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COVID-19-activated SREBP2 disturbs cholesterol biosynthesis and leads to cytokine storm

Signal Transduction and Targeted Therapy 2020年第1期5卷 910-920页

作者： Wonhwa Lee June Hong Ahn Hee Ho Park Hong Nam Kim Hyelim Kim Youngbum Yoo Hyosoo Shin Kyung Soo Hong Jong Geol Jang Chun Gwon Park Eun Young Choi Jong-Sup Bae Young-kyo Seo Aging Research Center Korea Research Institute of Bioscience and BiotechnologyDaejeon 34141Republic of Korea Division of Pulmonology and Allergy Department of Internal MedicineCollege of MedicineYeungnam University and Regional Center for Respiratory DiseasesYeungnam University Medical CenterDaegu 42415Republic of Korea Department of Biotechnology and Bioengineering Kangwon National UniversityChuncheonGangwon-do 24341Republic of Korea Center for BioMicrosystems Brain Science InstituteKorea Institute of Science and Technology(KIST)Seoul 02792Republic of Korea Division of Bio-Medical Science and Technology KIST SchoolKorea University of Science and TechnologySeoul 02792Republic of Korea College of Pharmacy Chungnam National UniversityDaejeon 34134Republic of Korea Department of Biomedical Engineering SKKU Institute for ConvergenceSungkyunkwan University(SKKU)SuwonRepublic of Korea Biomedical Institute for Convergence at SKKU(BICS) Sungkyunkwan University2066 Seobu-roJangan-guSuwon 16419Republic of Korea College of Pharmacy CMRIResearch Institute of Pharmaceutical SciencesBK21 Plus KNU Multi-Omics based Creative Drug Research TeamKyungpook National UniversityDaegu 41566Republic of Korea

Sterol regulatory element binding protein-2(SREBP-2)is activated by cytokines or pathogen,such as virus or bacteria,but its association with diminished cholesterol levels in COVID-19 patients is ***,we evaluated SREBP-2 activation in peripheral blood mononuclear cells of COVID-19 patients and verified the function of SREBP-2 in ***,we report the first observation of SREBP-2 C-terminal fragment in COVID-19 patients’blood and propose SREBP-2 C-terminal fragment as an indicator for determining *** confirmed that SREBP-2-induced cholesterol biosynthesis was suppressed by Sestrin-1 and PCSK9 expression,while the SREBP-2-induced inflammatory responses was upregulated in COVID-19 ICU *** an infectious disease mouse model,inhibitors of SREBP-2 and NF-κB suppressed cytokine storms caused by viral infection and prevented pulmonary *** results collectively suggest that SREBP-2 can serve as an indicator for severity diagnosis and therapeutic target for preventing cytokine storm and lung damage in severe COVID-19 patients.

关键词： cytokine diagnosis damage

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Computed tomography virtual endoscopy with angiographic imaging for the treatment of type Ⅳ-A choledochal cyst

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World Journal of Gastroenterology 2012年第28期18卷 3761-3764页

作者： Akihiko Tsuchida Yuichi Nagakawa Kazuhiko Kasuya Bunso kyo Takahisa Ikeda Yoshiaki Suzuki Tatsuya Aoki Takao Itoi Third Department of Surgery Tokyo Medical University Tokyo 160-0023 Japan Fourth Department of Internal Medicine Tokyo Medical University Tokyo 160-0023 Japan

Type Ⅳ-A choledochal cysts (CCs) are a congenital biliary anomaly which involve dilatation of the extrahepatic and intrahepatic bile ducts. We present the case of a 30-year-old woman with type Ⅳ-A CC, on whom threedimensional computed tomography (3D CT) and virtual endoscopy were performed. 3D CT revealed partial dilatation in the posterior branch of the intrahepatic bile duct and a relative stricture between it and the extrahepatic bile duct. Virtual endoscopy showed that this stricture was membrane-like and separated from the surrounding blood vessels. Based on these image findings, complete cyst resection, bile duct plasty for the stricture, and hepaticojejunostomy were safely performed. To the best of our knowledge, there are no reports of imaging by virtual endoscopy of the biliary tract which show the surrounding blood vessels running along the bile duct.

关键词： Choledochal cyst Bile duct dilatation Computed tomography Virtual endoscopy Bile duct plasty

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Effect of Cross-linking Agent on Barbituric Acid-initiated Resin

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Journal of Materials Science & Technology 2001年第1期17卷 27-28页

作者： Eun-Kyung Lee Hwan-Wook Ra and kyo-Han Kim Department of Dental Biomaterials, College of Dentistry, Kyungpook National University, Taegu 700-422, Korea Inn-Kyu Kang Department of Polymer Engineering, College of Engineering, Kyungpook National University, Kyungpook Natl Univ Coll Dent Dept Dent Biomat Taegu 700422 South Korea Kyungpook Natl Univ Coll Engn Dept Polymer Engn Taegu 700422 South Korea

To improve the tensile bond strength of denim bonding agents, the adhesion between denim and MMA resin was investigated by applying initiator systems containing 1-cyclohexyl-5-ethyl barbituric acid (CEB), copper acetyl acetonate (CAA), quaternary ammonium chloride (QAC). cupric ion, with the addition of TEGDMA, an.d pretreatment solution for denim, and an HEMA primer. The effects of a cross-linking agent on barbituric acid-initiated denim bonding resin were examined by measuring degree of conversion, molecular weight, hardness of bonding resin, and tensile bond strengths.

关键词： Figure Effect of Cross-linking Agent on Barbituric Acid-initiated Resin FTIR

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中国海水养殖发展状况与养殖海域赤潮生态防治

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海洋科学 2004年第7期28卷 71-75页

作者：杨宇峰姜胜王朝晖聂湘平 Ik kyo Chung 暨南大学水生生物研究所广东广州510632 Department of Marine Science Pusan National University

随着中国经济和社会的发展,陆地资源已难以满足人们对动物蛋白的需求.20世纪80年代以来,海水养殖业受到政府鼓励得以迅速发展,中国现已成为世界上海水养殖产量最高的国家[1,2].随着海水养殖业的发展,养殖海域富营养化和频发的赤潮等环... 详细信息

随着中国经济和社会的发展,陆地资源已难以满足人们对动物蛋白的需求.20世纪80年代以来,海水养殖业受到政府鼓励得以迅速发展,中国现已成为世界上海水养殖产量最高的国家[1,2].随着海水养殖业的发展,养殖海域富营养化和频发的赤潮等环境问题已成为海水养殖可持续发展的瓶颈.海域富营养化是赤潮发生的物质基础.要控制赤潮灾害发生的频率和减少赤潮灾害带来的损失,必须有效控制海水富营养化.作者将就中国海水养殖发展状况和养殖海域富营养化及赤潮问题进行评述,并对中国海水养殖海域赤潮生态防治提出对策和建议.……

关键词：中国海水养殖赤潮生态防治产量富营养化

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Knockdown of Dock7 in vivospecifically affects myelination by Schwann cells and increases myelin thickness in sciatic nerves without affecting axon thickness

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American Journal of Molecular Biology 2012年第3期2卷 210-216页

作者： Tomohiro Torii Yuki Miyamoto Motoshi Nagao Naoko Onami Hideki Tsumura Masahiro Maeda Kazuaki Nakamura Akito tanoue Junji Yamauchi Department of Pharmacology National Research Institute for Child Health and Development Tokyo Japan Immuno-Biological Laboratories Co. Ltd. Gunma Japan Laboratory Animal Resource Facility National Research Institute for Child Health and Development Tokyo Japan The Japan Human Health Sciences Foundation Tokyo Japan

During development of the peripheral nervous system (PNS), Schwann cells (SCs) wrap individual axons to form myelin sheaths, which act as surrounding insulators and markedly enhance the propagation of the action potential. In peripheral neuropathies such as Guillain-Barré syndrome (GBS) and inherited demyelinating Charcot-Marie-Tooth (CMT) disease and diabetic neuropathies, chronic demyelination and defective remyelination are repeated, causing more severe neuropathies. It is thus thought that development of a drug that promotes proper myelination with minimal side effects could provide an effective therapy for these diseases. As yet, however, little is known about therapeutic target molecules and genetically-modified mice for testing such approaches. We previously cloned the dock7 gene and characterized Dock7 as the regulator controlling SC myelination;however, an important issue, whether knockdown of Dock7 specifically affects myelination by SCs but not leaves neurons unaffected, has remained unclear. Here, we generate newly-produced transgenic mice harboring short-hairpin RNA (shRNA) targeting Dock7. We also describe that Dock7 shRNA transgenic mice exhibit enhanced myelin thickness without affecting axon thickness in sciatic nerves of the PNS, as reduced thickness of the axon diameter is the primary indicator of denatured neurons. Similarly, purified in vitro SC-neuronal cocultures established from transgenic mice exhibit enhanced formation of myelin segments, suggesting that knockdown of Dock7 promotes myelination by SCs. Collectively, Dock7 knockdown specifically affects SC myelination in sciatic nerves, providing evidence that Dock7 may be a promising drug-target-specific molecules for developing a therapy for peripheral neuropathies that aims to enhance myeliantion.

关键词： Dock7 Transgenic Mouse Schwann Cell Myelination Axon Diameter

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Analysis of a Linear Ultrasonic Motor Using Numerical and Analytic Method

Analysis of a Linear Ultrasonic Motor Using Numerical and An...

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第11届国际电机与系统学术会议

作者： Kyung-Pyo Yi Jong-Seok Rho Hyun-kyo Jung School of Electrical Engineering and Computer Science Seoul National UniversitySeoul151-744Korea

＜正＞This paper presents the analysis method for a linear ultrasonic motor using radial and nonaxisymmetric vibration modes of an annular *** displacement of the stator is analyzed by 3D finite element method,and the contact between the stator and the mover is analyzed by analytic *** analysis results of the model with stator radius of 10.00mm and thickness of 1.00mm is compared with experimental results to verify the analysis method.

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Utility of Miconazole Therapy for TrichosporonFungemia in Patients with Acute Leukemia

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Advances in Microbiology 2013年第8期3卷 47-51页

作者： Kazunori Nakase Kei Suzuki Taiichi kyo Yumiko Sugawara Shinichi Kageyama Naoyuki Katayama Cancer Center Mie University Hospital Tsu Japan Department of Hematology and Oncology Mie University Graduate School of Medicine Tsu Japan Department of Hematology and Oncology Mie University Graduate School of Medicine Tsu Japan Fourth Department of Internal Medicine Hiroshima Red Cross and Atomic-Bomb Survivors Hospital Hiroshima Japan

Invasive trichosporonosis is an extremely rare mycosis, but Trichosporon fungemia (TF) in patients with hematologic malignancies has been increasingly recognized to be a fulminant and highly lethal infection. Although the utility of azole therapy has been demonstrated in several observations, little is known about the efficacy of one of azoles, miconazole (MCZ). To assess its therapeutic role, we retrospectively investigated 6 cases of TF in patients with acute leukemia receiving MCZ containing regimens. Successful outcome was obtained in 4 patients [MCZ + amphotericin B (AmB) in 2, MCZ only and MCZ + fluconazole (FLCZ) + AmB in one each], but not in 2 (MCZ + FLCZ + AmB and MCZ + FLCZ in one each). Although MCZ and AmB exhibited good in vitro activities against isolates from all patients, FLCZ had such finding from only one patient. Considering the reportedly limited utility of AmB, MCZ seemed to play a critical role even in the combination therapies for TF. Despite the release of newer azoles and other classes of antifungals, the use of MCZ remains a potential therapeutic approach for TF in patients with acute leukemia.

关键词： Miconazole Trichosporon Fungemia Acute Leukemia

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Development of a Method to Produce Chromosome Lacking Lines (CLLs) in Nicotiana tabacumL. “Red Russian”

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American Journal of Plant Sciences 2017年第12期8卷 2923-2943页

作者： Hongshuo Liu Yasuhiro Ito Naho Muraida Yuuka Hayakawa kyo Itoyama Shuichi Ohsato Wataru Marubashi Graduate School of Agriculture Meiji University Kawasaki Japan

Monosomic lines of Nicotiana tabacum are helpful to confirm the location of genes on specific chromosomes. In the cross N. nudicaulis and N. tabacum, hybrid seedlings express lethal symptoms, which are controlled by the S subgenome of N. tabacum. To identify the responsible chromosome, we needed to produce chromosome lacking lines (CLLs) of N. tabacum L. “Red Russian” and use them to cross with N. nudicaulis. From a cross of (N. tabacum × N. tomentosiformis) × N. tabacum, 380 BC1 individuals were obtained. Using a Haplo-Q line (a monosomic line lacking the single linkage group 11) and N. tabacum, we found that qPCR is a simple and reliable screening method for CLLs of N. tabacum. The marker PT30342 is located on linkage group 11, and the -Ct value (Ct Actin - Ct PT30342) was 2.0 for a disomic line and was 1.097 for a Haplo-Q line. By the use of flow cytometry, qPCR and chromosome counting together as a screening method, we identified 6 CLLs lacking 2 to 6 chromosomes. Compared with conventional methods, our method is a rapid technique for making and screening CLLs ofthe S or S/T subgenome of N. tabacum. Further, these CLLs will be useful to identify the location of two or more factors on chromosomes controlling a variety of genetic problems affecting breeding. Here, we only made CLLs of the S or S/T subgenome of N. tabacum. We will use the method established in this study to produce CLLs of the T subgenome of N. tabacum, and gather a full set of CLLs of N. tabacum. qPCR could also be applied to the identification of chromosome aberrations in other plants.

关键词： Chromosome Lacking Lines Quantitative Real-Time Polymerase Chain Reaction Simple Sequence Repeat Marker Flow Cytometry Nicotiana tabacum L.

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Improvements in Au Wire Bondability of Rigid and Flexible Substrates using Plasma Cleaning

Improvements in Au Wire Bondability of Rigid and Flexible Su...

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第六届电子封装技术国际学术会议

作者： Jang-kyo Kim Peter Chou Kee Liu Ming Wai Ng Department of Mechanical Engineering Hong Kong University of Science and Technology Clear Water Bay Kowloon Hong Kong ASM Assembly Automation Ltd. 4/F Watson Centre 16 Kung Yip St. Kwai Chung Hong Kong ASM Assembly Automation Ltd. 4/F Watson Centre 16 Kung Yip St. Kwai Chung Hong Kong

Thermosonic Au wire bonding is the most widely used interconnection technology in the BGA packages. Compare with Au ball bonding, the lower wire loop and finer bond pitch of Au wedge bond makes its id

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菠萝组织培养分化植株的变异

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热带作物译丛 1980年第4期 47-51页

作者： kyo Wakasa 崔元方

组织培养在植物育种上有许多优点。特别要高度评价它在大量生产无性繁殖植株及诱导无病毒植株和变异体方面的作用。实际上,有些栽培植物已经应用组织培养技术来防除传染性病毒,并进行大量生产了。在这种情况下,得到的并非是变异体,而是... 详细信息

组织培养在植物育种上有许多优点。特别要高度评价它在大量生产无性繁殖植株及诱导无病毒植株和变异体方面的作用。实际上,有些栽培植物已经应用组织培养技术来防除传染性病毒,并进行大量生产了。在这种情况下,得到的并非是变异体,而是具有原株表现型的无性系。据报道,组织培养在无诱变处理的大量繁殖的个体中,关于有无变异,各人的结果是相互矛盾的(Holdgate在1977年认为无变异;Murashige在1974、1977年则认为有变

关键词：裔芽再分化菠萝凤梨属冠芽植株组织培养培养(生物) 变异体

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