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Entacapone promotes hippocampal neurogenesis in mice

Neural Regeneration Research 2021年第6期16卷 1005-1010页

作者： Dae Young Yoo Hyo Young Jung Woosuk Kim kyu ri hahn Hyun Jung Kwon Sung Min Nam Jin Young Chung Yeo Sung Yoon Dae Won Kim In Koo Hwang Department of Anatomy and Cell Biology College of Veterinary Medicineand Research Institute for Veterinary ScienceSeoul National UniversitySeoulSouth Korea Department of Anatomy College of MedicineSoonchunhyang UniversityCheonanSouth Korea Department of Biomedical Sciences and Research Institute for Bioscience and BiotechnologyHallym UniversityChuncheonSouth Korea Department of Biochemistry and Molecular Biology Research Institute of Oral SciencesCollege of DentistryGangneung-Wonju National UniversityGangneungSouth Korea Department of Anatomy College of Veterinary MedicineKonkuk UniversitySeoulSouth Korea Department of Veterinary Internal Medicine and Geriatrics College of Veterinary MedicineKangwon National UniversityChuncheonSouth Korea

Entacapone,a catechol-O-methyltransferase inhibitor,can strengthen the therapeutic effects of levodopa on the treatment of Parkinson’s ***,few studies are reported on whether entacapone can affect hippocampal neurogenesis in *** investigate the effects of entacapone,a modulator of dopamine,on proliferating cells and immature neurons in the mouse hippocampal dentate gyrus,60 mice(7 weeks old)were randomly divided into a vehicle-treated group and the groups treated with 10,50,or 200 mg/kg *** results showed that 50 and 200 mg/kg entacapone increased the exploration time for novel object *** staining results revealed that after entacapone treatment,the numbers of Ki67-positive proliferating cells,doublecortin-positive immature neurons,and phosphorylated cAMP response element-binding protein(pCREB)-positive cells were significantly *** blot analysis results revealed that treatment with tyrosine kinase receptor B(TrkB)receptor antagonist significantly decreased the exploration time for novel object recognition and inhibited the expression of phosphorylated TrkB and brain-derived neurotrophic factor(BDNF).Entacapone treatment antagonized the effects of TrkB receptor *** results suggest that entacapone treatment promoted hippocampal neurogenesis and improved memory function through activating the BDNF-TrkB-pCREB *** study was approved by the Institutional Animal Care and Use Committee of Seoul National University(approval ***-130730-1)on February 24,2014.

关键词： brain-derived neurotrophic factor entacapone hippocampus neurogenesis neurotrophic factor phosphorylated cAMP response element-binding protein tyrosine kinase receptor B receptor

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Improving Oxygen Binding of Desiccated Human Red Blood Cells

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Advances in Bioscience and Biotechnology 2016年第2期7卷 47-54页

作者： Steingrimur Stefansson David S. Chung Jamie Yoon Won Seok Yoo Young Wook Park George Kim David hahn Huyen Le Sung-Jae Chung Stephen P. Bruttig David H. Ho HeMemics Biotechnologies Inc. Rockville MD USA Division of Biology & Medicine Brown University Providence RI USA Earl Warren College UC San Diego CA USA Department of Chemistry Michigan University Ann Arbor MI USA Seoul International School Seongnam South Korea Fuzbien Technology Institute Rockville MD USA Nauah Solutions Mclean VA USA Marymount University School of Arts & Science Arlington VA USA

Desiccating human red blood cells (RBCs) to increase their storage life has been the subject of intense research for a number of years. However, drying RBCs invariably compromises their integrity and has detrimental effects on hemoglobin function due to autoxidation. We have previously demonstrated an RBC desiccation and rehydration process that preserves RBC antigenic epitopes better than frozen RBCs. This study expands on those observations by examining what effects this desiccation process has on RBC hemoglobin function with respect to oxygen binding properties. In this paper, we examined RBCs from normal donors which were desiccated to 25% moisture content and stored dry for 2 weeks at room temperature prior to rehydration with plasma followed by structural and functional studies. Our data showed that approximately 98% of the RBCs were intact upon rehydration based on hemolysis assays. Oxygen dissociation curves for the desiccated/rehydrated RBCs showed a left shift compared to fresh RBCs (pO2 = 17 mmHg vs. 26 mmHg, respectively). The desiccated/rehydrated RBCs also showed an increase in methemoglobin compared to fresh RBCs (4.5% vs 0.9%, respectively). 2,3-Diphosphoglycerate concentration of the desiccated/rehydrated RBCs was reduced by 20%. In conclusion, although this RBC dehydration process preserves RBC integrity and hemoglobin oxygen binding properties better than most other dehydration techniques described so far, further optimization and long-term studies are needed to make this procedure acceptable for human transfusion.

关键词： Desiccation Red Blood Cells Oxygen Binding Hemolysis Methemoglobin 2 3-Diphosphoglycerate

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矩阵域l_A^p的哈恩性质(英文)

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延边大学学报（自然科学版） 2009年第2期35卷 106-108页

作者：郑福崔成日渤海大学数学系辽宁锦州121013 延边大学理学院数学系吉林延吉133002

给出了两个关于矩阵域lAp(1≤p<∞)的哈恩性质的结果,从而推广了近期的类似结果.

关键词：哈恩性质矩阵域序列空间

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