to classical formulae,while Hong Kong,China and Taiwan,China are in the *** dosage of TOP50 in South Korea is significantly lower than that used in the China's Mainland;Hong Kong,China and Taiwan,China where the adherence to the classical f

关键词： Traditional herbal medicine Dosage Classical formulae China's Mainland Japan South Korea

International consensus on natural orifice specimen extraction surgery(NOSES)for colorectal cancer

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Gastroenterology Report 2019年第1期7卷 24-31,I0001页

作者： Xu Guan Zheng Liu Antonio Longo Jian-Chun Cai William Tzu-Liang Chen Lu-Chuan Chen Ho-kyung Chun Joaquim Manuel da Costa Pereira Sergey Efetov Ricardo Escalante Qing-Si He Jun-Hong Hu Cuneyt Kayaalp Seon-Hahn Kim Jim S.Khan Li-Jen Kuo Atsushi Nishimura Fernanda Nogueira Junji Okuda Avanish Saklani Ali A.Shafik Ming-Yin Shen Jung-Tack Son Jun-Min Song Dong-Hui Sun Keisuke Uehara Gui-Yu Wang Ye Wei Zhi-Guo Xiong Hong-Liang Yao Gang Yu Shao-Jun Yu Hai-Tao Zhou Suk-Hwan Lee Petr V.Tsarkov Chuan-Gang Fu Xi-Shan Wang The International Alliance of NOSES Department of Colorectal Surgery National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBejingChina Department of Coloproctology and Pelvic Diseases Humanitas GavazzeniBergamoItaly Department of Gastrointestinal Surgery Zhongshan Hospital of Xiamen UniversityXiamenChina Department of Surgery China Medical University HospitalTaichungTaiwanChina Department of Abdominal Surgery Fujian Medical University Cancer HospitalFuzhouChina Department of Surgery Kangbuk Samsung HospitalSungkyunkwan University School of MedicineSeoulSouth Korea Department of Surgery Hospital de BragaBragaPortugal Colorectal Surgery Department Sechenov First Moscow State Medical UniversityMoscowRussia Universidad Central de Venezuela Centro Medico LoiraCaracasVenezuela Department of General Surgery Shandong University Qilu HospitalJinanChina Department of General Surgery Huaihe Hospital of Henan UniversityKaifengChina Department of Gastrointestinal Surgery Inonu UniversityMalatyaTurkey Department of Surgery Korea University Anam HospitalKorea University College of MedicineSeoulSouth Korea Department of Colorectal Surgery Portsmouth Hospitals NHS TrustQueen Alexandra HospitalPortsmouthUK Division of Colorectal Surgery Taipei Medical University HospitalTaipeiTaiwanChina Department of Surgery Nagaka Chuo General HospitalNagaoka CityJapan Innovation Unit/Colorectal Cancer Osaka Medical College Hospital Cancer CenterOsakaJapan Department of GI Surgical Oncology Tata Memorial HospitalMumbaiIndia Department of Colorectal Surgery Cairo UniversityCairoEgypt Department of Anorectal Surgery First Affiliated HospitalZhengzhou UniversityZhengzhouChina Department of Gastric and Colorectal Surgery Jilin University First HospitalChangchunChina Division of Surgical Oncology Nagoya University Graduate School of MedicineNagoyaJapan Department of Colorectal Cancer Surgery The Second Affiliated Hospital of Harbin Medical

In recent years,natural orifice specimen extraction surgery(NOSES)in the treatment of colorectal cancer has attracted widespread *** potential benefits of NOSES including reduction in postoperative pain and wound complications,less use of postoperative analgesic,faster recovery of bowel function,shorter length of hospital stay,better cosmetic and psychological effect have been described in colorectal *** significant decrease in surgical trauma of NOSES have been observed,the potential pitfalls of this technique have been ***,several issues including bacteriological concerns,oncological outcomes and patient selection are raised with this new ***,it is urgent and necessary to reach a consensus as an industry guideline to standardize the implementation of NOSES in colorectal *** three rounds of discussion by all members of the International Alliance of NOSES,the consensus is finally completed,which is also of great significance to the long-term progress of NOSES worldwide.

关键词： colorectal cancer natural orifice specimen extraction surgery(NOSES) laparoscopy natural orifice transluminal endoscopic surgery(NOTES) transanal total mesorectal excision(TaTME)

Phase Ⅱ study of R-CVP followed by rituximab maintenance therapy for patients with advanced marginal zone lymphoma:consortium for improving survival of lymphoma(CISL)study

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Cancer Communications 2019年第1期39卷 526-535页

作者： Sung Yong Oh Won Seog Kim Jin Seok Kim Seok Jin Kim Dok Hyun Yoon Deok-Hwan Yang Won Sik Lee Hyo Jung Kim Ho-Young Yhim Seong Hyun Jeong Jong Ho Won Suee Lee Jee Hyun Kong Sung-Nam lim Jun Ho Ji kyung A.Kwon Gyeong-Won Lee Jae Hoon Lee Ho Sup Lee Ho-Jin Shin Cheolwon Suh Department of Internal Medicine Dong-A University HospitalBusan 49201Republic of Korea Department of Medicine Samsung Medical CenterSungkyunkwan University School of MedicineSeoul 06351Republic of Korea Division of Hematology Department of Internal MedicineYonsei University College of MedicineSeoul 03722Republic of Korea Department of Oncology Asan Medical CenterUniversity of Ulsan College of MedicineSongpa-guSeoul 05505Republic of Korea Department of Hematology-Oncology Chonnam National University Hwasun HospitalHwasun 58128Republic of Korea Department of Hematology Busan Paik HospitalInje University College of MedicineBusan 04511Republic of Korea Department of Internal Medicine Hallym University Sacred Heart HospitalHallym University College of MedicineAnyang 14068Republic of Korea Department of Internal Medicine Chonbuk National University HospitalJeonju 54907Republic of Korea Department of Hematology-Oncology Ajou University School of MedicineSuwon 16499Republic of Korea Department of Internal Medicine Soonchunhyang University Seoul HospitalSoonchunhyang University College of MedicineSeoul 04401Republic of Korea Division of Hematology-Oncology Department of Internal MedicineWonju Severance Christian HospitalYonsei University College of MedicineWonju 26426Republic of Korea Department of Internal Medicine Haeundae Paik HospitalInje University College of MedicineBusan 48108Republic of Korea Division of Hematology and Oncology Department of Internal MedicineSamsung Changwon HospitalSungkyunkwan University School of MedicineChangwon 51353Republic of Korea Division of Hematology-Oncology Department of Internal MedicineDongnam Institute of Radiological and Medical SciencesBusan 46033Republic of Korea Division of Hematology-Oncology Department of Internal MedicineGyeongsang National University HospitalGyeongsang National University College of MedicineJinju 52727Republic of Korea Department of Internal Medicine Gachon University Gil Medical CenterIncheon 21565Republic of

Background:The response rate and survival improvement for rituximab,a CD20-targeting monoclonal antibody,have been demonstrated in marginal zone lymphoma(MZL)as monotherapy and in combination with chemotherapeutic regimens,yet relapses still occur despite treatment ***,extending the period of remission in MZL patients remains an essential *** multicenter,single-arm,open-label phase II study evaluated the survival efficacy of 2 years of rituximab-maintenance therapy in patients with stage III-IV CD20-positive MZL who had responded to first-line R-CVP(rituximab,cyclophosphamide,vincristine,and prednisolone).The objective of this study was to determine whether rituximab maintenance following R-CVP warrants further ***:Prior to rituximab-maintenance therapy,patients received 6-8 cycles of first-line R-CVP therapy for stage III-IV ***(375 mg/m^(2)),cyclophosphamide(750 mg/m^(2)),and vincristine(1.4 mg/m^(2);maximum 2 mg)were administered via an intravenous infusion on day 1 of each 3-week cycle,while oral prednisolone(100 mg)was given on days 1-5 of each 3-week *** patients who achieved complete response(CR),partial response(PR),or stable disease(SD)to R-CVP treatment,were prescribed rituximab-maintenance therapy which was administered intravenously at a dose of 375 mg/m^(2) every 8 weeks for up to 12 *** primary endpoint was progression-free survival(PFS).Secondary endpoints were overall survival(OS)and treatment ***:47 patients were enrolled,of whom,45(96%)received rituximab-maintenance ***(33%)patients had nodal *** R-CVP first-line therapy,20(44%),22(49%),and 3(7%)patients achieved CR,PR,and SD,*** a median follow-up of 38.2 months,their observed 3-year PFS rate was 81%.During the rituximab-maintenance,6 PR and 1 SD patients achieved CR following the administration of *** LDH and the presence of B symptoms were found to be significant prognostic fac

关键词： Marginal zone Lymphoma Advanced stage Rituximab Cyclophosphamide Vincristine Maintenance Multicenter Open label Survival

尼可地尔在经皮冠状动脉介入治疗不稳定心绞痛时对心肌的保护作用

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首都食品与医药 2018年第1期25卷 104-104页

作者： Ju Han Kim Myung Ho Jeong kyung Ho Yun Kye Hun Kim Dong Koo Kang Seo Na Hong Sang Yup lim Sang Hyun Lee Yun Sang Lee Young Joon Hong Hyung Wook Park Weon Kim Young Keun Ahn Jeong Gwang Cho Jong Chun Park Jung Chaee Kang 田玉敬北京四环科宝制药有限公司 100070

（接2017年12月下）3讨论PCI治疗中的冠状动脉疾病患者均出现了心肌肌钙蛋白浓度升高的现象,这是由于PCI过程中心肌细胞被破坏所致。然而,心肌肌钙蛋白浓度并没有很好地被用于监测成功PCI之后对心肌细胞的破坏作用。心肌肌钙蛋白是控制... 详细信息

（接2017年12月下）3讨论PCI治疗中的冠状动脉疾病患者均出现了心肌肌钙蛋白浓度升高的现象,这是由于PCI过程中心肌细胞被破坏所致。然而,心肌肌钙蛋白浓度并没有很好地被用于监测成功PCI之后对心肌细胞的破坏作用。心肌肌钙蛋白是控制心肌收缩的一种蛋白,且在正常的血液中不会被检测到,因为它是心脏特性指标,

关键词：经皮冠状动脉介入治疗心肌细胞不稳定心绞痛保护作用尼可地尔心肌肌钙蛋白蛋白浓度冠状动脉疾病

尼可地尔在经皮冠状动脉介入治疗不稳定心绞痛时对心肌的保护作用

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首都食品与医药 2017年第24期24卷 160-160页

心肌损伤通常在经皮冠状动脉介入治疗(PCI)过程中出现,并且损伤可以通过对心肌酶的测试使之容易被监控。众所周知,尼可地尔是三磷酸腺苷ATP-敏感的K+通道的开启器,通过减小作用电位从而具有抗心律失常效应和保护心脏作用。比如,通过松... 详细信息

心肌损伤通常在经皮冠状动脉介入治疗(PCI)过程中出现,并且损伤可以通过对心肌酶的测试使之容易被监控。众所周知,尼可地尔是三磷酸腺苷ATP-敏感的K+通道的开启器,通过减小作用电位从而具有抗心律失常效应和保护心脏作用。比如,通过松弛血管平滑肌以减少微冠状动脉血流阻力。研究尼可地尔的心肌保护作用,IONA研究(尼可地尔对心绞痛的作用)即大规模对稳定型心绞痛进行的研究表明,尼可地尔口服给药能够减少冠心病致死率和非致命型心肌梗塞或胸痛意外住院治疗。目前已经对数个不稳定心绞痛(UAP)或急性心肌梗塞病人进行了尼可地尔心脏保护效应的研究评估,但还没有进行大规模研究。此研究的目的在于通过对经尼可地尔注射并PCI治疗12~48h后的不稳定心绞痛患者的心肌酶进行评估来预期考察尼可地尔的心脏保护作用。

关键词：尼可地尔介入治疗不稳定心绞痛心肌保护

International consensus on natural orifice specimen extraction surgery(NOSES)for gastric cancer(2019)

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Gastroenterology Report 2020年第1期8卷 5-10,I0001页

作者： Xu Guan Zheng Liu Amjad Parvaiz Antonio Longo Avanish Saklani Ali AShafik Jian-Chun Cai Charles Ternent Lin Chen Cuneyt Kayaalp Fatih Sumer Fernanda Nogueira Feng Gao Fang-Hai Han Qing-Si He Ho-kyung Chun Chang-Ming Huang Hai-Yang Huang Rui Huang Zhi-Wei Jiang Jim S Khan Joaquim Manuel da Costa Pereira JosephWNunoo-Mensah Jung Tack Son Liang Kang Keisuke Uehara Ping Lan Le-Ping Li Han Liang Bing-Rong Liu Juan Liu Dan Ma Ming-Yin Shen Mohammad Rashidul Islam Narimantas Evaldas Samalavicius Kai Pan Petr Tsarkov Xin-Yu Qin Ricardo Escalante Sergey Efetov Seung Kyu Jeong Suk-Hwan Lee Dong-Hui Sun Li Sun Tatiana Garmanova Yan-Tao Tian Gui-Yu Wang Guo-Jun Wang Guo-Rong Wang Xiao-Qiang Wang William Tzu-Liang Chen Woo Yong Lee Su Yan Zu-Li Yang Gang Yu Pei-Wu Yu Dan Zhao Yun-Shi Zhong Jian-Ping Wang Xi-Shan Wang The International Alliance of NOSES Department of Colorectal Surgery National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingP.R.China Poole Hospital NHS Trust PooleUK European Center of Coloproctology and Pelvic Diseases-Multimedica Hospital MilanItaly Department of GI Surgical Oncology Tata Memorial HospitalMumbaiIndia Department of Colorectal Surgery Cairo UniversityCairoEgypt Department of Gastrointestinal Surgery Zhongshan Hospital of Xiamen UniversityXiamenFujianP.R.China Section of Colon and Rectal Surgery Creighton University School of MedicineOmahaNEUSA Department of General Surgery Chinese People’s Liberation Army General HospitalBeijingP.R.China Department of Gastrointestinal Surgery Inonu UniversityMalatyaTurkey Department of Surgery Hospital de BragaBragaPortugal Department of Colorectal Cancer Surgery the Second Affiliated Hospital of Harbin Medical UniversityHarbinHeilongjiangP.R.China Department of Gastroenterological Surgery Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhouGuangdongP.R.China Department of General Surgery Shandong University Qilu HospitalJinanShandongP.R.China Department of Surgery Kangbuk Samsung HospitalSungkyunkwan University School of MedicineSeoulSouth Korea Department of Gastric Surgery Fujian Medical University Union HospitalFuzhouFujianP.R.China Department of General Surgery Jiangsu Province Hospital of Traditional Chinese MedicineNanjingJiangsuP.R.China Department of Colorectal Surgery PortsmouthHospitals NHSTrustQueen Alexandra HospitalPortsmouthUK King’s College Hospital LondonUK Department of Colorectal Surgery The Sixth Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdongP.R.China Division of Surgical Oncology Department of SurgeryNagoya University School of MedicineNagoyaJapan Department of Gastrointestinal Surgery Shandong Provincial Hospital Affiliated to Shandong UniversityJinanShandongP.R.China Department of Gastric Cancer

At present,natural orifice specimen extraction surgery(NOSES)has attracted more and more attention worldwide,because of its great advantages including minimal cutaneous trauma and post-operative pain,fast post-operative recovery,short hospital stay,and positive psychological ***,NOSES for the treatment of gastric cancer(GC)is still in its infancy,and there is great potential to improve its theoretical system and clinical ***,several key points including oncological outcomes,bacteriological concerns,indication selection,and standardized surgical procedures are raised with this innovative ***,it is necessary to achieve an international consensus to regulate the implementation of GC-NOSES,which is of great significance for healthy and orderly development of NOSES worldwide.

关键词： gastric cancer natural orifice specimen extraction surgery transanal specimen extraction transvaginal specimen extraction transoral specimen extraction consensus

如何设计高质量针刺临床研究:基于证据的专家共识

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英国医学杂志中文版 2022年第6期25卷 325-337页

作者：张誉清焦睿珉 Claudia M Witt 劳力行刘建平 Lehana Thabane Karen J Sherman Mike Cummings Dawn P Richards Eun-kyung Anna Kim Tae-Hun Kim Myeong Soo Lee Michael E Wechsler Benno Brinkhaus Jun J Mao Caroline A Smith 岗卫娟刘保延刘志顺刘岩郑晖吴佳霓 AloBSO Carrasco-Labra Mohit Bhandari Philip J Devereaux 景向红 Gordon Guyatt 中国中医科学院针灸研究所中国中医科学院广安门医院中加整合医学循证医学研究合作中心 Department of Health Research Methods Evidenceand ImpactMcMaster UniversityHamiltonONCanada 宁波诺丁汉大学宁波诺丁汉GRADE中心中国中医药循证医学中心 Institute for Complementary and Integrative Medicine University Hospital Zurich and University of ZurichZurichSwitzerland Virginia University of Integrative Medicine FairfaxVAUSA 北京中医药大学循证医学中心北京中医药大学国际循证中医药研究院 Department of Medicine Faculty of Health SciencesMcMaster UniversityHamiltonONCanada Kaiser Permanente Washington Health Research Institute Seattle WAUSA Department of Epidemiology University of WashingtonSeattle WAUSA British Medical Acupuncture Society LondonUK Patient and Public Engagement Clinical Trials OntarioTorontoONCanada Department of Western Medicine Virginia University of Integrative MedicineFairfaxVAUSA Korean Medicine Clinical Trial Center SeoulRepublic of Korea Korean Medicine Hospital SeoulRepublic of Korea kyung hee University SeoulRepublic of Korea Clinical Medicine Division Korea Institute of Oriental MedicineDaejeonRepublic of Korea Korean Convergence Medicine University of Science and TechnologyDaejeonRepublic of Korea National Jewish Health DenverCOUSA Institute of Social Medicine Epidemiology and Health EconomicsCharitéUniversit?ts medizin BerlinFreie Universit?t Berlin and Humboldt-Universittzu BerlinBerlinGermany Integrative Medicine Service Memorial Sloan Kettering Cancer CenterBendheim Integrative Medicine CenterNew YorkNY USA Translational Health Research Institute Western Sydney UniversityPenrithNew South WalesAustralia 中国中医科学院中国中医科学院广安门医院北京中医药大学东直门医院中医内科学教育部重点实验室成都中医药大学针灸推拿学院/第三附属医院 Center for Integrative Global Oral Health School of Dental MedicineUniversity of PennsylvaniaPhiladelphiaPAUSA

本针刺随机对照试验(Randomised controlled trials, RCT)专家共识是基于目前针刺试验面临的最普遍、最关键问题,由临床医生、研究人员、从事针灸和外科的临床试验专家、统计专家、临床流行病学和方法学专家以及患者组成的国际临床研究... 详细信息

本针刺随机对照试验(Randomised controlled trials, RCT)专家共识是基于目前针刺试验面临的最普遍、最关键问题,由临床医生、研究人员、从事针灸和外科的临床试验专家、统计专家、临床流行病学和方法学专家以及患者组成的国际临床研究小组联合制订。该共识将有助于临床试验资助者、注册者以及期刊编辑等评估针刺RCT方案及研究结果的相关性、重要性和质量。

关键词：临床流行病学针刺试验临床试验临床医生专家共识随机对照试验资助者期刊编辑