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1例乙状结肠癌术后并发急性溃疡性结肠炎

世界核心医学期刊文摘（胃肠病学分册） 2006年第8期2卷 51-52页

作者： Takakura M. Mochizuki n. Yamauchi K. 郑世成(译) 王顺涛(校) Department of Gastroenterology Hachioji Digestive Disease Hospital 177 -3 Yorozu-cho Hachioji Tokyo 192-0903 Japan 不详

We describe a case of ulcerative colitis (UC) where clinical symptoms began abruptly within a few weeks after colon resection. The patient, a 44- year-old woman, was first referred to our hospital for the treatment of colon cancer. During the past several years, she had not had any inflammatory bowel disease-like clinical symptoms, such as frequent diarrhea or abdominal discomfort. Before the operation, both macroscopic and microscopic examination revealed that no remarkable inflammatory change was associated with the cancer in any area of her colon. At 10 days after the operation, she started to complain of frequent watery diarrhea. Two weeks after the operation, she was readmitted to our hospital because of frequent bloody diarrhea, fever, and abdominal discomfort. Based on endoscopic and histological examinations, she was diagnosed as having severe UC and was treated with hyperalimentation, predonisolone, mesalazine, and granulocyte apheresis. However, she did not respond to this combination therapy. At 45 days after the first operation, owing to sudden onset hemorrhagic shock, she underwent a second colectomy. The resected specimen of the entire colon showed severe pancolitis, and histological examination revealed severe inflammatory changes in the lamina propria together with crypt distortion, all of which were consistent with UC.

关键词：急性溃疡性结肠炎乙状结肠癌术后并发次全结肠切除术水样腹泻腹部不适联合治疗炎症性肠病失血性休克切除术后

心脏外科手术后早期中心静脉血氧饱和度对患者预后预测及护理指导的价值

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当代医药论丛 2022年第19期20卷 1-4页

作者：黄梓贤张璐曾丽若何海林赵菲菲张崇健广东省人民医院广东省医学科学院广东广州510000

目的:分析心脏外科手术后早期中心静脉血氧饱和度(ScvO_(2))对患者预后预测的临床意义及对ICU早期识别患者病情并实施层级护理的指导价值。方法:连续选取181例心脏外科手术后的成人患者。术后入ICU后1 h内通过中心静脉导管采集标本测定S... 详细信息

目的:分析心脏外科手术后早期中心静脉血氧饱和度(ScvO_(2))对患者预后预测的临床意义及对ICU早期识别患者病情并实施层级护理的指导价值。方法:连续选取181例心脏外科手术后的成人患者。术后入ICU后1 h内通过中心静脉导管采集标本测定ScvO_(2),并按ScvO_(2)的水平将这些患者分为A组(ScvO_(2)>65%,143例)和B组(ScvO_(2)≤65%,38例)。对比分析两组患者的术中体外循环时间、主动脉阻断时间及术后ICU各观察指标。结果:A组患者的术中体外循环时间和主动脉阻断时间均短于B组患者,差异有统计学意义(P<0.05)。A组患者的术后呼吸机使用时间和重症监护时间均短于B组患者,其复合不良预后的发生率低于B组患者,差异有统计学意义(P<0.05)。采用ROC曲线评价心脏外科手术后ScvO_(2)对患者预后的预测价值,曲线下面积为0.783,P<0.01,提示心脏外科手术后早期ScvO_(2)对患者不良预后有较好的预测价值。结论:心脏外科手术后早期ScvO_(2)≤65%的患者术后呼吸机通气时间和ICU监护时间延长,术后并发症的发生率升高,ScvO_(2)能有效预测患者的预后。护士应当提高对术后低ScvO_(2)患者的关注度,综合优化护理程序及人员层级配置,提高护理质量,进而改善患者的预后。

关键词：心脏外科手术中心静脉血氧饱和度预后病情分级层级护理

noncontrast-enhanced MRI-based noninvasive Score for Portal hypertension(CHESS1802):An International Multicenter Study

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Journal of Clinical and Translational Hepatology 2021年第6期9卷 818-827页

作者： Yanna Liu Tianyu Tang necatiÖrmeci Yifei Huang Jitao Wang Xiaoguo Li Zhiwei Li Weimin An Dengxiang Liu Chunqing Zhang Changchun Liu Jinqiang Liu Chuan Liu Guangchuan Wang Cristina Mosconi Alberta Cappelli Antonio Bruno Seray Akçalar EmrecanÇelebioğlu EvrenÜstüner Sadık Bilgiç Zeynep Ellik ÖzgünÖmer Asiller Lei Li Haijun Zhang ning Kang Dan Xu Ruiling He Yan Wang Yang Bu Ye Gu Shenghong Ju Rita Golfieri Xiaolong Qi CHESS Center Institute of Portal HypertensionThe First Hospital of Lanzhou UniversityLanzhouGansuChina CHESS Center The Sixth People’s Hospital of ShenyangShenyangLiaoningChina Department of Infectious Disease Nanfang HospitalSouthern Medical UniversityGuangzhouGuangdongChina Department of Microbiology and Infec-tious Disease Center School of Basic Medical SciencesPeking University Health Science CenterBeijingChina Depart-ment of Radiology Zhongda HospitalMedical School of Southeast UniversityNanjingJiangsuChina Istanbul Health and Technology University Zytinburnu/İstanbulTurkey CHESS Working Party Xingtai People’s HospitalXingtaiHebeiChina Department of Hepatobiliary Surgery The Third People’s Hospital of ShenzhenShenzhenGuangdongChina Department of Radiology Fifth Medical Center of PLA General HospitalBeijingChina Department of Gastroenterol-ogy Shandong Provincial Hospital Affiliated to Shandong UniversityJinanShandongChina Department of Radiology IRCCS Azienda Ospedaliero-Universitaria di BolognaUniversity of BolognaItaly Department of Radiology Ankara University School of MedicineAnkaraTurkey Department of Gastroenterology Ankara University School of MedicineAnkaraTurkey Department of Hepatobiliary Surgery People’s Hospital of Ningxia Hui Autonomous RegionYinchuanNingxiaChina

Background and Aims:This study aimed to determine the performance of the non-invasive score using noncontrastenhanced MRI(CHESS-DIS score)for detecting portal hy-pertension in ***:In this international multicenter,diagnostic study(***,nCT03766880),patients with cirrhosis who had hepatic venous pressure gradient(HVPG)measurement and noncontrast-enhanced MRI were prospectively recruited from four university hospitals in China(n=4)and Turkey(n=1)between December 2018 and April 2019.A cohort of patients was retrospectively recruited from a university hospital in Italy between March 2015 and november *** segmentation of the liver on fat-suppressed T1-weighted MRI maps,CHESS-DIS score was calculated automatically by an in-house developed code based on the quantification of liver surface ***:A total of 149 patients were included,of which 124 were from four Chinese hospitals(training cohort)and 25 were from two international hospitals(validation cohort).A positive correlation between CHESS-DIS score and HVPG was found with the correlation coefficients of 0.36(pnd 0.55(pning and validation cohorts,*** area under the receiver operating characteristic curve of CHESS-DIS score in detection of clinically significant portal hypertension(CSPH)was 0.81 and 0.9 in the training and validation cohorts,*** intra-class correlation coefficients for assessing the inter-and intra-observer agreement were 0.846 and 0.841,***:A non-invasive score using noncontrast-enhanced MRI was developed and proved to be significantly correlated with invasive ***,this score could be used to detect CSPH in patients with cirrhosis.

关键词： Liver cirrhosis Advanced chronic liver disease Hepatic venous pressure gradient Liver surface nodularity Imaging

慢性HCV感染患者的循环血树突状细胞感染、功能障碍及其亚群

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世界核心医学期刊文摘（胃肠病学分册） 2005年第2期1卷 57-58页

作者： Tsubouchi E. Akbar Sk.Md.F. Horiike n. Onji M. 姜建涛 Third Dept. of Intern al Medicine Ehime University School of Medicine Shigenobu-Cho Onsen-Gun Eh ime 791-0295 Japan

Background. To understand interactions between dendritic cells (DCs) and virus es, in vitro-cultured monocyte-derived DCs are usually used for functional ana lyses. However, several recent studies indicate that circulating blood DCs are d ifferent from monocyte-derived DCs, both phenotypically and functionally. Indee d, circulating DCs act as functional antigen-presenting cells in vivo. This stu dy was conducted to evaluate the function of circulating blood DCs in patients w ith chronic hepatitis C and to examine whether circulating DCs from these patien ts were infected by hepatitis C virus (HCV). Methods. The phenotypes and biologi cal functions of circulating DCs from patients with chronic hepatitis C (n = 27) , patients with non-HCV chronic liver disease (n = 7), and normal volunteers (n = 13) were analyzed. The presence of the HCV genome sequence in circulating blo od IDS and in subsets of circulating IDS (myeloid DCs and plasmacytoid DCs) in p atients with chronic hepatitis C was assessed. Results. The stimulatory capacity of circulating DCs was significantly reduced in patients with chronic hepatitis C compared to patients with non-HCV chronic liver diseases and normal controls (P nA was identified in the overall population of circulating DCs , and in myeloid DCs and plasmacytoid DCs. nucleotide sequences of the 5 non-co ding region of HCV RnA showed marked differences between paired samples of circu lating DCs and sera from the same patients. Conclusions. Our results indicate th e dysfunction and infection of circulatory blood DCs in chronic HCV infection. T his may compromise the capacity of patients with hepatitis C to induce an effect ive antiviral immune response.

关键词：循环血树突状细胞亚群功能障碍慢性丙型肝炎丙型肝炎患者抗病毒慢性肝病患者免疫应答浆细胞样

丹麦úrhus县2型糖尿病随机人群中视网膜病变的患病率

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世界核心医学期刊文摘（眼科学分册） 2005年第2期1卷 8-9页

作者： Hove M.n. Kristensen J.K. Lauritzen T. Bek T. 杨建刚 Department of Ophtha lmology úrhus University Hospital DK-8000 úrhus C Denmark

Purpose: To determine the prevalence of diabetic retinopathy and the causes of visual impairment in an unselected population of type 2 diabetes patients, and to describe the risk factors for developing diabetic retinopathy in this populat ion. Methods: A total of 10851 type 2 diabetes patients were identified in the c ounty of úrhus. A representative sample of 378 patients underwent a routine ocu lar examination, including fundus photography. Blood pressure and serum haemoglo bin A1c, total cholesterol, high density lipoprotein cholesterol, triglyceride a nd apolipoprotein a were measured. Results: The prevalence of diabetic retinopat hy in the type 2 diabetes population was 31.5%. In all, 2.9%had proliferative diabetic retinopathy and 5.3%had clinically significant macular oedema. Of the latter, 8/20 (40%) were newly identified and had not yet been lasertreated. The re was a positive correlation between severity of retinopathy and duration of di abetes, HbA1c, systolic blood pressure and treatment with insulin. none of the p atients had social blindness (visual acuitynt (VA nclusion: The prevalence of diabetic retinop athy and visual impairment in this unselected type 2 diabetes population was low er than anticipated from the existing literature,and causes other than diabetic retinopathy contributed significantly to the occurrence of visual loss. A substa ntial number of the patients with vision-threatening diabetic maculopathy had n ot been referred for timely photocoagulation treatment.

关键词：视网膜病变 rhus 眼底照相视力损害黄斑水肿眼科常规检查光凝治疗高密度脂蛋白载脂蛋白总胆固醇

胰十二指肠切除术后早期经口肠内营养安全性和可行性的临床研究

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肠外与肠内营养 2011年第1期18卷 24-27页

作者：杨延辉赵白皖李园黄施恩刘伟峰金哲悟葛鹏磊孙君军河南科技大学第一附属医院肝胆外科河南洛阳471003 韩国国立全北大学医院肝胆胰移植外科韩国全罗北道561712 韩国大田太阳医院普通外科韩国大田366100

目的:探讨胰十二指肠切除术后早期经口肠内营养的安全性和可行性。方法:回顾性调查研究57例行胰十二指肠切除术的病人,随机分为早期经口肠内营养组(EOF,n=28,术后2 d内开始经口进食)和延迟进食组(DOF,n=29,术后超过5 d经口进食)。比较... 详细信息

目的:探讨胰十二指肠切除术后早期经口肠内营养的安全性和可行性。方法:回顾性调查研究57例行胰十二指肠切除术的病人,随机分为早期经口肠内营养组(EOF,n=28,术后2 d内开始经口进食)和延迟进食组(DOF,n=29,术后超过5 d经口进食)。比较两组病人术前和术后第1、7和14天血清清蛋白(ALB)、前清蛋白(PA)、转铁蛋白(TF)水平、淋巴细胞计数以及术后并发症和平均住院时间。结果:两组病人胰十二指肠切除术后PA水平明显下降(P<0.05)。两组病人术后并发症比较无显著性差异,但DOF组病人二次手术发生率较EOF组明显增多(P<0.05);同时DOF组病人住院时间也长于EOF组(P<0.05)。结论:胰十二指肠切除术后EOF不仅能改善病人的营养状况,不增加并发症的发生率,而且还可降低二次手术的发生率、缩短住院时间。

关键词：胰十二指肠切除术早期经口肠内营养并发症

Luminescence dating of bottom sediments from Lake Hovsgol,Mongolia(HDP-08)

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地球环境学报 2011年第1期 314-314页

作者： Ito K Hasebe n Kashiwaya K nakamura T Ganzawa Y Graduate School of natural Science and Technology Kanazawa University Institute of nature and Environmental Technology Kanazawa University Center for Chronological Research Nagoya UniversityFuro-choChikusa-kuNagoya 464-8602Japan Institute of Earth Science Hokkaido University of Education

To understand the past environmental change using geological archives（e.g.,core of sediments or ice）,establishing the reliable chronology is one of the most important key *** dating is a powerful mediod due to its applicability to quartz,which is common mineral found in various kinds of environment,and the datable age range being from present to 100 cal ka.A core of18 m in length were obtained in 2008 from Lake Hovsgol,Mongolia（HDP-08） for the purpose of reconstructing the climate-forcing environmental fluctuation in the central continent with high *** this study,optically stimulated luminescence（OSL） from quarts and red thermoluminescence（RTL） from carbonate were measured to estimate depositional ages the *** 16 samples were collected every 10 cm from the core using squire stainless tubes（1 cm × 1 cm） with the length of 4 *** surface part,which was exposed to light during core dividing procedures,was then removed in a dark *** chemical treatment to extract fine grained quarts,OSL were *** were measured on the bulk sediments based on the thermoluminescence colour images of particular components of *** was measured by MOSL-11 or MOSL-22 with x-ray source（MEDEC）.When the Des estimated from OSL and RTL are compared,they are identical for eleven samples within the error *** estimate annual dose,concentrations of radioisotopes(238U,234U,232Th and87Rb) were measured by laser ablation- inductively coupled plasma- mass spectrometry（LA-ICPMS）.Potassium concentration was measured by X-ray fluorescence spectrometry（XRF）.The OSL ages increase from（6.8 ± 3.7） ka to（72.4 ± 13.6） ka along with the depth,but are smaller than C *** may be caused by either or both of underestimation of water content in estimation of annual dose and overestimation of C ages due to reservoir effect.

关键词： Lake HDP-08 Luminescence dating of bottom sediments from Lake Hovsgol,Mongolia OSL

多发性神经病疑似病例中诊断性电生理学检查的临床应用

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世界核心医学期刊文摘（神经病学分册） 2005年第3期1卷 49-49页

作者： cho S.C. Siao-Tick chong P. So Y.T. 袁海峰 Department of neurology Stanford University School of Medicine 300 Pasteur Drive Stanford CA 94305 United States Dr.

Although paresthesias of the distal lower limbs are characteristic features of polyneuropathy, they may also herald the presence of a focal neuropathy, polyra diculopathy, or myelopathy. Electromyography and nerve conduction studies (EMG/n CS) are widely used in the evaluation of such symptoms, but their utility has no t been subjected to vigorous scrutiny. We investigated the clinical impact of th e electrodiagnostic consultation in assessing suspected polyneuropathy. When com pared with the clinical impression, the result of the electrodiagnostic consulta tion was confirmatory in only 39%of all patients, and changed the diagnosis or uncovered an additional diagnosis in 43%. An alternative diagnosis was likely w hen either weakness was present (75%) or the Achilles stretch reflex was preser ved (48%). These data support the use of EMG/nCS in the diagnostic evaluation o f patients presenting with distal paresthesias, especially in those with preserv ed Achilles reflexes or motor deficits.

关键词：多发性神经病疑似病例电生理学临床应用腱反射脊髓病诊断评估感觉异常肌无力神经传导

hfg12凝血酶原酶短干扰RnA表达质粒的构建及其效应

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中华肝脏病杂志 2008年第12期16卷 930-934页

作者：习东李黎高随朱传龙郭健文王鸣罗小平宁琴华中科技大学同济医学院附属同济医院感染性疾病研究所、感染科武汉430030 华中科技大学同济医学院附属儿科医院武汉

目的探索人fg12凝血酶原酶（hfg12）短干扰RnA（siRnA）在体外对hfg12凝血酶原酶基因表达的干预效应。方法构建产生hfg12短发夹状RnA（shRnA）的载体Phfg12shRnA，将其与hfg12-增强型绿色荧光蛋白（EGFP）融合基因表达质粒pEGFPhfg12共... 详细信息

目的探索人fg12凝血酶原酶（hfg12）短干扰RnA（siRnA）在体外对hfg12凝血酶原酶基因表达的干预效应。方法构建产生hfg12短发夹状RnA（shRnA）的载体Phfg12shRnA，将其与hfg12-增强型绿色荧光蛋白（EGFP）融合基因表达质粒pEGFPhfg12共转染到中国仓鼠卵母细胞（cho细胞），转染48h后，倒置荧光显微镜下观察EGFP在cho细胞中的表达，并通过流式细胞仪检测荧光细胞阳性率。将Phfg12shRnA和hfg12表达质粒pcDnA3．1-hfg12共转染到cho细胞，通过实时荧光定量PCR和免疫组织化学检测hfg12基因转录和蛋白表达水平的变化。分为4组：共转染P—hfg12shRnA和pcDnA3．1-hfg12为干预组，共转染无关序列shRnA表达质粒和pcDnA3．1-hfg12为非相关干预组，仅转染pcDnA3．1-hfg12为未干预组，不转染任何质粒为空白组。结果在cho细胞中，含Phfg12shRnA的干预组较未干预组和非相关干预组的绿色荧光强度明显减弱，荧光细胞数明显减少；荧光表达阳性细胞率：干预组α为6．5％±0．2％，未干预组α为40．1％±1．8％，两组比较，Χ^2=8．056，P〈0．01，差异有统计学意义。抑制效率达85．5％。hfg12shRnA显著抑制了hfg12mRnA和蛋白质的表达，干预组hfg12mRnA水平为0．11±0．01，未干预组为0．84±0．06，两组比较，F=10．7，P〈0．01，差异有统计学意义。结论P—hfg12shRnA可在体外高效特异地抑制hfg12基因转录和蛋白的表达，为进一步的体内干扰实验奠定了基础。

关键词：肝功能衰竭 RnA cho细胞 fg12凝血酶原酶