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Free radical scavenger effect of rebamipide in sperm processing and cryopreservation

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Asian Journal of Andrology 2003年第3期5卷 195-201页

作者： Nam Cheol park Hyun Jun park kyeong Mi Lee dong Gil Shin Department of Urology College of Medicine Pusan National University Busan 602 739 KoreaDepartment of Urology College of Medicine Pusan National University Busan 602 739 KoreaDepartment of Urology College of Medicine Pusan National University Busan 602 739 KoreaDepartment of Urology College of Medicine Pusan National University Busan 602 739 Korea

Aim: To study the effect of rebamipide added to semen samples and cryoprotectant on reactive oxygen species (ROS) production. Methods: Semen samples from 30 fertile and healthy volunteers were collected by masturbation after 2 days - 3 days of abstinence. After liquefaction, the specimens were diluted with sperm wash media to a uniform density of 20×106/mL. Rebamipide was added to semen samples and cryoprotectant to a final concentration of 10 μmol/L, 30 μmol/L, 100 μmol/L or 300 μmol/L. Specimens were incubated at 37 ℃ in a 0.5 % CO2 incubator for 1 h or cryopreserved at -196 ℃ LN2 for 3 days. The sperm motility and viability and the levels of ROS and lipid peroxidation of sperm membrance were assessed before and after incubation and cryopreservation by means of computer assisted semen analyzer, eosin-nigrosin stain, chemiluminescence and thiobarbituric acid assay, respectively. Results: The sperm motility was significantly increased after incubation with 100 μmol/L and 300 μmol/L rebamipide (P0.05). The levels of ROS and lipid peroxidation in semen were significantly decreased in proportion to the concentrations of rebamipide both after incubation and cryopreservation (P<0.05). Conclusion: Rebamipide is an effective free radical scavenger in semen in vitro.

关键词： male infertility reactive oxygen species rebamipide

Cardiff acne disability index： cross-cultural translation in Korean and its relationship with clinical acne severity, pathological patterns, and general quality of life

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Journal of Traditional Chinese Medicine 2017年第5期37卷 702-709页

作者： kyeong-Han Kim Sang-Chul Lee Young-Bae park Young-Jae park Department of Human Informatics of Korean Medicine Interdisciplinary Programs Kyung Hee University Seoul02447 Korea Department of Business Administration Korea Christian University Seoul07661 Korea Department of Biofunctional Medicine and Diagnostics College of Korean MedicineKyung Hee University Seoul02447 Korea Department of Diagnosis and Biofunctional Medicine Kyung Hee University Hospital at Gangdong Seoul 05278 Korea

OBJECTIVE: To culturally translate the cardiff acne disability index(CADI) into Korean, and to examine its relationship with clinical acne severity,pathological patterns, and general quality of life(Qo L).METHODS: The CADI was culturally and lin-guistically translated into Korean via translation,back-translation, and face validity test process. Two hundred and fifty-four Korean adolescents were asked to complete the Korean version of the CADI(K-CADI), the Phlegm Pattern, the Cold-Heat Pattern, and the Korean version of the General Health Questionnaires. A clinician estimated acne severity for the adolescents, using the Korean Acne Grading System. Finally, reliability and validity of the K-CADI was examined, and the relationships between acne severity, Phlegm, Cold, and Heat patterns, and Qo L level were examined via pathway ***: The K-CADI had satisfactory internal consistency(α = 0.827). The examination of construct validity indicated that the K-CADI had one factor(explaining 59.6% of the total variance). Pathway analysis showed satisfactory model fit(normal fit index = 0.960 and comparative fit index = 0.983),and acne-related Qo L was determinant to Phlegm,Heat, and Cold patterns(0.13-0.27 of β), and Phlegm and Heat patterns lowered one's Qo L level(0.17-0.34 of β).CONCLUSION: The K-CADI is a valid and reliable instrument. Phlegm and Heat patterns should be managed when treating acne since they have a moderating effect on general Qo L aggravation.

关键词： Acne vulgaris Quality of life Medicine East Asian Traditional Psychology adolescent Causality Cardiff acne disability index

Simple reactor for the synthesis of silver nanoparticles with the assistance of ethanol by gas-liquid discharge plasma

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Plasma Science and Technology 2019年第4期21卷 34-43页

作者： Pan LU dong-Wook KIM dong-Wha park Department of Chemistry and Chemical Engineering Inha University100 Inha-Ro.Michuhol-guIncheon 22212Republic of Korea Regional Innovation Center for Environmental Technology of Thermal Plasma(RIC-ETTP: Inha University100 Inha-RoMichuhol-gu.Incheon 22212.Republic of Korea

Atmospheric pressure plasma technology is gaining increasing importance because it is a simple and tunable synthesis process for the production of metallic *** addition to the development of the power supply,improving the reactor is also one of the main strategies to enhanee the *** this study,a simple reactor for the gas-liquid discharge plasma induced by argon gas was applied to synthesize silver nanopailicles from silver nitrate(AgNO3)in *** AC power supply with a peak voltage of 3.5 kV was *** frequency and on-time were set to 50 kHz and 2.5“s,*** oscilloscope showed that the rising time was approximately 2“*** ethanol was used as the source for the reactive reducing *** more additional comp on ents existed in the solution during the discharge and neither of the electrodes was in contact with the treated *** temperature in creased by 10°C within 1 min without a cooling *** was the main impurity and was expected to be produced from the decomposition of the organics under the *** elevated temperature decreased the organic by-products by evaporation and could also decrease the production of *** electron microscopy showed that the spherical silver nanoparticles with a size of approximately 10 nm were synthesized with a crystal structure and that a low concentration of ethanol prefers the production of the mono-dispersed colloid.

关键词： silver nanoparticles synthesis nonthermal plasma ethanol reduction gas-liquid discharge

Influence of the electrolyte conductivity on the critical current density and the breakdown voltage

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Chinese Journal of Chemical Engineering 2023年第7期59卷 169-175页

作者： Hae-Kyun park dong-Hyuk park Bum-Jin Chung Department of Nuclear Engineering Kyung Hee University 1732 Deogyeong-daeroGiheung-guYongin-siGyeonggi-do 17104Korea

The work investigates influence of the electrolyte conductivity on the onset of partial contact glow discharge electrolysis(CGDE)in a water *** current density(CCD)and breakdown voltage were measured together with in situ observation of hydrogen bubble behavior,whose influence has not been focused *** a fixed current during normal electrolysis,hydrogen coalescence adjacent to cathode surface was invigorated at a lower *** analyses elucidated the hydrogen coalescence characteristics by quantifying size and population of detached hydrogen *** CCD increased about 104% within given range of conductivity(11.50-127.48 mS·cm^(-1))due to impaired bubble coalescence,which delays hydrogen film formation on the ***,decreasing trend of breakdown voltage was measured with increased conductivity showing maximum drop of 74%.It is concluded that onset of partial CGDE is directly affected by hydrodynamic bubble behaviors,whereas the electrolyte conductivity affects the bubble formation characteristics adjacent to cathode electrode.

关键词： Water electrolysis Critical current density Breakdown voltage Electrolyte conductivity Hydrogen bubble behavior

Geodetic Analysis inside the South Korean Peninsula and Impact of the 2011 Tohoku–Oki(TO) Earthquake

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Acta Geologica Sinica(English Edition) 2022年第2期96卷 631-647页

作者： Kutubuddin ANSARI Kwan-dong park Integrated Geoinformation(IntGeo)Solution Private Limited New Delhi 110025India Department of Geoinformatic Engineering Inha University100 Inha-roIncheon 22212Korea

The most powerful Tohoku–Oki(TO) earthquake that occurred in Japan on 11 March 2011 affected Japan as well as South Korea. In the current study, we investigated contemporary geodetic deformation inside South Korea before and after the TO earthquake using Global Navigation Satellite System(GNSS) measurements from 01 January 2008 to 31 December 2017. Measured velocities of GNSS sites are modeled by Auto-regressive moving average(ARMA) method to analyze the long-term GNSS time-series variation and to investigate the secular tectonic crustal deformation. We found that the maximum co-seismic displacements during the TO earthquake reached up to 36.82 ± 0.21 mm in the east and 5.90 ± 0.08 mm in the north directions. The geometric model of the co-seismic thrust surface was characterized by a rectangular plane with a dip of 12.0° and strike 200°. The thrust is situated at 25 km hypocenter depth, with an area roughly ~470 km long and ~120 km wide. The seismicity pattern after the earthquake indicated that the compressional strain started to be replaced by the extensional strain during the post TO earthquake period from 2011 to 2014. Further, the strain became predominantly extensional during the period 2015 to 2017, revealing an effective rotational change that occurred inside the Korean Peninsula.

关键词： seismicity strain crustal deformation Auto-Regressive Moving Average Global Navigation Satellite System Tohoku-Oki earthquake

Differentiation of acute and chronic hepatitis B in IgM antiHBc positive patients

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World Journal of Gastroenterology 2015年第13期21卷 3953-3959页

作者： Ji Won park kyeong Min Kwak Sung Eun Kim Myoung Kuk Jang dong Joon Kim Myung Seok Lee Hyoung Su Kim Choong Kee park Department of Internal Medicine Hallym University Medical CenterAnyang 431-070South Korea Department of Occupational and Environmental Medicine Hallym University Medical CenterAnyang 431-070South Korea Department of Internal Medicine Hallym University Sacred Heart Hospital of Hallym University Medical Center Seoul 134-701South Korea Department of Internal Medicine Hallym University Medical CenterChuncheon 200-704South Korea

AIM: To identify the factors that differentiate acute hepatitis B(AHB) from chronic hepatitis B with acute exacerbation(CHB-AE).METHODS: From 2004 to 2013, a total of 82 patients(male n = 52, 63.4%; female n = 30, 36.6%) with clinical features of acute hepatitis with immunoglobulin M antibodies to the hepatitis B core antigen(Ig M antiHBc) were retrospectively enrolled and divided into two groups; AHB(n = 53) and CHB-AE(n = 29). The AHB group was defined as patients without a history of hepatitis B virus(HBV) infection before the episode and with loss of hepatitis B surface antigen within 6 mo after onset of acute hepatitis. Biochemical and virological profiles and the sample/cutoff(S/CO) ratio of Ig M anti-HBc were compared to determine the differential diagnostic ***: The multivariate analysis demonstrated that, the S/CO ratio of Ig M anti-HBc and HBV DNA levels were meaningful factors. The S/CO ratio of Ig M anti-HBc was significantly higher in the AHB group, while the HBV DNA level was significantly higher in the CHB-AE group. The optimal cutoff values of Ig M anti-HBc and HBV DNA levels for differentiating the two conditions were 8 S/CO ratio and 5.5 log10 IU/m L, respectively. The sensitivity and specificity were 96.2% and 89.7% for the S/CO ratio of Ig M anti-HBc and 81.1% and 72.4% for HBV DNA levels, respectively. The area under receiver operating characteristic curves of both the S/CO ratio of Ig M anti-HBc and HBV DNA levels were not significantly different(0.933 vs 0.844, P = 0.105). When combining Ig M anti-HBc and HBV DNA, the diagnostic power significantly improved compared to HBV DNA alone(P = 0.0056). The combination of these factors yielded a sensitivity and specificity of 98.1% and 86.2%, ***: The combination of the S/CO ratio of Ig M anti-HBc and HBV DNA levels was a useful tool for differentiating AHB from CHB-AE in patients with positive Ig M anti-HBc.

关键词： Acute hepatitis Differential diagnosis Chronic hep

Weldability evaluation and tensile strength estimation model for aluminum alloy lap joint welding using hybrid system with laser and scanner head

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中国有色金属学会会刊：英文版 2012年第S3期22卷 596-604页

作者： dong-Yoon KIM Young-Whan park Department of Mechanical Engineering Pukyong National University

Aluminum welding using a hybrid system with a laser and scanner welding head was performed under various welding conditions to verify the feasibility of applying an aluminum alloy to a car *** experimental material was 5J32 aluminum alloy,and the laser power,welding speed,and laser incidence angle were used as the control *** weld bead shape and the tensile shear strength were evaluated in order to understand the aluminum lap joint weld *** of variance (ANOVA) was conducted to identify the effect of the process variables on the tensile shear *** strength estimation models using three different regression models were also *** input variables were the laser power,welding speed,and laser incidence angle,and the output was the tensile shear *** the models,the second-order polynomial estimation model had the best estimation performance,and the average error rate of this model was 0.058.

关键词： laser welding scanner remote welding 5J32 aluminum alloy regression model

Refractory lipoatrophy treated with autologous whole blood injection:A case report

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World Journal of Clinical Cases 2025年第2期13卷 33-38页

作者： Wonnam Kim Jun Su park En Hyung Kim Department of Pharmacology School of Korean MedicinePusan National UniversityYangsan 50612GyeongnamSouth Korea Department of Dermatology College of MedicineChungbuk National UniversityCheongju 28644ChungbukSouth Korea Department of Dermatology Chungbuk National University HospitalCheongju 28644ChungbukSouth Korea

BACKGROUND Intramuscular corticosteroid injection may cause adverse effects such as dermal and/or subcutaneous atrophy,alopecia,hypopigmentation,and *** cutaneous atrophy can spontaneously resolve,several treatment options have been suggested for this *** SUMMARY In this paper,we report a case of corticosteroid injection induced lipoatrophy treated with autologous whole blood(AWB)injection,as the condition had been unresponsive to fractional laser therapy.A 29-year-old female patient visited the dermatology clinic complaining of skin depression on her right buttock area,which had appeared six months *** had been only subtle improvement at the margins after fractional CO_(2) laser treatment;therefore,after obtaining informed consent from the patient,AWB treatment was *** month after the first AWB injection,the size and depth of the lesion had noticeably improved,and a slight improvement was also observed in *** Close observation is the initial treatment of choice for steroid induced skin atrophy;however,for patients in need of immediate cosmetic improvement,AWB injection may be a safe and cost-effective alternative.

关键词： Atrophy Corticosteroid Subcutaneous fat Autologous whole blood injection Laser therapy Case report

Extended X-ray absorption fine structure (EXAFS) of FAPbI_(3) for understanding local structure-stability relation in perovskite solar cells

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Journal of Energy Chemistry 2022年第4期31卷 549-554页

作者： dong-Ho Kang Yong-Jun park Yun-Sung Jeon Nam-Gyu park School of Chemical Engineering and Center for Antibonding Regulated Crystals Sungkyunkwan UniversitySuwon 16419Korea

Perovskite solar cells (PSCs) employing formamidinium lead iodide (FAPbI_(3)) have shown high ***,operational stability has been issued due to phase instability of α phase FAPbI_(3) at ambient *** precursors in the perovskite precursor solution has been proposed to improve not only power conversion efficiency (PCE) but also device ***,there is a controversial issue on the beneficial effect on PCE and/or stability between excess FAI and excess PbI_(2).We report here extended X-ray absorption fine structure (EXAFS) of FAPbI_(3) to study local structural change and explain the effect of excess precursors on photovoltaic performance and *** films prepared from the precursor solution with excess PbI_(2)shows better stability than those from the one with excess FAI,despite similar PCE.A rapid phase transition from α phase to non-perovskite δ phase is observed from the perovskite film formed by excess ***,the (Pb-I) bond distance evaluated by the Pb L_(III)-edge EXAFS study is increased by excess FAI,which is responsible for the phase transition and poor device *** work can provide important insight into local structure-stability relation in the FAPbI_(3)-based PSCs.

关键词： Extended X-ray absorption fine structure EXAFS Excess precursor Local structure Stability Perovskite solar cells