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Hot snare polypectomy vs endoscopic mucosal resection using bipolar snare for intermediate size colorectal lesions:Propensity score matching

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World Journal of Gastroenterology 2023年第23期29卷 3668-3677页

作者： Nobuhisa Minakata Tatsuro Murano Masashi Wakabayashi Maasa Sasabe Takashi Watanabe Tomohiro Mitsui Hiroki Yamashita Atsushi Inaba Hironori Sunakawa Keiichiro Nakajo Tomohiro Kadota Kensuke shinmura Hiroaki Ikematsu Tomonori Yano Department of Gastroenterology and Endoscopy National Cancer Center Hospital EastKashiwa 2778577ChibaJapan Department of Biostatistics Division Center for Research Administration and SupportNational Cancer CenterKashiwa 2778577ChibaJapan

BACKGROUND Endoscopic resection(ER)with bipolar snare,in which the electric current only passes through the tissue between the device’s two electrodes,is a prominent method used to prevent perforation due to electricity *** using bipolar snare with or without submucosal injection enabled safe resection of colorectal lesions measuring 10-15 mm in an ex vivo porcine *** with bipolar snare is expected to have good treatment outcomes in 10-15 mm colorectal lesions,with high safety even without submucosal ***,no clinical reports have compared treatment outcomes with and without submucosal *** To compare the treatment outcomes of bipolar polypectomy with hot snare polypectomy(HSP)to those with endoscopic mucosal resection(EMR).METHODS In this single-centre retrospective study,we enrolled 10-15 mm nonpedunculated colorectal lesions(565 Lesions in 463 patients)diagnosed as type 2A based on the Japan Narrow-band Imaging Expert Team classification,resected by either HSP or EMR between January 2018 and June 2021 at the National Cancer Center Hospital *** were divided into HSP and EMR groups,and propensity score matching was *** the matched cohort,en bloc and R0 resection rates and adverse events were compared between the two *** Of the 565 lesions in 463 patients,117 lesions each in the HSP and EMR groups were selected after propensity score *** the original cohort,there was a significant difference in antithrombotic drug use(P<0.05),lesion size(P<0.01),location(P<0.01),and macroscopic type(P<0.05)between the HSP and EMR *** the matched cohort,the en bloc resection rates were comparable between both groups[93.2%(109/117)vs 92.3%(108/117),P=0.81],and there was no significant difference in the R0 resection rate[77.8%(91/117)vs 80.3%(94/117),P=0.64].The incidence of delayed bleeding was similar in both groups[1.7%(2/117)].Perforation occurred in the EMR group[0.9%(1/117)]but not in the HSP ***

关键词： Adenoma Cohort studies Colonoscopy Colorectal cancer Endoscopic mucosal resection Treatment outcome

Impaired suppressive activities of human MUTYH variant proteins against oxidative mutagenesis

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World Journal of Gastroenterology 2012年第47期18卷 6935-6942页

作者： Kazuya shinmura Masanori Goto Hong Tao Shun Matsuura Tomonari Matsuda Haruhiko Sugimura Department of Tumor Pathology Hamamatsu University School of MedicineShizuoka 431-3192Japan Research Center for Environmental Quality Management Kyoto UniversityShiga 520-0811Japan

AIM:To investigate the suppressive activity of MUTYH variant proteins against mutations caused by oxidative lesion,8-hydroxyguanine(8OHG),in human ***:p.R154H,p.M255V,p.L360P,and p.P377L MUTYH variants,which were previously found in patients with colorectal polyposis and cancer,were selected for use in this *** H1299 cancer cell lines inducibly expressing wild-type(WT) MUTYH(type 2) or one of the 4 above-mentioned MUTYH variants were established using the piggyBac transposon vector system,enabling the genomic integration of the transposon sequence for MUTYH *** expression was examined after cumate induction using Western blotting analysis and immunofluorescence *** intracellular localization of MUTYH variants tagged with FLAG was also immunofluorescently ***,the mutation frequency in the supF of the shuttle plasmid pMY189 containing a single 8OHG residue at position 159 of the supF was compared between empty vector cells and cells expressing WT MUTYH or one of the 4 MUTYH variants using a supF forward mutation ***:The successful establishment of human cell lines inducibly expressing WT MUTYH or one of the 4 MUTYH variants was concluded based on the detection of MUTYH expression in these cell lines after treatment with *** of the MUTYH variants and WT MUTYH were localized in the nucleus,and nuclear localization was also observed for FLAG-tagged *** mutation frequency of supF was 2.2 × 10-2 in the 8OHG-containing pMY189 plasmid and 2.5 × 10-4 in WT pMY189 in empty vector cells,which was an 86-fold increase with the introduction of *** mutation frequency(4.7 × 10-3) of supF in the 8OHG-containing pMY189 plasmid in cells overexpressing WT MUTYH was significantly lower than in the empty vector cells(P < 0.01).However,the mutation frequencies of the supF in the 8OHG-containing pMY189 plasmid in cells overexpressing the p.R154H,p.M255V,p.L360P,or p.P377L MUTYH variant were 1.84 × 10-2,1.55 × 10-2

关键词：体细胞突变蛋白质抑制性抗氧化免疫荧光分析电话号码载体系统穿梭质粒

Discriminant Analysis of the Linear Separable Data - Japanese 44 Cars

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Journal of Statistical Science and Application 2016年第4期4卷 165-178页

作者： Shuichi shinmura Faculty of Economics Seikei University Japan

Tuberous sclerosis patient with neuroendocrine carcinoma of the esophagogastric junction:A case report

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World Journal of Gastroenterology 2020年第45期26卷 7263-7271页

作者： Natsuki Ishida Takahiro Miyazu Satoshi Tamura Satoshi Suzuki Shinya Tani Mihoko Yamade Moriya Iwaizumi Satoshi Osawa Yasushi Hamaya Kazuya shinmura Haruhiko Sugimura Katsutoshi Miura Takahisa Furuta Ken Sugimoto First Department of Medicine Hamamatsu University School of MedicineHamamatsu 431-3192Japan Department of Endoscopic and Photodynamic Medicine Hamamatsu University School of MedicineHamamatsu 431-3192Japan Department of Laboratory Medicine Hamamatsu University School of MedicineHamamatsu 431-3192Japan Haruhiko Sugimura Department of Tumor PathologyHamamatsu University School of MedicineHamamatsu 431-3192Japan Department of Health Science Hamamatsu University School of MedicineHamamatsu 431-3192Japan Center for Clinical Research Hamamatsu University School of MedicineHamamatsu 431-3192Japan

BACKGROUND Tuberous sclerosis complex(TSC)is a rare inherited disease with non-cancerous tumor growths in the skin,brain,kidneys,heart,and *** co-occurrence of neuroendocrine neoplasm(NEN)with TSC is even *** have been few reports on the relationship between TSC and neuroendocrine tumors(NETs),and fewer on the relationship between TSC and neuroendocrine carcinoma(NEC),a subtype of *** is the first reported case of NEC occurring at the esophagogastric junction in a patient with *** SUMMARY A 46-year-old woman visiting our hospital for the treatment of TSC was admitted to the emergency department with tarry stools and *** tomography scans revealed thickness of the gastric cardia,multiple metastatic lesions of the liver,and enlarged lymph nodes near the lesser curvature of the *** revealed a type 3 tumor located from the esophagogastric junction to the fundus,and the pathological diagnosis by biopsy was *** patient was treated with seven courses of cisplatin+irinotecan,followed by eight courses of ramucirumab+nab-paclitaxel,one course of nivolumab,and two courses of S-1+***-three months after the first treatment,the patient died because of disease progression and deterioration of the general *** This case of NEC occurring in a patient with TSC indicates a difference in the occurrence of NETs and NECs.

关键词： Tuberous sclerosis complex Neuroendocrine carcinoma Neuroendocrine tumor mTOR inhibitor Esophagogastric junction Chemotherapy Case report

Three novel NEIL1 promoter polymorphisms in gastric cancer patients

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World Journal of Gastrointestinal Oncology 2010年第2期2卷 117-120页

作者： Masanori Goto Kazuya shinmura Shoichiro Tsugane Haruhiko Sugimura First Department of Pathology Hamamatsu University School of Medicine1-20-1 HandayamaHigashi WardHamamatsuShizuoka 431-3192Japan Epidemiology and Prevention Division Research Center for Cancer Prevention and ScreeningNational Cancer CenterTokyo 104-0045Japan

AIM:To identify genetic polymorphisms in the promoter region of the human base excision repair gene NEIL1 in gastric cancer ***:The NEIL1 promoter region in DNA from 80 Japanese patients with gastric cancer was searched for genetic polymorphisms by polymerase chain reaction-single-strand conformation polymorphism and subsequent sequencing ***:Three novel genetic polymorphisms,i.e.c.-3769C>T,c.-3170T>G,and c.-2681TA[8],were identified in the NEIL1 promoter region at an allele frequency of 0.6%,9.4%,and 4.4%,respectively,in Japanese gastric cancer ***:Three NEIL1 promoter polymorphisms detected in this study may be of importance in gastric carcinogenesis.

关键词： Gastric cancer NEIL1 Base excision repair Genetic polymorphism

EPH-EPHRIN in human gastrointestinal cancers

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World Journal of Gastrointestinal Oncology 2010年第12期2卷 421-428页

作者： Haruhiko Sugimura Hiroki Mori Masaru Tsuboi Kiyoko Nagura Hisaki Igarashi Ritsuko Nakamura Hiroko Natsume Tomoaki Kahyo Kazuya shinmura Hiroyuki Konno Yasushi Hamaya Shigeru Kanaoka Hideki Kataoka Department of Pathology I Hamamatsu University School of MedicineHamamatsu 431-3192Japan Department of Surgery II Hamamatsu Uni- versity School of MedicineHamamatsu431-3192Japan Department of Molecular Diagnostics Hamamatsu University School of MedicineHamamatsu 431-3192Japan Department of Medicine I Hamamatsu University School of MedicineHamamatsu431-3192Japan

Ever since its discovery two decades ago,the erythro- poietin-producing hepatoma (EPH)-EPHRIN system has been shown to play multifaceted roles in human gastroenterological cancer as well as ***,amplif ication and point mutations have been found in many human cancers and many investigators have shown correlations between these up-regulationsand tumor ***,the genes in this family are considered to be potential targets of cancer *** the other hand,the down-regulation of some members as a result of epigenetic changes has also been reported in some ***,the correlation between altered expressions and clinical prognosis seems to be inconclusive.A huge amount of protein-protein interaction studies on the EPH-EPHRIN system have provided a basic scheme for signal transductions,especially bi-directional signaling involving EPH-ERPHRIN molecules at the cell *** information also provides a manipulative strategy for harnessing the actions of these *** this review,we summarize the known alterations of EPH-EPHRIN genes in human tumors of the esophagus,stomach,colorectum,liver and pancreas and present the perspective that the EPH-EPHRIN system could be a potential target of cancer therapy.

关键词： Erythropoietin-producing hepatoma EPH-EPHRIN Gastric cancer Colorectal cancer Methylation Secreted form

椎板成形术联合椎弓根钉固定治疗脊髓型颈椎病伴痉挛性脑瘫:10年以上随访研究

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中国骨科临床与基础研究杂志 2021年第1期13卷 61-61页

作者： Demura S Kato S shinmura K 白朝晖(摘译) 不详

脊髓型颈椎病伴痉挛性脑瘫患者存在颈椎畸形及颈部重复性不自主运动,易导致围手术期内固定失败,其手术治疗对于术者而言是一个挑战。本研究对采用椎板成形术联合椎弓根钉后路关节融合术患者进行至少10年的长期随访,旨在评估该术式的远... 详细信息

脊髓型颈椎病伴痉挛性脑瘫患者存在颈椎畸形及颈部重复性不自主运动,易导致围手术期内固定失败,其手术治疗对于术者而言是一个挑战。本研究对采用椎板成形术联合椎弓根钉后路关节融合术患者进行至少10年的长期随访,旨在评估该术式的远期疗效。

关键词：脊髓型颈椎病不自主运动关节融合术痉挛性脑瘫随访研究椎板成形术椎弓根钉长期随访

摄取转运蛋白OATP8在肝癌发生不同过程中表达减少:与钆塞酸增强MRI的相关性

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国际医学放射学杂志 2011年第6期 606-606页

作者： A. Kitao O. Matsui N. Yoneda K. Kozaka R. shinmura W. Koda 闫晴晴 Department of Radiology Kanazawa University Graduate School of Medical Science13-1 Takaramachi Kanazawa 920-8640 Japan

目的研究肝结节有机阴离子转运多肽8(OATP8)的表达和钆塞酸增强MRI的增强率在肝癌发生的不同过程中的变化。材料与方法在图像分析方面,对71例手术切除的肝细胞癌(高、中及低分化肝癌)和1个发育不良结节(DN),计算肝胆期钆塞酸增强MRI增强... 详细信息

目的研究肝结节有机阴离子转运多肽8(OATP8)的表达和钆塞酸增强MRI的增强率在肝癌发生的不同过程中的变化。材料与方法在图像分析方面,对71例手术切除的肝细胞癌(高、中及低分化肝癌)和1个发育不良结节(DN),计算肝胆期钆塞酸增强MRI增强率[(1/增强后T1值-

关键词：肝细胞癌肝癌发生 MRI 钆塞酸有机阴离子转运多肽8

肝细胞癌交界性病变的恶性富血供病灶的检测:动态MDCT、动态MRI和SPIO增强MRI的对照研究

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国际医学放射学杂志 2008年第A06期31卷 514-514页

作者： R.shinmura O.Matsui M.Kadoya S.Kobayashi N.Terayama J.Sana-da 林笑丰 Department of Radiology Toyama Prefectural Central Hospital 2-2-78 Nishinagae Toyama 930-8550 Japan.

本研究目的是回顾性分析肝动脉成像CT(CT dur-ing hepatic arteriography,CTHA)所发现硬化肝内交界性结节中的富血供病灶,比较动态MDCT。

关键词：肝恶性病灶肝细胞癌 CT MRI