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The 2024 M_(j) 7.6 Noto Peninsula, Japan earthquake caused by the fluid flow in the crust

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Earthquake Research Advances 2024年第3期4卷 1-6页

作者： Yuzo ishikawa Ling Bai Center for Integrated Research and Education of Natural Hazards Shizuoka UniversityShizuoka422-8529Japan State Key Laboratory of Tibetan Plateau Earth System Environment and Resources(TPESER)Institute of Tibetan Plateau ResearchChinese Academy of SciencesBeijing100101China University of Chinese Academy of Sciences Beijing100049China

On January 1, 2024 at 16:10:09 JST, an M_(j) 7.6 earthquake struck the Noto Peninsula in the southern part of the Sea of Japan. This location has been experiencing an earthquake swarm for more than three years. Here, we provide an overview of this earthquake, focusing on the slip distribution of the mainshock and its relationship with the preceding swarm. We also reexamined the source areas of other large earthquakes that occurred around the Sea of Japan in the past and compared them with the Matsushiro earthquake swarm in central Japan from1964 to 1968. The difference between the Matsushiro earthquake swarm and the Noto earthquake swarm is the surrounding stress field. The Matsushiro earthquake swarm was a strike-slip stress field, so the cracks in the crust were oriented vertically. This allowed fluids seeped from the depths to rise and flow out to the surface. On the other hand, the Noto area was a reverse fault stress field. Therefore, the cracks in the earth's crust were oriented horizontally. Fluids flowing underground in deep areas could not rise and spread over a wide area in the horizontal plane. This may have caused a large amount of fluid to accumulate underground, triggering a large earthquake. Although our proposed mechanism does not take into account other complex geological conditions into consideration, it may provide a simple way to explain why the Noto swarm is followed by a large earthquake while other swarms are not.

关键词： The M 7.6 Noto Peninsular earthquake Earthquake swarm Fluid triggering Strike-slip fault Reverse fault

The 2023 Turkey earthquake doublet: Earthquake relocation, seismic tomography, and stress field inversion

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Earth and Planetary Physics 2024年第3期8卷 535-548页

作者： HuiLi Zhan Ling Bai Bagus Adi Wibowo ChaoYa Liu Kazuo Oike Yuzo ishikawa State Key Laboratory of Tibetan Plateau Earth System Environment and Resources(TPESER)Institute of Tibetan Plateau ResearchChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Center of Earthquake and Tsunami Agency of MeteorologyClimatology and GeophysicsJakarta 10610Indonesia University of Shizuoka Shizuoka 422-8526Japan Shizuoka University Shizuoka 422-8529Japan

On February 6,2023,two earthquakes with magnitudes of M_(W) 7.8 and M_(W) 7.5 struck southeastern Turkey,causing significant casualties and economic *** seismic events occurred along the East Anatolian Fault Zone,a convergent boundary between the Arabian Plate and the Anatolian *** this study,we analyze the M_(W) 7.8 and M_(W) 7.5 earthquakes by comparing their aftershock relocations,tomographic images,and stress field *** earthquakes were localized in the upper crust and exhibited steep dip ***,the aftershocks occurred either close to the boundaries of low and high P-wave velocity anomaly zones or within the low P-wave velocity anomaly *** East Anatolia Fault,associated with the M_(W) 7.8 earthquake,and the SürgüFault,related to the M_(W) 7.5 earthquake,predominantly experienced shear ***,their western sections experienced a combination of strike-slip and tensile stresses in addition to shear *** ruptures of the M_(W) 7.8 and M_(W) 7.5 earthquakes appear to have bridged a seismic gap that had seen sparse seismicity over the past 200 years prior to the 2023 Turkey earthquake sequence.

关键词： Turkey earthquake doublet earthquake relocation seismic tomography stress field seismicity

History of Western Philosophy and Quantum Language (Including Quantum Mechanics, Statistics, Fuzzy Logic, etc.)

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Journal of Applied Mathematics and Physics 2024年第5期12卷 1769-1795页

作者： Shiro ishikawa Department of Mathematics Faculty of Science and Technology Keio University Yokohama Japan

Although there are many different types of philosophy, many philosophers agree that the mainstream of Western philosophy (Socrates, Plato, Aristotle, Descartes, Kant, Wittgenstein) developed toward the perfection of Socrates’ absolutism. But can the absolutism maintain its central position after analytic philosophy? There are pessimistic views on this problem, such as that of R. Rorty, the standard-bearer of neo-pragmatism. Recently, I proposed quantum language (which is including quantum mechanics, statistics, fuzzy sets, etc.). I think that that this theory is not only one of the most fundamental scientific theories, but also the scientific final destination of Western philosophy. If so, Socrates’ dream has come true. The purpose of this paper is to discuss the above and to inform readers that quantum language has the power to create a paradigm shift from the classical mechanical world view to the quantum mechanical worldview.

关键词： Quantum Language Linguistic Copenhagen Interpretation Fuzzy Logic

Simple procedure for assessing diffuse subarachnoid hemorrhage successfully created using filament perforation method in mice

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Animal Models and Experimental Medicine 2024年第1期7卷 77-81页

作者： Tatsushi Mutoh Ryota Tochinai Hiroaki Aono Masayoshi Kuwahara Yasuyuki Taki Tatsuya ishikawa Department of Surgical Neurology Research Institute for Brain and Blood VesselsAkita Cerebrospinal and Cardiovascular CenterAkitaJapan Department of Aging Research and Geriatric Medicine Institute of DevelopmentAging and CancerTohoku UniversitySendaiJapan Department of Veterinary Pathophysiology and Animal Health Graduate School of Agriculture and Life SciencesThe University of TokyoTokyoJapan

The murine model of subarachnoid hemorrhage(SAH)is a valuable experimental tool for investigating molecular and cellular mechanisms,and the endovascular filament perforation technique can be used to simulate prominent pathophysiological features observed after human SAH;however,current validation methods for assessing an appropriate SAH model are ***,we introduce a simple procedure for se-lecting a mouse model of diffuse *** was induced in 24 mice using a standard filament perforation *** confirming survival at 24 h,SAH was scored 0-1 based on T2*-weighted images on whole-brain magnetic resonance imaging(MRI)and visual surveillance of the cisterna magna(CM)through the dura *** CM-based SAH grading correlated well with a reference parameter defined by extracted brain(r^(2)=0.53,p<0.0001).The receiver operating characteristic curve revealed a sensi-tivity of 85%and a specificity of 91%for detecting diffuse SAH,with a similar area under the curve(0.89±0.06[standard error of the mean])as the MRI-based grading(0.72±0.10,p=0.12).Our data suggest that confirming an SAH clot in the CM is a valuable way to select a clinically relevant diffuse SAH model that can be used in future experimental studies.

关键词： cisterna magna clot distribution filament perforation mouse model subarachnoid hemorrhage

A Revised Classification of Primary Iron Overload Syndromes

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Journal of Clinical and Translational Hepatology 2024年第4期12卷 346-356页

作者： Yasuaki Tatsumi Motoyoshi Yano Shinya Wakusawa Hiroaki Miyajima Tetsuya ishikawa Shinsaku Imashuku Atsuko Takano Wataru Nihei Ayako Kato Koichi Kato Hisao Hayashi Kentaro Yoshioka Kazuhiko Hayashi Department of Medical Biochemistry Faculty of Pharmaceutical SciencesToho UniversityFunabashiJapan Department of Gastroenterology Yokkaichi Municipal HospitalYokkaichiJapan Department of Medical Technology Shubun UniversityIchinomiyaJapan Department of Medicine and Neurology Tenryu Kohseikai ClinicHamamatsuJapan Department of Gastroenterology and Hepatology Nagoya University Graduate School of MedicineNagoyaJapan Department of Laboratory Medicine Uji-Tokushukai Medical CenterUjiJapan Department of Medicine Saiseikai Takaoka HospitalTakaokaJapan Department of Medicine Aichi-Gakuin University School of PharmacyNagoyaJapan Department of Gastroenterology FNPS Meijo HospitalNagoyaJapan

Background and Aims:The clinical introduction of hepcidin25(Hep25)has led to a more detailed understanding of its relationship with ferroportin(FP)and divalent metal transporter1 in primary iron overload syndromes(PIOSs).In 2012,we proposed a classification of PIOSs based on the Hep25/FP system,which consists of prehepatic aceruloplasminemia,hepatic hemochromatosis(HC),and posthepatic FP disease(FP-D).However,in consideration of accumulated evidence on PIOSs,we aimed to renew the ***:We reviewed the 2012 classification and retrospectively renewed it according to new information on ***:Iron-loading anemia was included in PIOSs as a prehepatic form because of the newly discovered erythroferrone-induced suppression of Hep25,and the state of traditional FP-D was remodeled as the BIOIRON *** key molecules responsible for prehepatic PIOSs are low transferrin saturation in aceruloplasminemia and increased erythroferrone production by erythroblasts in iron-loading *** PIOSs comprise four genotypes of HC,in each of which the synthesis of Hep25 is inappropriately reduced in the *** Hep25 synthesis is adequate in posthepatic PIOSs;however,two mutant FP molecules may resist Hep25 differently,resulting in SLC40A1-HC and FP-D,*** phenotypes are diagnosed using laboratory tests,including circulating Hep25,followed by suitable *** sequencing of the candidate genes may be outsourced to gene centers when *** kits for the prevalent mutations,such as C282Y,may be the first choice for a genetic analysis of HC in ***:The revised classification may be useful worldwide.

关键词： Ethnicity Ferroportin Hemochromatosis Hepcidin25 Iron overload syndrome

Aszonapyrone A Isolated from Neosartorya spinosa IFM 47025 Inhibits the NF-κB Signaling Pathway Activated by Expression of the Ependymoma-Causing Fusion Protein ZFTA-RELA

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Advances in Microbiology 2024年第9期14卷 448-467页

作者： Kazuki ishikawa Nao Kamiya Masaki Ishii Takashi Yaguchi Koji Ichinose Shinya Ohata Faculty of Pharmaceutical Sciences Teikyo Heisei University Nakano Tokyo Japan Research Institute of Pharmaceutical Sciences Faculty of Pharmacy Musashino University Nishitokyo-Shi Tokyo Japan Medical Mycology Research Center Chiba University Inohana Chiba Japan

Ependymoma is a rare and chemotherapy-resistant brain tumor, which has resulted in a delay in the development of drugs to treat it. A subclass of supratentorial ependymomas (ST-EPN), designated ST-EPN-zinc finger-translocation-associated (ZFTA, ST-EPN-ZFTA), exhibits the expression of a fusion protein comprising ZFTA and v-rel reticuloendotheliosis viral oncogene homolog A (RELA), an effector transcription factor of the nuclear factor-kappa B (NF-κB) pathway (ZFTA-RELA). The expression of ZFTA-RELA results in the hyperactivation of the oncogenic NF-κB signaling pathway, which ultimately leads to the development of ST-EPN-ZFTA. To identify inhibitors of the NF-κB signaling pathway activated by the expression of ZFTA-RELA, we used a doxycycline-inducible ZFTA-RELA-expressing NF-κB reporter cell line and found that extracts of the fungus Neosartorya spinosa IFM 47025 exhibited NF-κB inhibitory activity. We identified eight compounds [aszonapyrone A (2), sartorypyrone A (3), epiheveadride (4), acetylaszonalenin (5), (R)-benzodiazepinedione (6), aszonalenin (7), sartorypyrone E (8) and (Z, Z)-N,N’-(1,2-bis[(4-methoxyphenyl)methylene]-1,2-ethanediyl)bis-formamide (9)] from N. spinosa IFM 47025 culture extract using a variety of chromatographic techniques. The structures of these compounds were identified through the analysis of various instrumental data (1D, 2D-NMR, MS, and optical rotation). The NF-κB responsive reporter assay indicated that compounds 2, 3, 5, 7, and 9 exhibited inhibitory activity. We further evaluated the inhibitory activity of these compounds against the expression of endogenous NF-κB responsive genes (CCND1, L1CAM, ICAM1, and TNF) and found that compound 2 showed significant inhibitory activity. Further studies are required to elucidate the mechanism of action of compound 2, which may serve as a lead compound for the development of a novel therapy for ST-EPN-ZFTA.

关键词： Aszonapyrone A Neosartorya spinosa NF-κB Signaling Pathway Ependymoma ZFTA-RELA

“四大文明”学说的形成与传播:跨越世纪的对话

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中山大学学报（社会科学版） 2024年第4期64卷 1-12页

作者： [日]石川祯浩王丹(译) 京都大学人文科学研究所日本京都6068501 华东政法大学日语系上海200042

“四大文明”是中日两国世界史的“常识”。近年,两国分别有学者指出,“四大文明”学说只在本国通用,在世界其他国家并不存在。通过查找史料得知,“四大文明”学说源于卡尔·李特尔、卡普、西莱和黑格尔等西方思想家、历史学家,之后东... 详细信息

“四大文明”是中日两国世界史的“常识”。近年,两国分别有学者指出,“四大文明”学说只在本国通用,在世界其他国家并不存在。通过查找史料得知,“四大文明”学说源于卡尔·李特尔、卡普、西莱和黑格尔等西方思想家、历史学家,之后东亚的知识分子将其进行了概念化。这一传播过程跨越了历史学、地理学、人类学、文明学等学术领域的界限,是东西方知识分子对话的结果,同时也是一场跨越世纪的对话。

关键词： “四大文明”学说梁启超浮田和民卡尔·李特尔人文地理学黑格尔

同方期刊数据库博看期刊评论

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钼硼对低碳钢的复合强化作用

水钢科技 2018年第2期 53-62页

作者： kyohei ishikawa Hirofumi NAKAMURAO Ryulchi HOMMA Masaaki FUJIOKA Manabu HOSHINO 高长益刘立德叶雅妮张东升日本新日铁住友金属公司钢铁研究实验室日本新日铁住友金属公司君津研究开发实验室首钢水钢技术中心贵州六盘水553028

在硼合金钢中加入钼元素，通过抑制Fe23（C，B）6的析出，从而提高钢的硬度，这就是Mo—B复合效应。但是，由于以前关于这种复合效应的研究主要探讨的是Mo含量小于0．80％的钢。因此，产生复合效应的最大钼含量仍然不清楚。所以，在本... 详细信息

在硼合金钢中加入钼元素，通过抑制Fe23（C，B）6的析出，从而提高钢的硬度，这就是Mo—B复合效应。但是，由于以前关于这种复合效应的研究主要探讨的是Mo含量小于0．80％的钢。因此，产生复合效应的最大钼含量仍然不清楚。所以，在本研究中。我们探讨Mo含量大于0．80％、含C量为0．15％的钢，以确定产生Mo—B复合效应的最大钼含量。随着Mo含量增加到0．75％，Mo—B复合效应增大，然后呈下降趋势。随着Mo含量从1.0％增加到1．5％。则最佳B含量从12ppm下降到11ppm。在1．0％Mo-20ppmB钢和1．5％Mo-20ppmB钢中。析出相是M02FeB2而不是Fe23（C，B）60热力学计算表明，在20ppmB钢中，随着钼含量的增加，Mo2FeB2析出的起始温度上升。但是，甚至在950℃的加热温度，M02FeB2也能析出。因此，产生Mo-B复合强化效应的最大Mo含量主要取决于加热过程中Mo2FeB2的析出。

关键词：硬度硼偏析钼复合效应

Saccharomyces cerevisiae in neuroscience:how unicellular organism helps to better understand prion protein?

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Neural Regeneration Research 2021年第3期16卷 489-495页

作者： Takao ishikawa Department of Molecular Biology Institute of BiochemistryFaculty of BiologyUniversity of WarsawWarsawPoland

The baker's yeast Saccharomyces(S.)cerevisiae is a single-celled eukaryotic model organism widely used in research on life *** a unicellular organism,*** has some evident limitations in application to ***,yeast prions are extensively studied and they are known to share some hallmarks with mammalian prion protein or other amyloidogenic proteins found in the pathogenesis of Alzheimer's,Parkinson's,or Huntington's ***,the yeast *** has been widely used for basic research on aggregation properties of proteins in cellulo and on their ***,a yeast-based study revealed that some regions of mammalian prion protein and amyloidβ1–42 are capable of induction and propagation of yeast *** is one of the examples showing that evolutionarily distant organisms share common mechanisms underlying the structural conversion of prion proteins making yeast cells a useful system for studying mammalian prion *** has also been used to design novel screening systems for anti-prion compounds from chemical *** assays are cheap in maintenance and safe for the researcher,making them a very good choice to perform preliminary screening before further characterization in systems engaging mammalian cells infected with *** this review,not only classical red/white colony assay but also yeast-based screening assays developed during last year are *** analysis and research carried out using yeast prions force us to expect that prions are widely present in ***,the last few years brought us several examples indicating that the mammalian prion protein is no more peculiar protein–it seems that a better understanding of prion proteins nature-wide may aid us with the treatment of prion diseases and other amyloid-related medical conditions.

关键词： amyloid artificial prion baker's yeast budding yeast drug screening fusion protein neurodegenerative diseases prion protein yeast-based assay