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Extensive frontal focused ultrasound Check for updates mediated blood-brain barrier opening for the treatment of Alzheimer's disease:a proof-of-concept study

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Translational Neurodegeneration 2021年第4期10卷 573-583页

作者： So Hee Park kyoungwon baik Seun Jeon Won Seok Chang Byoung Seok Ye Jin Woo Chang Brain Research Institute Department of NeurosurgeryYonsei University College of MedicineSeoulKorea Department of Neurology Yonsei University College of MedicineSeoulKorea

Background:Focused ultrasound(FUS)-mediated blood-brain barrier(BBB)opening has shown efficacy in removal of amyloid plaque and improvement of cognitive functions in preclinical studies,but this is rarely reported in clinical *** study was conducted to evaluate the safety,feasibility and potential benefits of repeated extensive BBB ***:In this open-label,prospective study,six patients with Alzheimer's disease(AD)were enrolled at Severance Hospital in Korea between August 2020 and September *** of them completed the ***-mediated BBB opening,targeting the bilateral frontal lobe regions over 20 cm^(3),was performed twice at three-month *** resonance imaging,^(18)F-Florbetaben(FBB)positron emission tomography,Caregiver-Administered Neuropsychiatric Inventory(CGA-NPI)and comprehensive neuropsychological tests were performed before and after the ***:FUS targeted a mean volume of 21.1±2.7 cm^(3)and BBB opening was confirmed at 95.7%±9.4%of the targeted *** frontal-to-other cortical region FBB standardized uptake value ratio at 3 months after the procedure showed a slight decrease,which was statistically significant,compared to the pre-procedure value(-1.6%,0.986 vs 1.002,P=0.043).The CGA-NPI score at 2 weeks after the second procedure significantly decreased compared to baseline(2.2±3.0 vs 8.6±6.0,P=0.042),but recovered after 3 months(5.2±5.8 vs 8.6±6.0,P=0.89).No adverse effects were ***:The repeated and extensive BBB opening in the frontal lobe is safe and feasible for patients with *** addition,the BBB opening is potentially beneficial for amyloid removal in AD patients.

关键词： Alzheimer disease Focused ultrasound Blood-brain barrier Amyloid beta-peptides

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Post-Orogenic Tectonic Evolution of the Jiangnan-Xuefeng Orogenic Belt:Insights from Multiple Geochronometric Dating of the Mufushan Massif,South China

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Journal of Earth Science 2020年第5期31卷 905-918页

作者： Chuanbo Shen Di Hu kyoungwon Min Chaoqun Yang Xiaowei Zeng Hongyang Fu Xiang Ge Key Laboratory of Tectonics and Petroleum Resources Ministry of EducationChina University of GeosciencesWuhan 430074China School of Earth Resources China University of GeosciencesWuhan 430074China Department of Geological Sciences University of FloridaGainesvilleFlorida FL32611USA Department of Geosciences University of PadovaPadova 35137Italy

The Mufushan massif, as continental intra-plate magmatites located in the Jiangnan-Xuefeng orogenic belt of the South China. The Mufushan massif constitutes the largest Mesozoic intrusive complex, intruded the Mesoproterozoic Lengjiaxi Formation. Multiple geochronometric dating was used to reconstruct their evolution from emplacement to exhumation. The Mufushan granitoids were emplaced at ~150 Ma(U-Pb zircon) as post-orogenic magmatites contributing to Triassic crustal thickening. Onset of regional extension at ~128 Ma(40Ar/39Ar white mica and biotite) manifests a tectonic regime switch. Intense exhumation prior to ~55 Ma was followed by slow denudation and peneplanation for the next 37 Ma(~55–18 Ma). Accelerated cooling since ~18 Ma may have been caused by a far-field effect of the collision between IndiaAsia Plate or the Pacific-Plate subduction. Through a multi-geochronometric approach, this study provides a new comprehensive model for the cause of the intra-plate magmatism formation in the South China, and also established a reliable geochronological framework of the post-orogenic tectonic evolutions of the Jiangnan-Xuefeng orogenic belt.

关键词： tectonic evolution 40Ar/39Ar dating apatite fission track (U-Th-Sm)/He dating South China

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A Hybrid Instance Selection Using Nearest-Neighbor for Cross-Project Defect Prediction

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Journal of Computer Science & Technology 2015年第5期30卷 969-980页

作者： Duksan Ryu Jong-In Jang Jongmoon baik School of Computinq Korea Advanced Institute of Science and Technology Yuseong-gu Daejeon 305-701 Korea

Software defect prediction （SDP） is an active research field in software engineering to identify defect-prone modules. Thanks to SDP, limited testing resources can be effectively allocated to defect-prone modules. Although SDP requires sufficient local data within a company, there are cases where local data are not available, e.g., pilot projects. Companies without local data can employ cross-project defect prediction （CPDP） using external data to build classifiers. The major challenge of CPDP is different distributions between training and test data. To tackle this, instances of source data similar to target data are selected to build classifiers. Software datasets have a class imbalance problem meaning the ratio of defective class to clean class is far low. It usually lowers the performance of classifiers. We propose a Hybrid Instance Selection Using Nearest-Neighbor （HISNN） method that performs a hybrid classification selectively learning local knowledge （via k-nearest neighbor） and global knowledge （via na/ve Bayes）. Instances having strong local knowledge are identified via nearest-neighbors with the same class label. Previous studies showed low PD （probability of detection） or high PF （probability of false alarm） which is impractical to overall performance as well as high PD and low PF. use. The experimental results show that HISNN produces high overall performance as well as high PD and low PF.

关键词： software defect analysis instance-based learning nearest-neighbor algorithm data cleaning

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Probabilistic seismic performance assessment of lap-spliced RC columns retrofitted by steel wrapping jackets

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Earthquake Engineering and Engineering Vibration 2016年第2期15卷 223-238页

作者： Eunsoo Choi Heejung Youn baik-Soon Cho Department of Civil Engineering Hongik University Department of Civil Engineering CTRCInje University

In this study, the seismic fragility curves of two reinforced concrete（RC） columns that were lap-spliced at the bottom and retrofitted with steel wrapping jackets were generated. Their seismic performance was probabilistically assessed in comparison to that of lap-spliced or continuous reinforcement RC columns. This study used two types of steel wrapping jackets, a full jacket and a split jacket. Analytical models of the four types of columns were developed based on the experimental results of the columns using Open SEES, which is effective in conducting nonlinear time history analyses. A suite of ten artificial ground motions, modified from recorded ground motions, was used to perform nonlinear time history analyses of the analytical models with scaling of the peak ground acceleration from 0.1 g to 1.0 g in increments of 0.1 g. The steel wrapping jackets did not increase the medians for yield（slight damage state） of the lap-spiced column and did not exceed the corresponding median of the continuous reinforcement column. However, the two steel jackets increased the medians for failure by 1.872 and 2.017 times, respectively, and exceeded the corresponding median of the continuous reinforcement column by 11.8% and 20.5%, respectively.

关键词： columns reinforcement reinforced exceed acceleration scaling median assessed split probabilistic

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VQT:value cardinality and query pattern based R-schema to XML schema translation with implicit referential integrity

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2008年第12期9卷 1694-1707页

作者： Jinhyung KIM Dongwon JEONG Doo-Kwon baik Department of Computer Science and Engineering Korea UniversitySeoul 136-713Korea Department of Informatics and Statistics Kunsan National UniversityKunsan 573-701Korea

In this paper,we propose a new relational schema (R-schema) to XML schema translation algorithm, VQT, which analyzes the value cardinality and user query patterns and extracts the implicit referential integrities by using the cardinality property of foreign key constraints between columns and the equi-join characteristic in user queries. The VQT algorithm can apply the extracted implied referential integrity relation information to the R-schema and create an XML schema as the final result. Therefore, the VQT algorithm prevents the R-schema from being incorrectly converted into the XML schema, and it richly and powerfully represents all the information in the R-schema by creating an XML schema as the translation result on behalf of the XML DTD.

关键词： Value cardinality Query pattern Relational schema XML schema Implicit referential integrity relations Explicit referential integrity

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An XPath-based OWL storage model for effective ontology management in Semantic Web environment

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2009年第6期10卷 843-857页

作者： Jinhyung KIM Dongwon JEONG Doo-kwon baik Department of Computer Science and Engineering Korea University Department of Informatics and Statistics Kunsan National University

With the rapid growth of the Web, the volume of information on the Web is increasing exponentially. However, information on the current Web is only understandable to humans, and this makes precise information retrieval difficult. To solve this problem, the Semantic Web was proposed. We must use ontology languages that can assign data the semantics for realizing the Semantic Web. One of the representative ontology languages is the Web ontology language OWL, adopted as a recommen-dation by the World-Wide Web Consortium (W3C). OWL includes hierarchical structural information between classes or prop-erties. Therefore, an efficient OWL storage model that considers a hierarchical structure for effective information retrieval on the Semantic Web is required. In this paper we suggest an XPath-based OWL storage (XPOS) model, which includes hierarchical information between classes or properties in XPath form, and enables intuitive and effective information retrieval. Also, we show the comparative evaluation results for the performance of the XPOS model, Sesame, and the XML file system-based storage (XFSS) model, in terms of query processing and ontology updating.

关键词： XPath Web ontology language Hierarchical structure Ontology storage Semantic Web

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Physical Experiments to Investigate the Effects of Street Bottom Heating and Inflow Turbulence on Urban Street-Canyon Flow

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Advances in Atmospheric Sciences 2005年第2期22卷 230-237页

作者： Jae-Jin KIM Jong-Jin baik Climate Environment System Research Center Seoul National University Seoul 151-742 KoreaSchool of Earth and Environmental Sciences Seoul National University Seoul 151-742 Korea

The effects of street bottom heating and inflow turbulence on urbanstreet-canyon flow are experimentally investigated using a circulating water channel. Threeexperiments are carried out for a street canyon with a street aspect ratio of 1. Results from eachexperiment with bottom heating or inflow turbulence are compared with those without bottom heatingand appreciable inflow turbulence. It is demonstrated that street bottom heating or inflowturbulence increases the intensity of the canyon vortex. A possible explanation on how street bottomheating or inflow turbulence intensifies the canyon vortex is given from a fluid dynamicalviewpoint.

关键词： urban street-canyon flow street bottom heating inflow turbulence circulating water channel

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Ballistic limit velocity of small caliber projectiles against SS400 steel plates:Live fire experiments and empirical models

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Defence Technology（防务技术） 2024年第11期41卷 22-34页

作者： Jong-Hwan Kim Seungwon baik Jirui Fu Joon-Hyuk Park Mechanical&Systems Engineering Korea Military Academy574 Hwarang-roNowon-guSeoul17977South Korea Mechanical and Aerospace Engineering University of Central Florida4000 Central Florida BlvdOrlandoFL 32816United States

This study presents the ballistic limit velocity of small caliber projectiles against SS400 steel plate derived from live-fire ballistic experiments. Four different small caliber projectiles were tested against SS400 steel plates of 9 mm, 10 mm, and 12 mm thicknesses. The ballistic limit velocity was calculated using two standard methods, MIL-STD-662F and NIJ-STD-0101.06, and additionally using a support vector machine algorithm. The results show a linear relationship between the plate thickness and ballistic limit velocity. Further, the relative penetration performance among five different small caliber projectiles was analyzed using the Penetration Performance Ratio(PPR) introduced in this study, which suggests the potential of PPR to predict the ballistic limit velocity of other untested materials and/or different projectiles.

关键词： Live fire ballistic experiment SS400 Ballistic limit velocity Small caliber projectile

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Attempts to enhance the eradication rate of helicobacter pylori infection

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World Journal of Gastroenterology 2014年第18期20卷 5252-5262页

作者： Chang Seok Bang Gwang Ho baik Department of Internal Medicine Hallym University College of MedicineChuncheon 200-704South Korea

Increasing rates of antimicrobial resistance to clarithromycin and metronidazole present challenges in maintaining optimal eradication *** of local antibiotic resistance and consumption pattern is important in selecting a reliable *** addition,adverse effect profiles of therapeutic regimens are important and must be addressed to enhance compliance *** methods of enhancing the eradication rates of Helicobacter pylori(***)have been investigated,including changing combinations or durations of established drugs,adding adjuvant drugs,or development of new molecules or ***-containing quadruple,sequential,concomitant,and levofloxacin-based triple therapies are replacing the long-standing standard of the triple *** the encouraging results of these regimens,individualized approaches like treatment after antibiotics resistance test or CYP2C19genotyping would be the mainstream of future *** scientific,economic,and technical problems make these advance therapies unfit for widespread use,future development for *** therapy should be directed to overcome individualized antibiotic *** various novel regimens and additive agents have indicated favorable outcomes,more studies or validations are needed to become a mainstream *** therapy.

关键词： Helicobacter pylori Antimicrobial drug resistance Clarithromycin Metronidazole Microbial sensitivity tests

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Association between statin therapy and the risk of stroke in patients with moyamoya disease:a nationwide cohort study

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Stroke & Vascular Neurology 2023年第4期8卷 276-283,I0010-I0021页

作者： Joonsang Yoo Jimin Jeon Minyoul baik Jinkwon Kim Department of Neurology Yongin Severance HospitalYonsei College of MedicineYongin-siKorea(the Republic of) Institute for Innovation in Digital Healthcare Yonsei UniversitySeoulKorea(the Republic of)

Background and objective Knowledge regarding the pharmacological treatment for moyamoya disease(MMD),a chronic and progressive cerebrovascular disease conferring greater stroke risk,is *** the present study,whether statin therapy is associated with a reduced risk of stroke in patients with MMD was *** This was a retrospective cohort study in which the occurrence of stroke in patients with newly diagnosed MMD was investigated using the nationwide health insurance database in Korea from January 2007 to March 2021.A multivariable Cox proportional hazards regression model was constructed for stroke,in which statin therapy after MMD diagnosis was treated as a time-dependent *** was done for sex,age,presence of comorbidities,concurrent stroke,revascularisation surgery and treatment with *** The present study included 13373 newly diagnosed patients with MMD;40.8%had a concurrent stroke at the time of MMD *** the mean follow-up of 5.1±3.3 years,631 patients(4.7%)suffered a stroke event(haemorrhagic stroke:458 patients,ischaemic stroke:173 patients).Statin therapy after MMD diagnosis was significantly associated with a reduced risk of stroke(adjusted HR 0.74;95%CI 0.60 to 0.91,p=0.004).In the secondary outcome analysis,the risk of haemorrhagic stroke(adjusted HR 0.74;95%CI 0.58 to 0.95,p=0.018)and ischaemic stroke(adjusted HR 0.75;95%CI 0.52 to 1.08,p=0.124)were reduced with the statin *** statins was also associated with a lower risk of all-cause mortality(adjusted HR 0.47;95%CI 0.33 to 0.67,p<0.001).Conclusion In patients with MMD,statin therapy was associated with a reduced risk of subsequent *** findings indicate statin treatment may be beneficial for patients with MMD,however the results should be confirmed in randomised controlled trials.

关键词： patients diagnosis nationwide

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