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中国农业科学 2006年第10期39卷 1947-1955页

作者：孙明茂洪夏铁李圭星曹桂兰于元杰韩龙植中国农业科学院作物科学研究所/国家农作物基因资源与基因改良重大科学工程/农业部作物种质资源与生物技术重点开放实验室韩国农村振兴厅作物科学院山东农业大学农学院

微量元素营养失衡已成为影响人类健康的最重要因素之一,给个人和整个社会医疗体系带来沉重的负担。植物育种策略,尤其是籽粒富集微量元素的谷物育种被认为是克服微量元素营养失衡的最经济和有效的途径。现有的研究已证实,在水稻基因组... 详细信息

微量元素营养失衡已成为影响人类健康的最重要因素之一,给个人和整个社会医疗体系带来沉重的负担。植物育种策略,尤其是籽粒富集微量元素的谷物育种被认为是克服微量元素营养失衡的最经济和有效的途径。现有的研究已证实,在水稻基因组中存在控制籽粒高微量元素含量的基因位点,并且籽粒中微量元素含量的增加不仅不会影响到水稻产量,而且当种植于微量元素缺乏的土壤中,籽粒富集微量元素水稻品种的产量高于普通水稻。本文在概述水稻籽粒微量元素含量的遗传差异、环境效应的基础上,着重介绍了水稻籽粒微量元素含量的遗传、遗传相关和分子机理的研究现状以及籽粒富集微量元素水稻种质鉴定、筛选与创新现状,并提出今后以提高水稻籽粒微量元素含量为目标的功能性水稻研究的内容和方向为:提高水稻籽粒中微量元素的生物有效性,加强籽粒富集微量元素水稻种质的鉴定与筛选,进行籽粒微量元素积累的分子机理研究,积极开展籽粒富集微量元素的种质创新。

关键词：水稻种质微量元素含量遗传基因定位鉴定与创新

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减量FOLFIRINOX方案挽救性治疗吉西他滨抵抗的晚期胰腺癌:一项Ⅱ期研究

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癌症 2018年第8期37卷 327-335页

作者： Jung Hoon Kim Sang-Cheol Lee Sung Yong Oh Seo-Young Song Namsu Lee Eun Mi Nam Soonil Lee In Gyu hwang Hyo Rak Lee kyu Taek Lee Sang-Byung Bae han Jo Kim Joung Soon Jang Do Hyoung Lim Hyun Woo Lee Seok Yun Kang Jung Hun Kang Department of Internal Medicine Institute of Health SciencesGyeongsang National University Divsion of Hematology and Oncology Department of Internal MedicineSoonchunhyang University HospitalCheonan Department of Internal Medicine Dong-A University Hospital Department of Internal Medicine Kangwon National University School of Medicine Divsion of Hematology and Oncology Department of Internal MedicineSoonchunhyang University HospitalSeoul Department of Internal Medicine Ewha Womans UniversityCollege of Medicine Department of Internal Medicine Dankook University Hospital Department of Internal Medicine Chung-Ang UniversityCollege of Medicine Division of Hematology and Medical Oncology Department of Internal MedicineKorea Cancer Hospital Department of Hematology-Oncology Ajou University Hospital

背景与目的奥沙利铂、伊立替康、氟尿嘧啶和亚叶酸的联合化疗方案(FOLFIRINOX)极大提高了晚期胰腺癌患者的生存期。然而,FOLFIRINOX方案作为吉西他滨失败后二线治疗的疗效尚未进行前瞻性的检测。我们研究了减量FOLFIRINOX方案治疗吉西... 详细信息

背景与目的奥沙利铂、伊立替康、氟尿嘧啶和亚叶酸的联合化疗方案(FOLFIRINOX)极大提高了晚期胰腺癌患者的生存期。然而,FOLFIRINOX方案作为吉西他滨失败后二线治疗的疗效尚未进行前瞻性的检测。我们研究了减量FOLFIRINOX方案治疗吉西他滨抵抗的晚期胰腺癌患者的可行性和安全性。方法在14家医院进行了这一多中心II期前瞻、开放标签的单臂研究。经组织学确诊为胰腺浸润性导管腺癌、有可测量或可评价的病灶、东部肿瘤协作组体能状况评分0或1分、器官功能良好、年龄19岁或以上的患者符合入组条件。减量FOLFIRINOX方案的组成:奥沙利铂65 mg/m2、伊立替康135 mg/m2和亚叶酸400 mg/m2,第1天静脉注射;5?氟尿嘧啶2000 mg/m2,第1–2天持续静脉输注46 h;每2周重复。主要终点为FOLIFLIOX治疗起始后的无进展生存期。次要终点为客观缓解率、疾病控制率、总生存期、安全性和耐受性。采用Kaplan?Meier法评估了总生存期和无进展生存期。结果我们招募了来自14个中心的39例患者。客观缓解率为10.3%,疾病控制率为64.1%。6个月和1年总生存率分别为59.0%和15.4%。中位无进展生存期和总生存期分别为3.8个月[95%置信区间(confidence interval,CI)=1.5–6.0个月]和8.5个月(95%CI=5.6–11.4个月)。3或4级不良事件为中性粒细胞减少(41%)、恶心(10.3%)、食欲减退(10.3%)、贫血(7.7%)、黏膜炎(7.7%)、肺炎/胸膜融合(5.1%)和乏力(5.1%)。发生1例由感染性休克引起的治疗相关死亡。结论减量FOLFIRINOX方案有望作为二线方案治疗吉西他滨抵抗的胰腺癌。

关键词：减量FOLFIRINOX方案二线治疗胰腺癌吉西他滨

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High concentration of MMP-2 and MMP-9 reduce NK cell- mediated cytotoxicity against an oral squamous cell carcinoma cell line; an immune suppressive role for MMP-2 and MMP-9 in oral cancer patients

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中国口腔颌面外科杂志 2008年第B5期6卷 68-68页

作者： Mi-Jung Kim ha-Soon Jang Hee-Ran Lee Jong-Ho Lee Phill-Hoon Choung Myung-Jin Kim Bu-kyu Lee Department of Oral and Maxillofiwial Surgeo Asan Medical Ceater College of Medicine Ulsan University Seoul Korea Department of Cell Bilology Asan Institute for Life Science Asan Medical Center College of Medicine Ulsan University Department of Oral and Maxillofiwial Surgeory College of Dentistry Seoul National University Seoul Korea

Background:Recent studies have shown that MMPs driven from tumors influence the host immune system to alleviate anti-tumor activity。The aim of this study is to examine the influence of MMP-2 and MMP-9 on the natural killer (NK) cell。Methods: NK cells were pretreated with either MMP-2 or MMP-9 in the experimental group but not in the control group。NK cell cytotoxicity against oral squamous cell carcinoma cells were examined using the [Cr5 l] release assay and the expression levels of surface receptors on NK cells were measured by the flow cytometry respectively。Results: NK cell cytotoxicity was significantly reduced in the experimental group compared to the control group, Significant increases in KIR expression and decreases in NKG2D expression on the NK cells were observed in the experimental group。Conclusions: This study suggests an additional role of MMP-2 and MMP-9 in an immune escape mechanism of OSCC。

关键词：口腔癌鳞状细胞癌浓度细胞毒性

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Chemical characterization of rainwater over Suwon region during farming and non-farming periods

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Journal of Agricultural Chemistry and Environment 2013年第1期2卷 1-7页

作者： Min-Kyeong Kim Jong-Sik Lee Goo-Bok Jung Byong-Gu Ko Soon-Ik Kwon Min-Young Kim kyu-Ho So Sun-Gang Yun Department of Agricultural Environment National Academy of Agricultural Science Rural Development Administration (RDA) Suwon Republic of Korea Dresearch Planning Division Rural Development Administration Suwon Republic of Korea

Recently, special attention has been givento acid rain and its problem to environment such as acid precipitation and air pollution in East *** the present study, rainwater samples werecollected from Apr to Oct (farming period) and from Nov to Mar (non-farming period) in 2009 ~ 2011. The samples were chemically characterized for the assessment of emission sources. Suwon region, a typical agricultural area in Gyeonggi province (South Korea) was chosen as a study site. The content of ionic species and theirtemporal variation were used forfactor analysis, which was used to presume the natural and anthropogenic sources depending upon the farming and non-farming periods. The cationsobserved during farming and non-farming periods were?> Na+> Ca2+> K+> H+> Mg2+and Na+> N?>Ca2+> H+= Mg2+> K+, respectively. The anions during farming and non-farming periods were?>?> Cl- and?>?> Cl-, respectively. While the amounts of sulfate, one of the major dissolved components of rainwater were 113.5 and 177.0 ueq.L-1, the ones of NSS-?(Non-Sea Salt sulfate) were 93.7 and 87.1% during farming and non-farming periods, respectively. The comparison of observed pH values (pHobs) with the theoretical pH values (pHthe) showed that the neutralization of rainwater considerably went along during farming and non-farming periods. The highest amountof rainfall throughout the year was310.5 mmin August and its corre sponding nitrogen loading was5.03 kg·ha-1. The major ion contents for crop growth, , Ca2+, K+, Mg2+, were 49.4, 5.5, 18.1,1.4 kg·ha-1from April to October. The major contributions to the existing chemical ions in rainwaters during farming and non-farming periods were from the natural sources (sea and soil) and the anthropogenic sources (human and animal waste, vehicular emission + fossil fuels combustion), respectively.

关键词： Acidity Discharge Nutrient Rainwater

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East Asian VLBI Network observations of active galactic nuclei jets:imaging with KaVA+Tianma+Nanshan

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Research in Astronomy and Astrophysics 2021年第8期21卷 220-234页

作者：崔玉竹 Kazuhiro hada Motoki Kino Bong-Won Sohn Jongho Park Hyun-Wook Ro Satoko Sawada-Satoh Wu Jiang Lang Cui Mareki Honma 沈志强 Fumie Tazaki 安涛 Ilje Cho Guang-Yao Zhao Xiao-Peng Cheng Kotaro Niinuma Kiyoaki Wajima Ying-Kang Zhang Noriyuki Kawaguchi Juan-Carlos Algaba Shoko Koyama Tomoya Hirota Yoshinori Yonekura Nobuyuki Sakai Bo Xia Yong-Bin Jiang Lin-Feng Yu Wei Gou Ju-Yeon hwang Yong-Chen Jiang Yun-Xia Sun Dong-kyu Jung Hyo-Ryoung Kim Jeong-Sook Kim Hideyuki Kobayashi Jee-Won Lee Jeong-Ae Lee Hua Zhang Guang-Hui Li Zhi-Qiang Xu Peng Li Jung-Hwan Oh Se-Jin Oh Chung-Sik Oh Tomoaki Oyama Duk-Gyoo Roh Katsunori-M.Shibata 郭文 Rong-Bing Zhao Wei-Ye Zhong Jin-Qing Wang Wen-Jun Yang 闫浩 Jae-Hwan Yeom Bin Li 李笑飞 Jian-Ping Yuan Jian Dong Zhong Chen Kazunori Akiyama Keiichi Asada Do-Young Byun Yoshiaki hagiwara Jeffrey Hodgson Tae-Hyun Jung Kee-Tae Kim Sang-Sung Lee Kunwoo Yi Qing-Hui Liu Xiang Liu Ru-Sen Lu Masanori Nakamura Sascha Trippe Na Wang Xue-Zheng Wang 张波 Department of Astronomical Science The Graduate University for Advanced StudiesSOKENDAI2-21-1 OsawaMitakaTokyo 181-8588Japan Mizusawa VLBI Observatory National Astronomical Observatory of Japan2-12 HoshigaokaMizusawaOshuIwate 023-0861Japan Kogakuin University of Technology and Engineering Academic Support Center2665-1 NakanoHachiojiTokyo 192-0015Japan Korea Astronomy and Space Science Institute Yuseong-guDaejeon 34055Korea Department of Astronomy Yonsei University50 Yonsei-roSeodaemun-guSeoul 03722Korea Department of Astronomy and Space Science University of Science and Technology217 Gajeong-roDaejeonKorea Institute of Astronomy and Astrophysics Academia Sinica645 N Aohoku PIHiloHI 96720USA Graduate School of Sciences and Technology for Innovation Yamaguchi UniversityYoshida 1677-1YamaguchiYamaguchi 753-8512Japan Shanghai Astronomical Observatory Chinese Academy of SciencesShanghai 200030China Xinjiang Astronomical Observatory Chinese Academy of SciencesUrumqi 830011China Key Laboratory of Radio Astronomy Chinese Academy of SciencesNanjing 210008China Institute of Astronomy The University of Tokyo2-21-1 OsawaMitakaTokyo 181-0015Japan Instituto de Astrofísica de Andalucía-CSIC Glorieta de la Astronomia s/nGranada E-18008Spain Department of Physics Faculty of ScienceUniversity of MalayaKuala Lumpur 50603Malaysia Center for Astronomy Ibaraki University2-1-1 BunkyoMitoIbaraki 310-8512Japan Space Light Laboratory 77Yangjaedae-ro 86 roadGangdong-guSeoulKorea Massachusetts Institute of Technology haystack Observatory 99 Millstone RoadWestfordMA 01886USA National Radio Astronomy Observatory 520 Edgemont RdCharlottesvilleVA 22903USA Toyo University 5-28-20 HakusanBunkyo-kuTokyo 112-8606Japan Department of Physics and Astronomy Seoul National UniversityGwanak-guSeoul 08826Korea Max Planck Institute for Radio Astronomy Auf dem hiigel 69Bonn 53121Germany SNU Astronomy Research Center Seoul National UniversityGwanak-guSeoul 08826Korea

The East Asian Very Long Baseline Interferometry(VLBI) Network(EAVN) is a rapidly evolving international VLBI array that is currently promoted under joint efforts among China,Japan and *** aims at forming a joint VLBI Network by combining a large number of radio telescopes distributed over East Asian *** the combination of the Korean VLBI Network(KVN) and the VLBI Exploration of Radio Astrometry(VERA) into Ka VA,further expansion with the joint array in East Asia is actively *** we report the first imaging results(at 22 and 43 GHz) of bright radio sources obtained with Ka VA connected to Tianma 65-m and Nanshan 26-m Radio Telescopes in *** test the EAVN imaging performance for different sources,we observed four active galactic nuclei(AGN) having different brightness and *** a result,we confirmed that the Tianma 65-m Radio Telescope(TMRT) significantly enhances the overall array sensitivity,a factor of 4 improvement in baseline sensitivity and 2 in image dynamic range compared to the case of Ka VA *** addition of the Nanshan 26-m Radio Telescope(NSRT) further doubled the east-west angular *** the resulting high-dynamic-range,high-resolution images with EAVN(Ka VA+TMRT+NSRT),various fine-scale structures in our targets,such as the counter-jet in M87,a kink-like morphology of the 3 C 273 jet and the weak emission in other sources are successfully *** demonstrates the powerful capability of EAVN to study AGN jets and to achieve other science goals in *** expansion of EAVN will further enhance the angular resolution,detection sensitivity and frequency coverage of the network.

关键词： galaxies:active galaxies:jets instrumentation:interferometers radio continuum:galaxies

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