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Neural Regeneration Research 2025年第3期20卷 819-820页

作者： Rayudu Gopalakrishna Jennifer Aguilar Emily lee William J.Mack Department of Integrative Anatomical Sciences Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCAUSA Department of Neurological Surgery Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCAUSA

The dietary polyphenolic compounds resveratrol and quercetin prevent neurodegenerative diseases in experimental models;however, they reach the brain only in nanomolar concentrations in the glucuronidated and sulfated ... 详细信息

关键词： resveratrol molar dated

Mismatching between nest volume and clutch volume reduces egg survival and fledgling success in black-tailed gulls

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Current Zoology 2016年第5期62卷 451-456页

作者： Who-seung lee Jeong-Chil Yoo Korea Institute of Ornithology and Department of Biology Kyung Hee University Seoul 02447 Korea Center for Stock Assessment Research University of California Santa Cruz Santa Cruz CA 95080 USA

A longstanding suggestion posits that parents prefer to match nest volume and clutch size （clutch volume）, but few studies have tested this in colonial seabirds that nest in the open. Here, we demonstrate the effects of nest-clutch volume matching on egg survival, hatching, and fledgling success in black-tailed gulls Larus crassirostris on Hongdo Island, Korea. We show that the volume mismatch, defined as the difference between nest volume and total egg volume （the sum of all eggs＇ volume in the clutch）, was positively related to egg and chick mortality caused by predation, but was not significantly related to hatching success incurred by insulation during the incubation period. Although nest volume was negatively related to laying date, we found that the mismatch was positively related to laying date. Our results support the claim that well-matched nest-clutch volume may contribute to survival of eggs and chicks, and ultimately breeding success.

关键词： black-tailed gulls clutch size egg survival fledgling success nest volume.

Post-laparotomy heterotopic ossification of the xiphoid process: A case report

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World Journal of Clinical Cases 2023年第36期11卷 8568-8573页

作者： seung Soo lee Department of Surgery Kyungpook National University HospitalDaegu 41944South Korea Department of Surgery School of MedicineKyungpook National UniversityDaegu 41944South Korea

BACKGROUND Heterotopic ossification(HO)represents all types of extraskeletal ossification in the *** occurs in various areas,including the skin,subcutaneous tissue,muscle,and *** excision is recommended for symptomatic *** radiotherapy,oral nonsteroidal anti-inflammatory drugs,and topical sealants,such as bone wax,have been recommended as preventive *** HO is rare in occurrence,these recommendations are based on personal experiences,and there is a lack of information on individualized treatments depending on its *** SUMMARY A 62-year-old male was admitted for symptomatic HO along a laparotomy *** excision was performed for an 11 cm-sized ossification originating from the xiphoid process,and bone wax was applied to the excisional ***,the surgical wound failed to *** several weeks of saline-soaked gauze dressing,delayed wound closure was *** patient was finally discharged eight weeks after the *** HO can occur in various areas of the body,a treatment strategy that may be effective for some may not be for *** wax has been used as a topical sealant over excisional margins in the shoulder,elbow,and temporomandibular ***,in our case,its application on an abdominal surgical wound delayed its primary healing *** valuable lesson was that,when choosing a treatment method for HO based on available research data,its location must be *** Complete excision should be the priority treatment option for symptomatic HO along the laparotomy *** wax application is not *** Tip:Heterotopic ossification(HO)represents all types of extraskeletal ossification,and occurs in various areas,including the skin,muscle,and *** are some suggested treatment and preventive approaches for symptomatic HO,which include surgical excision and preventive measures such as postoperative radiotherapy,oral nonsteroidal anti-inflam-matory drug

关键词： Heterotopic ossification Joints Laparotomy Waxes Wound healing Case report

Preparation of TiAlN/ZrN and TiCrN/ZrN multilayers by RF magnetron sputtering

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中国有色金属学会会刊：英文版 2009年第4期19卷 795-799页

作者： Jong-Kook lee G won-seung YANG Department of Advanced Materials Engineering Chosun University BK21 Education Center of Mould Technology for Advanced Materials and Parts Chosun University

Titanium-based nitride coatings on cutting tools,press molds and dies can be used to prolong their life cycle because of their superior corrosion and oxidation ***/ZrN and TiCrN/ZrN multilayer coatings were prepared by RF magnetron sputtering,and their microstructural evolution and corrosion resistance during heat treatment were *** TiAlN/ZrN and TiCrN/ZrN multilayer coatings are degraded by heating up to 600 ℃ with the formation of oxides particles on the *** the heat treatment,the TiCrN/ZrN and TiAlN/ZrN multilayer coatings show the lowest corrosion current density and the highest polarization resistance at temperature range of 400-500 ℃.Consequently,the TiAlN/ZrN and TiCrN/ZrN multilayer coatings show good corrosion resistance at temperature range of 400-500 ℃ during heating.

关键词：射频磁控溅射溅射制备氮化锆多层膜钛铝耐腐蚀性腐蚀电流密度

Angelica tenuissima Nakai Ameliorates Cognitive Impairment and Promotes Neurogenesis in Mouse Model of Alzheimer's Disease

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Chinese Journal of Integrative Medicine 2018年第5期24卷 378-384页

作者： Minji Choi Younghyurk lee seung-Hun Cho Department of Psychiatry Hospital of Korean Medicine Kyung Hee University Medical Center

Objective: To research Angelica tenuissima Nakai(ATN) for use in novel Alzheimer’s disease(AD) therapeutics. Methods: The effect of a 30% ethanol extract of ATN(KH032) on AD-like cognitive impairment and neuropathological and neuroinflammatory changes induced by bilateral intracerebroventricular injections of β-amyloid(Aβ) peptide(Aβ1-42) was investigated. Male C57 Bl/6 mice were randomly divided into 4 groups, 10 in each group. KH032-treated groups were administrated with a low or high dose of KH032(50 and 200 mg/kg, respectively), intragastrically for 16 days; distilled water was applied in the sham and negative groups. Open field test, Y maze and Morris water maze test were used for behavior test and cognitive ability. In addition, the neuroprotective effects of KH032 in Aβ1-42-infused mice on the histopathological markers [neuronspecific nuclear protein(Neu N), Aβ1-42] of neurodegeneration were examined. The levels of glial fibrillary acidic protein(GFAP), Neu N, phosphorylation extracellular signal-regulated kinase(ERK)/ERK, brain-derived neurotrophic factor(BDNF), phosphorylation c AMP response element-binding(CREB)/CREB protein expression were measured by Western blot. Results: KH032 treatment ameliorated cognitive impairments, reduced the overexpression of Aβ1-42, and inhibited neuronal loss and neuroinflammatory response in the Aβ1-42-infused mice. Moreover, KH032 treatment enhanced BDNF expression levels in the hippocampus. Finally, KH032 treatment increased phosphorylation of ERK1/2 and CREB, vital for ERK-CREB signaling. Conclusions: KH032 attenuated cognitive deficits in the Aβ1-42-infused mice by increasing BDNF expression and ERK1/2 and CREB phosphorylation and inhibiting neuronal loss and neuroinflammatory response, suggesting that KH032 has therapeutic potential in neurodegenerative disorders such as AD.

关键词： Alzheimer's disease Angelica tenuissima Nakai beta amyloid cognitive impairment neurogenesis

The complex of Fas-associated factor 1 with Hsp70 stabilizes the adherens junction integrity by suppressing RhoA activation

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Journal of Molecular Cell Biology 2022年第6期14卷 14-29页

作者： Soonhwa Song Joon kyu Park Sang Chui Shin Jae-Jin lee seung Kon Hong In-Kang Song Bokyung Kim Eun Joo Song Kong-Joo lee Eunice EunKyeong Kim Graduate School of Pharmaceutical Sciences College of PharmacyEwha Womans UniversitySeoul 03760Republic of Korea Biomedical Research Institute Korea Institute of Science and Technology(KIST)Seoul 02792Republic of Korea Technology Support Center Korea Institute of Science and Technology(KIST)Seoul 02792Republic of Korea

Fas-associated factor 1 (FAF1) is a scaffolding protein that plays multiple functions, and dysregulation of FAF1 is associated withmany types of diseases such as cancers. FAF1 contains multiple ubiquitin-related domains (UBA, UBL1, UBL2, UAS, and UBX), eachdomain interacting with a specific partner. In particular, the interaction of UBL1 with heat shock protein 70 (Hsp70) is associatedwith tumor formation, although the molecular understanding remains unknown. In this study, the structural analysis revealed thatHis160 of FAF1 is important for its interaction with Hsp70. The association of Hsp70 with FAF1 is required for the interaction withIQGAP1. FAF1 negatively regulates RhoA activation by FAF1–Hsp70 complex formation, which then interacts with IQGAP1. Thesesteps play a key role in maintaining the stability of cell-to-cell junction. We conclude that FAF1 plays a critical role in the structureand function of adherens junction during tissue homeostasis and morphogenesis by suppressing RhoA activation, which induces theactivation of Rho-associated protein kinase, phosphorylation of myosin light chain, formation of actin stress fiber, and disruptionof adherens junction. In addition, depletion of FAF1 increased collective invasion in a 3D spheroid cell culture. These results provideinsightinto how the FAF1–Hsp70 complex acts as a novelregulator ofthe adherens junction integrity. The complex can be a potentialtherapeutic target to inhibit tumorigenesis and metastasis.

关键词： human Fas-associated factor 1(FAF1) heat shock protein 70(Hsp70) adherens junction RhoA activation IQGAP1 X-ray crystallography FAF1–Hsp70 complex

Colonic J-pouch anal anastomosis after ultralow anterior resection with upper sphincter excision for low-lying rectal cancer

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World Journal of Gastroenterology 2005年第17期11卷 2570-2573页

作者： Jae-Gahb Park Min Ro lee Seok-Byung Lim Chang Won Hong Sang Nam Yoon Sung-Bum Kang seung Chul Heo seung-Yong Jeong kyu Joo Park Department of Surgery Seoul National University College of Medicine 28 Yongon-dongChongno-guSeoul 110-744Korea Cancer Research Institute and Cancer Research CenterSeoul National University28 Yongon-dongChongno-guSeoul 110-744Korea Research Institute and HospitalNational Cancer Center809 Madu-dongIlsan-guGoyangGyeonggi 411-764Korea Department of Surgery Seoul National University College of Medicine 28 Yongon-dongChongno-guSeoul 110-744Korea Research Institute and Hospital National Cancer Center 809 Madu-dongIlsan-guGoyangGyeonggi 411-764Korea

AIM:There is some evidence of functional superiority of colonic J-pouch over straight coloanal anastomosis (CM) in ultralow anterior resection (ULAR) or intersphincteric resection. On the assumption that colonic J-pouch anal anastomosis is superior to straight CM in ULAR with upper sphincter excision (USE: excision of the upper part of the internal sphincter) for low-lying rectal cancer, we compare functional outcome of colonic J-pouch vsthe straight CM. METHODS: Fifty patients of one hundred and thirty-three rectal cancer patients in whom lower margin of the tumors were located between 3 and 5 cm from the anal verge received ULAR including USE from September 1998 to January 2002. Patients were randomized for reconstruction using either a straight (n = 26) or a colonic J-pouch anastomosis (n = 24) with a temporary diverting-loop ileostomy. All patients were followed-up prospectively by a standardized questionnaire [Fecal Inco-ntinence Severity Index (FISI) scores and Fecal Incontinence Quality of Life (FIQL) scales]. RESULTS: We found that, compared to straight anastomosis patients, the frequency of defecation was significantly lower in J-pouch anastomosis patients for 10 mo after ileostomy takedown. The FISI scores and FIQL scales were significantly better in J-pouch patients than in straight patients at both 3 and 12 mo after ileostomy takedown. Furthermore, we found that FISI scores highly correlated with FIQL scales. CONCLUSION: This study indicates that colonic J-pouch anal anastomosis decreases the severity of fecal incontinence and improves the quality of life for 10 mo after ileostomy takedown in patients undergoing ULAR with USE for low-lying rectal cancer.

关键词： Upper sphincter excision Ultralow anterior resection Coloanal anastomosis Rectal cancer

Multifunctional Ir–Ru alloy catalysts for reversal-tolerant anodes of polymer electrolyte membrane fuel cells

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Journal of Materials Science & Technology 2021年第1期60卷 105-112页

作者： seung Woo lee Bongho lee Chaekyung Baik Tae-Yang Kim Chanho Pak Graduate Program of Energy Technology School of Integrated TechnologyInstitute of Integrated TechnologyGwangju Institute of Science and TechnologyGwangju 61005Republic of Korea Research Institute for Solar and Sustainable Energies Gwangju Institute of Science and TechnologyGwangju 61005Republic of Korea

To address the problem of fuel starvation in fuel-cell electric vehicles,which causes cell voltage reversal and results in cell failure when repeated continuously,we developed a reversal-tolerant anode(RTA) to promote water oxidation in preference to carbon *** carbon-supported Ir-Ru alloys with different compositions are employed as RTA catalysts in an acidic polyol solution and are shown to exhibit composition-dependent average crystallite sizes of <5.33 *** adopted approach allows the generation of relatively well-dispersed Ir-Ru alloy nanoparticles on the carbon support without severe *** activity of IrRu_(2)/C for the hydrogen oxidation reaction is 1.10 times that of the stateof-the-art Pt/C *** reversal testing by simulation of fuel starvation reveals that the durability of IrRu_(2)/C(~7 h) significantly exceeds that of the conventional Pt/C catalyst(~10 min) and is the highest value reported so ***,the developed Ir-Ru alloy catalyst can be used to fabricate practical RTAs and replace Pt catalysts in the anodes of polymer electrolyte membrane fuel cells.

关键词： Polymer electrolyte membrane fuel cell Polyol process Reversal-tolerant anode Oxygen evolution reaction Hydrogen oxidation reaction

Ru/NiMnB spherical cluster pillar for highly proficient green hydrogen electrocatalyst at high current density

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Journal of Energy Chemistry 2025年第1期100卷 397-408页

作者： Md Ahasan Habib Shusen Lin Mehedi Hasan Joni Sumiya Akter Dristy Rutuja Mandavkar Jae-Hun Jeong Jihoon lee Department of Electronic Engineering College of Electronics and Information Kwangwoon University

Advanced OER/HER electrocatalytic alternatives are crucial for the wide adaptation of green hydrogen ***,Ru/NiMnB spherical cluster pillar （SCP）,denoted as Ru/NiMnB,is synthesized using a combination of electro-deposition and hydrothermal *** investigation of Ru doping in the NiMnB matrix revealed significant improvements in electrocatalytic *** Ru/NiMnB SCPs demonstrate superior OER/HER activity with low overpotentials of 150 and 103 mV at 50mA/cm2in 1 M KOH,making them highly competitive with state-of-the-art ***,the Ru/NiMnB SCPs exhibit a low 2-E cell voltage of 2.80 V at ultra-high current density of 2,000 m A/cm2in 1 M KOH,outperforming the standard benchmark electrodes of RuO2||Pt/C,thereby positioning Ru/NiMnB as one of the best bifunctional *** SCPs exhibit exceptional high-current characteristics,stability and corrosion resistance,as evidenced by continuous operation at 1,000 mA/cm2high-current density for over 150 h in 6 M KOH at elevated temperatures under harsh industrial *** a small amount of Ru incorporation significantly enhances the electrocatalytic performances of NiMnB,attributed to increased active sites and improved intrinsic properties such as conductivity,adsorption/desorption capability and reaction ***,Ru/NiMnB SCPs present a promising bi-functional electrode concept for efficient green H2production.

关键词： Advanced electrocatalyst High current Corrosion resistance Industrial requirement

Smooth cutting pattern generation technique for membrane structures using geodesic line on subplane and spline interpolation

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Journal of Central South University 2013年第11期20卷 3131-3141页

作者： SHON Su-deok lee seung-jae lee Kang-guk School of Architectural Engineering Korea University of Technology and Education Research Center for Building safety Kyungpook National University

Practical techniques for smooth geodesic patterning of membrane structures were *** the geodesic search,adjustment of the subplane of the extracted elements series was proposed,and various spline approximation methods were used to flatten the strip for the generation of a smooth *** search approach is very simple,and the geodesic line could be easily attained by the proposed method without the need for a difficult computation *** cutting patterning can also be generated by spline approximation without the noise in discrete nodal ***,the geodesic cutting pattern saved about 21%of the required area for the catenary model due to the reduction of the curvature of the planar pattern seam line.

关键词： membrane structures cutting pattern generation geodesic line spline interpolation triangular mesh sub-plane