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Septic cardiomyopathy phenotype in the critically ill may depend on antimicrobial resistance

Journal of Intensive Medicine 2024年第3期4卷 355-361页

作者： Vasiliki Tsolaki kyriaki parisi George E.Zakynthinos Efrosini Gerovasileiou Nikitas Karavidas Vassileios Vazgiourakis Epaminondas Zakynthinos Demosthenes Makris Intensive Care Unit University Hospital of LarissaUniversity of Thessaly Faculty of MedicineLarissaGreece Third Cardiology Clinic University of AthensSotiria HospitalAthensGreece Respiratory Department University Hospital of LarissaUniversity of Thessaly Faculty of MedicineLarissaGreece

Background Sepsis is a life-threatening organ dysfunction,and septic cardiomyopathy(SCM)may complicate the course of the *** with multidrug-resistant(MDR)pathogens has been linked with worse *** study aims to evaluate SCM in patients with infections caused by different antimicrobial-resistant *** This retrospective study included patients with sepsis/septic shock,hospitalized,and intubated in the intensive care unit of the University Hospital of Larissa between January 2022 and September 2023 with echocardiographic data during the first two days after infection *** patients were divided into two groups:non-MDR-SCM group and MDR-SCM *** cardiac function was compared between the two *** A total of 62 patients were included in the ***-four patients comprised the MDR-SCM and 18 the non-MDR-SCM ***-six patients(41.9%)presented with left ventricular(LV)systolic dysfunction,and≤35%right ventricular fractional area change(RVFAC)was present in 56.4%.LV systolic function was more severely impaired in the non-MDR-SCM group(left ventricular ejection fraction,35.8%±4.9%vs.45.6%±2.4%,P=0.049;LV outflow tract velocity time integral,[10.1±1.4]cm vs.[15.3±0.74]cm,P=0.001;LV-Strain,–9.02%±0.9%vs.–14.02%±0.7%,P=0.001).The MDR-SCM group presented with more severe right ventricular(RV)dilatation(right ventricular end-diastolic area/left ventricular end-diastolic area,0.81±0.03 vs.0.7±0.05,P=0.042)and worse RV systolic function(RVFAC,32.3%±1.9%vs.39.6%±2.7%,P=0.035;tricuspid annular plane systolic excursion,[15.9±0.9]mm vs.[18.1±0.9]mm,P=0.165;systolic tissue Doppler velocity measured at the lateral tricuspid annulus,[9.9±0.5]cm/s vs.[13.1±0.8]cm/s,P=0.002;RV-strain,–11.1%±0.7%vs.–15.1%±0.9%,P=0.002).Conclusion SCM related to MDR infection presents with RV systolic dysfunction predominance,while non-MDR-SCM is mainly depicted with LV systolic dysfunction impairment.

关键词： Septic cardiomyopathy Multidrug-resistant pathogen Left ventricular failure Right ventricular dysfunction Left/right ventricular longitudinal strain Ventriculoarterial Coupling

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Stable and Accurate Second-Order Formulation of the Shifted Wave Equation

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Communications in Computational Physics 2010年第1期7卷 103-137页

作者： Ken Mattsson Florencia parisi Department of Information Technology Uppsala UniversityP.O.Box 337S-75105 UppsalaSweden FaMAF Universidad Nacional de CordobaMedina Allende S/N Ciudad Universitaria5000 CordobaArgentina

High order finite difference approximations are derived for a one-dimensional model of the shifted wave equation written in second-order form. Thedomain is discretized using fully compatible summation by parts operators and theboundary conditions are imposed using a penalty method, leading to fully explicittime integration. This discretization yields a strictly stable and efficient scheme. Theanalysis is verified by numerical simulations in one-dimension. The present study isthe first step towards a strictly stable simulation of the second-order formulation ofEinstein’s equations in three spatial dimensions.

关键词： High-order finite difference methods wave equation numerical stability second derivatives Einstein’s equations

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Neuroinflammation as a target for glaucoma therapy

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Neural Regeneration Research 2019年第3期14卷 391-394页

作者： Adornetto Annagrazia Rossella Russo parisi Vincenzo Department of Pharmacy Health and Nutritional Sciences Section of Preclinical and Translational Pharmacology University of Calabria Visual Neurophysiology and Neurophthalmology Research Unit IRCCS G.B.Bietti Foundation

The pathogenesis of glaucoma is still not fully clarified but a growing body of evidence suggests that neuroinflammation and immune response are part of the sequence of pathological events leading to the optic neuropathy. Indeed, inflammation-involving the activation and proliferation of resident glial cells(astrocytes, Muller cells and microglia) and the release of a plethora of anti-and pro-inflammatory cytokines, chemokines and reactive oxygen species-has been reported as common features in clinical and experimental glaucoma. In the insulted retina, as for other neuronal tissues, pathogenic and reparative aspects coexist in the inflammatory process, with extent and persistency affecting the final outcome. In view of this, therapies aimed at modulating the immune and inflammatory responses may represent a promising approach for limiting the optic nerve damage and the loss of retinal ganglion cells associated with glaucoma.

关键词： glaucoma retinal ganglion cells neuroinflammation neurodegeneration microglia oxidative stress inflammasome immune response

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Catalyst-Free Synthesis and Shape Control of CdTe Nanowires

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Nano Research 2011年第9期4卷 824-835页

作者： Xiaoping Jin Marta Kruszynska Jurgen parisi Joanna Kolny-Olesiak University of Oldenburg Department of Physics Energy and Semiconductor Research Laboratory Carl-von-Ossietzky-Str. 9-11 26129Oldenburg Germany

The procedure reported here allows for the size and shape control of CdTe nanowires by means of colloidal chemistry. Thus, ultrathin, straight, saw-tooth-like and one-sided branched nanowires with zinc blende structures could be synthesized. Their formation does not require any catalyst and is most likely due to the oriented attachment of nanoparticles formed in the beginning of the reaction. The use of oleylamine as a solvent turned out to be crucial in order to achieve CdTe nanowires. The reaction between oleic acid and oleylamine in the presence of CdO proved to be essential, not only to activate the Cd precursor but also to provide reaction conditions facilitating nanowire formation by oriented attachment.

关键词： Nanowires CdTe amine activation oriented attachment shape control

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Endotics system vs colonoscopy for the detection of polyps

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World Journal of Gastroenterology 2010年第43期16卷 5452-5456页

作者： Emanuele Tumino Rodolfo Sacco Marco Bertini Michele Bertoni Giuseppe parisi Alfonso Capria Operative Unit of Gastroenterology and Metabolic Diseases Department of Gastroenterology Pisa University Hospital Institute of Internal Medicine University of Foggia

AIM: To compare the endotics system (ES), a set of new medical equipment for diagnostic colonoscopy, with video-colonoscopy in the detection of polyps. METHODS: Patients with clinical or familial risk of colonic polyps/carcinomas were eligible for this study. After a standard colonic cleaning, detection of polyps by the ES and by video-colonoscopy was performed in each patient on the same day. In each single patient, the assessment of the presence of polyps was performed by two independent endoscopists, who were randomly assigned to evaluate, in a blind fashion, the presence of polyps either by ES or by standard colonoscopy. The frequency of successful procedures (i.e. reaching to the cecum), the time for endoscopy, and the need for sedation were recorded. Sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of the ES were also calculated. RESULTS: A total of 71 patients (40 men, mean age51.9 ± 12.0 years) were enrolled. The cecum was reached in 81.6% of ES examinations and in 94.3% of colonoscopies (P = 0.03). The average time of endoscopy was 45.1 ± 18.5 and 23.7 ± 7.2 min for the ES and traditional colonoscopy, respectively (P < 0.0001). No patient required sedation during ES examination, compared with 19.7% of patients undergoing colonoscopy (P < 0.0001). The sensitivity and specificity of ES for detecting polyps were 93.3% (95% CI: 68-98) and 100% (95% CI: 76.8-100), respectively. PPV was 100% (95% CI: 76.8-100) and NPV was 97.7% (95% CI: 88-99.9). CONCLUSION: The ES allows the visualization of the entire colonic mucosa in most patients, with good sensitivity/specificity for the detection of lesions and without requiring sedation.

关键词： Colonoscopy Diagnosis Endotics system Polyps Sedation

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Duodenal duplication cyst causing severe pancreatitis:Imaging findings and pathological correlation

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World Journal of Gastroenterology 2006年第10期12卷 1630-1633页

作者： Alessandro Guarise Niccolo' Faccioli Mauro Ferrari Luigi Romano Alice parisi Massimo Falconi Department of Radiology Negrar VeronaItaly Department of Surgery University of Verona VeronaItaly Department of Pathology University of Verona VeronaItaly Department of Radiology University of Verona VeronaItaly

We here report a case of a 18-year-old man with a history of recurrent abdominal pain and a previous episode of severe acute pancreatitis. Abdominal ultrasonography, contrast enhanced multislice computer tomography, endoscopic retrograde cholangiopancreatography, endoscopic ultrasonography and magnetic resonance imaging demonstrated a cystic mass lesion. Only on delayed phase magnetic resonance images after GadoliniumBOPTA injection, it was possible to demonstrate the lesion's relationship with the biliary tree, differentiating the lesion from intraluminal duodenal diverticulum, and to achieve the diagnosis of duodenal duplication cyst, a recognized rare cause of acute pancreatitis. The diagnosis was confirmed by histology.

关键词： Pancreatitis Congenital anomalies Duodenal duplication cyst Ultrasonography Computed Tomography Cholangiopancreatography Magnetic Resonance Imaging

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Monitoring the abundance of saproxylic red-listed species in a managed beech forest by landsat temporal metrics

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Forest Ecosystems 2022年第4期9卷 529-539页

作者： Francesco parisi Elia Vangi Saverio Francini Gherardo Chirici Davide Travaglini Marco Marchetti Roberto Tognetti GeoLAB-Laboratorio di Geomatica Forestale Dipartimento di Scienze e Tecnologie AgrarieAlimentariAmbientali e ForestaliUniversita degli Studi di FirenzeVia San Bonaventura 1350145FirenzeItaly Dipartimento di Bioscienze e Territorio Universita degli Studi del MoliseContrada Fonte Lappone86090 PescheIserniaItaly Fondazione per il Futuro delle Citta FirenzeItaly Dipartimento Agricoltura Ambiente e AlimentiUniversita degli Studi del MoliseVia De SanctisI-86100CampobassoItaly

Background:Rapid climate changes lead to an increase in forest disturbance,which in turn lead to growing concerns for *** saproxylic beetles are relevant indicators for studying different aspects of biodiversity,most are smaller than 2 mm and difficult to ***,together with a high number of species and trophic roles,make their study remarkably challenging,time-consuming,and *** Landsat mission provides data since 1984 and represents a powerful tool in this *** we believe that remote sensing data cannot replace on-site sampling and analysis,in this study we aim to prove that the Landsat Time Series(TS)may support the identification of insects’hotspots and consequently guide the selection of areas where to concentrate field ***:With this aim,we constructed a Landsat-derived NDVI TS(1984–2020)and we summarised the NDVI trend over time by calculating eight Temporal Metrics(TMs)among which four resulted particularly successful in predicting the amount of saproxylic insects:(i)the slope of the regression line obtained by linear interpolating the NDVI values over time;(ii)the Root Mean Square Error(RMSE)between the regression line and the NDVI TS;(iii)the median,and the(iv)minimum values of the NDVI *** study area consists of four monitoring sectors in a Mediterranean-managed beech forest located in the Apennines(Molise,Italy),where 60 window flight traps for flying beetles were ***,the saproxylic beetle's biodiversities of monitoring sectors were quantified in terms of species richness and ***,the capability of TMs in predicting the richness of saproxylic beetles family and trophic categories was assessed in terms of Pearson's product-moment ***:The alpha diversity and species richness analysis indicate dissimilarities across the four monitored sectors(Shannon and Simpson's index ranging between 0.67 to 2.31 and 0.69 to 0.88,respectively),with Landsat TS resulting in

关键词： Alpha-diversity Beetle assemblages Biodiversity hotspots Normalized difference vegetation index Temporal metrics

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Applicability of tooth derived stem cells in neural regeneration

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Neural Regeneration Research 2016年第11期11卷 1704-1707页

作者： Ludovica parisi Edoardo Manfredi Centro Universitario di Odontoiatria University of Parma Parma Italy Dip. Scienze Biomediche Biotecnologiche e Traslazionali University of Parma Parma Italy

Within the nervous system, regeneration is limited, and this is due to the small amount of neural stem cells, the inhibitory origin of the stem cell niche and often to the development of a scar which constitutes a mechanical barrier for the regeneration. Regarding these aspects, many efforts have been done in the re- search of a cell component that combined with scaffolds and growth factors could be suitable for nervous regeneration in regenerative medicine approaches. Autologous mesenchymal stem cells represent nowa- days the ideal candidate for this aim, thank to their multipotency and to their amount inside adult tissues. However, issues in their harvesting, through the use of invasive techniques, and problems involved in their ageing, require the research of new autologous sources. To this purpose, the recent discovery of a stem cells component in teeth, and which derive from neural crest cells, has came to the light the possibility of using dental stem cells in nervous system regeneration. In this work, in order to give guidelines on the use of dental stem cells for neural regeneration, we briefly introduce the concepts of regeneration and regenerative medicine, we then focus the attention on odontogenesis, which involves the formation and the presence of a stem component in different parts of teeth, and finally we describe some experimental approaches which are exploiting dental stem cells for neural studies.

关键词： multipotent stem cells odontogenesis regeneration brain spinal cord teeth

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Grafting effects on bioactive compounds,chemical and agronomic traits of‘Corbarino’tomato grown under greenhouse healthy conditions

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Horticultural Plant Journal 2023年第2期9卷 273-284页

作者： Mario parisi Alfonso Pentangelo Antonietta D’Alessandro Giovanna Festa Gianluca Francese Alejandra Navarro Vincenzo Onofaro Sanajà Giuseppe Mennella CREA Research Centre for Vegetable and Ornamental Crops Via Cavalleggeri 25PontecagnanoSA 84098Italy

In tomatoes,grafting onto resistant rootstocks represents an effective strategy to control several soil-borne diseases that reduce crop profitability,especially for landraceswith little or no resistance tomultiple pathogens/*** this study,the high-value‘Corbarino’tomato landrace was grafted onto seven commercial Solanum interspecific rootstocks to evaluate graft compatibility,yield performance,and qualitative characteristics under greenhouse healthy *** rootstocks were themost effective in improving fruit yield without negatively affecting the carpometric,technological,and health-related traits of the traditional tomato.‘Dinafort’rootstock increased fresh and dry yield,harvest index,and fruit/clusters,while mean fruit weight,shape index,total and soluble solid content,simple sugars,organic acids,flavonoids,ascorbic acid,and trans-lycopene content did not differ with respect to the ungrafted‘Corbarino’.‘Interpro’rootstock also showed promising results for the overall yield and quality traits,although it reduced the trans-lycopene content in the fruit.‘Silex’rootstock showed the highest harvest index as result of decreased *** fruit quality induced by‘Silex’was satisfactory and high levels of simple sugars,flavonoids,ascorbic acid,and trans-lycopene were also ***,graft success,especially for‘Dinafort’and‘Silex’,needs to be improved by investigating more suitable methods for seedling production,grafting,acclimatization,etc.

关键词： Solanum lycopersicum L Local variety Yield Graft compatibility Sugars Organic acids Health-related compounds

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Focus on gastroesophageal reflux disease in patients with cystic fibrosis

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World Journal of Gastroenterology 2020年第41期26卷 6322-6334页

作者： Annarita Bongiovanni Sara Manti Giuseppe Fabio parisi Maria Papale Enza Mulè Novella Rotolo Salvatore Leonardi Department of Clinical and Experimental Medicine Pediatric Respiratory UnitSan Marco HospitalUniversity of CataniaCatania 95123Italy

Gastroesophageal reflux disease(GERD) is a common gastrointestinal disorder in cystic fibrosis(CF), and based on various studies, its prevalence is elevated since childhood. There are several pathogenetic mechanisms on the basis of association between CF and GERD. However, there are no specific guidelines for GERD in CF patients, so diagnosis is based on guidelines performed on patients not affected by CF. The aim of this review is to provide the pathophysiology, diagnostic and therapeutic options, complications, and future directions in the management of GERD patients with CF.

关键词： Adult Children Cystic Fibrosis Gastroesophageal reflux

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