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Expression of Ki-67,p53,and K-ras in chronic pancreatitis and pancreatic ductal adenocarcinoma

World Journal of Gastroenterology 2005年第43期11卷 6765-6769页

作者： Seok Jeong Don Haeng Lee Jung Il Lee Jin-Woo Lee Kye sook Kwon Pum-Soo kim Hyung Gil kim Yong Woon Shin Young Soo kim Young Bae kim Division of Gastroenterology Department of Pathology

AIM： To examine surgical specimens of pancreas with either chronic pancreatitis or pancreatic cancer in order to study whether ductal hyperplasia and dysplasia in pancreas represent precursor lesions for pancreatic cancer. METHODS： We examined expression of Ki-67, CEA, p53, and K-ras, in the surgical specimens of pancreas with adenocarcinomas （n = 11） and chronic pancreatitis （n = 12）. Cellular proliferation was assessed by Ki-67 proliferation index using the proliferation marker Ki-67. In specimens with pancreas cancer, we divided pancreas epithelium into normal （n = 7）, ductal hyperplasia （n = 3）, dysplasia （n = 4）, and cancerous lesion （n = 11） after hematoxylin and eosin staining, Ki-67, and CEA immunohistochemical staining. In cases with chronic pancreatitis, the specimen was pathologically examined as in cases with pancreas cancer, and they were also determined as normal （n = 10）, ductal hyperplasia （n = 4）, or dysplasia （n = 5）. p53 and K-ras expression were also studied by immunohistochemical staining. RESULTS： In pancreatic cancer, the Ki-67 index was 3.73±3.58 in normal site, 6.62±4.39 in ductal hyperplasia, 13.47：1：4.02 in dysplasia and 37.03±10.05 in cancer tissue, respectively. Overall, p53 was positive in normal ducts, ductal hyperplasia, dysplasia, and carcinoma cells in 0 of 14 （0%）, 0 of 7 （0%）, 7 of 9 （78%）, and 10 of 11 （91%）, respectively, and K-ras was positive in 0 of 8 （0%）, 1 of 3 （33%）, 4 of 6 （67%）, 4 of 5 （80%）, respectively. CONCLUSION： Our results favorably support the hypothesis that ductal hyperplasia and dysplasia of the pancreas might be precursor lesions for pancreas cancer. Further evaluation of oncogenes by the molecular study is needed.

关键词： Ki-67 p53 K-ras Chronic pancreatitis Pancreatic ductal adenocarcinoma

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Aralia elata inhibits neurodegeneration by downregulating O-GlcNAcylation of NF-κB in diabetic mice

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International Journal of Ophthalmology(English edition) 2017年第8期10卷 1203-1211页

作者： Seong-Jae kim Min-Jun kim Mee- Young Ckoi Yoon-sook kim Ji-Myong Yoo Eun-Kyung Hong Sunmi Ju Wan-Sung Choi Department of Ophthalmology School of MedicineGyeongsang National University Jinju 52727 Korea Department of Anatomy and Convergence Medical Science School of Medicine Gyeongsang National University Jinju52727 Korea Institute of Health Science Gyeongsang National UniversityJinju 52727 Korea Medvill Co. Ltd. Seoul 08511 Korea Division of Pulmonology and Allergy Department ofInternal Medicine School of Medicine Gyeongsang NationalUniversity Jinju 52727 Korea

AIM： To investigate the role of O-GIcNAcylation of nuclear factor-kappa B （NF-KB） in retinal ganglion cell （RGC） death and analysedthe effect of Aralia elata （AE） on neurodegen- eration in diabetic mice. METHODS： C57BL/6mice with streptozotocin-induced diabetes were fed daily with AE extract or control （CTL） diet at the onset of diabetes mellitus （DM）. Two months af- tar injection of streptozotocin or saline, the degree of cell death and the expression of O-GIcNAc transferase （OGT）, N-acetyl-b-D-glucosaminidase （OGA）, O-GIcNAcylated pro- teins, and O-GIcNAcylation of NF-KB were examined. RESULTS： AE did not affect the metabolic status of diabetic mice. The decrease in the inner retinal thickness （P〈0.001 vs CTL, P〈0.01 vs DM） and increases in RGCs with terminal deoxynucleotidyl transferase-mediated dUTP nick end labelling （P〈0.001 vs CTL, P〈0.0001 vs DM）, glial activation, and active caspase-3 （P〈0.0001 vs CTL, P〈0.0001 vs DM） were blocked in diabetic retinas of AE extract-fed mice. Expression levels of protein O-GIcNAcylation and OGT were increased in diabetic retinas （P〈0.0001 vs CTL）, and the level of O-GIcNAcylation of the NF-KB p65 subunit was higher in diabetic retinas than in controls （P〈0.0001 vs CTL）. AE extract downregulated O-GIcNAcylation of NF-KB and prevented neurodegeneration induced by hyperglycemia （P〈0.0001 vs DM）. CONCLUSION： O-GIcNAcylation of NF-KB is concerned in neuronal degeneration and that AE prevents diabetes-in- duced RGC apoptosis via downregulation of NF-KB O-GI- cNAcylation. Hence, O-GIcNAcylation may be a new object for the treatment of DR, and AE may have therapeutic pos- sibility to prevent diabetes-induced neurodegeneration.

关键词： Aralia elata diabetic retinopathy neurode- generation nuclear factor-kappa B O-GlcNAc O-GlcNAc transferase mice

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Intestinal Behet's disease appearing during treatment with adalimumab in a patient with ankylosing spondylitis

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World Journal of Gastroenterology 2013年第32期19卷 5389-5392页

作者： sook Hee Chung Soo Jung Park Sung Pil Hong Jae Hee Cheon Tae Il kim Won Ho kim Department of Internal Medicine and Institute of Gastroenterology Yonsei University College of Medicine

Behet’s disease(BD)is a chronic inflammatory disease affecting multiple organ systems,such as the skin,joints,blood vessels,central nervous system,and gastrointestinal *** BD is characterized by intestinal ulcerations and gastrointestinal *** medical treatment of intestinal BD includes corticosteroids and *** have been several reports of tumor necrosis factor-α (TNF-α)blockers being successful in treatment of refractory intestinal ***,we report on a patient who was diagnosed with intestinal BD despite treatment with the fully humanized TNF-α blocker(adalimumab)for underlying ankylosing *** patient achieved clinical remission and complete mucosal healing through the addition of a steroid and azathioprine to the adalimumab regimen.

关键词： Intestinal Behet's disease Tumor necrosis factor-α Adalimumab

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Sigmoidorectal intussusception of adenoma of sigmoid colon treated by laparoscopic anterior resection after sponge-on-the-stick-assisted manual reduction

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World Journal of Gastroenterology 2006年第1期12卷 146-149页

作者： Ki-Jae Park Hong-Jo Choi Sung-Heun kim Sang-Young Han sook-Hee Hong Jin-Han Cho Hyung-Ho kim Department of Surgery Dong-A University College of MedicinePusanSouth Korea Department of Internal Medicine Dong-A University College of Medicine.PusanSouth Korea Department of Pathology Dong-A University College of MedicinePusanSouth Korea Department of Radiology Dong-A University College of MedicinePusanSouth Korea Department of Surgery Seoul National University Bundang HospitalBundangKyunggi-DoSouth Korea

We present herein a case report of sigmoidorectal intussusception as an unusual case of sigmoid adenomatous polyp. The patient was a 56-year-old man who suffered from rectal bleeding for one day. He initially visited his general practitioner and was diagnosed as having an intraluminal mass of 15 cm from the anal verge. Several hours after admission to our coloproctology clinic, he suddenly presented with lower abdominal cramping pain with rectal bleeding during his bowel preparation using polyethylene glycol electrolyte solution. An emergency colonoscopy revealed that the invaginated colon with polypoid mass was protruded to the lower rectum. Gastrograffin enema showed that the invaginated bowel segment was 3 cm from the anal verge. CT scan showed the typical finding of intussusception. We performed laparoscopic anterior resection and anastomosis after the sponge-on-the-stickassisted manual reduction. The permanent pathologic finding showed villotubular adenoma of the sigmoid colon.

关键词： Sigmoidorectal intussusception Adenomatouspolyp Laparoscopic resection

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Colonoscopy evaluation after short-term anti-tuberculosis treatment in nonspecific ulcers on the ileocecal area

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World Journal of Gastroenterology 2008年第32期14卷 5051-5058页

作者： Young sook Park Dae Won Jun Seong Hwan kim Han Hyo Lee Yun Ju Jo Moon Hee Song Nam In kim Jun Seok Lee Department of Internal Medicine Eulji University School of Medicine Eulji Medical Center

AIM: To evaluate the eff icacy of colonoscopy follow-up after short-term anti-tuberculosis treatment in patients with nonspecific ulcers on ileocecal areas being suspicious of tuberculous colitis. METHODS: We prospectively analyzed the colonoscopic fi ndings before and after short term anti- tuberculosis treatment in 18 patients with nonspecifi c ulcers on the ileocecal area and compared them with 7 patients of confi rmed tuberculous colitis by acid-fast bacilli or caseating granuloma on colonic biopsy. RESULTS: Mean duration for short-term follow- up was 107.3 d with combined chemotherapy containing isoniazid, rifampicin, ethambutol and pyrazinamide. Seven patients with tuberculous colitis showed complete healing of active ulcers after short- term medication. After short-term anti-tuberculosis treatment, follow-up colonoscopy findings devided 18 patients with nonspecific ulcers into two groups by ulcer state. One is the "suspicious tuberculous colitis group" showing healing of ulcers and erosions and another is the "suspicious inflammatory bowel disease group" showing active ulcers with or without aggravation of the lesion. Finally, all 9 of the "suspicious tuberculous colitis group" were diagnosed as tuberculous colitis showing no recurrence of ulcers after termination of 9 mo of anti-tuberculosis medication. Patients of the "suspicious inflammatorybowel disease group" were f inally diagnosed as Crohn's disease or nonspecifi c colonic ulcers during long-term follow up. CONCLUSION: Follow-up colonoscopy shows a healing stage ulcer or scarring change without an active ulcer with just 2 mo to 3 mo of medication in patients with tuberculous colitis. Colonoscopy follow-up after short term anti-tuberculosis trial in patients with nonspecif ic ulcers on the ileocecal area is valuable in making early differential diagnosis of tuberculous colitis.

关键词： Colonoscopy Short-term Anti-tuberculosis medication Tuberculous colitis Ileocecal ulcer

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World Journal of Gastroenterology 2014年第45期20卷 17120-17126页

作者： sook Hee Chung Soo Jung Park Hye Sun Lee Sung Pil Hong Jae Hee Cheon Tae Ⅱ kim Won Ho kim Department of Internal Medicine and Institute of Gastroenterology Yonsei University College of Medicine Department of Internal Medicine and institute of Gastroenterology Ajou University College of Medicine Department of Biostatistics Yonsei University College of Medicine

AIM: To investigate differences of clinical characteristics and disease courses between familial and sporadic inflammatory bowel disease (IBD) patients.

关键词： Inflammatory bowel disease Family history Crohn’ s disease Ulcerative colitis Clinical characteristics

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The KDM4B–CCAR1–MED1 axis is a critical regulator of osteoclast differentiation and bone homeostasis

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Bone Research 2021年第3期9卷 323-335页

作者： Sun-Ju Yi You-Jee Jang Hye-Jung kim Kyubin Lee Hyerim Lee Yeojin kim Junil kim Seon Young Hwang Jin sook Song Hitoshi Okada Jae-Il Park Kyuho Kang Kyunghwan kim Department of Biological Sciences and Biotechnology Chungbuk National UniversityCheongjuChungbukRepublic of Korea Korea Basic Science Institute Gwangju Center at Chonnam National UniversityGwangjuRepublic of Korea New Drug Development Center KBIO Osong Medical Innovation FoundationCheongjuChungbukRepublic of Korea Data Convergence Drug Research Center Therapeutics&Biotechnology DivisionKorea Research Institute of Chemical TechnologyDaejeonRepublic of Korea Department of Biochemistry Kindai University Faculty of MedicineOsakasayamaOsakaJapan

Bone undergoes a constant and continuous remodeling process that is tightly regulated by the coordinated and sequential actions of bone-resorbing osteoclasts and bone-forming *** studies have shown that histone demethylases are implicated in osteoblastogenesis;however,little is known about the role of histone demethylases in osteoclast ***,we identified KDM4B as an epigenetic regulator of osteoclast *** of KDM4B significantly blocked the formation of tartrate-resistant acid phosphatase-positive multinucleated *** with myeloid-specific conditional knockout of KDM4B showed an osteopetrotic phenotype due to osteoclast *** analysis revealed that KDM4B physically and functionally associates with CCAR1 and MED1 in a *** genome-wide chromatin immunoprecipitation(ChIP)-sequencing,we revealed that the KDM4B–CCAR1–MED1 complex is localized to the promoters of several osteoclast-related genes upon receptor activator of NF-κB ligand *** demonstrated that the KDM4B–CCAR1–MED1 signaling axis induces changes in chromatin structure(euchromatinization)near the promoters of osteoclast-related genes through H3K9 demethylation,leading to NF-κB p65 recruitment via a direct interaction between KDM4B and ***,small molecule inhibition of KDM4B activity impeded bone loss in an ovariectomized mouse *** together,our findings establish KDM4B as a critical regulator of osteoclastogenesis,providing a potential therapeutic target for osteoporosis.

关键词： formation. critical MED1

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Diabetic factors associated with gastrointestinal symptoms in patients with type 2 diabetes

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World Journal of Gastroenterology 2010年第14期16卷 1782-1787页

作者： Jeong Hwan kim Hyung Seok Park Soon Young Ko Sung Noh Hong In-Kyung Sung Chan Sub Shim Kee-Ho Song Dong-Lim kim sook Kyung kim Jeeyoung Oh Department of Internal Medicine Digestive Disease Center Konkuk University School of Medicine Konkuk University Medical Center Seoul 143-729 South Korea Medical Immunology Center Institute of Biomedical Science and Technology Konkuk University School of Medicine Konkuk University Medical Center Seoul 143-729 South Korea Department of Internal Medicine Konkuk University School of Medicine Konkuk University Medical Center Seoul 143-729 South Korea Department of Neurology Konkuk University School of Medicine Konkuk University Medical Center Seoul 143-729 South Korea

AIM: To determine whether gastrointestinal (GI) symptoms are more frequent in type 2 diabetic patients and to examine which diabetic factors are associated with the symptoms. METHODS: Consecutive subjects with diabetes and age-/gender-matched normal controls were recruited for this study. GI symptoms were assessed using a structured questionnaire divided into two GI symptomcategories (upper and lower GI symptoms), and consisting of 11 individual symptoms. In the diabetic patient group, diabetic complications including peripheral neuropathy, nephropathy and retinopathy, glycosylated hemoglobin (HbA1c) level and diabetes duration were evaluated. RESULTS: Among the total 190 diabetic patients and 190 controls enrolled, 137 (72%) of the diabetic patients and 116 (62%) of the controls had GI symptoms. In the diabetic patient group, 83 (43%) had upper GI symptoms and 110 (58%) lower GI symptoms; in the control group, 59 (31%) had upper GI symptoms and 104 (55%) lower GI symptoms. This difference between the two groups was significant for only the upper GI symptoms (P = 0.02). Among the diabetic factors, the HbA1c level was the only independent risk factor for upper GI symptoms in the multiple logistic regression analysis (odds ratio = 2.01, 95% confidence interval: 1.02-3.95). CONCLUSION: Type 2 diabetes was associated with an increased prevalence of upper GI symptoms and these symptoms appeared to be independently linked to poor glycemic control, as measured by the HbA1c levels.

关键词： Diabetes HbA1c Upper gastrointestinal symptoms

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Growth of single crystals in the (Na_(1/2)Bi_(1/2))TiO_(3)-(Sr_(1-x)Ca_(x))TiO_(3) system by solid state crystal growth

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Journal of Advanced Ceramics 2021年第5期10卷 973-990页

作者： Phan Gia LE Huyen Tran TRAN Jong-sook LEE John G.FISHER Hwang-Pill kim Wook JO Won-Jin MOONC School of Materials Science and Engineering Chonnam National University77 Yongbong-roBuk-guGwangju 61186Republic of Korea School of Materials Science and Engineering Ulsan National Institute of Science and Technology50 UNIST-gilEonyang-eupUlju-gunUlsan 44919Republic of Korea Korea Basic Science Institute Gwangju Center77 Yongbong-roBuk-guGwangju 61186Republic of Korea

Ceramics based on(Na_(1/2)B_(1/2))TiO_(3) are promising candidates for actuator applications because of large strains generated by an electric field-induced phase *** example,the(1-x)(Na_(1/2)Bi_(1/2))TiO_(3)-xSrTiO_(3) system exhibits a morphotropic phase boundary at x=0.2-0.3,leading to high values of inverse piezoelectric constant d_(33),which can be further improved by the use of single *** our previous work,single crystals of (Na_(1/2)B_(1/2))TiO_(3)-SrTiO_(3) and (Na_(1/2)Bi_(1/2))TiO_(3)-TiO_(3) were grown by the solid state crystal growth *** in the(Nai/2Bi/2)TiO3-SrTiO3 system was sluggish whereas the (Na_(1/2)B_(1/2))TiO_(3)-CaTiO_(3) single crystals grew *** the present work,0.8(Na_(1/2)Bi_(1/2))Ti0_(3)-0.2(Sr_(1-x)Ca_(x))Ti0_(3) single crystals(with x=0.0,0.1,0.2,0.3,0.4)were produced by the solid state crystal growth technique in an attempt to improve crystal growth *** dependence of mean matrix grain size,single crystal growth distance,and electrical properties on the Ca concentration was investigated in *** investigations indicated that at x=0.3 the matrix grain growth was suppressed and the driving force for single crystal growth was *** Sr with Ca increased the shoulder temperature T_(s) and temperature of maximum relative permittivity T_(max),causing a decrease in inverse piezoelectric properties and a change from normal to incipient ferroelectric behavior.

关键词： (Na_(1/2)Bi_(1/2))TiO_(3) lead-free piezoelectric single crystal microstructure electrical properties

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Stereotactic body radiotherapy for isolated paraaortic lymph node recurrence from colorectal cancer

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World Journal of Gastroenterology 2009年第48期15卷 6091-6095页

作者： Mi-sook kim Chul Koo Cho Kwang Mo Yang Dong Han Lee Sun Mi Moon Young Joo Shin Department of RadiationOncology and Surgery Korea Institute of Radiological & Medical Sciences

AIM： To evaluate the efficacy and complications of stereotactic body radiotherapy in localized paraaortic lymph node recurrence from colorectal cancer. METHODS： From 2003 to 2009, 7 patients with paraaortic lymph node recurrence （1-3 lesions） from colorectal cancer were treated with stereotactic body radiotherapy. Total gross tumor volumes ranged from 4 to 40 mL. The doses were escalated from 36 Gy/patient to 51 Gy/patient and were delivered in 3 fractions. RESULTS： One and 3 year overall survival rates were 100% and 71.4%, respectively, and median survival was 37 mo. Grade IV intestinal obstruction was reported in 1 of 7 patients. This patient received 48 Gy in 3 fractions with a maximum point dose to the intestine of 53 Gy and V45Gy = 3.6 mL. However, 6 patients received an intestinal maximum point dose of 〈 51 Gy and V45Gy of 〈 1 mL, and did not develop any severe complications. CONCLUSION： This pilot study suggests selected paraaortic lymph node recurrence （1-3 closed lesions） that failed to respond to chemotherapy can be potentially salvaged by stereotactic body radiotherapy.

关键词： Stereotactic body radiotherapy Paraaortic lymph node recurrence Colorectal cancer

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