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Diagnosing isolated superior mesenteric artery dissection and thrombosis using point-of-care ultrasonography:A case series

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World Journal of Emergency Medicine 2022年第3期13卷 239-241页

作者： sin Youl Park Won Joon jeong Department of Emergency Medicine Yeungnam University Medical CenterDaegu 42415Republic of Korea Department of Emergency Medicine Chungnam National University HospitalDaejeon 301721Republic of Korea

Dear editor,Most superior mesenteric artery (SMA) dissections occuralongwithaorticdissections;isolatedSMA dissectionsarerare(incidencerateof0.06%).[1] A diagnosis of SMA dissection is generally made using contrast-enhancedcomputedtomography(CECT);however, bedside point-of-care ultrasound (POCUS)may hasten the process. Herein, we present a case series of isolated SMA dissections that were suspected and confirmed using POCUS and CECT, respectively.

关键词： point process editor

Effect of intermetallic compound thickness on anisotropy of Al/Cu honeycomb rods fabricated by hydrostatic extrusion process

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Transactions of Nonferrous Metals Society of China 2016年第2期26卷 456-463页

作者： Tae-hyuk LEE Moon-soo SIM sin-hyeong JOO kyoung-tae PARK Ha-guk jeong Jong-hyeon LEE Graduate School of Department of Advanced Materials Engineering Chungnam National University Rapidly Solidified Materials Research Center Chungnam National University Graduate School of Energy Science & Technology Chungnam National University Rare Metal R&D Group Korea Institute of Industrial Technology Advanced Fusion Process R&D Group Korea Institute of Industrial Technology

The effect of intermetallic compound （IMC） thickness on the thermal and mechanical properties of Al/Cu honeycomb rods was investigated. The Al/Cu honeycomb rods were fabricated using repeated hydrostatic extrusions at 200 ℃. During the process, an IMC layer with 1μm in thickness was generated at the Al/Cu interface. Different IMC thicknesses were obtained by post-heat treatment at 420 ℃ for 0.5 to 2 h. The IMC thickness increased to 10.1μm. The IMC layers were identified as Al2Cu （θ）, AlCu （η2）, and Al4Cu9（γ1） phases. The thermal conductivities in the longitudinal direction and cross direction decreased by 11.9% （（268±4.8） to （236±4.4） W/（m·K）） and 10.4% （（210±3.2） to （188±2.8） W/（m＆#183;K））, respectively, with increasing IMC thickness. The ultimate tensile strength and elongation of the Al/Cu honeycomb rod are （103±8.4） MPa and （73±6.2）%, respectively. The ultimate tensile strength increased to （131±6.5） MPa until the IMC thickness reached 7.7μm. It subsequently decreased to （124±3.9） MPa until the IMC thickness reached 10.1μm. The elongation of the Al/Cu honeycomb rod then sharply decreased to （29±2.5）% with increasing IMC thickness.

关键词： intermetallic compound Al/Cu honeycomb rod anisotropy thermal conductivity tensile strength hydrostatic extrusion

Restenosis of a drug eluting stent on the previous bioresorbable vascular scaffold successfully treated with a drug-coated balloon: A case report

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World Journal of Clinical Cases 2021年第3期9卷 758-763页

作者： Hyun Gyung Jang Kyehwan Kim Hyun Woong Park Jin-sin Koh Young-Hoon jeong jeong Rang Park MinGyu Kang Department of Internal Medicine Gyeongsang National University School of Medicine and Gyeongsang National University HospitalJinjuSouth Korea Department of Internal Medicine Gyeongsang National University School of Medicine and Gyeongsang National University Changwon HospitalChangwonSouth Korea

BACKGROUND The in-stent restenosis(ISR)rates are reportedly inconsistent despite the increased use of second-generation drug eluting stent(DES).Although bioresorbable vascular scaffold(BVS)have substantial advantages with respect to vascular restoration,the rate of scaffold thrombosis is higher with BVS than with *** treatment strategies have not been established for DES-ISR to *** SUMMARY We report on a case of a 60-year-old man patient with acute coronary *** had a history of ST-segment elevation myocardial infarction associated with very late scaffold thrombosis and treated with a *** angiography revealed significant stenosis,suggesting DES-ISR on the previous *** coherence tomography(OCT)identified a plaque rupture and a disrupted scaffold strut in the neointimal proliferation of *** treat the DES-ISR on the previous BVS,we opted for a drug-coated balloon(DCB)after a balloon angioplasty using a semi-compliant and non-compliant *** patient did not experience adverse cardiovascular events on using a DCB following the use of intensive dual antiplatelet therapy and statin for 24 *** This case highlights the importance of OCT as an imaging modality for characterizing the mechanism of target lesion *** use of a DCB following the administration of optimal pharmacologic therapy may be an optimal strategy for the treatment and prevention of recurrent BVS thrombosis and DES-ISR.

关键词： Bioresorbable vascular scaffold thrombosis In-stent restenosis Drug-coated balloon Optical coherence tomography Intensive dual antiplatelet therapy Case report

New insights in the pathogenesis of alcohol-related liver disease:The metabolic,immunologic,and neurologic pathways

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Liver Research 2023年第1期7卷 1-8页

作者： Tom Ryu Kyurae Kim Sung Eun Choi Katherine Po sin Chung Won-Il jeong Laboratory of Liver Research Graduate School of Medical Science and EngineeringKAISTDaejeonRepublic of Korea

Alcohol-related liver disease(ALD)became an important health issue *** chronic alcohol consumption,the development of ALD might be caused by metabolic and immunologic factors,such as reactive oxygen species(ROS)and pro-inflammatory *** example,hepatic cytochrome P4502E1 enzyme increases ROS production and stimulates de novo lipogenesis after alcohol *** addition,damage-and pathogen-associated molecular patterns stimulate their specific receptors in nonparenchymal cells,including Kupffer cells,hepatic stellate cells(HSCs),and lymphocytes,which result in hepatocyte death and infiltration of pro-inflammatory cells(e.g.,neutrophils and macrophages)in the ***,our studies have suggested the novel involvement of neurologic signaling pathways(e.g.,endocannabinoid and glutamate)through the metabolic synapse between hepatocytes and HSCs in the development of alcohol-related hepatic ***,agouti-related protein and beta2-adrenergic receptors aggravate hepatic ***,organ-crosstalk has emerged as a critical issue in *** alcohol consumption induces dysbiosis and barrier disruption in the gut,leading to endotoxin leakage into the portal circulation,or lipolysis-mediated transport of triglycerides from the adipose tissue to the *** summary,this review addresses multiple pathogeneses of ALD,provides novel neurologic signaling pathways,and emphasizes the importance of organ-crosstalk in the development of ALD.

关键词： Alcohol-related liver disease(ALD) Cannabinoid receptor Steatohepatitis Lipopolysaccharide(LPS) Metabotropic glutamate receptor(mGluR) Toll-like receptor 4(TLR4)

Switching-on of serotonergic calcium signaling in activated hepatic stellate cells

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World Journal of Gastroenterology 2011年第2期17卷 164-173页

作者： Kyu-Sang Park Pyo-Jin sin Dong Hyeon Lee Seung-Kuy Cha Min-jeong Kim Na-Hyun Kim Soon-Koo Baik Seong-Woo jeong In Deok Kong Department of Physiology and Institute of Lifelong Health Yonsei University Wonju College of Medicine Department of Physiology College of MedicinePochon CHA University Department of Basic Nursing Science Keimyung University College of Nursing Department of Internal Medicine Yonsei University Wonju College of Medicine

AIM:To investigate serotonergic Ca 2+ signaling and the expression of 5-hydroxytryptamine(5-HT) receptors,as well as Ca 2+ transporting proteins,in hepatic stellate cells(HSCs) . METHODS:The intracellular Ca 2+ concentration([Ca 2+ ]i) of isolated rat HSCs was measured with a fluorescence microscopic imaging *** PCR was per-formed to determine the transcriptional levels of 5-HT receptors and endoplasmic reticulum(ER) proteins involved in Ca 2+ storage and release in cultured rat HSCs. RESULTS:Distinct from quiescent cells,activated HSCs exhibited[Ca 2+ ]i transients following treatment with 5-HT,which was abolished by U-73122,a phospholipase C *** of 5-HT2A and 5-HT2B receptors,but not 5-HT3,was prominent during trans-differentiation of *** with ritanserin,a 5-HT2 antagonist,inhibited[Ca 2+ ]i changes upon application of *** of type 1 inositol-5'-triphosphate receptor and type 2 sarcoplasmic/endoplasmic reticulum Ca 2+ ATPase were also increased during activation of HSCs and serve as the major isotypes for ER Ca 2+ storage and release in activated *** 2+ binding chaperone proteins of the ER,including calreticulin,calnexin and calsequestrin,were up-regulated following activation of HSCs. CONCLUSION:The appearance of 5-HT-induced[Ca 2+ ]i response accompanied by upregulation of metabotropic 5-HT2 receptors and Ca 2+ transporting/chaperone ER proteins may participate in the activating process of HSCs.

关键词： Hepatic stellate cells 5-hydroxytryptamine Intracellular Ca 2+ transient Sarcoplasmic/endoplasmic reticulum Ca 2+ ATPase Inositol-5’-triphosphate receptor Endoplasmic reticulum chaperone

Clinical implication of FDG uptake of bone marrow on PET/CT in gastric cancer patients with surgical resection

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World Journal of Gastroenterology 2017年第13期23卷 2385-2395页

作者： jeong Won Lee Moon-Soo Lee Il Kwon Chung Myoung Won Son Young sin Cho Sang Mi Lee Department of Nuclear Medicine Institute of Integrative MedicineCatholic Kwandong University College of MedicineInternational St.Mary's Hospital Department of Surgery Soonchunhyang University Hospital Division of Gastroenterology Department of Internal MedicineSoonchunhyang University Hospital Department of Nuclear Medicine Soonchunhyang University Hospital

AIM To determine the relationship between F-18 fluorodeoxyglucose(FDG) uptake of bone marrow(BM) on positron emission tomography/computed tomography(PET/CT) and clinical factors and to assess the prognostic value of FDG uptake of BM in gastric *** We retrospectively enrolled 309 gastric cancer patients who underwent staging FDG PET/CT and curative surgical resection. FDG uptake of primary tumor was visually classified as positive or negative FDG uptake. Mean FDG uptake of BM(BM SUV) and BM-to-liver uptake ratio(BLR) were measured. The relationships of BM SUV or BLR with clinical factors were evaluated. The prognostic values of BM SUV, BLR, and other clinical factors for predicting recurrence-free survival(RFS) and overall survival(OS) were *** Of 309 patients, 38 patients(12.3%) experienced cancer recurrence and 18 patients(5.8%) died. Patients with advanced gastric cancer, positive FDG uptake, and recurrence had higher values of BM SUV and BLR than those with early gastric cancer, negative FDG uptake, and no recurrence(P < 0.05). BM SUV and BLR were significantly correlated with hemoglobin level, neutrophil-to-lymphocyte ratio, and platelet-tolymphocyte ratio(P < 0.05). On multivariate analysis, multiple tumors, T stage, lymph node metastasis, tumor involvement of resection margin, and BLR were significantly associated with RFS(P < 0.05). T stage, lymph node metastasis, hemoglobin level, and BLR were significantly associated with OS(P < 0.05). CONCLUSION BLR on PET/CT was an independent prognostic factor for RFS and OS in gastric cancer patients with curative surgical resection.

关键词： F-18 fluorodeoxyglucose Positron emission tomography Prognosis Bone marrow Gastric cancer

Kohn–Sham time-dependent density functional theory with Tamm–Dancoff approximation on massively parallel GPUs

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npj Computational Materials 2023年第1期9卷 1556-1567页

作者： Inkoo Kim Daun jeong Won-Joon Son Hyung-Jin Kim Young Min Rhee Yongsik Jung Hyeonho Choi Jinkyu Yim Inkook Jang Dae sin Kim Innovation Center Samsung ElectronicsHwaseong 18448Republic of Korea Department of Chemistry Korea Advanced Institute of Science and Technology(KAIST)Daejeon 34141Republic of Korea Samsung Advanced Institute of Technology Samsung ElectronicsSuwon 16678Republic of Korea

We report a high-performance multi graphics processing unit(GPU)implementation of the Kohn–Sham time-dependent density functional theory(TDDFT)within the Tamm–Dancoff *** algorithm on massively parallel computing systems using multiple parallel models in tandem scales optimally with material size,considerably reducing the computational wall time.A benchmark TDDFT study was performed on a green fluorescent protein complex composed of 4353 atoms with 40,518 atomic orbitals represented by Gaussian-type functions,demonstrating the effect of distant protein residues on the *** the largest molecule attempted to date to the best of our knowledge,the proposed strategy demonstrated reasonably high efficiencies up to 256 GPUs on a custom-built state-of-the-art GPU computing system with Nvidia A100 *** believe that our GPU-oriented algorithms,which empower first-principles simulation for very large-scale applications,may render deeper understanding of the molecular basis of material behaviors,eventually revealing new possibilities for breakthrough designs on new material systems.

关键词： GPUs graphics massive

The first observation of Ni nanoparticle exsolution from YSZ and its application for dry reforming of methane

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Materials Reports(Energy) 2021年第2期1卷 70-76页

作者： Sangwook Joo Chaehyun Lim Ohhun Kwon Linjuan Zhang Jing Zhou Jian-Qiang Wang Hu Young jeong Yong-wook sin Sihyuk Choi Guntae Kim Department of Energy Engineering Ulsan National Institute of Science and Technology(UNIST)Ulsan698-798Republic of Korea Key Laboratory of Interfacial Physics and Technology Shanghai Institute of Applied PhysicsChinese Academy of SciencesShanghai201800PR China UNIST Central Research Facilities and School of Materials Science and Engineering Ulsan National Institute of Science and Technology(UNIST)Ulsan44919Republic of Korea Materials&Devices Advanced Research Institute LG ElectronicsSeoulRepublic of Korea Department of Mechanical Engineering Kumoh National Institute of TechnologyGyeongbuk39177Republic of Korea

Ni nanocatalysts produced through exsolution have shown strong resistance to particle sintering and carbon coking in a beneficial dry reforming of methane(DRM)reaction utilizing greenhouse gases such as CH_(4)and CO_(2).However,most of the existing oxide supports for exsolution have been limited to perovskite oxide,while studies on fluorite support have been rarely conducted due to the limited solubility despite its excellent redox *** we demonstrate that 3 mol%Ni can be successfully dissolved into the yttria-stabilized zirconia(YSZ)lattice and be further exsolved to the surface in a reducing *** YSZ decorated with exsolved Ni nanoparticles shows enhanced catalytic activity for DRM reaction compared to the conventional cermet type of bulk ***,the catalytic activity is extremely stable for about 300 h without significant *** results suggest that the YSZ-based fluorite structure can be utilized as one of the support oxides for exsolution.

关键词： Dry forming of methane Exsolution Yttria-stabilized zirconia(YSZ) Ni nanoparticle

Laser micromachining of CNT/Fe/Al_2O_3 nanocomposites

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中国有色金属学会会刊：英文版 2009年第B9期19卷 189-193页

作者： Kwang-Ryul KIM Byoung-Deog CHOI Jun-sin YI Sung-Hak CHO Yong-Ho CHOA Dong-Soo SHIN Dong-Ho BAE Myung-Chang KANG Young-Keun jeong School of Information and Communication Engineering Sungkyunkwan University Korea Institute of Machinery and Materials Department of Chemical Engineering Hanyang University NANOBASE Inc. School of Mechanical Engineering Sungkyunkwan University National Core Research Center for Hybrid Materials Solution Pusan National University

CNT/Fe/Al2O3 mixed powders were synthesized from Fe/Al2O3 nanopowders using thermal CVD for the homogeneous dispersion of carbon nanotubes CNTs. CNTs consisted of MWNT, and the diameter was approximately 20-30 nm. After sintering, CNTs were homogenously located throughout Al2O3 grain boundary and were buckled. A femto-second laser installed with special optical systems was used for micromachining of the nanocomposites. The relationship between material ablation rate and energy fluence was theoretically investigated and compared with experimental results from cross-sectional SEM analysis. The nanocomposites which have higher content of CNT show a fairly good machining result due to its higher thermal conductivity and smaller grain size as well as lower light transmittance.

关键词：纳米复合材料激光光学系统热化学气相沉积碳纳米管 Al2O3 扫描电镜分析均匀分散纳米粉体