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Effect of Abnormal Posture on Quality of Life in Patients with Parkinson’s Disease

Advances in Parkinson's Disease 2016年第2期5卷 7-14页

作者： kyohei mikami Makoto Shiraishi Tsutomu Kamo Noborito Neurology Clinic Kawasaki Japan Division of Neurology St. Marianna University School of Medicine Kawasaki Japan

Background: Relationship between abnormal posture and QOL of Parkinson's disease is not clear. Objectives: To clarify the association between quality of life (QOL) and abnormal posture in patients with Parkinson’s disease (PD) and examine which QOL dimensions are involved. Methods: This study retrospectively examined PD patients (n = 57) who had undergone outpatient rehabilitation between January and March 2014. Evaluation items were Modified Hoehn Yahr (H-Y) stage, Unified Parkinson’s Disease Rating Scale (UPDRS)-Part III score, Timed Up and Go test (TUG, 3-m walking) result, Parkinson’s Disease Questionnaire (PDQ)-39 score, and the angle of forward and lateral trunk flexion in the standing position. Statistical analysis was performed to reveal the relationship between the total PDQ-39 score and individual evaluation items and which QOL dimensions were affected by abnormal posture due to forward or lateral flexion. Results: A total of 38 PD patients (17 men, 21 women;mean age, 73.2 ± 8.6 years) were enrolled. Among the evaluation items, lateral flexion angle showed a significant correlation with the total PDQ-39 score (r = 0.422, P = 0.008). PDQ-39 dimensions showing an association with forward flexion were activities of daily living (ADL) (P = 0.002) and communication (P = 0.007), whereas ADL (P = 0.004), communication (P = 0.021), and social support (P = 0.029) were associated with lateral flexion. Mobility was not associated with forward or lateral flexion. Conclusion: The present findings revealed a correlation between lateral flexion and QOL in PD patients. Among the PDQ-39 dimensions, ADL and communication were associated with abnormal posture.

关键词： Parkinson’s Disease Abnormal Postural Quality of Life Parkinson’s Disease Questionnaire (PDQ)-39

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Effects of COVID-19 on Outpatient Visitation of Japanese Parkinson’s Disease and Parkinsonism Patients Receiving Rehabilitation

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Advances in Parkinson's Disease 2022年第2期11卷 11-22页

作者： kyohei mikami Makoto Shiraishi Kazuki Yoshida Ken Kumai Ryoma Aoki Keisuke Shiraishi Natsumi Takahashi Tomomi Matsushima Akika Yoshimoto Takuya Iwamoto Tsutomu Kamo Department of Rehabilitation Noborito Neurology Clinic Kawasaki City Japan Department of Neurology St. Marianna University School of Medicine Kawasaki City Japan Department of Neurology Noborito Neurology Clinic Kawasaki City Japan

Background: Rehabilitation is effective for preventing progression of Parkinson’s disease (PD) and parkinsonism, but access to services during the COVID-19 pandemic was difficult. The Japanese already practice high levels of social distancing and personal restraint and are keenly aware of dangers related to infectious disease. We therefore presume that many patients discontinued rehabilitation due to behavioral restraint. Objectives: We investigated whether PD patients and parkinsonism patients attending outpatient rehabilitation facilities in Japan initiated rehabilitation interruptions and their associated reasons before and during the COVID-19 pandemic. Methods: Subjects were PD and parkinsonism patients attending a neurology clinic outpatient rehabilitation department in Japan before and during the first year of the COVID-19 pandemic (February 1, 2019, to January 31, 2021). Patients lost to follow-up were investigated as to how long they attended rehabilitation until interruption. We classified factors causing rehabilitation interruption into COVID-19-related factors, disease factors and social reasons. Results: Among 259 subjects (125 men, 134 women, mean age: 76.6 ± 8.5 years), 133 patients (51.4%) initiated interruption of rehabilitation therapy. Cumulative incidence of interruption events was significantly higher during than before the COVID-19 pandemic (p Conclusions: Cumulative incidence of interruption events increased in Japanese PD and parkinsonian patients attending an outpatient rehabilitation facility during the COVID-19 pandemic, primarily due to COVID-19-related factors. Patients and their families need education and guidance to facilitate continuous rehabilitation.

关键词： Parkinson’s Disease Parkinsonism COVID-19 Rehabilitation Outpatient

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Excellentπ-Bowl Semiconductors Based on C_(70)Subunit

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CCS Chemistry 2024年第2期6卷 353-364页

作者： Meng Chen Yuxiao Duan Xinyue Liu Qian Zhan Hironobu Hayashi kyohei Matsuo Hiroko Yamada Guangpeng Gao Yonghao Zheng Lei Zhang Beijing Advanced Innovation Center for Soft Matter Science and Engineering Beijing University of Chemical TechnologyBeijing 100029 School of Optoelectronic Science and Engineering University of Electronic Science and Technology of China(UESTC)Chengdu 610054 Division of Materials Science Nara Institute of Science and Technology(NAIST)IkomaNara 630-0192 Key Laboratory of Cluster Science of Ministry of Education Beijing Key Laboratory of Photoelectronic/Electrophotonic Conversion MaterialsSchool of Chemistry and Chemical EngineeringBeijing Institute of TechnologyBeijing 100081

As open substructures of fullerenes,aromaticπ-bowls are promising candidates as new organic semiconductors,as well as attractive hosts for *** demonstrate herein the synthesis and characterization of a novel C_(2v)symmetricπ-bowl,pyracyleno[6,5,4,3,2,1-pqrstuv]pentaphene(3).Bowl 3 was equipped with two distinctive reactive sites,allowing for bromination and cross-coupling reactions to readily yield functionalized bowls with two 2,4,6-trimethylphenyl(5)and triethylsilyl(TES)-ethynyl(6)substituents,***-temperature 1H NMR analysis and density functional theory(DFT)calculations indicated bowl-to-bowl inversions of 3,5,and 6 at room *** alternating the substituents,the crystal structures of the threeπ-bowls 3,5,and 6 could be controlled from 1D linear to 1D slipped to 2D herringbone packing motifs,providing insight into the packing behavior ofπ-bowls.1H NMR titration study indicated that the TES-ethynyl substituent enhanced the ability ofπ-bowl to bind C_(70)with an association constant of 2485 M−*** C_(70)molecules withπ-bowls 3 and 6 formed 1:1 complexes,in which C_(70)molecules aggregated into zig-zag and 1D linear arrays,*** hole mobility of 2.3 cm^(2)V^(−1)^s(−1)and electron mobility of 0.16 cm^(2)V^(−1)^s(−1)ofπ-bowl 3 and its complex with C_(70)were demonstrated,respectively,which proved a great value for the development of aromaticπ-bowl semiconductors with tunable properties for organic electronic devices.

关键词： organic semiconductor π-bowl fullerene crystal engineering mobility

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Combined laparoscopic and thoracoscopic repair of adult right-sided Bochdalek hernia with massive liver prolapse: A case report

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World Journal of Clinical Cases 2024年第14期12卷 2420-2425页

作者： Shinya mikami Sae Kimura Yoshitsugu Tsukamoto Masaki Hiwatari Yasuhito Hisatsune Asako Fukuoka Tsunehisa Matsushita Takeharu Enomoto Takehito Otsubo Department of Gastrointestinal and General Surgery St.Marianna University School of MedicineKanagawa 216-8511Japan

BACKGROUND A Bochdalek hernia(BH)is a congenital diaphragmatic hernia that often develops in the neonatal *** typically occurs on the left side of the diaphragm.A right-sided BH in an adult is *** SUMMARY A 45-year-old man was referred to our hospital because of an abnormal shadow seen on chest radiography during a medical check-up.A chest radiograph showed elevation of the right *** tomography showed prolapse of multiple intraabdominal organs into the right thoracic cavity,corresponding to a right-sided *** herniated contents included the stomach,transverse colon,and left lobe of the *** left lobe of the liver was enlarged,particularly the medial *** surgery was ***,the left lobe of the liver was completely trapped in the thoracic ***,thoracoscopic manipulation had to be performed to return the liver to the abdominal *** hernia was repaired with interrupted nonabsorbable sutures and reinforced with *** Combined laparoscopic and thoracoscopic surgery was successfully performed for right-sided BH with massive liver prolapse and abnormal liver morphology.

关键词： Bochdalek hernia Right-sided Adult Laparoscopic and thoracoscopic repair Liver prolapse Abnormal liver morphology Case report

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Myeloid immunosuppression and immune checkpoints in the tumor microenvironment

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Cellular & Molecular Immunology 2020年第1期17卷 1-12页

作者： kyohei Nakamura Mark J.Smyth Immunology in Cancer and Infection Laboratory QIMR Berghofer Medical Research InstituteHerston 4006 QLDAustralia

Tumor-promoting inflammation and the avoidance of immune destruction are hallmarks of *** innate immune cells,such as neutrophils,monocytes,and macrophages,are critical mediators for sterile and nonsterile inflammation,persistent inflammation,such as that which occurs in cancer,is known to disturb normal *** disturbance leads to the generation of immunosuppressive myeloid cells,such as myeloid-derived suppressor cells(MDSCs)and tumor-associated macrophages(TAMs).Due to their potent suppressive activities against effector lymphocytes and their abundance in the tumor microenvironment,immunosuppressive myeloid cells act as a major barrier to cancer ***,various therapeutic approaches directed toward immunosuppressive myeloid cells are actively being tested in preclinical and clinical *** include antiinflammatory agents,therapeutic blockade of the mobilization and survival of myeloid cells,and immunostimulatory *** recently,immune checkpoint molecules expressed on tumor-infiltrating myeloid cells have emerged as potential therapeutic targets to redirect these cells to eliminate tumor *** this review,we discuss the complex crosstalk between cancer-related inflammation and immunosuppressive myeloid cells and possible therapeutic strategies to harness antitumor immune responses.

关键词： myeloid macrophage innate immunity immune checkpoint inflammation

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A modified generalized scaling law for the similitude of dynamic strain in centrifuge modeling

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Earthquake Engineering and Engineering Vibration 2023年第3期22卷 589-600页

作者： Ma Qiang Ling Daosheng Meng Di kyohei Ueda Zhou Yanguo MOE Key Laboratory of Soft Soils and Geoenvironmental Engineering Institute of Geotechnical EngineeringCenter for Hypergravity Experiment and Interdisciplinary ResearchZhejiang UniversityHangzhou 310058China Disaster Prevention Research Institute Kyoto UniversityGokashoUjiKyoto 611-0011Japan

Soil strain is the key parameter to control the elasto-plastic deformation and even the failure *** overcome the defect that the strain of the model soil is always smaller than that of the prototype in Iai′s generalized scaling law(GSL),a modified scaling law was proposed based on Iai′s GSL to secure the same dynamic shear strain between the centrifuge model and the prototype by modulating the amplitude and frequency of the input motion at the base.A suite of dynamic centrifuge model tests of dry sand level ground was conducted with the same overall scaling factor(λ=200)under different centrifugal accelerations by using the technique of“modeling of models”to validate the modified *** test results show that the modified GSL could achieve the same dynamic strain in model as that of the prototype,leading to better modeling for geotechnical problems where dynamic strain dominates the response or failure of ***,the applicability of the proposed scaling law and possible constraints on geometry scaling due to the capability limits of existing centrifuge shaking tables are discussed.

关键词： deep deposit seismic response generalized scaling law centrifuge model test

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TREM2 marks tumor-associated macrophages

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Signal Transduction and Targeted Therapy 2020年第1期5卷 493-494页

作者： kyohei Nakamura Mark J.Smyth QIMR Berghofer Medical Research Institute Herston 4006 QLDAustralia

Immunosuppressive myeloid cells are recognized as a key barrier for cancer *** an integrated technology for single-cell RNA-sequencing and intracellular protein measurements,A recent paper published in Cell provides e... 详细信息

关键词： tumor immunotherapy myeloid

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An analysis of the acquisition of a monetary function by cryptocurrency using a multi-agent simulation model

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Financial Innovation 2022年第1期8卷 2338-2367页

作者： kyohei Shibano Gento Mogi Department of Technology Management for Innovation School of EngineeringThe University of TokyoTokyoJapan

Many types of cryptocurrencies,which predominantly utilize blockchain technology,have emerged *** issuers plan to circulate their original cryptocurrencies for monetary *** study investigates whether issuers can stimulate cryptocurrencies to attain a monetary *** use a multi-agent model,referred to as the Yasutomi model,which simulates the emergence of *** analyze two scenarios that may result from the actions taken by the *** scenarios focus on increases in the number of stores that accept cryptocurrency payments and situations whereby the cryptocurrency issuer designs the cryptocurrency to be attractive to people and conducts an *** find that a cryptocurrency can attain a monetary function in two *** such case occurs when 20%of all agents accept the cryptocurrency for payment and 50%of the agents are aware of this *** second case occurs when the issuer continuously airdrops a cryptocurrency to a specific person while maintaining the total volume of the cryptocurrency within a range that prevents it from losing its attractiveness.

关键词： Cryptocurrency Blockchain Social acceptance of cryptocurrency Emergence of currency

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Surface manipulation of a triple-conducting cathode for protonic ceramic fuel cells to enhance oxygen reduction activity and CO_(2) tolerance

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Journal of Energy Chemistry 2023年第12期87卷 450-459,I0012页

作者： Wenwen Zhang Hiroki Muroyama Yuichi mikami Toshiaki Matsui Koichi Eguchi Department of Energy and Hydrocarbon Chemistry Graduate School of EngineeringKyoto UniversityNishikyo-kuKyoto 615-8510Japan Technology Division Panasonic Holdings Corporation3-1-1 Yagumo-naka-machiMoriguchi CityOsaka 570-8501Japan

One of the main obstacles limiting the performance of protonic ceramic fuel cells(PCFCs) is the sluggish kinetics of the oxygen reduction reaction(ORR) at reduced ***,the surface manipulation of a triple-conducting cathode BaCe_(0.5)Pr_(0.3)Y_(0.2)O_(3-δ)(BCPY) by an efficient catalyst coating PrNi_(0.5)Co_(0.5)O_(3-δ)(PNC) to enhance the ORR activity and CO_(2) tolerance is *** developed PNC-coated BCPY cathode achieves the polarization resistance of 0.25 and 1.00 Ω cm^(2) at 600 and 500 ℃,respectively,approximately 1/5 of that for the pristine BCPY cathode(0.99 and 4.79 Ω cm^(2)),while maintaining an excellent CO_(2) *** single cell on a BaZr_(0.8)Yb_(0.2)O_(3-δ) electrolyte also exhibits a high peak power density of 0.79 W cm^(-2)at 700 ℃ and a stable operation for 200 h at 600 ℃.Such high ORR activity is mainly attributed to the synergistic effect of BCPY support and PNC ***,BCPY provides a tripleconducting path(mainly protons),and PNC nanoparticles facilitates surface oxygen exchange and steam adsorption/desorption processes due to the enriched surface oxygen *** study will provide a new design strategy for developing high-performance PCFCs cathode.

关键词： Triple-conducting cathode Surface manipulation Oxygen reduction reaction CO_(2)tolerance Protonic ceramicfuel cells

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Topographical and hydrological effects on meso-scale vegetation in desert steppe, Mongolia

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Journal of Arid Land 2017年第1期9卷 132-142页

作者： Batdelger GANTSETSEG Masahide ISHIZUKA Yasunori KUROSAKI Masao mikami Information and Research Institute of Meteorology Hydrology and Environment Ulaanbaatar 15160 Mongolia Faculty of Engineering Kagawa University Takamatsu 761-03 96 Japan Arid Land Research Center Tottori University Tottori 680-0001 Japan Japan Meteorological Business Support Center Tokyo 101-0054 Japan

This study investigated the seasonal variations of the normalized difference vegetation index（NDVI） and its relationships with climatic variables and topography in a small-scale（20 km×20 km） area（i.e., Tsogt-Ovoo village） within the desert steppe zone of Mongolia using in-situ observed climate data and satellite remote sensing data. We found that the topography is very important for vegetation growth in the desert steppe although the summer precipitation is the constraining factor. The unexpectedly high NDVI（up to 0.56）, as well as the high aboveground biomass, in the valley bottom was primarily resulted from the topography-modulated redistribution of overland flow after relatively heavy precipitation events during the growing season. This makes the valley bottoms in desert steppes not only reliable feeding resources for livestock but also heavens for wild lives. But, the detected large standard deviation of annual maximum NDVI（NDVI_（max）） from 2000 to 2013 in the valley bottom in response to rather variable precipitation implies that the valley bottoms under desert steppe climates are more vulnerable to climatic change.

关键词： topography climatic variable desert valley vegetation soil moisture Terra-MODIS NDVI

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