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Science China Chemistry 2018年第8期61卷 957-965页

作者： Arruri Sathyanarayana Shin-ya Nakamura kyohei hisano Osamu Tsutsumi Katam Srinivas Ganesan Prabusankar Department of Applied Chemistry Ritsumeikan University 1-1-1 Nojihigashi Department of Chemistry Indian Institute of Technology

Thermally stable, solid-state luminescent organic materials are highly desired for the development of practical *** we synthesized new gold(I) complexes with N-heterocyclic carbene ligands, which have the ability to form strong metalorganic bond. Consequently, their thermochemical stability is enhanced at temperatures around 300 °C. Precise design of the molecular structure of the ligands, with a focus on ensuring low steric hindrance around Au atoms in order to limit disturbances to Au/Au interactions, provided a complex with a densely packed crystal with a shorter intermolecular Au–Au distance(3.17 ?)than the typical distance. In the solid state, this complex exhibited strong aurophilic interactions, which generated intense phosphorescence even in air at room temperature(quantum yield=16%) in spite of absence of any phosphorescence in *** behavior is characteristic for solid-state luminescence referred to as aggregation-controlled emission. Furthermore, the gold(I) complex displays capacity for mechano-and vapo-chromism—that is, the ability to change color reversibly in response to the application of external stimuli. We believe that the proposed design framework, which involves controlling thermal stability and luminescence property separately, provides a new opportunity for the development of practical applications using solid-state luminescent organic molecules.

关键词： Au complex N-heterocyclic carbene phosphorescence mechanochromism aggregation-induced emission

Aggregation-enhanced direct S_(0)-T_(n) transitions and room-temperature phosphorescence in gold(I)-complex single crystals

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Aggregate

Aggregate 2022年第1期3卷 159-167页

作者： Akihiro Ando Kazuhisa Ozaki Urara Shiina Eikichi Nagao kyohei hisano Kenji Kamada Osamu Tsutsumi Department of Applied Chemistry Ritsumeikan UniversityKusatsuJapan Nanomaterials Research Institute(NMRI) National Institute of Advanced Industrial Science and Technology(AIST)IkedaJapan

The design of efficient aggregation-induced emission materials requires an improved understanding of photophysical processes in aggregated ***,the photophysical behavior of an Au(I)complex(R6)that exhibits intense roomtemperature phosphorescence(RTP)in crystals is *** addition,the photophysical processes related to RTP are discussed based on the structure of the molecular aggregates and the primary structure of the *** extremely efficient S_(0)-T_(n) direct transition is found to occur in the R6 ***,intermolecular Au-Au interactions and the internal/external heavy-atom effects of Au atoms are demonstrated to enhance the electronic transitions involving intersystem crossing,namely,direct S_(0)-T_(n) excitation,radiative T_(1)-S_(0) transition(phosphorescence),and S_(1)-T_(n) intersystem *** of the dense molecular packing,both Au-Au interactions and heavy-atom effects play important roles in the *** a result,R6 shows more efficient RTP in crystals than in *** insights into the mechanism of highly efficient RTP in Au(I)-complex crystals are expected to advance the development of new luminogens for a variety of sensing and imaging applications.

关键词： aggregation-induced emission aurophilic interaction gold(I)complex phosphorescence spin-forbidden transition

GRAND UNIFIED THEORIES

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Chinese Physics C 2016年第10期40卷 290-302页

作者： A. Hebecker J. hisano U. Heidelberg Nagoya U.

16.1. The Standard Model The Standard Model （SM） may be defined as the renormalizable field theory with gauge group GSM = SU（3）C × SU（2）L × U（1）y, with 3 generations of fermions in the representation

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Institutionalisation of Genetic Resource Management with Farmers： Cases of Traditional Vegetables in Japan

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Journal of Agricultural Science and Technology(B) 2013年第6期3卷 399-413页

作者： Aki Imaizumi Shuji hisano The Graduate School of Agriculture Kyoto University Kyoto 606-8502 Japan The Graduate School of Economics Kyoto University Kyoto 606-8501 Japan

Nearly all countries have seed organisations and private seed companies, laws and technical regulations to govern their while the role of the farmers＇ seed system has formal seed system, run by formal public been marginalised especially in developed countries. Local traditional varieties that are largely taken care of and nurtured by farmers＇ seed system have also been excluded from the formal seed system. Nowadays, however, it is quite common to see locally-sourced vegetables on supermarket shelves, while an increasing number of consumers visit farmers＇ market and become aware of local traditional vegetables available only through such channels. It is in this context that many local governments, public agricultural experimental stations and even private seed companies are becoming interested in the use and management of local traditional varieties of vegetables in Japan. The objective of this paper is to elucidate some characteristics of and factors behind the condition, potentiality and limitations of farmers＇ seed systems vis-a-vis the expected role of public experimental stations and locally-based seed companies, especially when it comes to the use and management of local traditional vegetables and their genetic resources in Japan. This paper is based on our case studies, in which we conducted in some interviews with relevant local actors in addition to literature and statistical surveys.

关键词： Farmers' seed system local vegetables genetic resources institutionalisation

Lysophosphatidic acid induced nuclear translocation of nuclear factor-κB in Panc-1 cells by mobilizing cytosolic free calcium

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World Journal of Gastroenterology 2008年第28期14卷 4473-4479页

作者： Yoshiyuki Arita Tetsuhide Ito Takamasa Oono Ken Kawabe Terumasa hisano Ryoichi Takayanagi Department of Medicine and Bioregulatory Science Graduate School of Medical SciencesKyushu UniversityFukuoka 812-8582Japan

AIM: To clarify whether Lysophosphatidic acid (LPA) activates the nuclear translocation of nuclear factor-κB (NF-κB) in pancreatic cancer. METHODS: Panc-1, a human pancreatic cancer cell line, was used throughout the study. The expression of LPA receptors was confirmed by reverse-transcript polymerase chain reaction (RT-PCR). Cytosolic free calcium was measured by fluorescent calcium indicator fura-2, and the localization of NF-κB was visualized by immunofluorescent method with or without various agents, which effect cell signaling. RESULTS: Panc-1 expressed LPA receptors, LPA1, LPA2 and LPA3. LPA caused the elevation of cytosolic free calcium dose-dependently. LPA also caused the nuclear translocation of NF-κB. Cytosolic free calcium was attenuated by pertussis toxin (PTX) and U73122, an inhibitor of phospholipase C. The translocation of NF-κB was similarly attenuated by PTX and U73122, but phorbol ester, an activator of protein kinase C, alone did not translocate NF-κB. Furthermore, the translocation of NF-κB was completely blocked by Ca2+ chelator BAPTA-AM. Thapsigargin, an endoplasmic- reticulum Ca2+-ATPase pump inhibitor, also promoted the translocation of NF-κB. Staurosporine, a proteinkinase C inhibitor, attenuated translocation of NF-κB induced by LPA. CONCLUSION: These findings suggest that protein kinase C is activated endogenously in Panc-1, and protein kinase C is essential for activating NF-κB with cytosolic calcium and that LPA induces the nuclear translocation of NF-κB in Panc-1 by mobilizing cytosolic free calcium.

关键词： Lysophosphatidic acid Nuclear translocation Nuclear factor-κB Cytosolic free calcium Panc-1

Risk factors for de novo hepatitis B during solid cancer treatment

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World Journal of Clinical Cases 2020年第24期8卷 6264-6273页

作者： Rie Sugimoto Masayuki Furukawa Takeshi Senju Yoshihusa Aratake Yuki Tanaka Hiroki Inada Tatsuya Noguchi Lingaku Lee Masami Miki Yuji Maruyama Risa Hashimoto Terumasa hisano Mototsugu Shimokawa Department of Hepato-Biliary-Pancreatology National Hospital Organization Kyushu Cancer CenterFukuoka City 811-1395Fukuoka PrefectureJapan National Hospital Organization Kyushu Cancer Center Clinical Research InstituteFukuoka City 811-1395Fukuoka PrefectureJapan Department of Biostatistics Yamaguchi University Graduate School of MedicineUbe City 755-8505Yamaguchi PrefectureJapan

BACKGROUND Reactivation of hepatitis B virus(HBV)during anticancer treatment is a critical *** treating patients with solid tumors,it is unclear whether specific cancer types or treatments affect HBV reactivation in hepatitis B surface antigen(HBsAg)-negative and hepatitis B core antibody(HBcAb)-positive patients,socalled de novo hepatitis B *** risk of de novo hepatitis B may vary based on different background *** To determine the frequency and risk factors for de novo hepatitis B during solid tumor *** This retrospective cohort study comprised 1040 patients without HBsAgs and with HBcAbs and/or hepatitis B surface antibodies(HBsAbs).The patients were treated for solid cancer from 2008 to 2018 at the National Kyushu Cancer Center and underwent HBV DNA *** characteristics and disease and treatment information were *** DNA measurements were performed using TaqMan polymerase chain reaction(PCR).To identify the risk factors associated with HBV DNA expression,the age,sex,original disease,pathology,treatment method,presence or absence of hepatitis C virus(HCV),and HBsAb and/or HBcAb titers of all subjects were *** patients with HBV DNA,the time of appearance,presence of HBsAgs and HBsAbs at the time of appearance,and course of the subsequent fluctuations in virus levels were also *** Among the 1040 patients,938 were HBcAb positive,and 102 were HBcAb negative and HBsAb *** DNA expression was observed before the onset of treatment in nine patients(0.9%)and after treatment in 35 patients(3.7%),all of whom were HBcAb *** HBV reactivation group showed significantly higher median HBcAb values[9.00(8.12-9.89)vs 7.22(7.02-7.43),P=0.0001]and significantly lower HBsAb values(14 vs 46,P=0.0342)than the group without ***,the reactivated group showed a significantly higher proportion of cancers in organs related to digestion and absorption(79.0%vs 58.7%,

关键词： Hepatitis B Reactivation Solid cancer treatment Digestion and absorption organ Hepatitis B surface antibody Hepatitis B core antibody titer

Chemoradiotherapy with twice-weekly administration of low-dose gemcitabine for locally advanced pancreatic cancer

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World Journal of Gastroenterology 2008年第34期14卷 5311-5315页

作者： Hisato Igarashi Tetsuhide Ito Ken Kawabe Terumasa hisano Yoshiyuki Arita Toyoma Kaku Ryoichi Takayanagi Department of Medicine and Bioregulatory Science Graduate School of Medical ScienceKyushu University

AIM:To evaluate the chemoradiotherapy for locally advanced pancreatic cancer utilizing low dose gemcitabine as a radiation sensitizer administered twice weekly. METHODS: We performed a retrospective analysis of chemoradiotherapy utilizing gemcitabine administered twice weekly at a dose of 40 mg/m2. After that, maintenance systemic chemotherapy with gemcitabine, at a dose of 1000 mg/m2, was administered weekly for 3 wk with 1-wk rest until disease progression or unacceptable toxicity developed. RESULTS: Eighteen patients with locally advanced unresectable pancreatic cancer were enrolled. Three of those patients could not continue with the therapy; one patient had interstitial pneumonia during radiation therapy and two other patients showed liver metastasis or peritoneal metastasis during an early stage of the therapy. The median survival was 15.0 mo and the overall 1-year survival rate was 60%, while the median progression-free survival was 8.0 mo. The subgroup which showed the reduction of tumor development, more than 50% showed a tendency for a better prognosis; however, other parameters including age, gender and performance status did not correlate with survival. The median survival of the groups that died of liver metastasis and peritoneal metastasis were 13.0 mo and 27.7 mo, ***: Chemoradiotherapy with low-dose gemcitabine administered twice weekly could be effective to patients with locally advanced pancreatic cancer; however, patients developing liver metastases had a worse prognosis. Another chemoradiotherapy strategy might be needed for those patients, such as administrating one or two cycles of chemotherapy initially, followed by chemoradiotherapy for the cases with no distant metastases.

关键词： Advanced pancreatic cancer Chemoradio-therapy Gemcitabine Radiosensitizer Tumor marker

Review of the literature laparoscopic surgery for metastatic hepatic leiomyosarcoma associated with smooth muscle tumor of uncertain malignant potential: Case report

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World Journal of Hepatology 2018年第4期10卷 402-408页

作者： Keisuke Fukui Nobuhisa Takase Taiichiro Miyake Koji hisano Eri Maeda Tohru Nishimura Koichiro Abe Akihito Kozuki Tomohiro Tanaka Naoki Harada Manabu Takamatsu Kunihiko Kaneda Department of Surgery Kakogawa Central City Hospital

Metastatic hepatic leiomyosarcoma is a rare malignant smooth muscle *** report a case of metastatic hepatic leiomyosarcoma associated with smooth muscle tumor of uncertain malignant potential(STUMP).A 68-year-old female presented with a liver mass(60 mm × 40 mm, Segment 4).She underwent left salpingooophorectomy for an ovary tumor with STUMP in a broad ligament 6 years *** FDG-PET showed obvious metabolically active foci, abnormal metabolically active foci other than the lesion were not detected.A malignant liver tumor was strongly suspected and laparoscopic partial liver resection was performed with vessel-sealing devices using the crush clamping method and Pringle *** findings revealed metastatic liver leiomyosarcoma associated with STUMP in a broad *** case is an extremely rare case of malignant transformation from primary STUMP to metastatic hepatic *** provides important evidence regarding the treatment for metastatic hepatic leiomyosarcoma associated with STUMP.

关键词： Leiomyosarcoma Smooth muscle tumor Hepatic neoplasm Neoplasm metastasis Laparoscopic surgery Liver resection

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IgA肾病患儿治疗的研究进展

中华儿科杂志 2007年第4期45卷 244-247页

作者： James C. M. Chan Man-Chun Chiu Satoshi hisano Ching-Yuang Lin 管娜（翻译）丁洁（审校） The Barbara Bush Children＇s Hospital Maine Medical Center Portland Maine USA The Department of Paediatrics Princess Margaret Hospital Hong Kong China Department of Pathology Fukuoka University Fukuoka Japan Children＇s Hospital Changhua Christian Hospital Institute of Medical Research Chang Jung Christian UniversityTaiwanChina 不详

1968年IgA肾病首次被描述，最初称为Berger病。先证者为法国患儿，表现为急性上呼吸道感染数天后出现无症状肉眼血尿。肾活检显示系膜区显著扩大、IgA沉积，因此被命名为IgA肾病。此后40年临床治疗实践中，对该病自然病程了解逐渐增多... 详细信息

1968年IgA肾病首次被描述，最初称为Berger病。先证者为法国患儿，表现为急性上呼吸道感染数天后出现无症状肉眼血尿。肾活检显示系膜区显著扩大、IgA沉积，因此被命名为IgA肾病。此后40年临床治疗实践中，对该病自然病程了解逐渐增多，但对其发病机制知之甚少。20世纪80年代，D，Amico和其他学者已经认识到IgA肾病是世界上最常见的肾小球肾炎。因此，Julian等指出该病对1％以上的人口有影响。

关键词： IgA肾病临床治疗患儿急性上呼吸道感染 IgA沉积肾小球肾炎肉眼血尿自然病程

Improved techniques for double-balloon-enteroscopy-assisted endoscopic retrograde cholangiopancreatography

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World Journal of Gastroenterology 2012年第46期18卷 6843-6849页

作者： Takashi Osoegawa Yasuaki Motomura Kazuya Akahoshi Naomi Higuchi Yoshimasa Tanaka Terumasa hisano Souichi Itaba Junya Gibo Mariko Yamada Masaru Kubokawa Yorinobu Sumida Hirotada Akiho Eikichi Ihara Kazuhiko Nakamura Department of Gastroenterology Aso Iizuka Hospital Department of Medicine and Bioregulatory Science Graduate School of Medical Sciences Kyushu University

AIM: To investigate the clinical outcome of double balloon enteroscopy (DBE)-assisted endoscopic retrograde cholangiopancreatography (DB-ERCP) in patients with altered gastrointestinal anatomy. METHODS: Between September 2006 and April 2011, 47 procedures of DB-ERCP were performed in 28 patients with a Roux-en-Y total gastrectomy (n = 11), Billroth Ⅱ gastrectomy (n = 15), or Roux-en-Y anastomosis with hepaticojejunostomy (n = 2). DB-ERCP was performed using a short-type DBE combined with several technical innovations such as using an endoscope attachment, marking by submucosal tattooing,selectively applying contrast medium, and CO2 insufflations. RESULTS: The papilla of Vater or hepaticojejunostomy site was reached in its entirety with a 96% success rate (45/47 procedures). There were no significant differences in the success rate of reaching the blind end with a DBE among Roux-en-Y total gastrectomy (96%), Billroth Ⅱ reconstruction (94%), or pancreatoduodenectomy (100%), respectively (P = 0.91). The total successful rate of cannulation and contrast enhancement of the target bile duct in patients whom the blind end was reached with a DBE was 40/45 procedures (89%). Again, there were no significant differences in the success rate of cannulation and contrast enhancement of the target bile duct with a DBE among Roux-en-Y total gastrectomy (88 %), Billroth Ⅱ reconstruction (89%), or pancreatoduodenectomy (100%), respectively (P = 0.67). Treatment was achieved in all 40 procedures (100%) in patients whom the contrast enhancement of the bile duct was successful. Common endoscopic treatments were endoscopic biliary drainage (24 procedures) and extraction of stones (14 procedures). Biliary drainage was done by placement of plastic stents. Stones extraction was done by lithotomy with the mechanical lithotripter followed by extraction with a basket or by the balloon pull-through method. Endoscopic sphincterotomy was performed in 14 procedures with a needle precutting knife us

关键词： Double-balloon enteroscopy Endoscopic retrograde cholangiopancreatography Pathological anatomy Pancreatobiliary disease