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Differentiation of acute and chronic hepatitis B in IgM antiHBc positive patients

World Journal of Gastroenterology 2015年第13期21卷 3953-3959页

作者： Ji Won Park kyeong min kwak Sung Eun Kim Myoung Kuk Jang Dong Joon Kim Myung Seok Lee Hyoung Su Kim Choong Kee Park Department of Internal Medicine Hallym University Medical CenterAnyang 431-070South Korea Department of Occupational and Environmental Medicine Hallym University Medical CenterAnyang 431-070South Korea Department of Internal Medicine Hallym University Sacred Heart Hospital of Hallym University Medical Center Seoul 134-701South Korea Department of Internal Medicine Hallym University Medical CenterChuncheon 200-704South Korea

AIM: To identify the factors that differentiate acute hepatitis B(AHB) from chronic hepatitis B with acute exacerbation(CHB-AE).METHODS: From 2004 to 2013, a total of 82 patients(male n = 52, 63.4%; female n = 30, 36.6%) with clinical features of acute hepatitis with immunoglobulin M antibodies to the hepatitis B core antigen(Ig M antiHBc) were retrospectively enrolled and divided into two groups; AHB(n = 53) and CHB-AE(n = 29). The AHB group was defined as patients without a history of hepatitis B virus(HBV) infection before the episode and with loss of hepatitis B surface antigen within 6 mo after onset of acute hepatitis. Biochemical and virological profiles and the sample/cutoff(S/CO) ratio of Ig M anti-HBc were compared to determine the differential diagnostic ***: The multivariate analysis demonstrated that, the S/CO ratio of Ig M anti-HBc and HBV DNA levels were meaningful factors. The S/CO ratio of Ig M anti-HBc was significantly higher in the AHB group, while the HBV DNA level was significantly higher in the CHB-AE group. The optimal cutoff values of Ig M anti-HBc and HBV DNA levels for differentiating the two conditions were 8 S/CO ratio and 5.5 log10 IU/m L, respectively. The sensitivity and specificity were 96.2% and 89.7% for the S/CO ratio of Ig M anti-HBc and 81.1% and 72.4% for HBV DNA levels, respectively. The area under receiver operating characteristic curves of both the S/CO ratio of Ig M anti-HBc and HBV DNA levels were not significantly different(0.933 vs 0.844, P = 0.105). When combining Ig M anti-HBc and HBV DNA, the diagnostic power significantly improved compared to HBV DNA alone(P = 0.0056). The combination of these factors yielded a sensitivity and specificity of 98.1% and 86.2%, ***: The combination of the S/CO ratio of Ig M anti-HBc and HBV DNA levels was a useful tool for differentiating AHB from CHB-AE in patients with positive Ig M anti-HBc.

关键词： Acute hepatitis Differential diagnosis Chronic hep

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Development of polyimide films reinforced with boron nitride and boron nitride nanosheets for transparent flexible device applications

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Nano Research 2018年第5期11卷 2366-2378页

作者： You Jin min kyeong-Hee Kang Dae-Eun Kim Department of Mechanical Engineering Yonsei University 50 Yonsei-ro Seodaemun-gu Seoul 03722 Republic of Korea

The benefits of reinforcing polyimide （PI） films with boron nitride （BN） particles and boron nitride nanosheets （BNNSs） were assessed with the aim of enhancing their thermal, optical, and mechanical properties for flexible device applications. BNNSs were prepared from BN particles using a liquid-phase exfoliation method assisted by an ultrasonic probe-type sonicator and centrifugator. PI-based composite films blended with BNNSs and BN particles were fabricated at various concentrations via mechanical stirring and spin coating. The transparency of the PI/BNNS composite films remained almost the same as that of pure PI films up to 3 wt.% whereas the transparency of the PI/BN composite films decreased with increasing concentration of the BN fillers at 550 nm. The thermal stability improved significantly with increasing concentrations of both BN and BNNS relative to that of pure PI films. The temperature for 5% weight loss of the PI/BNNS composite film was higher than that of the PI/BN composite film at the same filler concentration. The composite films with 2 wt.% BN or BNNS showed the lowest wear rate, and the PI/BNNS composite films showed more stable frictional behavior compared to the PI/BN composite films. In addition, bending tests showed that the PI/BNNS composite films exhibited excellent flexibility compared to the PI/BN composite films. Overall, the results indicate that the BNNS can be effectively used as a filler that can enhance the thermal and mechanical properties of polymer materials for flexible device applications.

关键词： polyimide (PI) boron nitride (BN) transparency thermal properties flexibility tribology

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Peri-infarct reorganization of an injured corticospinal tract in a patient with cerebral infarction

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Neural Regeneration Research 2021年第8期16卷 1671-1672页

作者： min kyeong Cho Sung Ho Jang Department of Physical Medicine and Rehabilitation College of MedicineYeungnam UniversityNamkuDaeguRepublic of Korea

Corticospinal tract(CST), a major neural tract in the human brain for motor function, is involved mainly in the movement of the distal extremities(Jang and Lee, 2019). Recovery of an injured CST is essential for good recovery of impaired motor function in stroke patients(Jang and Lee, 2019). Peri-infarct reorganization of an injured CST is an important mechanism underlying recovery of motor function in stroke patients(Jang, 2007). In this study, we reported on a patient with cerebral infarction who showed recovery of an injured CST by periinfarct reorganization using diffusion tensor tractography(DTT) and transcranial magnetic stimulation(TMS).

关键词： infarct infarction cerebral

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Elucidating Ion Transport Phenomena in Sulfide/Polymer Composite Electrolytes for Practical Solid-State Batteries

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Nano-Micro Letters 2023年第10期15卷 416-432页

作者： kyeong‑Seok Oh Ji Eun Lee Yong‑Hyeok Lee Yi‑Su Jeong Imanuel Kristanto Hong‑Seok min Sang‑Mo Kim Young Jun Hong Sang Kyu kwak Sang‑Young Lee Department of Chemical and Biomolecular Engineering Yonsei University50 Yonsei‑roSeodaemun‑guSeoul 03722Republic of Korea Department of Chemical and Biological Engineering Korea University145 Anam‑roSeongbuk‑guSeoul 02841Republic of Korea School of Energy and Chemical Engineering Ulsan National Institute of Science and Technology(UNIST)50 UNIST‑gilEonyang‑eupUlju‑gunUlsan 44919Republic of Korea Hyundai Motor Company 150Hyundaiyeonguso‑roNamyang‑eupHwaseong‑siGyeonggi‑do 18280Republic of Korea

Despite the enormous interest in inorganic/polymer composite solid-state electrolytes(CSEs)for solid-state batteries(SSBs),the underlying ion transport phenomena in CSEs have not yet been ***,we address this issue by formulating a mechanistic understanding of bi-percolating ion channels formation and ion conduction across inorganic-polymer electrolyte interfaces in CSEs.A model CSE is composed of argyrodite-type Li_6PS_5Cl(LPSCl)and gel polymer electrolyte(GPE,including Li~+-glyme complex as an ion-conducting medium).The percolation threshold of the LPSCl phase in the CSE strongly depends on the elasticity of the GPE ***,manipulating the solvation/desolvation behavior of the Li~+-glyme complex in the GPE facilitates ion conduction across the LPSCl-GPE *** resulting scalable CSE(area=8×6(cm×cm),thickness~40μm)can be assembled with a high-mass-loading LiNi_(0.7)Co_(0.15)Mn_(0.15)O_(2)cathode(areal-mass-loading=39 mg cm~(-2))and a graphite anode(negative(N)/positive(P)capacity ratio=1.1)in order to fabricate an SSB full cell with bi-cell *** this constrained cell condition,the SSB full cell exhibits high volumetric energy density(480 Wh L_(cell)~(-1))and stable cyclability at 25℃,far exceeding the values reported by previous CSE-based SSBs.

关键词： Solid-state batteries Composite solid-state electrolytes Ion transport phenomena Bi-percolating ion channels Interfacial resistance

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Wave-Tide-Surge Coupled Simulation for Typhoon Maemi

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China Ocean Engineering 2013年第2期27卷 141-158页

作者： Byung Ho Choi Byung Il min kyeong Ok Kim Jin Hee Yuk Department of Civil and Environmental Engineering Sungkyunkwan University Marine Environments & Conservation Research Division Korea Institute of Ocean Science & Technology Supercomputing Center Korea Institute of Science and Technology Information

The main task of this study focuses on studying the effect of wave-current interaction on currents, storm surge and wind wave as well as effects of current induced wave refraction and current on waves by using numerical models which consider the bottom boundary layer and sea surface roughness parameter for shallow and smooth bed area around Korean Peninsula. The coupled system （unstructured-mesh SWAN wave and ADCIRC） run on the same unstructured mesh. This identical and homogeneous mesh allows the physics of wave-circulation interactions to be correctly resolved in both models. The unstructured mesh can be applied to a large domain allowing all energy from deep to shallow waters to be seamlessly followed. There is no nesting or overlapping of structured wave meshes, and no interpolation is required. In response to typhoon Maemi （2003）, all model components were validated independently, and shown to provide a faithful representation of the system＇s response to this storm. The waves and storm surge were allowed to develop on the continental shelf and interact with the complex nearshore environment. The resulting modeling system can be used extensively for prediction of the typhoon surge. The result show that it is important to incorporate the wave-current interaction effect into coastal area in the wave-tide-surge coupled model. At the same time, it should consider effects of depth-induced wave breaking, wind field, currents and sea surface elevation in prediction of waves. Specially, we found that：（1） wave radiation stress enhanced the current and surge elevation otherwise wave enhanced nonlinear bottom boundary layer decreased that, （2） wind wave was significantly controlled by sea surface roughness thus we cautiously took the experimental expression. The resulting modeling system can be used for hindcasting （prediction） the wave-tide-surge coupled environments at complex coastline, shallow water and fine sediment area like areas around Korean Peninsula.

关键词： typhoon Maemi finite element model tide-surge-wave coupling

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The CONSTANS-like 4 transcription factor,AtCOL_4,positively regulates abiotic stress tolerance through an abscisic acid-dependent manner in Arabidopsis

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Journal of Integrative Plant Biology 2015年第3期57卷 313-324页

作者： Ji-Hee min Jung-Sung Chung kyeong-Hwan Lee Cheol Soo Kim Department of Plant Biotechnology Chonnam National University Department of Agronomy Gyeongsang National University Department of Rural and Biosystems Engineering Chonnam National University

The precise roles of the B-box zinc finger family of transcription factors in plant stress are poorly *** analysis was performed on AtCOL4,an Arabidopsis thaliana ***-like 4 protein that is a putative novel transcription factor,and which contains a predicted transcriptional activation *** of an AtCOL4 promoter-b-glucuronidase（GUS） construct revealed substantial GUS activity in whole *** expression of AtCOL4 was strongly induced by abscisic acid（ABA）,salt,and osmotic *** in atcol4 resulted in increased sensitivity to ABA and salt stress during seed germination and the cotyledon greening *** contrast,AtCOL4-overexpressing plants were less sensitive to ABA and salt stress compared to the wild ***,in the presence of ABA or salt stress,the transcript levels of other ABA biosynthesis and stress-related genes were enhanced induction in AtCOL4-overexpressing and WT plants,rather than in the atcol4 ***,AtCOL4 is involved in ABA and salt stress response through the ABA-dependent signaling *** together,these findings provide compelling evidence that AtCOL4 is an important regulator for plant tolerance to abiotic stress.e

关键词： Abscisic acid B-box zinc finger family transcription factor salt stress

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Effects of Craddition on Charpy impact energy in austenitic 0.45C-24Mn-(0,3,6)Cr steels

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Journal of Materials Science & Technology 2020年第15期47卷 21-30页

作者： Seok Gyu Lee Bohee Kim min Cheol Jo kyeong-min Kim Junghoon Lee Jinho Bae Byeong-Joo Lee Seok Su Sohn Sunghak Lee Center for Advanced Aerospace Materials Pohang University of Science and TechnologyPohang37673South Korea Steel Products Design Team Hyundai SteelDangjin31779South Korea Steel Products Research Group 1 Technical Research LaboratoriesPOSCOGwangyang57807South Korea Department of Materials Science and Engineering Korea UniversitySeoul02841South Korea

Effects of Cr addition(0,3,and 6 wt%) on Charpy impact properties of Fe-C-Mn-Cr-based steels were studied by conducting dynamic compression tests at room and cryogenic *** room temperature,deformation mechanisms of Charpy impacted specimens were observed as twinning induced plasticity(TWIP) without any transfo rmation induced plasticity(TRIP) in all the *** cryogenic temperature,many twins were populated in the Cr-added steels,but,interestingly,fine ε-martensite was found in the OCr steel,satisfying the Shoji-Nishiyama(S-N) orientation relationship,{111}γ//{0002}ε and γ//ε.Even though the cryogenic-temperature staking fault energies(SFEs) of the three steel were situated in the TWIP regime,the martensitic transformation was induced by Mn-and Cr-segregated *** the OCr steel,SFEs of low-(Mn,Cr) bands lay between the TWIP and TRIP regimes which were sensitively affected by a small change of *** dynamic compressive test results well showed the relation between segregation bands and the *** of Cr were known as not only increasing the SFE but also promoting the carbide *** order to identify the possibility of carbide formation,a precipitation kinetics simulation was conducted,and the predicted fractions of precipitated M23C6 were negligible,0.4-1.1×10-5,even at the low cooling rate of 10℃/s.

关键词： Austenitic high-Mn steels Charpy impact energy Split Hopkinson pressure bar Twinning induced plasticity(TWIP) Transformation induced plasticity(TRIP) Stacking fault energy(SFE)

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Wire-Shaped 3D-Hybrid Supercapacitors as Substitutes for Batteries

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Nano-Micro Letters 2020年第2期12卷 211-223页

作者： kyeong‑Nam Kang Ananthakumar Ramadoss Jin‑Wook min Jong‑Chul Yoon Deokjung Lee Seok Ju Kang Ji‑Hyun Jang School of Energy and Chemical Engineering Low Dimensional Carbon Materials CenterUlsan National Institute of Science and TechnologyUlsan 44919Republic of Korea Laboratory for Advanced Research in Polymeric Materials Central Institute of Plastic Engineering and TechnologyBhubaneswar 751024India School of Mechanical Aerospace and Nuclear EngineeringUlsan National Institute of Science and TechnologyUlsan 44919Republic of Korea

We report a wire-shaped three-dimensional(3D)-hybrid supercapacitor with high volumetric capacitance and high energy density due to an interconnected 3D-configuration of the electrode allowing for large number of electrochemical active sites,easy access of electrolyte ions,and facile charge transport for flexible wearable *** interconnected and compact electrode delivers a high volumetric capacitance(gravimetric capacitance)of 73 F cm−3(2446 F g−1),excellent rate capability,and cycle *** 3D-nickel cobalt-layered double hydroxide onto 3D-nickel wire(NiCo LDH/3D-Ni)//the 3D-manganese oxide onto 3D-nickel wire(Mn3O4/3D-Ni)hybrid supercapacitor exhibits energy density of 153.3 Wh kg−1 and power density of 8810 W kg−*** red lightemitting diode powered by the as-prepared hybrid supercapacitor can operate for 80 min after being charged for tens of seconds and exhibit excellent electrochemical stability under various deformation *** results verify that such wire-shaped 3D-hybrid supercapacitors are promising alternatives for batteries with long charge–discharge times,for smart wearable and implantable devices.

关键词： Three-dimensional(3D)metal current collector Flexible hybrid supercapacitor Wire-shaped supercapacitor High energy density device Fast charging energy storage system

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Long-lasting,reinforced electrical networking in a high-loading Li_(2)S cathode for high-performance lithium–sulfur batteries

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Carbon Energy 2023年第8期5卷 1-14页

作者： Hun Kim kyeong-Jun min Sangin Bang Jang-Yeon Hwang Jung Ho Kim Chong SYoon Yang-Kook Sun Department of Energy Engineering Hanyang UniversitySeoulRepublic of Korea Department of Materials Science and Engineering Chonnam National UniversityGwangjuRepublic of Korea Institute for Superconducting&Electronic Materials(ISEM) Australian Institute of Innovative Materials(AIIM)University of WollongongNew South WalesNorth WollongongAustralia Department of Materials Science and Engineering Hanyang UniversitySeoulRepublic of Korea

Realizing a lithium sulfide(Li_(2)S)cathode with both high energy density and a long lifespan requires an innovative cathode design that maximizes electrochemical performance and resists electrode ***,a high-loading Li_(2)S-based cathode with micrometric Li_(2)S particles composed of two-dimensional graphene(Gr)and one-dimensional carbon nanotubes(CNTs)in a compact geometry is developed,and the role of CNTs in stable cycling of high-capacity Li–S batteries is *** a dimensionally combined carbon matrix,CNTs embedded within the Gr sheets create robust and sustainable electron diffusion pathways while suppressing the passivation of the active carbon *** a unique point,during the first charging process,the proposed cathode is fully activated through the direct conversion of Li_(2)S into S_(8) without inducing lithium polysulfide *** direct conversion of Li_(2)S into S_(8) in the composite cathode is ubiquitously investigated using the combined study of in situ Raman spectroscopy,in situ optical microscopy,and cryogenic transmission electron *** composite cathode demonstrates unprecedented electrochemical properties even with a high Li_(2)S loading of 10 mg cm^(–2);in particular,the practical and safe Li–S full cell coupled with a graphite anode shows ultra-long-term cycling stability over 800 cycles.

关键词： carbon nanotubes electrical network high energy high loading Li_(2)S cathode lithium-sulfur batteries

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Ex situ aging effect on sulfonated poly(ether ether ketone) membrane:Hydration-dehydration cycling and hydrothermal treatment

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Journal of Energy Chemistry 2022年第7期31卷 583-592,I0014页

作者： Seung-Young Choi kyeong Sik Jin Polymer&Materials Chemistry Department of ChemistryLund UniversitySE-22100Sweden Center for Hydrogen·Fuel Cell Research Korea Institute of Science and Technology(KIST)Seoul 02792Republic of Korea Pohang Accelerator Laboratory Pohang University of Science and Technology(POSTECH)PohangKyungbuk 37673Republic of Korea

Prolonged hydrothermal treatment for sulfonated poly(ether ether ketone) membranes induces mechanical degradation and developing hydrophilic-hydrophobic phase separation, simultaneously. The enhanced phase separation provides incremental proton conductivity to the membranes, whereas mechanical degradation drastically reduces device stability. On this basis, we describe here the effects of two different ex situ aging processes on sulfonated poly(ether ether ketone) membranes: hydrationdehydration cycling and prolonged hydrothermal treatment. Both aged membranes exhibited enhanced phase separation under the hydrated conditions, as characterized by small angle X-ray ***, when the aged membranes were dried again, the nanostructure of the membranes aged via the hydration-dehydration cycling was recoverable, whereas that of the membranes aged via prolonged hydrothermal treatment was irreversible. Furthermore, the two differently aged membranes showed clear differences in thermal, mechanical, and electrochemical properties. Finally, we implemented both aged membranes in fuel cell application. The sample aged via hydration-dehydration cycling maintained its improved cell performance, whereas the sample aged via hydrothermal treatment showed drastically reduced cell performance after durability test for 50 h.

关键词： Sulfonated poly(ether ether ketone) Humidity cycle test Ex situ aging Proton exchange membrane Fuel cell

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