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MicroRNA Regulation in Extreme Environments: Differential Expression of MicroRNAs in the Intertidal Snail Littorina littorea During Extended Periods of Freezing and Anoxia

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Genomics, Proteomics & Bioinformatics 2012年第5期10卷 302-309页

作者： kyle K.Biggar Samantha F.Kornfeld Yulia Maistrovski Kenneth B.Storey Institute of Biochemistry&Department of Biology Carleton University

Several recent studies of vertebrate adaptation to environmental stress have suggested roles for microRNAs （miRNAs） in regulating glo- bal suppression of protein synthesis and/or restructuring protein expression patterns. The present study is the first to characterize stress- responsive alterations in the expression of miRNAs during natural freezing or anoxia exposures in an invertebrate species, the intertidal gastropod Littorina littorea. These snails are exposed to anoxia and freezing conditions as their environment constantly fluctuates on both a tidal and seasonal basis. The expression of selected miRNAs that are known to influence the cell cycle, cellular signaling pathways, carbohydrate metabolism and apoptosis was evaluated using RT-PCR. Compared to controls, significant changes in expression were observed for miR-la-1, miR-34a and miR-29b in hepatopancreas and for miR-la-1, miR-34a, miR-133a, miR-125b, miR-29b and miR-2a in foot muscle after freezing exposure at -6 ~C for 24 h （P 〈 0.05）. In addition, in response to anoxia stress for 24 h, significant changes in expression were also observed for miR-la-1, miR-210 and miR-29b in hepatopancreas and for miR-1 a-1, miR-34a, miR-133a, miR-29b and miR-2a in foot muscle （P 〈 0.05）. Moreover, protein expression of Dicer, an enzyme responsible for mature microRNA processing, was increased in foot muscle during freezing and anoxia and in hepatopancreas during freezing. Alterations in expression of these miRNAs in L. littorea tissues may contribute to organismal survival under freezing and anoxia.

关键词： Freeze tolerance Anaerobiosis Metabolic rate depression Periwinkle Marine mollusk

Monte-Carlo拟合算法及其在电子动量谱学实验数据处理中应用的研究

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物理学报 2010年第3期59卷 1695-1701页

作者：张哲 kyle Obergfell 韩先明陈向军合肥微尺度物质科学国家实验室中国科学技术大学近代物理系合肥230026 Department of Physics&Astronomy Butler UniversityIndianapolisIN 46208USA

介绍了一种新的Monte-Carlo曲线拟合算法,由于新算法具有比其他迭代算法拟合更加稳定的优势,解决了电子动量谱学实验数据处理中遇到的电离能谱能峰叠加引起的拟合效果不佳的问题.利用VB语言编写的基于以上方法的拟合程序处理CF2Br2分子... 详细信息

介绍了一种新的Monte-Carlo曲线拟合算法,由于新算法具有比其他迭代算法拟合更加稳定的优势,解决了电子动量谱学实验数据处理中遇到的电离能谱能峰叠加引起的拟合效果不佳的问题.利用VB语言编写的基于以上方法的拟合程序处理CF2Br2分子的动量谱学实验数据,与基于Levenberg-Marquardt算法的PeakFit软件处理的结果进行比较,结果明显优于后者,并由此明确的重新指认了之前动量谱学方法无法指认的CF2Br2分子的价壳层最外四个轨道4b2,2a2,4b1和6a1的排序,肯定了Hartree-Fock和外价壳层格林函数方法(OVGF)的理论计算结果,而修正了光电子谱学实验的指认.

关键词：电子动量谱 Monte-Carlo方法 CF2Br2 轨道排序

Development of starch-based films reinforced with cellulosic nanocrystals and essential oil to extend the shelf life of red grapes

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Food Bioscience 2022年第3期47卷 403-412页

作者： Sneh Punia Bangar William Scott Whiteside Fatih Ozogul kyle D.Dunno George Armstrong Cavender Paul Dawson Department of Food Nutrition and Packaging SciencesClemson UniversitySC 29634USA Department of Seafood Processing Technology Faculty of FisheriesCukurova UniversityBalcaliAdana01330Turkey Department of Packaging Science Rochester Institute of TechnologyRochesterNYUSA

Packaging material has an important role in extending the shelf-life of *** study investigated the effectiveness of cellulose nanocrystals(CNCs)derived from Kudzu(Pueraria montana)vine to reinforce to starch-based *** addition,the essential oil was incorporated into these nanocomposite films to evaluate further improvement in film properties and *** packaging materials,including the pearl millet starch(PMS),PMS reinforced with Kudzu CNCs,and PMS reinforced with Kudzu CNCs stabilized pickering emulsion containing clove bud oil(CBO),was used to develop biodegradable nanocomposite *** films were investigated for their thermal,morphological,mechanical,and barrier *** addition,the films were used as packaging material to improve the shelf life of the grapes for 15 days at 5℃.PMS films reinforced with Kudzu CNCs stabilized pickering emulsion of CBO were most effective in extending the shelf life of red grapes up to 15 days at 5℃ by maintaining the weight,firmness,and soluble solids in grapes for a longer duration during *** study suggests that PMS+Kudzu CNCs+EO films have the potential for commercial packaging of fruits during short storage periods without adversely affecting their quality and sensory attributes.

关键词： Packaging material Nanocomposites Cellulose nanocrystals Red grapes Shelf life

Requirements for the transfer of lead-free piezoceramics into application

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Journal of Materiomics 2018年第1期4卷 13-26页

作者： Jurij Koruza Andrew J.Bell Till Fromling kyle G.Webber Ke Wang Jürgen Rodel Institute of Materials Science Technische Universit€at DarmstadtAlarich-Weiss-Str.264287 DarmstadtGermany Institute for Materials Research School of Chemical and Process EngineeringUniversity of LeedsLeeds LS29JTUK Department of Materials Science and Engineering Friedrich-Alexander-Universit€at Erlangen-NürnbergMartensstr.591058 ErlangenGermany State Key Laboratory of New Ceramics and Fine Processing School of Materials Science and EngineeringTsinghua University100084 BeijingChina

The recent review for the Restriction of Hazardous Substances Directive(RoHS)by the expert committee,appointed by the European Union,stated that the replacement of PZT“…may be scientifically and technologically practical to a certain degree…”,although replacement“…is scientifically and technically still impractical in the majority of applications.”Thus,two decades of sustained research and development may be approaching fruition,at first limited to a minority of ***,it is of paramount importance to assess the viability of lead-free piezoceramics over a broad range of application-relevant *** are identified and discussed in turn:***,***,*** and Thermal Properties,*** Conductivity,and *** is suggested that the worldwide efforts into the development of lead-free piezoceramics now require a broader perspective to bring the work to the next stage of development by supporting implementation into real *** about pertinent research requirements into a wide range of secondary properties,measurement techniques,and salient literature are provided.

关键词： Piezoceramics Ferroelectrics Lead-free Application Actuators Sensors

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Kwanzaa

英语沙龙（高中） 2015年第12期 34-35,60页

作者： Marcia and kyle Baynes

Elevated L-lactate Promotes Major Cellular Pathologies Associated with Neurodegenerative Diseases

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Neuroscience Bulletin 2021年第3期37卷 380-384页

作者： Andrew DChapp Jessica EBehnke kyle MDriscoll Taija Hahka Zoe LaLonde Zhiying Shan Qing-Hui Chen Department of Kinesiology and Integrative Physiology Michigan Technological UniversityHoughtonMI 49931USA Department of Biological Sciences Michigan Technological UniversityHoughtonMI 49931USA

Dear Editor,Small,short-chain fatty acids(SCFAs)(acetic acid,propionic acid,and butyric acid:conjugate bases,acetate,propionate,and butyrate)as well as the alpha-hydroxy acid,L-lactic acid(conjugate base,L-lactate)are important energy substrates and signaling molecules in the central nervous system(CNS)[1,2].L-lactic acid is produced by glycolysis[3]and gut microbes[4]and is released in large quantities during exercise[5].

关键词： conjugate bases quantities

Review of cost and surgical time implications using virtual patient specific planning and patient specific implants in midface reconstruction

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Plastic and Aesthetic Research 2022年第1期9卷 614-627页

作者： Michael Lawless Brian Swendseid Natalia von Windheim kyle VanKoevering Nolan Seim Matthew Old Department of Otolaryngology-Head and Neck Surgery The Ohio State University Comprehensive Cancer CenterThe Ohio State UniversityColumbusOH 43212USA Center for Design and Manufacturing Excellence The Ohio State University College of EngineeringThe Ohio State UniversityColumbusOH 43212USA

Aim:Summarize the available data on midfacial virtual patient specific planning and patient specific implants,highlighting the financial costs and savings,and additionally emphasize the potential cost implications of transitioning to“in-house”virtual 3D modeling and ***:Review of current ***:Current literature suggests cost benefits of virtual patient specific planning and patient specific implants in the form of improved ischemia time,better boney apposition between flaps,and reduced patient *** reduction of complications includes a reduction in blood loss and time spent in the intensive care unit from flap *** boney apposition results in a higher likelihood of boney union and a further reduction in failure and *** benefits of virtual patient specific planning and patient specific implants are shown in the form of improved reconstructive surgeon mental ***-house production of 3D models and presurgical planning provides additional cost benefits for providers as they can produce viable models at a fraction of the price of that which is produced by industrial *** can also construct and use models in an expedient manner compared to industrial models,allowing for the opportunity to be utilized in more acute *** foundation of developing an in-house workflow is adequate funding,resources,and clinical *** also must focus on appropriate quality and safety measures,as well as appropriate workflow development for adequate production of ***:Virtual patient specific planning and patient specific implants show benefits in midfacial reconstructive outcomes,resulting in realized financial and temporal gains for both patient and *** gains may be enhanced by moving to in-house planning and printing.

关键词： Virtual patient specific planning midface maxillofacial reconstruction head and neck cost 3D-printing

Assessment of oxidative and UV-C treatments for inactivating bacterial biofilms from groundwater wells

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Frontiers of Environmental Science & Engineering 2015年第1期9卷 39-49页

作者： kyle E. MURRAY Erin I. Manitou-ALVAREZ Enos C. INNISS Frank G. HEALY Adria A. BODOUR Oklahoma Geological Survey University of Oklahoma Norman OK 73019-0628 USA ERA Environmental Consulting Dollard des Ormeaux Montreal Quebec H9B 2C81 Canada Department of Civil and Environmental Engineering University of Missouri-Columbia MO 65211-2200 USA Department of Biology Trinity University One Trinity Place San Antonio TX 78212 USA Air Force Center for Engineering and the Environment (AFCEE) San Antonio TX 78236 USA

Microorganisms are ubiquitous in natural environments and in water supply infrastructure including groundwater wells. Sessile-state microorganisms may build up on well surfaces as biofilms and, if excessive, cause biofouling that reduces well productivity and water quality. Conditions can be improved using biocides and other traditional well rehabilitation measures; however, biofilm regrowth is inevitable given the continuous introduction of microorganisms from the surrounding environment. Alternative and less invasive well maintenance approaches are desirable for reducing biofilm densities while also minimizing harmful disinfection-by- products. The primary objective of this research was to evaluate effectiveness of alternative treatments for inacti- vating microorganisms comprising biofilms. A novel approach was designed for in situ growth of biofilms on steel coupons suspended from ＇chandeliers＇. After more than 100 days of in situ growth, biofilms were harvested, sampled, and baseline biofilm densities quantifed through cultivation. Ultraviolet-C （UV-C） and oxidative treatments including hydrogen peroxide （H2O2）, ozone （O3） and mixed oxidants were then applied to the biofilms in laboratory-scale treatments. Microbial inactivation was assessed by comparing treated versus baseline biofilm densities. H2O2 was the most effective treatment, and decreased density below baseline by as much as 3.1 orders of magnitude. Mixed oxidants were effective for the well having a lower density biofilm, decreasing density below baseline by as much as 1.4 orders of magnitude. Disparity in the response to treatment was apparent in the wells despite their spatial proximity and common aquifer source, which suggests that microbiological communities are more heterogeneous than the natural media from which they originate.

关键词： aquifer biofouling hydrogen peroxide sustainability well rehabilitation

特“立”“独”行之美—创新首款外置声卡SoundBlasterBxtigy

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微型计算机 2002年第6期22卷 26-32页

作者：牟缜 kyle