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Patients with irritable bowel syndrome-diarrhea have lower disease-specific quality of life than irritable bowel syndrome-constipation

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World Journal of Gastroenterology 2015年第26期21卷 8103-8109页

作者： Prashant Singh kyle Staller Kenneth Barshop Elaine Dai Jennifer Newman Sonia Yoon Shahar Castel Braden Kuo GI Unit GRJ 719Department of MedicineMassachusetts General Hospital Pritzker School of Medicine University of Chicago Division of Gastroenterology Weill Cornell Medical College

AIM: To determine effect of irritable bowel syndrome(IBS) subtype on IBS-specific quality of life(QOL) questionnaire and its ***: We studied IBS patients visiting our functional gastroenterology disorder clinic at a tertiary care center of Unites *** and IBS subtype were diagnosed using Rome-Ⅲ *** was assessed using IBS-QOL *** assesses quality of life along eight subscales: dysphoria,interference with activities,body image,health worry,food avoidance,social reactions,sexual health,and effect on ***-QOL and its subscales were both scored on a range of 0-100 with higher scores suggestive of better *** of overall IBS-QOL scores and subscale scores are expressed as means with 95%*** compared mean IBS-QOL score and its subscales among various *** of variance(ANOVA) was used to compare the mean difference between more than two groups after controlling for age and gender.A posthoc analysis using Bonferroni correction was used only when P value for ANOVA was less than ***: Of 542 patients screened,243 had IBS as per Rome-Ⅲ ***-mixed(IBS-M) was the most common IBS subtype(121 patients,49.8%) followed by IBS- diarrhea(IBS-D)(56 patients,23.1%),IBSconstipation(IBS-C)(54 patients,22.2%) and IBSunspecified(IBS-U)(12 patients,4.9%).Overall IBSQOL scores were significantly different among various IBS-subtypes(P = 0.01).IBS-QOL of patients with IBS-D(61.6,95%CI: 54.0-69.1) and IBS-M(63.0,95%CI: 58.1-68.0) was significantly lower than patients with IBS-C(74.5,95%CI: 66.9-82.1)(P = 0.03 and 0.02 respectively).IBS-D patients scored significantly lower than IBS-C on food avoidance(45.0,95%CI: 34.8-55.2 vs 61.1,95%CI: 50.8-71.3,P = 0.04) and interference with activity(59.6,95%CI: 51.4-67.7 vs 82.3,95%CI: 74.1-90.6,P < 0.001).IBS-M patients had more interference in their activities(61.6,95%CI: 56.3-66.9 vs 82.3,95%CI: 74.1-90.6,P = 0.001) and greater impact on their relationshi

关键词： Irritable bowel syndrome Irritable bowelsyndrome subtype Quality of life Irritable bowelsyndrome-quality of life Constipation Diarrhea

全“芯”体验“硬”的滋味—SANBAKIA DM—6100HD数字解码器试用报道

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微型计算机 2002年第4期22卷 38-44页

作者： kyle

MicroRNA Regulation in Extreme Environments: Differential Expression of MicroRNAs in the Intertidal Snail Littorina littorea During Extended Periods of Freezing and Anoxia

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Genomics, Proteomics & Bioinformatics 2012年第5期10卷 302-309页

作者： kyle K.Biggar Samantha F.Kornfeld Yulia Maistrovski Kenneth B.Storey Institute of Biochemistry&Department of Biology Carleton University

Several recent studies of vertebrate adaptation to environmental stress have suggested roles for microRNAs （miRNAs） in regulating glo- bal suppression of protein synthesis and/or restructuring protein expression patterns. The present study is the first to characterize stress- responsive alterations in the expression of miRNAs during natural freezing or anoxia exposures in an invertebrate species, the intertidal gastropod Littorina littorea. These snails are exposed to anoxia and freezing conditions as their environment constantly fluctuates on both a tidal and seasonal basis. The expression of selected miRNAs that are known to influence the cell cycle, cellular signaling pathways, carbohydrate metabolism and apoptosis was evaluated using RT-PCR. Compared to controls, significant changes in expression were observed for miR-la-1, miR-34a and miR-29b in hepatopancreas and for miR-la-1, miR-34a, miR-133a, miR-125b, miR-29b and miR-2a in foot muscle after freezing exposure at -6 ~C for 24 h （P 〈 0.05）. In addition, in response to anoxia stress for 24 h, significant changes in expression were also observed for miR-la-1, miR-210 and miR-29b in hepatopancreas and for miR-1 a-1, miR-34a, miR-133a, miR-29b and miR-2a in foot muscle （P 〈 0.05）. Moreover, protein expression of Dicer, an enzyme responsible for mature microRNA processing, was increased in foot muscle during freezing and anoxia and in hepatopancreas during freezing. Alterations in expression of these miRNAs in L. littorea tissues may contribute to organismal survival under freezing and anoxia.

关键词： Freeze tolerance Anaerobiosis Metabolic rate depression Periwinkle Marine mollusk

Rumor recognition behavior of social media users in emergencies

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Journal of Management Science and Engineering 2022年第1期7卷 36-47页

作者： Xuejun Ding Xiaxia Zhang Ruoshi Fan Qiaochu Xu kyle Hunt Jun Zhuang School of Management Science and Engineering Dongbei University of Finance and EconomicsDalian116025China School of Business Administration Northeastern UniversityShenyang110169China Department of Industrial and Systems Engineering University at BuffaloBuffaloNY14260USA

Social media rumors not only affect the health of online social networks,but also reduce the quality of information accessed by its *** the case of emergencies,the rapid spread of rumors often triggers mass anxiety and *** study integrates the planned behavior(TPB)and deterrence(TD)theories to study the factors affecting the rumor recognition behavior of social media *** structural equation model(SEM)method is used to test the proposed ***,the interaction between various factors is analyzed to evaluate their impact on the rumor recognition behavior exhibited by social media users in *** results demonstrate that certainty and severity have significant positive effects on subjective *** addition,subjective norms,attitude,and perceived behavioral control all affect the rumor recognition behavior of social media users,and involvement negatively moderates the relationship between the subjective norms and ***,insights into the formulation of rumor control strategies during emergencies are presented based on the empirical analysis.

关键词： Social media Emergency Online rumors Recognition behavior Influence factor

Designing a Drought Monitoring System for Caribbean SIDS

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Journal of Geoscience and Environment Protection 2023年第2期11卷 69-89页

作者： kyle Alexander Gabrielle Thongs Innovative Surveying and Mapping Ltd. Port of Spain Trinidad Department of Geography The UWI St. Augustine Trinidad

There are limited drought studies for the Caribbean. This is concerning since drought is not only one of the most devastating disasters in the region, but it is also one of the least understood disasters. Very few papers analyze new ways to identify and monitor this disaster. Another major arguable gap in research is the Caribbean’s sole focus on the meteorological drought and disregard of the agricultural drought. This is an important omission because of the significant negative impacts drought has on the Caribbean occurs in the agricultural and forestry sectors. Not considering this in drought monitoring systems in the Caribbean means that a major part of the phenomena is overlooked. Therefore, this study has focused on bridging this gap. It has sought to establish a system to strengthen drought’s early warning. To accomplish this, three predetermined conditions of drought, precipitation, land surface temperature and vegetation conditions were used to derive the Standard Precipitation Index (SPI), the Temperature Condition Index (TCI) and the Vegetation Condition Index (VCI), in order to analyze drought conditions. The drought vulnerability map found that the SPI, TCI and VCI all correlated with past drought events. The study also produced an agricultural drought map. This study, therefore, aims to build resilience by providing accurate information on the duration, intensity and spatial variability of droughts in Caribbean Small Island Developing States (SIDS).

关键词： Drought Climate Change Caribbean SIDS GIS SPI

Development of starch-based films reinforced with cellulosic nanocrystals and essential oil to extend the shelf life of red grapes

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Food Bioscience 2022年第3期47卷 403-412页

作者： Sneh Punia Bangar William Scott Whiteside Fatih Ozogul kyle D.Dunno George Armstrong Cavender Paul Dawson Department of Food Nutrition and Packaging SciencesClemson UniversitySC 29634USA Department of Seafood Processing Technology Faculty of FisheriesCukurova UniversityBalcaliAdana01330Turkey Department of Packaging Science Rochester Institute of TechnologyRochesterNYUSA

Packaging material has an important role in extending the shelf-life of *** study investigated the effectiveness of cellulose nanocrystals(CNCs)derived from Kudzu(Pueraria montana)vine to reinforce to starch-based *** addition,the essential oil was incorporated into these nanocomposite films to evaluate further improvement in film properties and *** packaging materials,including the pearl millet starch(PMS),PMS reinforced with Kudzu CNCs,and PMS reinforced with Kudzu CNCs stabilized pickering emulsion containing clove bud oil(CBO),was used to develop biodegradable nanocomposite *** films were investigated for their thermal,morphological,mechanical,and barrier *** addition,the films were used as packaging material to improve the shelf life of the grapes for 15 days at 5℃.PMS films reinforced with Kudzu CNCs stabilized pickering emulsion of CBO were most effective in extending the shelf life of red grapes up to 15 days at 5℃ by maintaining the weight,firmness,and soluble solids in grapes for a longer duration during *** study suggests that PMS+Kudzu CNCs+EO films have the potential for commercial packaging of fruits during short storage periods without adversely affecting their quality and sensory attributes.

关键词： Packaging material Nanocomposites Cellulose nanocrystals Red grapes Shelf life

Monte-Carlo拟合算法及其在电子动量谱学实验数据处理中应用的研究

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物理学报 2010年第3期59卷 1695-1701页

作者：张哲 kyle Obergfell 韩先明陈向军合肥微尺度物质科学国家实验室中国科学技术大学近代物理系合肥230026 Department of Physics&Astronomy Butler UniversityIndianapolisIN 46208USA

介绍了一种新的Monte-Carlo曲线拟合算法,由于新算法具有比其他迭代算法拟合更加稳定的优势,解决了电子动量谱学实验数据处理中遇到的电离能谱能峰叠加引起的拟合效果不佳的问题.利用VB语言编写的基于以上方法的拟合程序处理CF2Br2分子... 详细信息

介绍了一种新的Monte-Carlo曲线拟合算法,由于新算法具有比其他迭代算法拟合更加稳定的优势,解决了电子动量谱学实验数据处理中遇到的电离能谱能峰叠加引起的拟合效果不佳的问题.利用VB语言编写的基于以上方法的拟合程序处理CF2Br2分子的动量谱学实验数据,与基于Levenberg-Marquardt算法的PeakFit软件处理的结果进行比较,结果明显优于后者,并由此明确的重新指认了之前动量谱学方法无法指认的CF2Br2分子的价壳层最外四个轨道4b2,2a2,4b1和6a1的排序,肯定了Hartree-Fock和外价壳层格林函数方法(OVGF)的理论计算结果,而修正了光电子谱学实验的指认.

关键词：电子动量谱 Monte-Carlo方法 CF2Br2 轨道排序

Requirements for the transfer of lead-free piezoceramics into application

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Journal of Materiomics 2018年第1期4卷 13-26页

作者： Jurij Koruza Andrew J.Bell Till Fromling kyle G.Webber Ke Wang Jürgen Rodel Institute of Materials Science Technische Universit€at DarmstadtAlarich-Weiss-Str.264287 DarmstadtGermany Institute for Materials Research School of Chemical and Process EngineeringUniversity of LeedsLeeds LS29JTUK Department of Materials Science and Engineering Friedrich-Alexander-Universit€at Erlangen-NürnbergMartensstr.591058 ErlangenGermany State Key Laboratory of New Ceramics and Fine Processing School of Materials Science and EngineeringTsinghua University100084 BeijingChina

The recent review for the Restriction of Hazardous Substances Directive(RoHS)by the expert committee,appointed by the European Union,stated that the replacement of PZT“…may be scientifically and technologically practical to a certain degree…”,although replacement“…is scientifically and technically still impractical in the majority of applications.”Thus,two decades of sustained research and development may be approaching fruition,at first limited to a minority of ***,it is of paramount importance to assess the viability of lead-free piezoceramics over a broad range of application-relevant *** are identified and discussed in turn:***,***,*** and Thermal Properties,*** Conductivity,and *** is suggested that the worldwide efforts into the development of lead-free piezoceramics now require a broader perspective to bring the work to the next stage of development by supporting implementation into real *** about pertinent research requirements into a wide range of secondary properties,measurement techniques,and salient literature are provided.

关键词： Piezoceramics Ferroelectrics Lead-free Application Actuators Sensors

Elevated L-lactate Promotes Major Cellular Pathologies Associated with Neurodegenerative Diseases

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Neuroscience Bulletin 2021年第3期37卷 380-384页

作者： Andrew DChapp Jessica EBehnke kyle MDriscoll Taija Hahka Zoe LaLonde Zhiying Shan Qing-Hui Chen Department of Kinesiology and Integrative Physiology Michigan Technological UniversityHoughtonMI 49931USA Department of Biological Sciences Michigan Technological UniversityHoughtonMI 49931USA

Dear Editor,Small,short-chain fatty acids(SCFAs)(acetic acid,propionic acid,and butyric acid:conjugate bases,acetate,propionate,and butyrate)as well as the alpha-hydroxy acid,L-lactic acid(conjugate base,L-lactate)are important energy substrates and signaling molecules in the central nervous system(CNS)[1,2].L-lactic acid is produced by glycolysis[3]and gut microbes[4]and is released in large quantities during exercise[5].

关键词： conjugate bases quantities