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Will the collaboration of surgery and external radiotherapy open new avenues for hepatocellular carcinoma with portal vein thrombosis?

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World Journal of Gastroenterology 2022年第7期28卷 704-714页

作者： Jung wan Choe Hye yoon Lee Chai Hong Rim Department ofInternal Medicine Korea University Ansan HospitalAnsan 15355South Korea Department of Surgery Korea University Ansan HospitalAnsan 15355South Korea Department of Radiation Oncology Korea University Ansan HospitalAnsan 15355South Korea

Portal invasion of hepatocellular carcinoma(HCC)occurs in 12.5%-40%of patients diagnosed with cancer and yields poor clinical *** it is a common cause of inoperability,sorafenib was regarded as the standard treatment for HCC in the Barcelona Clinic of Liver Cancer ***,the median survival of the Asian population was only approximately 6 mo,and the tumor response rate was less than moderate(<5%).Various locoregional modalities were performed,including external beam radiotherapy(EBRT),transarterial chemoembolization,hepatic arterial infusion chemotherapy,and surgery,alone or in *** them,EBRT is a noninvasive method and can safely treat tumors involving the major *** EBRT has been commonly performed,especially in East Asian countries,where locally invasive HCC is highly *** surgery is not commonly indicated,pioneering studies have demonstrated encouraging results in recent ***,the combination of neo-or adjuvant EBRT and surgery has been recently used and has significantly improved the outcomes of HCC patients,as reported in a few randomized *** systemic modality,a combination of novel immunotherapy and vascular endothelial growth factor inhibitor showed results superior to that of sorafenib as a first-line *** clinical trials investigating the combined use of these novel agents,surgery,and EBRT are expected to improve the prognosis of HCC with portal invasion.

关键词： Surgery Hepatocellular carcinoma Radiotherapy Systemic treatment

Quantum-dot and organic hybrid light-emitting diodes employing a blue common layer for simple fabrication of full-color displays

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Nano Research 2022年第7期15卷 6477-6482页

作者： Suhyeon Lee Donghyo Hahm Suk-Young yoon Heesun Yang wan Ki Bae Jeonghun Kwak Department of Electrical and Computer Engineering Seoul National UniversitySeoul 08826Republic of Korea Inter-university Semiconductor Research Center(ISRC) Seoul National UniversitySeoul 08826Republic of Korea SKKU Advanced Institute of Nanotechnology(SAINT) School of Nano Science&TechnologySungkyunkwan University(SKKU)Suwon 16419Republic of Korea Department of Materials Science and Engineering Hongik UniversitySeoul 04066Republic of Korea

Colloidal quantum-dot(QD)light-emitting diodes(QLEDs)have been in the forefront of future display devices due to their outstanding optoelectronic ***,a complicated solution-process for patterning the red,green,and blue QDs deteriorates the QLED performance and limits the resolution of full-color ***,we report a novel concept of QD–organic hybrid light-emitting diodes by introducing an organic blue common layer(BCL)which is deposited through a common mask over the entire *** from the optimized device structure,red and green QLEDs retained their color coordinates despite the presence of the ***,adopting the BCL improved the external quantum efficiency of green and red QLEDs by 38.4%and 11.7%,respectively,due to the Förster resonance energy transfer from the BCL to the adjacent QD *** the BCL structure,we could simply demonstrate a full-color QD-organic hybrid device in a single *** believe that this device architecture is practically applicable for easier fabrication of solution-processed,highresolution,and full-color displays with reduced process steps.

关键词： quantum-dot light-emitting diode(QLEDs) organic light-emitting diode blue common layer full-color display reduced process step

Hole‑Transport Management Enables 23%‑Efficient and Stable Inverted Perovskite Solar Cells with 84%Fill Factor

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Nano-Micro Letters 2023年第8期15卷 154-166页

作者： Liming Liu Yajie Ma Yousheng wang Qiaoyan Ma Zixuan wang Zigan Yang Meixiu wan Tahmineh Mahmoudi yoon‑Bong Hahn Yaohua Mai Institute of New Energy Technology College of Information Science and TechnologyJinan UniversityGuangzhou 510632People’s Republic of China Guangdong Mellow Energy Co. Ltd.Guangzhou 510630People’s Republic of China Key Laboratory of New Semiconductors and Devices of Guangdong Higher Education Institutes Jinan UniversityGuangzhou 510632People’s Republic of China School of Semiconductor and Chemical Engineering Solar Energy Research CenterJeonbuk National University567 BaekjedaeroDeokjin‑guJeonju‑siJeollabuk‑do 54896Republic of Korea

NiO_(x)-based inverted perovskite solar cells(PSCs)havepresented great potential toward low-cost,highly efficient and stablenext-generation ***,the presence of energy-levelmismatch and contact-interface defects between hole-selective contacts(HSCs)and perovskite-active layer(PAL)still limits device ***,we report a graded configuration based on bothinterface-cascaded structures and p-type molecule-doped compositeswith two-/three-dimensional formamidinium-based *** find that the interface defects-induced non-radiativerecombination presented at HSCs/PAL interfaces is remarkably suppressedbecause of efficient hole extraction and ***,astrong chemical interaction,halogen bonding and coordination bondingare found in the molecule-doped perovskite composites,whichsignificantly suppress the formation of halide vacancy and parasitic metallic *** a result,NiO_(x)-based inverted PSCs present a power-conversion-efficiency over 23%with a high fill factor of 0.84 and open-circuit voltage of 1.162 V,which are comparable to the best reported around 1.56-electron volt bandgap ***,devices with encapsulation present high operational stability over 1,200 h during T_(90) lifetime measurement(the time as a function of PCE decreases to 90%of its initial value)under 1-sun illumination in ambient-air conditions.

关键词： Inverted NiO_(x)-based perovskite solar cells Hole-transport management Interface-induced defect passivation High performance and stability

Cobalt phosphide nanoarrays with crystalline-amorphous hybrid phase for hydrogen production in universal-pH

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Nano Research 2020年第9期13卷 2469-2477页

作者： Hyunseok yoon Hee Jo Song Bobae Ju Dong-wan Kim School of Civil Environmental and Architectural EngineeringKorea UniversitySeoul 02841Republic of Korea

To accomplish mass hydrogen production by electrochemical water-splitting,it is a necessary to develop robust,highly active,stable,and cost-effective hydrogen evolution reaction(HER)electrocatalysts that perform comparably to Pt in the universal pH *** this work,cobalt phosphide hybrid nanosheets supported on carbon felt(CoP HNS/CF)are presented,which exhibit the superior electrocatalytic hydrogen production under a *** these nanosheets,a single CoP HNS is composed of polycrystalline CoP and oxygen-enriched amorphous Co-O-P *** from its unique nanoarchitecture,as-fabricated CoP HNS/CF exhibits a tremendous electrocatalytic HER activity and outperforms Pt/C as well as state-of-the-art CoP electrocatalysts in *** acidic and neutral media,the CoP HNS/CF shows superior electrocatalytic activity while maintaining its original hybrid crystalline-amorphous phase and *** alkaline medium,the unexpected phase and morphological reorganization of CoP HNS/CF results in outstanding electrocatalytic *** HNS/CF not only achieves high electrocatalytic activity and kinetics,but also a stable and long operating lifetime even under a high current density of 500 mA cm'***,the fabrication of CoP HNS/CF can be scaled up easily,and the large CoP HNS/CF electrode also exhibits similar electrocatalytic activity and stability.

关键词： cobalt phosphide self-supporting electrocatalyst hydrogen evolution reaction universal-ph large-scale

All-in-one glycol chitosan nanoparticles for co-delivery of doxorubicin and anti-PD-L1 peptide in cancer immunotherapy

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Bioactive Materials 2023年第10期28卷 358-375页

作者： Sukyung Song Man Kyu Shim Suah Yang Jaewan Lee wan Su Yun Hanhee Cho Yujeong Moon Jin Young Min Eun Hee Han Hong Yeol yoon Kwangmeyung Kim College of Pharmacy Graduate School of Pharmaceutical SciencesEwha Womans UniversitySeoul03760Republic of Korea Medicinal Materials Research Center Biomedical Research DivisionKorea Institute of Science and Technology(KIST)Seoul02792Republic of Korea KU-KIST Graduate School of Converging Science and Technology Korea UniversitySeoul02841Republic of Korea Department of Bioengineering Korea UniversitySeoul02841Republic of Korea Research Center for Bioconvergence Analysis Korea Basic Science Institute(KBSI)Cheongju28119Republic of Korea Department of Toxicology College of PharmacyChungnam National UniversityDaejeon34134Republic of Korea

Synergistic immunotherapy of immune checkpoint blockade (ICB) and immunogenic cell death (ICD) has shown remarkable therapeutic efficacy in various cancers. However, patients show low response rates and undesirable outcomes to these combination therapies owing to the recycling mechanism of programmed death-ligand 1 (PD-L1) and the systemic toxicity of ICD-inducing chemotherapeutic drugs. Herein, we propose all-in-one glycol chitosan nanoparticles (CNPs) that can deliver anti-PD-L1 peptide (PP) and doxorubicin (DOX) to targeted tumor tissues for a safe and more effective synergistic immunotherapy. The PP-CNPs, which are prepared by conjugating ᴅ-form PP (NYSKPTDRQYHF) to CNPs, form stable nanoparticles that promote multivalent binding with PD-L1 proteins on the targeted tumor cell surface, resulting in effective lysosomal PD-L1 degradation in contrast with anti-PD-L1 antibody, which induces recycling of endocytosed PD-L1. Consequently, PP-CNPs prevent subcellular PD-L1 recycling and eventually destruct immune escape mechanism in CT26 colon tumor-bearing mice. Moreover, the ICD inducer, DOX is loaded into PP-CNPs (DOX-PP-CNPs) for synergistic ICD and ICB therapy, inducing a large number of damage-associated molecular patterns (DAMPs) in targeted tumor tissues with minimal toxicity in normal tissues. When the DOX-PP-CNPs are intravenously injected into CT26 colon tumor-bearing mice, PP and DOX are efficiently delivered to the tumor tissues via nanoparticle-derived passive and active targeting, which eventually induce both lysosomal PD-L1 degradation and substantial ICD, resulting in a high rate of complete tumor regression (CR: 60%) by a strong antitumor immune response. Collectively, this study demonstrates the superior efficacy of synergistic immunotherapy using all-in-one nanoparticles to deliver PP and DOX to targeted tumor tissues.

关键词： Chitosan nanoparticle Synergistic immunotherapy Immune checkpoint blockade Multivalent binding Immunogenic cell death

Monitoring of non-point source pollutants load from a mixed forest land use

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Journal of Environmental Sciences 2010年第6期22卷 801-805页

作者： Sung wan yoon Se Woong Chung Dong Geun Oh Jae Woon Lee Department of Environmental Engineering Chungbuk National University Geum River Environmental Research Center National Institute of Environmental Research

The aim of this study was to determine the unit load of NPS （non-point source） pollutants including organic variables such as BOD （biochemical oxygen demand）, COD （chemical oxygen demand） and DOC （dissolved organic carbon）, nitrogen and phosphorus constituents, and suspended solids （SS） and their event mean concentration （EMC） of runoff flows from a water-shed of mixed forest land use by intensive field experiments. Field monitoring for continuous measurements of rainfall, flow, and water quality was conducted over 12 storm events during 2008-2009 using automated and manual sampling methods. The EMCs of individual runoff event were estimated for each water quality constituent based on the flow rate and concentration data of runoff discharge. The average EMCs of BOD, COD, DOC, SS, TN （total nitrogen）, NH4^＋-N, NO3^--N, TP （total phosphorus）, PO4^3-P from the mixed forest land were 1.794, 3.498, 1.462, 10.269, 0.862, 0.044, 0.634, 0.034, and 0.005 mg/L, respectively. The annual unit loads of BOD, COD, DOC, SS, TN, NH4^＋-N, NO3^--N, TP and PO4^3--P were estimated as 66.9, 133.2, 55.5, 429.8, 36.5, 1.6, 26.9, 1.3 and 0.1 kg/（ha·yr）, respectively. In addition, affecting parameters on the EMCs were investigated by statistic analysis of the field data. As a result, significant correlations with precipitation, rainfall intensity, and total runoff flows were found in most constituents.

关键词： event mean concentration mixed forest land use non-point source pollutant load unit load

Clinical outcomes of endoscopic papillectomy of ampullary adenoma: A multi-center study

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World Journal of Gastroenterology 2022年第17期28卷 1845-1859页

作者： Seong Ji Choi Hong Sik Lee Jiyeong Kim Jung wan Choe Jae Min Lee Jong Jin Hyun Jai Hoon yoon Hyo Jung Kim Jae Seon Kim Ho Soon Choi Department of Internal Medicine Hanyang University College of MedicineSeoul 04763South Korea Division of Gastroenterology and Hepatology Department of Internal MedicineKorea University College of MedicineSeoul 02841South Korea Lab of Biostatistical Consulting and Research Medical Research Collaborating CenterIndustry-University Cooperation FoundationHanyang UniversitySeoul 04763South Korea

BACKGROUND Ampullary adenoma is a rare premalignant lesion,but its incidence is *** papillectomy has become the first treatment of choice for ampullary adenomas due to its safety and effectiveness,thereby replacing surgical ***,recurrence rates and adverse events after endoscopic papillectomy were reported in up to 30%of *** To review the long-term outcomes of endoscopic papillectomy and investigate the factors that affect these *** We retrospectively analyzed the data of patients who underwent endoscopic papillectomy for ampullary adenoma at five tertiary hospitals between 2013 and *** evaluated clinical outcomes and their risk *** definitions of outcomes were as follow:(1)curative resection:complete endoscopic resection without recurrence;(2)endoscopic success:treatment of ampullary adenoma with endoscopy without surgical intervention;(3)early recurrence:reconfirmed adenoma at the first endoscopic surveillance;and(4)late recurrence:reconfirmed adenoma after the first endoscopic *** A total of 106 patients were included for *** the included patients,81(76.4%)underwent curative resection,99(93.4%)had endoscopic success,showing that most patients with noncurative resection were successfully managed with *** patients(15.1%)had piecemeal resection,22 patients(20.8%)had shown positive/uncertain resection margin,11 patients(16.1%)had an early recurrence,13 patients(10.4%)had a late recurrence,and 6 patients(5.7%)had a *** multivariate analysis,a positive/uncertain margin[Odds ratio(OR)=4.023,P=0.048]and piecemeal resection(OR=6.610,P=0.005)were significant risk factors for early and late recurrence,*** resection was also a significant risk factor for non-curative resection(OR=5.424,P=0.007).Twenty-six patients experienced adverse events(24.5%).CONCLUSION Endoscopic papillectomy is a safe and effective treatment for ampullary ***

关键词： Endoscopic papillectomy Ampullary adenoma Clinical outcome Recurrence Adverse event

Anti-inflammatory and Antimicrobial Effects of Anthocyanin Extracted from Black Soybean on Chronic Bacterial Prostatitis Rat Model

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Chinese Journal of Integrative Medicine 2018年第8期24卷 621-626页

作者： Byung Il yoon Woong Jin Bae Yong Sun Choi Su Jin Kim U Syn Ha Sung-Hoo Hong Dong wan Sohn Sae Woong Kim Department of Urology International St Mary's HospitalThe Catholic Kwandong University of Korea Department of Urology College of MedicineThe Catholic University of Korea

Objective： To investigated the anti-inflammatory and antimicrobial effects of anthocyanins extracted from black soybean on the chronic bacterial prostatitis（CBP） rat ***： The SpragueDawley rats were divided into 4 groups,including control,ciprofloxacin,anthocyanins and anthocyanins with ciprofloxacin groups（n=8 in each group）.Then,drip infusion of bacterial suspension（Escherichia coli Z17O2：K1：H^-） into Sprague-Dawley rats was conducted to induce *** 4 weeks,results of prostate tissue,urine culture,and histological analysis on the prostate were analyzed for each ***： The use of ciprofloxacin,anthocyanins,and anthocyanins with ciprofloxacin showed statistically significant decreases in bacterial growth and improvements in the reduction of prostatic inflammation compared with the control group（P〈0.05）.The anthocyanins with ciprofloxacin group showed a statistically significant decrease in bacterial growth and improvement in prostatic inflammation compared with the ciprofloxacin group（P〈0.05）.Conclusions： These results suggest that anthocyanins may have anti-inflammatory and antimicrobial effects,as well as a synergistic effect with ***,we suggest that the combination of anthocyanins and ciprofloxacin may be effective in treating CBP to obtain a higher rate of treatment success.

关键词： prostatitis anti-bacterial agents anthocyanins

Novel Antiinvasive and Antimetastatic Effects of Synthetic Protease Inhibitor on Human Colon Cancer Cells

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Novel Antiinvasive and Antimetastatic Effects of Synthetic P...