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Bone Research 2023年第2期11卷 354-367页

作者： Eun Jung Lee Kyoung Jin Lee Seungpil Jung kyong hwa park Serk In park Department of Biochemistry and Molecular Biology Korea University College of MedicineSeoulRepublic of Korea The BK21 Graduate Program Department of Biomedical SciencesKorea University College of MedicineSeoulRepublic of Korea Division of Breast and Endocrine Surgery Department of SurgeryKorea University Anam HospitalSeoulRepublic of Korea Division of Oncology and Hematology Department of Internal MedicineKorea University Anam HospitalSeoulRepublic of Korea Vanderbilt Center for Bone Biology Vanderbilt University School of MedicineNashvilleTNUSA

Myeloid-derived suppressor cells(MDSCs)are bone marrow(BM)-derived immunosuppressive cells in the tumor microenvironment,but the mechanism of MDSC mobilization from the BM remains *** investigated how BM stromal cell activation by PTH1R contributes to MDSC ***1R activation by parathyroid hormone(PTH)or PTH-related peptide(PTHrP),a tumor-derived counterpart,mobilized monocytic(M-)MDSCs from murine BM without increasing immunosuppressive *** vitro cell-binding assays demonstrated thatα4β1 integrin and vascular cell adhesion molecule(VCAM)-1,expressed on M-MDSCs and osteoblasts,respectively,are key to M-MDSC binding to *** PTH1R activation,osteoblasts express VEGF-A and IL6,leading to Src family kinase phosphorylation in *** inhibitors suppressed PTHrP-induced MDSC mobilization,and Src activation in M-MDSCs upregulated two proteases,ADAM-17 and MMP7,leading to VCAM1 shedding and subsequent disruption of M-MDSC tethering to ***,our data provide the molecular mechanism of M-MDSC mobilization in the bones of tumor hosts.

关键词： MMP7 suppressor regulated

Conversion of N-doped biochar from carotenoid-extracted Tetraselmis suecica and its application to produce supercapacitors

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Journal of Environmental Sciences 2025年第5期151卷 410-423页

作者： Se Hun Lee Kang Hyun Lee Sang-hwa Lee Soo Kweon Lee Ok Sung Jeon Young Pyo Jeon Dongpyo Hong Young Joon Yoo Sang Yoon park Hah Young Yoo Advanced Institute of Convergence Technology(AICT) Seoul National UniversitySuwon 16229Republic of Korea Department of Biotechnology Sangmyung University20 Hongjimun 2-GilJongno-GuSeoul 03016Republic of Korea Department of Bio-Convergence Engineering Dongyang Mirae University445-8Gyeongin-roGuro-guSeoul 08221Republic of Korea Fermentation team Lotte R&D Center210 Magokjungang-RoGangseo-GuSeoul 07594Republic of Korea School of Electronic Engineering Kyonggi UniversityGyeonggi-do 16227Republic of Korea

Microalgae are one of the promising feedstocks for biorefinery,contributing significantly to net-zero emissions through carbon capture and ***,the disposal of microalgal byproducts from the manufacturing process causes additional environmental pollution,thus,a new application strategy is *** this study,the Tetraselmis suecica byproduct from the carotenoid extraction process was carbonized and converted into *** converted biochar was proved to be nitrogen-doped biochar(NDB),up to 4.69%,with a specific surface area of 206.59m^(2)/g andwas used as an electrode for a *** NDB electrode(NDB-E)in half-cell showed a maximum specific capacitance of 191 F/*** a full-cell test,the NDB-E exhibited a high energy density of 7.396 Wh/kg and a high-power density of 18,100 W/kg,and maintained specific capacity of 95.5%after charge and discharge of 10,000 *** conclusion,our study demonstrated that the carotenoid-extracted microalgal byproducts are a useful resource for the supercapacitor *** approach is the first to convert *** into active materials for supercapacitors.

关键词： Microalgae Tetraselmis suecica Carbonization N-doped biochar Supercapacitor

Novel transparent high-entropy sesquioxide ceramics with high physicochemical plasma etching resistance

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JOURNAL OF ADVANCED CERAMICS 2025年第1期14卷 163-176页

作者： Shin, Yu-Bin Ham, Su Been Kim, Ha-Neul Kim, Mi-Ju Ko, Jae-Woong Lee, Jae-Wook park, Young-Jo Kim, Jung-Hyung Lee, Hyo-Chang Jung, Young hwa Lee, Jung Woo Ma, Ho Jin Korea Inst Mat Sci Nano Mat Res Div Chang Won 51508 Gyeongsangnam South Korea Pusan Natl Univ Dept Mat Sci & Engn Pusan 46241 South Korea Korea Res Inst Stand & Sci Semicond Integrated Metrol Team Daejeon 34113 South Korea Korea Aerosp Univ Dept Semicond Sci Engn & Technol Goyang 10540 South Korea Korea Aerosp Univ Sch Elect & Informat Engn Goyang 10540 South Korea Pohang Accelerator Lab PLS II Beamline Div Pohang 37673 South Korea

High-entropy ceramics exhibit novel intrinsic properties. Hence, they have been explored for a wide range of applications ranging from thermal insulation and energy storage to advanced optical components. Recently, the semiconductor industry has faced a demand for higher-performance chips, necessitating higher aspect ratios in wafer fabrication and further miniaturization of linewidths. Therefore, novel materials with high plasma etching resistance and minimal contaminant generation are needed. The plasma-etching resistance displayed by high-entropy ceramics can be an innovative solution to this emerging challenge. In this study, we successfully fabricated single-phase high-entropy sesquioxide ceramics with high optical transparency, dense microstructure, and minimal residual pores. A structural analysis of the fabricated samples revealed a single-phase structure with excellent phase homogeneity. An evaluation of the plasma-etching resistance of high-entropy ceramics revealed for the first time a low etching rate of 8 nm/h compared with that of conventional plasma-resistant materials. These comprehensive characterizations of high-entropy ceramics indicate that they are promising candidates for significantly improving the production yield of semiconductors and for a wide range of potential applications, such as next-generation active optical ceramics.

关键词： high-entropy ceramics plasma etching resistance transparent ceramics sintering semiconductor manufacturing

Ventral hernia after high-intensity focused ultrasound ablation for uterine fibroids treatment:A case report

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World Journal of Clinical Cases 2022年第30期10卷 11204-11209页

作者： Jung-Woo park hwa Yeon Choi Department of Obstetrics and Gynecology Dong-A University College of MedicineBusan 49201South Korea

BACKGROUND High-intensity focused ultrasound(HIFU) ablation is a minimally invasive approach in gynecology that is used to manage uterine *** this procedure is safe and effective,adverse outcomes are becoming a major *** SUMMARY We present a case of ventral hernia that occurred as a rare and delayed complication of HIFU ablation for uterine fibroids *** patient came to the hospital with abdominal bloating that occurred 6 mo after ultrasound-guided HIFU ablation for managing uterine *** ventral hernia,which occurred due to atrophied muscle layers following the procedure,was confirmed by imaging studies and intraoperative *** required a hernia repair with mesh and hysterectomy for definitive treatment of uterine *** High-intensity ultrasound ablation should be performed only on appropriate *** should be educated about potential complications of the procedure and the possibility of subsequent ***-procedural long-term follow-up for detecting delayed adverse effects is important.

关键词： Uterine fibroids High-intensity focused ultrasound ablation Conservative treatment Ventral hernia Complication Case report

Intraoperative neurophysiological monitoring in spinal surgery

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World Journal of Clinical Cases 2015年第9期3卷 765-773页

作者： Jong-hwa park Seung-Jae Hyun Department of Neurosurgery Spine CenterSeoul National University Bundang Hospital Seoul National University College of Medicine

Recently, many surgeons have been using intraoperative neurophysiological monitoring(IOM) in spinal surgery to reduce the incidence of postoperative neurological complications, including level of the spinal cord, cauda equina and nerve root. Several established technologies are available and combined motor and somatosensory evoked potentials are considered mandatory for practical and successful IOM. Spinal cord evoked potentials are elicited compound potentials recorded over the spinal cord. Electrical stimulation is provoked on the dorsal spinal cord from an epidural electrode. Somatosensory evoked potentials assess the functional integrity of sensory pathways from the peripheral nerve through the dorsal column and to the sensory cortex. For identification of the physiological midline, the dorsal column mapping technique can be used. It is helpful for reducing the postoperative morbidity associated with dorsal column dysfunction when distortion of the normal spinal cord anatomy caused by an intramedullary cord lesion results in confusion in localizing the midline for the myelotomy. Motor evoked potentials(MEPs) consist of spinal, neurogenic and muscle MEPs. MEPs allow selective and specific assessment of the functional integrity of descending motor pathways, from the motor cortex to peripheral muscles. Spinal surgeons should understand the concept of the monitoring techniques and interpret monitoring records adequately to use IOM for the decision making during the surgery for safe surgery and a favorable surgical outcome.

关键词： Motor-evoked potentials Somatosensoryevoked potentials Intraoperative neurophysiological monitoring Direct wave Spinal surgery

A review of understanding electrocatalytic reactions in energy conversion and energy storage systems via scanning electrochemical microscopy

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Journal of Energy Chemistry 2024年第4期91卷 155-177页

作者： Jihye park Jong hwan Lim Jin-Hyuk Kang Jiheon Lim Ho Won Jang Hosun Shin Sun hwa park Interdisciplinary Materials Measurement Institute Korea Research Institute of Standards and ScienceDaejeon 34113Republic of Korea Department of Material Science and Engineering Seoul National UniversitySeoul 08826Republic of Korea Department of Applied Measurement Science University of Science and TechnologyDaejeon 34113Republic of Korea

To address climate change and promote environmental sustainability,electrochemical energy conversion and storage systems emerge as promising alternative to fossil fuels,catering to the escalating demand for *** optimal energy efficiency and cost competitiveness in these systems requires the strategic design of electrocatalysts,coupled with a thorough comprehension of the underlying mechanisms and degradation behavior occurring during the electrocatalysis *** electrochemical microscopy(SECM),an analytical technique for studying surface electrochemically,stands out as a powerful tool offering electrochemical *** possesses remarkable spatiotemporal resolution,enabling the visualization of the localized electrochemical activity and surface *** review compiles crucial research findings and recent breakthroughs in electrocatalytic processes utilizing the SECM methodology,specifically focusing on applications in electrolysis,fuel cells,and metal–oxygen batteries within the realm of energy conversion and storage *** with an overview of each energy system,the review introduces the fundamental principles of SECM,and aiming to provide new perspectives and broadening the scope of applied research by describing the major research categories within SECM.

关键词： Scanning electrochemical microscopy Electrocatalyst Electrocatalysis Water splitting Fuel cell Metal-oxygen battery

On the global existence of weak solutions for the Cucker-Smale-Navier-Stokes system with shear thickening

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Science China Mathematics 2018年第11期61卷 2033-2052页

作者： Seung-Yeal Ha hwa Kil Kim Jae-Myoung Kim Jinyeong park Department of Mathematical Sciences and Research Institute of Mathematics Seoul National University Seoul 08826 Republic of Korea Korea Institute for Advanced Study Seoul 02455 Republic of Korea Department of Mathematics Education Hannam University Daejeon 34430 Republic of Korea Department of Mathematical Sciences Seoul National University Seoul 08826 Republic of Korea Department of Mathematics and Research Institute of Natural Sciences Hanyang University Seoul 04763 Republic of Korea

We study the large-time dynamics of Cucker-Smale(C-S)flocking particles interacting with nonNewtonian incompressible *** of particles and fluids were modeled using the kinetic Cucker-Smale equation for particles and non-Newtonian Navier-Stokes system for fluids,respectively and these two systems are coupled via the drag force,which is the main flocking(alignment)mechanism between particles and *** present a global existence theory for weak solutions to the coupled Cucker-Smale-Navier-Stokes system with shear *** also use a Lyapunov functional approach to show that sufficiently regular solutions approach flocking states exponentially fast in time.

关键词： emergence flocking Cucker-Smale model Navier-Stokes equation non-Newtonian fluid

Panax ginseng induces the expression of CatSper genes and sperm hyperactivation

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Asian Journal of Andrology 2014年第6期16卷 845-851页

作者： Eun hwa park Do Rim Kim Ha Young Kim Seong Kyu park Mun Seog Chang Department of Prescriptionology College of Korean Medicine Kyung Hee Unversity Seoul Korea.

The cation channel of sperm （CatSper） protein family plays important roles in male reproduction and infertility. The four members of this family are expressed exclusively in the testis and are localized differently in sperm. To investigate the effects of Panax ginseng treatment on the expression of CatSper genes and sperm hyperactivation in male mice, sperm motility and CatSper gene expression were assessed using a computer-assisted semen analysis system, a Fluoroskan Ascent microplate fluorometer to assess Ca2＊ influx, *** polymerase chain reaction, Western blotting and immunofluorescence. The results suggested that the Ca2＊ levels of sperm cells treated with P. ginseng were increased significantly compared with the normal group. The P. ginseng-treated groups showed increased sperm motility parameters, such as the curvilinear velocity and amplitude of lateral head displacement. Taken together, the data suggest that CatSper messenger ribonucleic acid levels were increased significantly in mouse testes in the P. ginseng-treated group, as was the protein level, with the exception of CatSper2. In conclusion, P. ginseng plays an important role in improving sperm hyperactivation via CatSper gene expression.

关键词： Ca2+ CatSper hyperactivation panax Einseng

Characterization and Photocatalytic Efficiency of TiO_2 /Ti Beads Fabricated by Simple Heat-Treatment

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Journal of Materials Science & Technology 2012年第2期28卷 184-192页

作者： Altangerel Amarjargal Leonard D.Tijing Mi-hwa Yu Chae-hwa Kim Chan-Hee park Dong-Won Kim Cheol-Sang Kim Department of Bionanosystem Engineering Chonbuk National University Power Engineering School Mongolian University of Science and Technology Division of Mechanical Design Engineering Chonbuk National University Department of Industrial and Information Systems Engineering Chonbuk National University

The goal of the present study was to investigate the photocatalytic efficiency of titanium dioxide （TiO2） formed on titanium （Ti） bead substrate （referred herein as TiO2/Ti beads） by heat treatment when exposing to ultraviolet （UV） light irradiation. Escherichia coli was used as the model test organism. The results show 4-log and 7-log decrease in bacterial concentration after a test time of 15 and 120 min, respectively, using TiO2/Ti beads irradiated with UV light in a tin-foil covered beaker. This article presents the potential of TiO2 on Ti bead substrate formed by simple heat-treatment together with UV light for bacterial inactivation.

关键词： Photocatalysis Titanium dioxide Bacterial inactivation Heat treatment Escherichia coli

2D reduced graphene oxide-titania nanocomposites synthesized under different hydrothermal conditions for treatment of hazardous organic pollutants

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Particuology 2018年第1期16卷 165-173页

作者： Migyeong Kim Won-hwa Hong Woong Kim Sung Hyuk park Wan-Kuen Jo Department of Environmental Engineering Kyungpook National University Daegu 702-701 Republic of Korea School of Architecture Kyungpook National University Daegu 702-701 Republic of Korea Department of Materials Science and Metallurgical Engineering Kyungpook National University Daegu 702-701 Republic of Korea

Two-dimensional reduced graphene oxide-titania （RGO-TiO2） composites were prepared using a single- step hydrothermal method under various hydrothermal reaction conditions. The morphological and surface characteristics of the RGO-TiO2 composites and reference materials were determined. The RGO-TiO2 composites showed photocatalytic activity for the decomposition of two target pollutants that was superior to both pure TiO2 and RGO under fluorescent daylight lamp illumination. The photo- catalytic activity of the RGO-TiO2 composite increased as the hydrothermal treatment time increased from 1 to 24 h, but then it decreased as the time increased to 36 h, which indicated the presence of an optimal treatment time. RGO-TiO2 composites activated by violet light-emitting diodes （LEDs） displayed lower decomposition efficiency than those activated by a daylight lamp, likely because of the lower light intensity of violet LEDs （0.2 mW/cm2） when compared with that of the daylight lamp （1.4mW/cm2）. However, the photocatalytic decomposition of the target pollutants using the RGO-TiO2 composite was more energy-efficient using the violet LEDs. The photocatalytic reaction rates increased as the residence time decreased, whereas the reverse was true for the decomposition efficiency.

关键词： TiO2 composite Continuous-flow mode Hydrothermal time VioletLight emitting diode