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Management of hepatocellular carcinoma in the elderly

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World Journal of Hepatology 2015年第11期7卷 1521-1529页

作者： Mauro Borzio Elena Dionigi Giancarlo parisi Ivana Raguzzi Rodolfo Sacco Unità di Gastroenterologia Azienda Ospedaliera di Melegnano Dipartimento di Medicina Ospedale Santa Maria del Prato Unità di Gastroenterologia Ospedale Cisanello

Mean age of hepatocellular carcinoma(HCC) patients has been progressively increasing over the last decades and ageing of these patients is becoming a real challenge in every day clinical practice. Unfortunately, international guidelines on HCC management do not address this problem exhaustively and do not provide any specific recommendation. We carried out a literature search in MEDLINE database for studies reporting on epidemiology, clinical characteristics and treatment outcome of HCC in elderly patients. Available data seem to indicate that in elderly patients the outcome of HCC is mostly influenced by liver function and tumor stage rather than by age and the latter should not influence treatment allocation. Age is not a risk for resection and older patients with resectable HCC and good liver function could gain benefit from surgery. Mild comorbidities do not seem a contraindication for surgery in aged patients. Conversely, major resection in elderly, even when performed in experienced high-volume centres, should be avoided. Both percutaneous ablation and transarterial chemoembolization are not contraindicated in aged patients and safety profile of these procedures is acceptable. Sorafenib is a viable option for advanced HCC in elderly provided that a careful evaluation of concomitant comorbidities, particularly cardiovascular ones, is taken into account. Available data seem to suggest that in either elderly and younger, treatment is a main predictor of outcome. Consequently, a nihilistic attitude of physicians towards under- or no-treatment of aged patients should not be longer justified.

关键词： Hepatocarcinoma Epidemiology Cirrhosis Elderly Treatment

Maize Seeds Submitted to Thermotherapy and Analyzed by Dynamic Speckle

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Journal of Agricultural Science and Technology(B) 2018年第2期8卷 115-121页

作者： Lucas Sacramoni Peixoto Gisela Maiara Silva Armando Kazuo Fujii Joao José Dias parisi Rosa Helena Aguiar Juliana Aparecida Fracarolli School of Agricultural Engineering University of Campinas (UNICAMP) Av. Candido Rondon 501 Campinas 13083-875 SP Brazil

The quality of the seeds used for sowing is fundamental for a high productivity and quality of the crop. Therefore, eradicating pathogens is essential for the plant to develop in the best possible way. The eradication of those pathogens can be accomplished by means of treatments that consist of the application of substances to the seeds or by performing physical procedures. Thermotherapy is a physical treatment, in which the seed is exposed to a given thermal energy, such as heated air or steam, and can be highly efficient for controlling those pathogens, in addition to reducing environmental damage and costs. The present work aimed to evaluate the efficiency of thermotherapy in two ways： wet heat （water） and dry heat （water vapor）, both at 60 °C, alternating the exposure time to the thermal sources. The treatment with humid heat with a time of exposure of 5 min was the most efficient, since it presented higher germination percentages （83%） and less occurrence of Fusarium sp. （33%）. It was observed that the most efficient thermotherapy is in the control of Fusarium, the most aggressive is for the quality of the seed. The quality of the treatments was evaluated through standard methodologies, according to the rules for seed analysis, such as germination and sanitation tests. Biospeckle laser was used to identify the microbial activity in these seeds, through activity maps generated by laser speckle contrast analysis （LASCA） processing. In this way, the research involving thermotherapy can be done by varying the temperature and the time of exposure to obtain values that considerably reduce the pathogenic agents and preserve the quality, in order to maintain the values of germination and vigor acceptable for commercialization.

关键词： Thermal treatment wet heat dry heat Fusarium germination.

Molecular Cloning and Characterization of a Candidate ENOX Protein of <i>Saccharomyces cerevisiae</i>with a 25 Min Period Insensitive to Simalikalactone D Inhibition and Melatonin

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Advances in Biological Chemistry 2014年第5期4卷 339-350页

作者： Aya F. Ryuzoji Debby H. parisi Sara Dick James Kim Dorothy M. Morré D. James Morré Department of Biology Valparaiso University Valparaiso USA Mor-NuCo Inc. Purdue Research Park West Lafayette USA

A yeast deletion library was screened based on NADH fluorescence using a 384-well plate assay to identify a yeast isolate lacking a previously identified cell surface oxidase exhibiting an oscillatory pattern with a period length of 25 min and resistant to the ENOX1-specific inhibitor simalikalactone D (YNOX for yeast-specific ENOX = ENOX4). The cDNA was cloned from a yeast over expression library using NADH fluorescence analyzed by Fast Fourier transform and decomposition fits. The objective was to identify and sequence an ENOX homologue in Saccharomyces cerevisiae with a 25 min rather than a 24 min period length (YNOX). The finding identified YDR005C as the yeast ENOX protein with a temperature-independent 25 min period length and insensitive to inhibition by simalikalactone D. The encoded protein was expressed in bacteria and characterized. Gel slices corresponding to 55 kDa and 39 kDa His-tagged proteins exhibited 25 min oscillatory patterns not inhibited by 1 μM simalikalactone D for both NADH oxidation and reduced coenzyme Q10 oxidation as well as a protein disulfide-thiol interchange activity which alternated with the oxidative activities. Activities were phased by low-frequency electromagnetic fields but, in contrast, to yeast ENOX1, not by addition of melatonin. The assay in the presence of D2O shifted the length of the oscillatory period from 25 min to 32 min. The YDR005C deletion mutant cells lacked the ENOX4 clock output present in the wild type yeast.

关键词： Biological Clock ECTO-NOX (ENOX) Proteins YNOX = ENOX4 Ultradian Oscillator Yeast (Saccharomyces cerevisiae)

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中国集成电路 2019年第3期28卷 77-80页

作者： Carmelo parisi Alessio Corsaro Richard Hildenbrandt STMicroelectronics

电机驱动市场特别是家电市场对系统的能效、尺寸和稳健性的要求越来越高。为满足市场需求,意法半导体针对不同的工况提供了多种功率开关技术,例如IGBT和最新的超结功率MOSFET。本文在实际工况下的一个低功耗电机驱动电路(例如小功率冰... 详细信息

电机驱动市场特别是家电市场对系统的能效、尺寸和稳健性的要求越来越高。为满足市场需求,意法半导体针对不同的工况提供了多种功率开关技术,例如IGBT和最新的超结功率MOSFET。本文在实际工况下的一个低功耗电机驱动电路(例如小功率冰箱压缩机)内测试了基于这两种功率技术的SLLIMMTM-nano(小型低损耗智能模压模块),并从电热性能两个方面对这两项技术进行了详细的分析和比较。

关键词：能效功率电机意法工况电路驱动压缩机

Pre-operative clinical and instrumental factors as antireflux surgery outcome predictors

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World Journal of Gastrointestinal Surgery 2016年第11期8卷 719-728页

作者： Salvatore Tolone Giorgia Gualtieri Edoardo Savarino Marzio Frazzoni Nicola de Bortoli Manuele Furnari Giuseppina Casalino Simona parisi Vincenzo Savarino Ludovico Docimo Division of General and Bariatric Surgery Second University of Naples Division of Gastroenterology Department of Surgery Oncology and Gastroenterology University of Padua Division of Gastroenterology Baggiovara Hospital Division of Gastroenterology Department of Internal Medicine University of Pisa Division of Gastro-enterology Department of Internal Medicine University of Genoa

Gastroesophageal reflux disease(GERD) is nowadays a highly prevalent, chronic condition, with 10% to 30% of Western populations affected by weekly symptoms. Many patients with mild reflux symptoms are treated adequately with lifestyle modifications, dietary changes, and low-dose proton pump inhibitors(PPIs). For those with refractory GERD poorly controlled with daily PPIs, numerous treatment options exist. Fundoplication is currently the most commonly performed antireflux operation for management of GERD. Outcomes described in current literature following laparoscopic fundoplication indicate that it is highly effective for treatment of GERD; early clinical studies demonstrate relief of symptoms in approximately 85%-90% of patients. However it is still unclear which factors, clinical or instrumental, are able to predict a good outcome after surgery. Virtually all demographic, esophagogastric junction anatomic conditions, as well as instrumental(such as presence of esophagitis at endoscopy, or motility patterns determined by esophageal high resolution manometry or reflux patterns determined by means of pH /impedance-pH monitoring) and clinical features(such as typical or atypical symptoms presence) of patients undergoing laparoscopic fundoplication for GERD can be factors associated with symptomatic relief. With this in mind, we sought to review studies that identified the factors that predict outcome after laparoscopic total fundoplication.

关键词： Gastroesophageal reflux disease Antireflux surgery Outcome predictors Fundoplication Nissen Laparoscopy High resolution manometry ImpedancepH monitoring

Behavioral Risk Factors for Chronic Non-Communicable Diseases in Adults and Elderly People in the City of Ribeirão Preto—SP

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Journal of Biosciences and Medicines 2022年第12期10卷 42-54页

作者： Jennifer Vieira Paschoalin Marques Carla Regina de Souza Teixeira Maria Lucia Zanetti Vívian Saraiva Veras Paula parisi Hodniki Luis Fernando Costa Pereira Fundamental Nursing Department Escola de Enfermagem de Ribeir&atilde o Preto Universidade de S&atilde o Paulo Ribeir&atilde o Preto Brazil

Aims: to analyze the presence and simultaneity of behavioral risk factors for chronic non-communicable disease (NCD) in adults and the elderly. Methods: quantitative, cross-sectional and observational study. Healthy and unhealthy eating are classified according to the frequency of food consumption. Smoking is expressed by the percentage of smokers. Harmful alcohol consumption by the percentage of individuals who consumed alcoholic beverages at least once in the last 30 days. Classification of the level of physical inactivity required to practice at least 150 minutes of physical activity. Results: the sample constituted 719 people, 535 adults and 184 elderly. The behavioral risk factor reported by most adults 499 (93.3%) and elderly 156 (84.8%) was unhealthy eating. Frequency 72% higher of smoking, four times higher of harmful alcohol consumption and 10% higher of unhealthy food among adults when compared to the elderly. The simultaneity between risk factors was 39% greater in adults than in the elderly. Discussion: risk factors evaluated in this study are key aspects of the development of NCDs. Adults have 2.43 times the chance of presenting two risk factors and 7.73 times the chance of presenting three in relation to the elderly. Conclusion: To achieve more effective and differentiated results, knowing and directing measures to control behavioral risk factors, whether isolated or concurrent, requires specific knowledge.

关键词： Risk Factors Chronic Disease Adult Elderly People Health Unic System

Bortezomib-Induced Bilateral Eye Swelling and Cutaneous Adverse Reaction in a Patient with Plasma Cell Leukemia—A Case Report

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Case Reports in Clinical Medicine 2023年第11期12卷 452-456页

作者： Azeezat Ariwoola Ehab A. M. Elagab Tahira Fardous Saburi Oyewale Sara parisi Heather Williams Amal M. Shediwah Islam A. Mahmoud Ratesh Khillan School of Public Health Rutgers University New Brunswick USA Department of Pathology College of Medicine Najran University Najran Saudi Arabia Brooklyn Cancer Care New York USA Department of Surgery University of Ilorin Teaching Hospital Ilorin Nigeria Shiqaq Primary Health Center MOH Al Darb Saudi Arabia SUNY Downstate University Hospital New York USA

Bortezomib, a proteasome inhibitor, is an established therapy against plasma cell leukemia—a variant of plasma cell dyscrasias. Its most frequent side effects have been listed as peripheral neuropathy, neuropathic pain, thrombocytopenia, and gastrointestinal problems. Allergic skin reaction is a rarely documented side effect in patients receiving bortezomib-based chemotherapy. A combination therapy consisting of intravenous bortezomib, oral Revlimid tablets, and oral dexamethasone tablets has been prescribed for the patient after his recent diagnosis of plasma cell leukemia. While receiving his third treatment cycle, he developed an allergic reaction (skin rash) involving the neck, and wrists, and mild bilateral eye swelling. The infusion was stopped immediately and then ciprofloxacin ophthalmic solution and oral diphenhydramine 25 mg were prescribed to the patient with significant improvement in his clinical condition. He was temporarily taken off bortezomib. At a follow-up visit a week later, a significant improvement was noticed in his condition. Rash had reduced on neck and wrists, and eye swelling had reduced as well. As of the time of writing this case report, he has been temporarily taken off bortezomib, but other medications in the treatment regimen were continued as prescribed.

关键词： Plasma Cell Leukemia Hematology Bortezomib Chemotherapy

Clinical impact of selective transarterial chemoembolization on hepatocellular carcinoma:A cohort study

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World Journal of Gastroenterology 2009年第15期15卷 1843-1848页

作者： Rodolfo Sacco Marco Bertini Pasquale Petruzzi Michele Bertoni Irene Bargellini Giampaolo Bresci Graziana Federici Luigi Gambardella Salvatore Metrangolo Giuseppe parisi Antonio Romano Antonio Scaramuzzino Emanuele Tumino Alessandro Silvestri Emanuele Altomare Claudio Vignali Alfonso Capria Gastroenterology Department Pisa University Hospital Institute of Interna Medicine University of Foggia Department of Diagnostic and Interventional Radiology Pisa University Hospital

AIM： To prospectively long term clinical impact evaluate the short and of selective transarterial chemoembolization （TACE） on fiver function in patients with hepatocellular carcinoma （HCC）. To assess side effects in relation to treatments. To analyze the overall survival and HCC progression free survival probability. METHODS： One hundred and seventeen cirrhotic patients with HCC were enrolled. Baseline liver function included Child-Pugh score and serum levels of alanine- aminotransferase （ALT）, prothrombin time （PT） and bilirubin. According to Cancer Liver Italian Program （CLIP） and Barcelona Clinic Liver Cancer （BCLC） staging systems, 71 patients were eligible for TACE; 32 had previously received treatment for HCC. No significant differences in liver function were observed between previously treated and not treated patients. TACE was performed by selective catheterization of the arteries nourishing the lesions. While hospitalized, patients underwent clinical, hematologic and ultrasonographic assessments. One month after TACE a CT scan was performed to assess tumor response. A second TACE was performed ＂on demand＂ Liver function tests were checked in all patients every four months. RESULTS： After first TACE, the mean Child-Pugh score increased from a mean baseline 5.62 ±1.12 to 6.11 ±1.57 at discharge time （P 〈 0.0001）, decreasing after four months to 5.81 ± 0.73 （not significant）. ALT, PT and bilirubin significantly （P 〈 0.0001） increased 24 h after TACE and progressively decreased until discharge. After the second TACE, variations in Child-Pugh score, ALT, PT and bilirubin were comparable to that described after the first TACE. No major complications were observed. The mean follow-up was 14.7 ＋ 6.3 mo （median： 16 mo）. Only one patient died. No other patient experienced important long term worsening of clinical status. The overall survival probability at twenty-four months was 98.18% with a correspondent HCC progression free survival probability of 69%. CONCLUSION：

关键词： Hepatocellular carcinoma Transarterialchemoembolization Liver function Liver cirrhosis Child-Pugh score

图形视网膜电图和视觉诱发电位对检测高眼压和青光眼视功能损害的临床能力

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世界核心医学期刊文摘（眼科学分册） 2006年第6期2卷 46-47页

作者： parisi V. Miglior S. Manni G. 曹绪胜(译) 不详 Fondazione Per I' OftalmologiaG. B. Bietti Via Santa MariaGoretti 66 00199Rome Italy

Objective: To assess the presence of normal or abnormal pattern electroretinogram (PERG) and visual evoked potential (VEP)-responses in patients with ocular hypertension or open-angle glaucoma (OAG). Design: Retrospective,cross-sectional,case-control study. Participants: Eighty normal control subjects (mean age,51.77± 6.04 years; 80 eyes),68 ocular hypertension patients (mean age,51.58± 7.12; 68 eyes; intraocular pressure IOP -2 decibels dB),and 84 OAG patients (mean age,52.77± 5.28; 84 eyes; IOP 0.01) between electrophysiological parameters and age,IOP before or under medical treatment,HFA,and corneal thickness values. Significant correlations (P<0.01) were observed in OAG eyes between electrophysiological results and HFA values. Pattern

关键词：图形视网膜电图视觉诱发电位高眼压症青光眼视功能损害临床能力 P100潜伏期正常对照组潜伏期延长检测开角型青光眼