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Long-term follow up of endoscopic resection for type 3 gastric NET

World Journal of Gastroenterology 2013年第46期19卷 8703-8708页

作者： Yong Hwan Kwon Seong Woo Jeon Gwang Ha Kim Jin Il Kim Il-Kwun Chung Sam Ryong Jee Heung Up Kim Geom Seog Seo Gwang Ho Baik Kee Don Choi jeong Seop moon Department of Internal Medicine Kyungpook National University Hospital Department of Internal Medicine Busan National University School of Medicine Department of Internal Medicine Catholic University of Korea College of Medicine Department of Internal Medicine Soonchunhyang University Department of Internal Medicine Inje University Pusan Paik Hospital Department of Internal Medicine Jeju National University School of Medicine Department of Internal Medicine Digestive Disease Research InstituteWonkwang University College of Medicine Department of Internal Medicine Hallym University College of Medicine Department of Internal Medicine University of Ulsan College of MedicineAsan Medical Center Department of Internal Medicine Inje University Seoul Paik Hospital

AIM:To clarify the short and long-term results and to prove the usefulness of endoscopic resection in type 3gastric neuroendocrine tumors(NETs).METHODS:Of the 119 type 3 gastric NETs diagnosed from January 1996 to September 2011,50 patients treated with endoscopic resection were enrolled in this *** endoscopic resection,endoscopic mucosal resection(EMR)or endoscopic submucosal dissection(ESD)was *** efficacy,complications,and follow-up results were evaluated ***:EMR was performed in 41 cases and ESD in 9 *** complete resection was performed in 40 cases(80.0%)and incomplete resection specimens were observed in 10 cases(7 vs 3 patients in the EMR vs ESD group,P=0.249).Upon analysis of the incomplete resection group,lateral or vertical margin invasion was found in six cases(14.6%)in the EMR group and in one case in the ESD group(11.1%).Lymphovascular invasions were observed in two cases(22.2%)in the ESD group and in one case(2.4%)in the EMR group(P=0.080).During the follow-up period(43.73;13-60 mo),there was no evidence of tumor recurrence in either the pathologically complete resection group or the incomplete resection *** recurrence was reported during *** addition,no mortality was reported in either the complete resection group or the incomplete resection group for the duration of the follow-up ***:Less than 2 cm sized confined submucosal layer type 3 gastric NET with no evidence of lymphovascular invasion,endoscopic treatment could be considered at initial treatment.

关键词： Stomach Neuroendocrine tumor Endo-scopic resection Treatment Carcinoid

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Charge transfer in graphene/polymer interfaces for CO2 detection

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Nano Research 2018年第7期11卷 3529-3536页

作者： Myungwoo Son Yusin Pak Sang-Soo Chee Francis Malar Auxilia Kihyeun Kim Byung-Kee Lee Sungeun Lee Sun Kil Kang Chaedeok Lee jeong Soo Lee Ki Kang Kim Yun Hee Jang Byoung Hun Lee Gun-Young Jung moon-Ho Ham School of Materials Science and Engineering Research Institute for Solar and Sustainable Energies Gwangju Institute of Science & Technology 723 Cheomdangwagi-ro Buk-gu Gwangju 61005 Republic of Korea Materials & Devices Advanced Research Institute LG Electronics Woomyeon R&D Campus 38 Baumoe-ro Seocho-gu Seoul 06763 Republic of Korea Department of Energy and Materials Engineering Dongguk University Seoul 04620 Republic of Korea Energy Systems Engineering Daegu Gyeongbuk Institute of Science & Technology 333 Technojungang-daero Hyeonpung-myeon Dalseong-gun Daegu 42988 Republic of Korea

Understanding charge transfer processes between graphene and functional materials is crucial from the perspectives of fundamental sciences and potential applications, including electronic devices, photonic devices, and sensors. In this study, we present the charge transfer behavior of graphene and amine-rich polyethyleneimine （PEI） upon CO2 exposure, which was significantly improved after introduction of hygroscopic polyethylene glycol （PEG） in humid air. By blending PEI and PEG, the number of protonated amine groups in PEI was remarkably increased in the presence of water molecules, leading to a strong electron doping effect on graphene. The presence of CO2 gas resulted in a large change in the resistance of PEI/PEG-co-functionalized graphene because of the dramatic reduction of said doping effect, reaching a maximum sensitivity of 32% at 5,000 ppm CO2 and an applied bias of 0.1 V in air with 60% relative humidity at room temperature. This charge transfer correlation will facilitate the development of portable graphene-based sensors for real-time gas detection and the extension of the applications of graphene-based electronic and photonic devices.

关键词： graphene polyethyleneimine (PEI) polyethylene glycol carbon dioxide charge transfer

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Reevaluation of the expanded indications in undifferentiated early gastric cancer for endoscopic submucosal dissection

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World Journal of Gastroenterology 2022年第15期28卷 1548-1562页

作者： Jiyoung Yoon Seung-Yeon Yoo Young Soo Park Kee Don Choi Beom Su Kim moon-Won Yoo In Seob Lee jeong Hwan Yook Ga Hee Kim Hee Kyong Na Ji Yong Ahn jeong Hoon Lee Kee Wook Jung Do Hoon Kim Ho June Song Gin Hyug Lee Hwoon-Yong Jung Department of Gastroenterology Asan Medical CenterUniversity of Ulsan College of MedicineSeoul 05505South Korea Department of Pathology Asan Medical CenterUniversity of Ulsan College of MedicineSeoul 05505South Korea Department of Surgery Asan Medical CenterUniversity of Ulsan College of MedicineSeoul 05505South Korea

BACKGROUND Although the criteria for the indication of endoscopic submucosal dissection(ESD)for undifferentiated early gastric cancer(UD-EGC)have been recently proposed,accumulating reports on the non-negligible rate of lymph node metastasis(LNM)after indicated ESD raise questions on the reliability of the current *** To investigate the prevalence and risk factors of LNM in UD-EGC cases meeting the expanded indication for *** We retrospectively reviewed 4780 UD-EGC cases that underwent surgical resection between January 2008 and February 2019 at Asan Medical Center,a tertiary university hospital in *** identify the risk factors of LNM of UDEGC meeting the expanded criteria for ESD,we performed a case-control study by matching the cases with LNM to those without at a ratio of 1:*** reviewed the clinical,endoscopic,and histologic features of the cases to identify features with a significant difference according to the presence of *** and multivariate logistic regression analyses were performed to estimate the odds ratios(ORs).RESULTS Of the 4780 UD-EGC cases,1240(25.9%)were identified to meet the expanded indication for *** the 1240 cases,14(1.1%)cases had *** the various clinical,endoscopic,and histopathological features that were evaluated,mixed histology(tumors consisting of 10%-90%of signet ring cells)had a marginally significant association(P=0.059)with the risk of ***,diffuse blurring of the muscularis mucosae(MM)underneath the tumorous epithelium,a previously unrecognized histologic feature,had a significant association with the absence of LNM(P=0.028).Multivariate logistic regression analysis showed that the blurring of MM was the only explanatory variable significantly associated with a reduced risk of LNM(OR:0.12,95%CI:0.02-0.95;P=0.045).CONCLUSION The risk of LNM is higher than expected when using the current expanded indication for *** evaluation could provide useful clues for reducing the

关键词： Gastric cancer Undifferentiated carcinoma Endoscopic submucosal dissection Lymph node metastasis

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“在X上”与“（?）”、“（?）”对比研究

“在X上”与“（?）”、“（?）”对比研究

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作者：张文祯（JANG moon jeong）南京大学

学位级别：硕士

对比语言学是语言学中的一个分支,任务是对两种或两种以上的语言进行共时的对比研究,描述它们之间的异同,特别是其中的不同之处,并将这类研究应用于其他有关领域。框式介词,又称“框式结构”,是指由前置词加后置词构成的使介词支配的成... 详细信息

对比语言学是语言学中的一个分支,任务是对两种或两种以上的语言进行共时的对比研究,描述它们之间的异同,特别是其中的不同之处,并将这类研究应用于其他有关领域。框式介词,又称“框式结构”,是指由前置词加后置词构成的使介词支配的成分夹在中间的一种介词类型。此概念最初是由当代语言类型学的创始人Greenberg（1995）在研究闪语族和伊朗语族部分语言的语序类型演变时提出的,后来中国学者刘丹青首次提出“框式介词”的术语:典型的框式结构,是指前后有两个不连贯的词语相互照应,相互依存,形成一个框架式。它具有特殊的语法意义和特定的语用功能,如果去除其中一个（主要是后面一个）,该结构便会散架。使用的时候,只要往空白处填装合适的词语就可以了,这比起临时组合的短语结构具有某些特殊的优势。本文采用语言对比方法来考察框式介词中“在X上”与后置词的韩语“（?）（?）”之间的异同点。本文首先通过“CCL预料库”、“Trends21（?）（?）（或者＜（?）21＞（?））”、“（?）”与“（?）（?）”分析和对比“在X上”与“（?）”、“（?）”的语义。其次,本文在前人研究的基础上对比“在X上”与“（?）”、“（?）”的句法语义和特点。本文中“在X上”、“（?）”与“（?）”的语言对比共分三个部分来讨论:（一）、“在X上”、“（?）”与“（?）”语义分析及其分类,此部分讨论“在X上”与“（?）”、“（?）”的语义方面。本文首先把语言空间区分为原始意义和从原始意义派生出来的引申意义。其次,原始意义里面分为参照物与目的物接触和目的物与参照物不接触。并且参照物与目的物接触时还分为目的物平行放置接触于参照物的表面的平行放置的方向、垂直放置的方向、水平放置的面朝下的方向。参照物与目的物的接触方向是平行放置时还可以依照参照物的种类来区分为无界的参照物场所、有界的参照物场所、身体部位、封闭或者开放的三维物体、三维容器性一般物体、一般事物。水平放置的面朝下的方向可以分直接接触性关系和间接接触性关系。事物存在的范围-参照物的范围内存在的内容按照参照物的种类来区分为:参照物是抽象场所或者场所,目的物是具体实体或者内容;封闭性三维物体的抽象场所或者场合,目的物是具体实体或者具体事件;参照物是封闭性三维容器性的,目的物是内容或者物体;参照物是驱身部位,目的物是内容;参照物是抽象物体,目的物是具体内容;参照物是抽象物体,目的物是具体内容;参照物是某事情,目的物是内容;参照物是意识性物体,目的物是内容;参照物是某种特点,目的物是具体内容;参照物是媒介,目的物是内容或者物体;参照物是程度,目的物是具体内容;参照物是顺序或者阶段,目的物是具体内容;参照物是数量,目的物是具体内容。事物的涉及范围-事物涉及的事物的一侧面里面包括参照物是某条件,目的物是参照物涉及的内容和参照物是整体事物,目的物是涉及内容。（二）、“在X上”与“（?）”、“（?）”的省略方位词,本部分专门讨论“在X上”、“（?）”与“（?）”的方位词“上”、“（?）”和“（?）”的强制性条件与非强制性的条件的对比。（三）、“在X上”、“（?）”和“（?）”句法,在储泽祥研究“在+处所”的三种句式的基础上对比“在X上”的三种格式与“（?）”和“（?）”的句法格式。然后基于A式:PP+NP+VP,B式:NP+在X上+VP,C式:NP+VP+在X上的三种格式,对比“在X上”可以充当主语、状语、宾补语、宾语的情况,以及“（?）”与“（?）”可以充当的句法成分的情况。本文通过研究得到的结论如下:（一）“在X上”、“（?）”和“（?）”语义共同性。首先,原始语义中的“在X上”、“（?）”和“（?）”都可以表示目的物和参照物接触和不接触。它们表示目的物和参照物接触当中目的物与参照物的方向是平行放置时,目的物与参照物的接触方向平行放置时,都可以是无界的场所、有界的场所、开放的三维建筑、开放的交通工具、一般物体。其次,“在X上”、“（?）”和“（?）”表示基于原始意义引申时,“在X上”、“（?）”和“（?）”都可以采取的参照物是抽象物体、意识性物体、媒体、程度、顺序或者阶段、数量。（二）表示原始语义的平行放置的方向时,只能采用“在X上”与“（?）”,而“（?）”不能使用的情况是:参照物是原始语义当中目的物与参照物接触时参照物属于身体部位、三维容器性一般物体。“（?）”不能表示垂直放置的方向,而“在X上”与“（?）”都可以表示参照物与目的物的接触方向是垂直放置和水平放置的面朝下的参照物内接触目的物。（三）“在X上“与“（?）”可以采用,而“（?）”不能采用的参照物是抽象场所、封闭性三维物体的抽象场所或者场合、封闭性三维容器性的时间。（四）“在X上”、“（?）”和“（?）”省略方位词时,“在X上”的“X”单独表示处所,并且能单独充当介词“在”的宾语时

关键词：在X上 (?) 对比研究框式介词

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Effect of hexagonal-BN on phase transformation of additive-free Si_3N_4 /SiC nanocomposites prepared from amorphous precursor

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Transactions of Nonferrous Metals Society of China 2013年第2期23卷 420-425页

作者： Alfian NOVIYANTO Dang-Hyok YOON Kyungseok LEE Young moon KIM Doo-In KIM Young-Keun jeong Kwang Ho KIM Sehun KWON Young-Hwan HAN School of Materials Science and Engineering Yeungnam University Gyeongsan 712-749 Korea National Core Research Center for Hybrid Materials Solution Pusan National University Samsung Mobile Display Korea

Si3N4/SiC nanocomposites are well known and attractive for advanced ceramic applications due to excellent mechanlcal and thermal properties, which make them suitable for use in turbine engines, heat exchangers, and other sophisticated applications. However, without the presence of additives, the fabrication of Si3N4/SiC composites is difficult. The additives form a liquid phase during sintering and facilitate the densification of the composite. However, the additives present a drawback at high temperatures since they decrease the mechanical properties of the composites. Recently, Si3N4/SiC composites were fabricated via the polymer precursor route without any additives, using electric field assisted sintering （EFAS）. In this study, fully densified Si3N4/SiC nanocomposites incorporating hexagonal-BN were successfully fabricated by hot pressing without any additives at 1700 ℃ for 2 h under vacuum at a pressure of 50 MPa （via the amorphous precursor route）. Moreover, the incorporation of additives and h-BN is found to decrease the content of SiC. The phase transformation, densification, microstructure, and mechanical properties were discussed and presented.

关键词： Si3N4/SiC hot pressing hexagonal-BN additives sintering

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Rapid crystallization-driven high-efficiency phase-pure deep-blue Ruddlesden–Popper perovskite light-emitting diodes

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Advanced Photonics 2023年第1期5卷 8-18页

作者： Gyumin Jang Hyowon Han Sunihl Ma Junwoo Lee Chan Uk Lee Wooyong jeong Jaehyun Son Dongki Cho Ji-Hee Kim Cheolmin Park Jooho moon Yonsei University Department of Materials Science and EngineeringSeoulRepublic of Korea Sungkyunkwan University Department of Energy ScienceSuwonRepublic of Korea Institute for Basic Science Center for Integrated Nanostructure PhysicsSuwonRepublic of Korea

Perovskite light-emitting diodes(PeLEDs)are considered as promising candidates for nextgeneration solution-processed full-color ***,the external quantum efficiencies(EQEs)and operational stabilities of deep-blue(3 is hampered completely,so that phase-pure 2D-RPP films with bandgaps suitable for deep-blue PeLEDs can be obtained *** uniquely developed rapid crystallization method also enables formation of randomly oriented 2D-RPP crystals,thereby improving the transfer and transport kinetics of the charge ***,high-performance deep-blue PeLEDs emitting at 437 nm with a peak EQE of 0.63%are successfully *** color coordinates are confirmed to be(0.165,0.044),which match well with the Rec.2020 standard blue gamut and have excellent spectral stability.

关键词： Ruddlesden–Popper perovskite rapid crystallization deep-blue light-emitting diodes phase purity randomly oriented crystals

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Novel monoclonal antibody against beta 1 integrin enhances cisplatin efficacy in human lung adenocarcinoma cells

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The Journal of Biomedical Research 2016年第3期30卷 217-224页

作者： Min-Young Kim Woon-Dong Cho Kwon Pyo Hong Da Bin Choi jeong won Hong Soseul Kim Yoo Ri moon Seung-Myoung Son Ok-Jun Lee Ho-Chang Lee Hyung Geun Song Department of Pathology Chungbuk National University College of MedicineCheongju28644Republic of Korea Research Institute Chungbuk National University College of MedicineCheongju28644Republic of Korea

The use of anti-beta 1 integrin monoclonal antibody in lung cancer treatment has proven beneficial. Here, we developed a novel monoclonal antibody （mAb）, called P5, by immunizing mice with human peripheral blood mononuclear cells （PBMC）. Its anti-tumor effect is now being tested, in a clinical phase Ⅲ trial, in combinato- rial treatments with various chemical drugs. To confirm that P5 indeed binds to beta 1 integrin, cell lysates were immunoprecipitated with commercial anti-beta 1 integrin mAb （TS2/16） and immunoblotted against P5 to reveal a 140 kDa molecular weight band, as expected. Immunoprecipitation with P5 followed by LC/MS protein sequence analysis further verified P5 antigen to be beta 1 integrin. Cisplatin treatment upregulated cell surface expression of beta 1 integrin in A549 cells, while causing inhibition of cell growth. When cells were co-treated with different concentrations of P5 mAb, the cisplatin-mediated inhibitory effect was enhanced in a dose-dependent manner. Our findings show that a combinatorial treatment of P5 mAb and cisplatin in A549 cells resulted in a 30% increase in apoptosis, compared to baseline, and significantly more when compared to either the cisplatin or P5 alone group. The entire peptide sequences in CDR from variable region of Ig heavy and light chain gene for P5 mAb are also disclosed. Together, these results provide evidence of the beneficial effect of P5 mAb in combinatorial treatment of human lung adenocarcinoma.

关键词： CD29 beta 1 integrin lung adenocarcinoma monoclonal antibody cisplatin

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Prediction of Perineural Invasion and Its Prognostic Value in Patients with Prostate Cancer

Prediction of Perineural Invasion and Its Prognostic Value i...

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第十七届全国泌尿外科学术会议

作者： jeong Zoo Lee Hong Koo Ha Wan Lee moon Kee Chung Department of Urology Pusan National University School of MedicineBusanKorea

Purpose The prognostic significance ofperineural invasion by prostate cancer is *** investigated the association between perineural invasion and clinico-pathological factors and the effect of perineural invasion on su...

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Usefulness of colonic tattooing using indocyanine green in patients with colorectal tumors

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World Journal of Clinical Cases 2018年第13期6卷 632-640页

作者： Jae Ho Park Hee Seok moon In Sun Kwon Gee Young Yun Seo Hee Lee Dae Hwa Park Ju Seok Kim Sun Hyung Kang Eaum Seok Lee Seok Hyun Kim Jae Kyu Sung Byung Seok Lee Hyun Yong jeong Division of Gastroenterology Department of Internal Medicine Chungnam National University Hospital Chungnam National University college of Medicine Clinical Trials Center Chungnam National University Hospital

AIM To prove that tattooing using indocyanine green(ICG) is feasible in laparoscopic surgery for a colon *** From January 2012 to December 2016, all patients who underwent laparoscopic colonic surgery were retrospectively screened, and 1010 patients with colorectal neoplasms were included. Their lesions were tattooed with ICG the day before the operation. The tattooed group(TG) included 114 patients, and the non-tattooed group(NTG) was selected by propensity score matching of subjects based on age, sex, tumor staging, and operation method(n = 228). In total, 342 patients were enrolled. Between the groups, the changes in [Delta(Δ), preoperative-postoperative] the hemoglobin and albumin levels, operation time, hospital stay, oral ingestion period, transfusion, and perioperative complications were compared. RESULTS Preoperative TG had a shorter operation time(174.76 ± 51.6 min vs 192.63 ± 59.9 min, P < 0.01), hospital stay(9.55 ± 3.36 d vs 11.42 ± 8.23 d, P < 0.01), and postoperative oral ingestion period(1.58 ± 0.96 d vs 2.81 ± 1.90 d, P < 0.01). The Δ hemoglobin(0.78 ± 0.76 g/dL vs 2.2 ± 1.18 g/dL, P < 0.01) and Δ albumin(0.41 ± 0.44 g/dL vs 1.08 ± 0.39 g/dL, P < 0.01) levels were lower in the TG. On comparison of patients in the "N0" and "N1 or N2" groups, the N0 colon cancer group had a better operation time, length of hospital stay, oral ingestion period, Δ hemoglobin, and Δ albumin results than those of the N1 or N2 group. The operation methods affected the results, and laparoscopic anterior resection(LAR) showed similar results. However, for left and right hemicolectomy, both groups showed no difference in operation time or hospital *** Preoperative tattooing with ICG is useful for laparoscopic colectomy, especially in the N0 colon cancer group and LAR.

关键词： Colorectal neoplasm Laparoscopic surgery Endoscopic tattoo Indocyanine green Perioperative

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Thioredoxin Reductase Type C （NTRC） Orchestrates Enhanced Thermotolerance to Arabidopsis by Its Redox-Dependent Holdase Chaperone Function

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Molecular Plant 2013年第2期6卷 323-336页

作者： Ho Byoung Chae jeong Chan moon Mi Rim Shin Yong Hun Chi Young Jun Jung Sun Yong Lee Ganesh M. Nawkar Hyun Suk Jung Jae Kyung Hyun Woe Yeon Kim Chang Ho Kang Dae-Jin Yun Kyun Oh Lee Sang Yeol Lee Division of Applied Life Science (BK21 Program) and PMBBRC Gyeongsang National University 501 Jinju-daero Jinju 660-701 Korea Division of Electron Microscopic Research Korea Basic Science Institute 113 Gwahangno Yuse0ng-guDaejeon 303-333 Korea

Genevestigator analysis has indicated heat shock induction of transcripts for NADPH-thioredoxin reduc-tase, type C （NTRC） in the light. Here we show overexpression of NTRC in Arabidopsis （NTRC°E） resulting in enhanced tolerance to heat shock, whereas NTRC knockout mutant plants （ntrcl） exhibit a temperature sensitive phenotype. To investigate the underlying mechanism of this phenotype, we analyzed the protein＇s biochemical properties and protein structure. NTRC assembles into homopolymeric structures of varying complexity with functions as a disulfide reductase, a foldase chaperone, and as a holdase chaperone. The multiple functions of NTRC are closely correlated with protein structure.. Complexes of higher molecular weight （HMW） showed stronger activity as a holdase chaperone, while low molecular weight （LMW） species exhibited weaker holdase chaperone activity but stronger disulfide reductase and fol-dase chaperone activities. Heat shock converted LMW proteins into HMW complexes. Mutations of the two active site Cys residues of NTRC into Ser （C217/454S-NTRC） led to a complete inactivation of its disulfide reductase and foldase chaperone functions, but conferred only a slight decrease in its holdase chaperone function. The overexpression of the mutated C217/454S-NTRC provided Arabidopsis with a similar degree of thermotolerance compared with that of NTRC°E plants. However, after prolonged incubation under heat shock, NTRC°E plants tolerated the stress to a higher degree than C217/454S-NTRC°E plants. The results suggest that the heat shock-mediated holdase chaperone function of NTRC is responsible for the increased thermotolerance of Arabidopsis and the activity is significantly supported by NADPH.

关键词： NADPH-thioredoxin reductase type C (NTRC) oligomeric complexes disulfide reductase foldase and holdasechaperone functions redox thermotolerance.

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