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Search for microglia-specific peptides:advances in the discovery toolbox

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Neural Regeneration Research 2025年第2期20卷 471-472页

作者： Ivan Sarabia kyle M.Koss Department of Surgery University of ArizonaTucsonAZUSA

Uncontrolled and chronic inflammatory states in the central nervous system(CNS)are the hallmark of neurodegenerative pathology and every injury or stroke-related *** key mediators of these neuroinflammatory states are glial cells known as microglia,the resident immune cell at the core of the inflammatory event,and astroglia,which encapsulate inflammatory insults in proteoglycan-rich scar *** gliotic scar blocks significant portions of healthy axonal networking,preventing *** most neuroinflammation is exclusively based on the responses of said microglia,their phenotypes are suggested to follow those of macrophages;M1 and M2 are opposites of pro-and ***,microglial phenotypes have been identified to be on an inflammatory spectrum encompassing developmental,homeostatic,and reparative behaviors as opposed to their ability to affect devastating cell death cascades and scar tissue formation.

关键词： inflammation pathology death

Image analysis and machine learning-based malaria assessment system

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Digital Communications and Networks 2022年第2期8卷 132-142页

作者： kyle Manning Xiaojun Zhai Wangyang Yu School of Computer Science and Electronic Engineering University of EssexColchesterCO43SQUK Key Laboratory of Modern Teaching Technology Ministry of EducationSchool of Computer Science Shaanxi Normal UniversityXi'anChina

Malaria is an important and worldwide fatal disease that has been widely reported by the World Health Organization(WHO),and it has about 219 million cases worldwide,with 435,000 of those *** common malaria diagnosis approach is heavily reliant on highly trained experts,who use a microscope to examine the ***,there is a need to create an automated solution for the diagnosis of *** of the main objectives of this work is to create a design tool that could be used to diagnose malaria from the image of a blood *** this paper,we firstly developed a graphical user interface that could be used to help segment red blood cells and infected cells and allow the users to analyze the blood ***,a Feed-forward Neural Network(FNN)is designed to classify the cells into two *** achieved results show that the proposed techniques can be used to detect malaria,as it has achieved 92%accuracy with a database that contains 27,560 benchmark images.

关键词： Malaria assessment system Image analysis Image segmentation Artificial intelligence

Switch mode capacitive pressure sensors

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Microsystems & Nanoengineering 2022年第6期8卷 47-60页

作者： Nabil Shalabi kyle Searles Kenichi Takahata Department of Electrical and Computer Engineering University of British ColumbiaVancouverBC V6T 1Z4Canada School of Biomedical Engineering University of British ColumbiaVancouverBC V6T 1Z3Canada

Switch mode capacitive pressure sensors are proposed as a new class of microfabricated devices that transform pressure into a mechanically switching capacitance to form an analog-to-digital signal with zero power,high sensitivity,and a high signal-to-noise ratio.A pressure-sensitive gold membrane suspended over a capacitive cavity makes ohmic contact with patterned gold leads on the substrate,closing circuits to fixed on-chip capacitors outside the cavity and leading to significant step *** function is achieved by allocating the switch leads on the part of the counter electrode area,while the remaining area is used for touch mode analog capacitive *** sensor microchip is prototyped through a novel design approach to surface micromachining that integrates micro-Tesla valves for vacuum sealing the sensor cavity,showing an unprecedented response to applied *** a gauge pressure range of 0–120 mmHg,the sensor exhibits an increase of 13.21 pF with resultant switch events,each of which ranges from 2.53–3.96 pF every 12–38 mmHg,in addition to the touch mode linear capacitive increase between *** equivalent sensitivity is 80–240 fF/mmHg,which is 11–600×more than commercial and reported touch mode sensors operating in similar pressure *** sensor is further demonstrated for wireless pressure tracking by creating a resonant tank with the sensor,showing a 32.5–101.6 kHz/mmHg sensitivity with frequency jumps led by the switch *** developed sensor,with its promising performance,offers new application opportunities in a variety of device areas,including health care,robotics,industrial control,and environmental monitoring.

关键词： mode cavity sealing

Biocompatibility and degradation of tendon-derived scaffolds

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Regenerative Biomaterials 2016年第1期3卷 1-11页

作者： kyle AAlberti Qiaobing Xu Department of Biomedical Engineering Tufts University4 Colby StreetMedfordMA 02155USA

Decellularized extracellular matrix has often been used as a biomaterial for tissue engineering *** function,once implanted can be crucial to determining whether a tissue engineered construct will be successful,both in terms of how the material breaks down,and how the body reacts to the material’s presence in the first *** is one of the primary components of extracellular matrix and has been used for a number of biomedical *** comprised of highly aligned collagen fibrils can be fabricated directly from decellularized tendon using a slicing,stacking,and rolling technique,to create two-and three-dimensional ***,the degradation characteristics of the material are evaluated in vitro,showing that chemical crosslinking can reduce degradation while maintaining fiber *** vivo,non-crosslinked and crosslinked samples are implanted,and their biological response and degradation evaluated through histological sectioning,trichrome staining,and immunohistochemical staining for ***-crosslinked samples are rapidly degraded and lose fiber morphology while crosslinked samples retain both macroscopic structure as well as fiber *** cellular response of both materials is also *** in vivo response demonstrates that the decellularized tendon material is biocompatible,biodegradable and can be crosslinked to maintain surface features for extended periods of time in *** study provides material characteristics for the use of decellularized tendon as biomaterial for tissue engineering.

关键词： biocompatibility biodegradable scaffolds animal

On the role of traditional ecological knowledge as a collaborative concept:a philosophical study

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Ecological Processes 2013年第1期2卷 73-84页

作者： kyle Powys Why Department of Philosophy Michigan State University368 Farm Lane#503East LansingMI 48824USA

Introduction:The concept of traditional ecological knowledge(TEK),along with synonymous or closely related terms like indigenous knowledge and native science,has some of its origins in literatures on international development and adaptive *** is a tendency to want to determine one definition for TEK that can satisfy every stakeholder in every *** a scan of environmental science and policy literatures reveals there to be differences in definitions that make it difficult to form a *** should be explored instead is the role that the concept of TEK plays in facilitating or discouraging cross-cultural and cross-situational collaboration among actors working for indigenous and non-indigenous institutions of environmental governance,such as tribal natural resources departments,federal agencies working with tribes,and co-management ***:This is a philosophical paper that explores how the concept of TEK is defined in science and policy literatures and what purpose it serves for improving cooperative environmental and natural resources stewardship and management between indigenous and non-indigenous *** philosophical method applied here is one that outlines numerous possible meanings of a concept(TEK,in this paper)and the implications of each meaning for science and ***:In science and policy literatures,there are different definitions of *** can brew over TEK when people hold definitions that are based on different *** are two kinds of assumptions about the meaning of *** first kind refers to assumptions about the mobilization of TEK,or what I call knowledge *** second kind involves assumptions about how to understand the relationship between TEK and disciplines like ecology or biology,or,in other words,the relation between TEK and *** positions that fall under the two kinds of assumptions(knowledge mobilization;TEK and science)can generate disagreement

关键词： knowledge instead creating

Erythroid Lineage Cells in the Liver:Novel Immune Regulators and Beyond

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Journal of Clinical and Translational Hepatology 2020年第2期8卷 177-183页

作者： Li Yang kyle Lewis Division of Gastroenterology Hepatology and NutritionCincinnati Children’s Hospital Medical CenterCincinnatiOHUSA Division of Gastroenterology Hepatology&Nutrition Developmental Biology Center for Stem Cell and Organoid MedicineCincinnati Children’s Hospital Medical CenterCincinnatiOHUSA

The lineage of the erythroid cell has been revisited in recent years. Instead of being classified as simply inert oxygen carriers, emerging evidence has shown that they are a tightly regulated in immune potent population with potential devel-opmental plasticity for lineage crossing. Erythroid cells have been reported to exert immune regulatory function through secreted cytokines, or cell-cell contact, depending on the conditions of the microenvironment and disease models. In this review, we explain the natural history of erythroid cells in the liver through a developmental lens, as it offers perspec-tives into newly recognized roles of this lineage in liver biology. Here, we review the known immune roles of erythroid cells and discuss the mechanisms in the context of disease models and stages. Then, we explore the capability of erythroid lineage as a cell source for regenerative medicine. We propose that the versatile lineage of erythroid cells provides an underappreciated and potentially promising area for basic and translational research in the field of liver disease.

关键词： Erythroblast Immune suppression Liver inflammation Hepatogenesis

Understanding the connection between blasting and highwall stability

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International Journal of Mining Science and Technology 2019年第1期29卷 99-103页

作者： R.Quentin Eades kyle Perry Department of Mining and Nuclear Engineering Missouri University of Science and Technology

Surface mines continue to implement highwalls for several reasons, such as increasing recovery, improving margins, and justifying higher stripping ratios. Highwall stability is a complex issue that is dependent upon a variety of mining and geologic factors, and a safe design is necessary for a successful surface operation. To improve highwall stability, it is important to understand the connection between local geology and blasting. Explosives are employed throughout the mining industry for primary rock breakage. There are a number of controlled blasting techniques that can be implemented to improve highwall *** include line drilling, smooth wall blasting, trim blasting, buffer blasting, air decking, and presplitting. Each of these techniques have associated advantages and disadvantages. Understanding local geology is necessary for selecting the appropriate controlled blasting technique. Furthermore, understanding the limitations and conditions for successful implementation of each technique is necessary. A discussion of the impact of geologic conditions on highwall stability is provided. Additionally, discussion is provided for the successful incorporation of the controlled blasting techniques listed above, and the associated mining and geologic factors that influence the selection and design of controlled blasting ***, a new methodology is proposed.

关键词： Controlled blasting Highwall stability Presplitting Surface mining

Design of a high-performance centrifugal compressor with new surge margin improvement technique for high speed turbomachinery

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Propulsion and Power Research 2018年第1期7卷 19-29页

作者： Sagar Pakle kyle Jiang School of Engineering University of BirminghamEdgbastonBirmingham B152TTUnited Kingdom

This paper presents the design of a centrifugal compressor for high-speed *** main focus of the research is to develop a centrifugal compressor with improved aerodynamic *** a meridional frame has a significant effect on overall performance of the compressor,special attention has been paid to the end wall *** shroud profile is design with bezier curve and hub profile with circular arc *** blade angle distribution has been arranged in a manner that it merges with single value at impeller *** rake angle is positive at leading edge and negative at trailing edge with identical ***,three-dimensional straight line element approach has been used for this design for better *** verification of the aerodynamic performance has been carried out using CFD software with consideration of a single blade passage and vaneless *** result has been compared with matching size aftermarket compressor stage gas stand *** compressor stage with Trim 55 provides 34%increase in choke flow at 210000 RPM as compared to gas stand data with 87%peak stage efficiency at 110000 *** addition,new surge margin improvement technique has been proposed by means of diffuser *** technique provides an average of 16%improvement in surge margin compared to standard diffuser stage with 55 trim compressor *** mechanical integrity has been validated at maximum RPM with the aluminum alloy 2014-T6 as a fabrication material.

关键词： Centrifugal compressor Aerodynamic performance Surge margin Blade angles Stress analysis Computational fluid dynamics

Flow cytometry and stroke: from current methodology to future applications

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Neural Regeneration Research 2022年第8期17卷 1748-1750页

作者： Sylvie Amu kyle Malone Cancer Research@UCC University College CorkCorkIreland Department of Pharmacology and Therapeutics Western Gateway BuildingUniversity College CorkCorkIreland School of Pharmacy University College CorkCorkIreland

Flow cytometry is a versatile technique for analyzing stroke-induced changes in the immune *** other methods of cell identification such as immunohistochemistry,the technique is rapid,highly sensitive,and capable of quantifying multiple markers in cell *** cell sorters,flow cytometers can also produce highly enriched populations of viable cells for functional *** aim of this perspective is to appraise current flow cytometry methods in the field of stroke,provide guidance on best practices,and outline some of the future applications of the technique in pre-clinical and clinical stroke research.

关键词： viable Flow versatile