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A survey on the real-world clinical utilization of a traditional acupuncture in Republic of Korea:Sa-am acupuncture

Journal of Integrative Medicine 2024年第5期22卷 570-578页

作者： Ji-Yeun Park Ye-Seul lee Hi-Joon Park Seungmin Kathy lee Ji-Won lee Song-Yi Kim College of Korean Medicine Daejeon UniversityDaejeon 34520Republic of Korea Jaseng Spine and Joint Research Institute Jaseng Medical FoundationSeoul 06110Republic of Korea Acupuncture and Meridian Science Research Center Kyung Hee UniversitySeoul 02447Republic of Korea Department of Korean Medicine Korean Medical CenterLusail 201184Qatar Virginia University of Integrative Medicine ViennaVA 22182USA Department of Anatomy and Acupoint College of Korean MedicineGachon UniversitySeongnamGyeonggi 13120Republic of Korea Department of Ophthalmology Otolaryngologyand DermatologyCollege of Korean MedicineDongguk UniversityGoyangGyeonggi 10326Republic of Korea

Objective This study investigated the clinical details and usage of Sa-am acupuncture in Korean medicine clinics and explored how practicing Korean medicine doctors(KMDs)think about Sa-am *** We conducted a questionnaire-based survey of KMDs who utilize Sa-am acupuncture in their *** study comprehensively investigated issues related to clinical application of Sa-am acupuncture,needling techniques used during treatment,training methods,and directions for its future *** We analyzed 572 *** average of 50%of the patients visiting Korean medicine clinics were receiving Sa-am *** most prevalent indication for Sa-am acupuncture use was digestive *** patients’appetite level and digestive function were most frequently used indicators for selecting acupuncture *** prescription compositions,Jung-Gyuk formulas were more frequently used than Seung-Gyuk *** the needle along the flow of the channel or against the flow of the channel was most *** acupuncture style most frequently used in combination with Sa-am acupuncture was Ashi point *** of Sa-am acupuncture included its versatility,easy application,and good *** included the lack of rigorous education and training programs,difficulty in applying the principles for beginners,and insufficient clinical research *** In clinics where Sa-am acupuncture is available,KMDs were providing Sa-am acupuncture to about half of their *** were not using all of the tonification and sedation techniques which may be due to time constraints or simply a lack of ***-am acupuncture demonstrated high utility in clinical practice and high satisfaction based on the efficacy and *** training programs and high-quality research are needed to help expand the use of Sa-am acupuncture.

关键词： Sa-am acupuncture Traditional East Asian medicine Acupuncture education Acupoint selection

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Nuclear receptor coactivator 6 is a critical regulator of NLRP3 inflammasome activation and gouty arthritis

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Cellular & Molecular Immunology 2024年第3期21卷 227-244页

作者： Kang-Gu lee Bong-Ki Hong Saseong lee Naeun lee Seung-Whan Kim Donghyun Kim Wan-Uk Kim Center for Integrative Rheumatoid Transcriptomics and Dynamics The Catholic University of KoreaSeoul 06591Republic of Korea Department of Biomedicine&Health Sciences The Catholic University of KoreaSeoul 06591Republic of Korea Department of Pharmacology Asan Medical CenterUniversity of Ulsan College of MedicineSeoul 05505Republic of Korea Bio-Medical Institute of Technology University of UlsanSeoul 05505Republic of Korea Department of Microbiology and Immunology Seoul National University College of MedicineSeoul 03080Republic of Korea Institute of Infectious Diseases Seoul National University College of MedicineSeoul 03080Republic of Korea Division of Rheumatology Department of Internal MedicineThe Catholic University of KoreaSeoul 06591Republic of Korea

Transcriptional coactivators regulate the rate of gene expression in the *** receptor coactivator 6(NCOA6),a coactivator,has been implicated in embryonic development,metabolism,and cancer pathogenesis,but its role in innate immunity and inflammatory diseases remains ***,we demonstrated that NCOA6 was expressed in monocytes and macrophages and that its level was increased under proinflammatory ***,nuclear NCOA6 was found to translocate to the cytoplasm in activated monocytes and then become incorporated into the inflammasome with NLRP3 and ASC,forming cytoplasmic ***,NCOA6 associated with the ATP hydrolysis motifs in the NACHT domain of NLRP3,promoting the oligomerization of NLRP3 and ASC and thereby instigating the production of IL-1βand active *** note,Ncoa6 deficiency markedly inhibited NLRP3 hyperactivation caused by the Nlrp3^(R258W) gain-of-function mutation in *** ablation of Ncoa6 substantially attenuated the severity of two NLRP3-dependent diseases,folic-induced acute tubular necrosis and crystal-induced arthritis,in *** with these findings,NCOA6 was highly expressed in macrophages derived from gout patients,and NCOA6-positive macrophages were significantly enriched in gout macrophages according to the transcriptome profiling ***,NCOA6 is a critical regulator of NLRP3 inflammasome activation and is therefore a promising target for NLRP3-dependent diseases,including gout.

关键词： Nuclear receptor coactivator 6 Nuclear-to-cytoplasmic translocation NLRP3 inflammasome NACHT domain Gouty arthritis

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Nanoscale materials transformations revealed by liquid phase TEM

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Nano Research 2024年第10期17卷 9152-9165页

作者： Qiubo Zhang Daewon lee Haimei Zheng Materials Sciences Division Lawrence Berkeley National LaboratoryBerkeleyCalifornia 94720USA Department of Materials Science and Engineering University of CaliforniaBerkeleyCalifornia 94720USA

Nanoscale materials often undergo structural,morphological,or chemical changes,especially in solution processes,where heterogeneity and defects may significantly impact the transformation *** phase transmission electron microscopy(TEM),allowing us to track dynamic transformations of individual nanoparticles,has become a powerful platform to reveal nanoscale materials transformation pathways and address challenging issues that are hard to approach by other *** the development of modern liquid cells,implementing advanced imaging and image analysis methods,and strategically exploring diverse systems,significant advances have been made in liquid phase TEM,including improved high-resolution imaging through liquids at the atomic level and remarkable capabilities in handling complex systems and *** the past more than a decade,we spent much effort in developing and applying liquid phase TEM to elucidate how atomic level heterogeneity and defects impact various physicochemical processes in liquids,such as growth,self-assembly of nanoparticles,etching/corrosion,electrodeposition of alkali metals,catalyst restructuring during reactions,and so *** article provides a brief review of the liquid phase TEM study of nanoscale materials transformations,focusing on the growth of nanomaterials with distinct shape/hierarchical structures,such as one-dimensional(1D)growth by nanoparticle attachment,two-dimensional(2D)growth with nanoparticles as intermediates,core-shell structure ripening,solid-liquid interfaces including those in batteries and electrocatalysis,highlighting the impacts of heterogeneity and defects on broad nanoscale transformation pathways.

关键词： liquid phase transmission electron microscopy(TEM) liquid cells nanomaterials growth transformations pathways solid-liquid interface heterogeneity and fluctuations

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Heat-induced leaf epidermal cell damage triggers autophagy-mediated mesophyll cell expansion in Arabidopsis

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Plant Communications 2024年第3期5卷 5-8页

作者： Yunji Namgung Hong Gil lee Hongwoo lee Pil Joon Seo Department of Chemistry Seoul National UniversitySeoul 08826Republic of Korea Plant Genomics and Breeding Institute Seoul National UniversitySeoul 08826Republic of Korea Research Institute of Basic Sciences Seoul National UniversitySeoul 08826Republic of Korea

Dear Editor,Plants have evolved intricate mechanisms to recognize fluctuating environments,relay signals,and ultimately recover from the cellular and tissue damage imposed by environmental *** wounding,mechanical damage is recognized via cellular compounds released from damaged cells(Vega-Munoz et al.,2020)or changes in turgor pressure and cell-wall properties(Hoermayer et al.,2020).

关键词： damage Arabidopsis wound

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Difficulties, strategies, and recent research and development of layered sodium transition metal oxide cathode materials for high-energy sodium-ion batteries

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Journal of Energy Chemistry 2024年第3期90卷 40-57,I0003页

作者： Kouthaman Mathiyalagan Dongwoo Shin Young-Chul lee Department of Nano Science and Technology Convergence Gachon University1342 Seongnam-DaeroSujeong-GuGyeonggi-DoSeongnam-Si 13120Republic of Korea Department of Bio Nano Technology Gachon University1342 Seongnam-DaeroSujeong-GuGyeonggi-DoSeongnam-Si 13120Republic of Korea

Energy-storage systems and their production have attracted significant interest for practical *** are the foundation of sustainable energy sources for electric vehicles(EVs),portable electronic devices(PEDs),*** recent decades,Lithium-ion batteries(LIBs) have been extensively utilized in largescale energy storage devices owing to their long cycle life and high energy ***,the high cost and limited availability of Li are the two main obstacles for *** this regard,sodium-ion batteries(SIBs) are attractive alternatives to LIBs for large-scale energy storage systems because of the abundance and low cost of sodium *** is one of the most important components in the battery,which limits cost and performance of a *** the classified cathode structures,layered structure materials have attracted attention because of their high ionic conductivity,fast diffusion rate,and high specific ***,we present a comprehensive review of the classification of layered structures and the preparation of layered ***,the review article discusses extensively about the issues of the layered materials,namely(1) electrochemical degradation,(2) irreversible structural changes,and(3) structural instability,and also it provides strategies to overcome the issues such as elemental phase composition,a small amount of elemental doping,structural design,and surface alteration for emerging *** addition,the article discusses about the recent research development on layered unary,binary,ternary,quaternary,quinary,and senary-based O3-and P2-type cathode materials for high-energy *** review article provides useful information for the development of high-energy layered sodium transition metal oxide P2 and O3-cathode materials for practical SIBs.

关键词： O3-type P2-type Cathode materials Sodium-ion batteries Layered structure

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Self-assembly of tau fragments as a key pathologic event in tauopathies

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Neural Regeneration Research 2024年第12期19卷 2565-2566页

作者： Ly Thi Huong Luu Le Jung Hoon lee Min Jae lee Department of Biochemistry and Molecular Biology Seoul National University College of MedicineSeoulKorea

Tau protein is encoded by the microtubuleassociated protein tau(MAPT)gene and stabilizes microtubules in the *** has unique biophysical properties that make it both highly water-soluble and positively *** tau is an intrinsically disordered protein lacking defined secondary structures,it can acquire highly organized-sheet structures and stack into a filamentous inclusion such as a paired helical filament(PHF).

关键词： tau pathologic assembly

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Mathematical modeling and simulations of stress mitigation by coating polycrystalline particles in lithium-ion batteries

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Applied Mathematics and Mechanics(English Edition) 2024年第6期45卷 947-962页

作者： N.IQBAL J.CHOI S.F.SHAH C.lee S.lee Department of Mechanical Roboticsand Energy EngineeringDongguk University-SeoulSeoul 04620Republic of Korea

A chemo-mechanical model is developed to investigate the effects on the stress development of the coating of polycrystalline Ni-rich LiNixMnyCo_(z)O_(2)(x≥0.8)(NMC)particles with poly(3,4-ethylenedioxythiophene)(PEDOT).The simulation results show that the coating of primary NMC particles significantly reduces the stress generation by efficiently accommodating the volume change associated with the lithium diffusion,and the coating layer plays roles both as a cushion against the volume change and a channel for the lithium transport,promoting the lithium distribution across the secondary particles more ***,the lower stiffness,higher ionic conductivity,and larger thickness of the coating layer improve the stress *** paper provides a mathematical framework for calculating the chemo-mechanical responses of anisotropic electrode materials and fundamental insights into how the coating of NMC active particles mitigates stress levels.

关键词： lithium-ion battery(LIB) polycrystalline particle coating finite element simulation Ni-rich LiNixMnyCo_(z)O_(2)(x>0.8)(NMC)

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Suboptimal Feature Selection Techniques for Effective Malicious Traffic Detection on Lightweight Devices

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Computer Modeling in Engineering & Sciences 2024年第8期140卷 1669-1687页

作者： So-Eun Jeon Ye-Sol Oh Yeon-Ji lee Il-Gu lee Department of Future Convergence Technology Engineering Sungshin Women’s UniversitySeoul02844Korea Department of Convergence Security Engineering SungshinWomen’s UniversitySeoul02844Korea

With the advancement of wireless network technology,vast amounts of traffic have been generated,and malicious traffic attacks that threaten the network environment are becoming increasingly *** signature-based detection methods,static analysis,and dynamic analysis techniques have been previously explored for malicious traffic detection,they have limitations in identifying diversified malware traffic *** research has been focused on the application of machine learning to detect these ***,applying machine learning to lightweight devices like IoT devices is challenging because of the high computational demands and complexity involved in the learning *** this study,we examined methods for effectively utilizing machine learning-based malicious traffic detection approaches for lightweight *** introduced the suboptimal feature selection model(SFSM),a feature selection technique designed to reduce complexity while maintaining the effectiveness of malicious traffic *** performance was evaluated on various malicious traffic,benign,exploits,and generic,using the UNSW-NB15 dataset and SFSM sub-optimized hyperparameters for feature selection and narrowed the search scope to encompass all *** improved learning performance while minimizing complexity by considering feature selection and exhaustive search as two steps,a problem not considered in conventional *** experimental results showed that the detection accuracy was improved by approximately 20%compared to the random model,and the reduction in accuracy compared to the greedy model,which performs an exhaustive search on all features,was kept within 6%.Additionally,latency and complexity were reduced by approximately 96%and 99.78%,respectively,compared to the greedy *** study demonstrates that malicious traffic can be effectively detected even in lightweight device *** verified the possibility of detecting various attack

关键词： Feature selection lightweight device machine learning Internet of Things malicious traffic

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Disparities in the impact of economic well-being on self-esteem in adulthood:Race and ethnicity

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World Journal of Psychiatry 2024年第2期14卷 296-307页

作者： Jaewon lee School of Social Work Inha UniversityIncheon 22212South Korea

BACKGROUND Most studies have defined economic well-being as socioeconomic status,with little attention given to whether other indicators influence *** is known about racial/ethnic disparities in the relationship between economic wellbeing and self-esteem during *** To explore the impact of economic well-being on self-esteem in adulthood and differences in the association across race/*** The current study used data from the National Longitudinal Survey of Youth *** final sample consisted of 2267 African Americans,1425 Hispanics,and 3678 non-Hispanic *** linear regression analyses and logistic regression analyses were *** African Americans and Hispanics were more likely to be in poverty in comparison with non-Hispanic *** African Americans were unemployed than *** who received fringe benefits,were more satisfied with jobs,and were employed were more likely to have higher levels of *** was negatively associated with *** effects were found between African Americans and job satisfaction predicting *** The role of employers is important in cultivating employees’*** outcomes or feelings of happiness from the workplace may be more important to non-Hispanic Whites compared to African Americans and Hispanics.

关键词： Economic well-being Self-esteem Racial/Ethnic disparities Adulthood

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YOLO-Based Damage Detection with StyleGAN3 Data Augmentation for Parcel Information-Recognition System

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Computers, Materials & Continua 2024年第7期80卷 195-215页

作者： Seolhee Kim Sang-Duck lee Department of Electrical and Computer Engineering Sungkyunkwan UniversitySuwon16419Republic of Korea Logistics System Research Division Korea Railroad Research InstituteUiwang16105Republic of Korea

Damage to parcels reduces customer satisfactionwith delivery services and increases return-logistics *** can be prevented by detecting and addressing the damage before the parcels reach the ***,various studies have been conducted on deep learning techniques related to the detection of parcel *** study proposes a deep learning-based damage detectionmethod for various types of *** is intended to be part of a parcel information-recognition systemthat identifies the volume and shipping information of parcels,and determines whether they are damaged;this method is intended for use in the actual parcel-transportation *** this purpose,1)the study acquired image data in an environment simulating the actual parcel-transportation process,and 2)the training dataset was expanded based on StyleGAN3 with adaptive discriminator ***,3)a preliminary distinction was made between the appearance of parcels and their damage status to enhance the performance of the parcel damage detection model and analyze the causes of parcel ***,using the dataset constructed based on the proposed method,a damage type detection model was trained,and its mean average precision was *** model can improve customer satisfaction and reduce return costs for parcel delivery companies.

关键词： Parcel delivery service damage detection damage classification data augmentation generative adversarial network

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