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Hepatobiliary & Pancreatic Diseases International 2024年第6期23卷 573-578页

作者： nam Hee Kim Ji Hun kang Hong Joo Kim Division of Gastroenterology Department of Internal MedicineKangbuk Samsung HospitalSungkyunkwan University School of MedicineSeoulKorea Department of Radiology Hanyang University Guri HospitalHanyang University College of MedicineGuriKorea

Background:The association between non-obese or lean nonalcoholic fatty liver disease(NAFLD)and gallbladder polyps(GBPs)has not yet been *** aimed to determine whether NAFLD is an independent risk factor for the development of GBPs,even in non-obese and lean ***:We analyzed a cohort of 331208 asymptomatic adults who underwent abdominal ultrasonography(US).The risk of GBP development was evaluated according to the obesity and NAFLD ***:The overall prevalence of NAFLD and GBPs≥5 mm was 28.5%and 2.9%,*** prevalence of NAFLD among 160276 lean,77676 overweight and 93256 obese participants was 8.2%,31.2%,and 61.1%,*** with NAFLD had a significantly higher incidence of GBPs with a size of≥5 mm[adjusted odds ratio(OR)=1.18;95%confidence interval(CI):1.11–1.25].A higher body mass index and its categories were also significantly associated with an increased risk of GBPs≥5 ***,risk of GBPs≥5 mm was significantly increased even in NAFLD individuals who are not obese(lean:adjusted OR=1.36,95%CI:1.19-1.54;overweight:adjusted OR=1.14,95%CI:1.03–1.26,respectively).Conclusions:Non-obese/lean NAFLD is an independent risk factor for GBP development,suggesting that NAFLD may play an important role in the pathogenesis of GBPs regardless of the obesity ***,a more thorough evaluation for GBPs may be necessary when hepatic steatosis is detected on abdominal US,even in non-obese or lean individuals.

关键词： Nonalcoholic fatty liver disease Non-obese Lean Gallbladder polyps

Impacts of Nutlin-3a and exercise on murine double minute 2-enriched glioma treatment

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Neural Regeneration Research 2025年第4期20卷 1135-1152页

作者： Yisheng Chen Zhongcheng Fan Zhiwen Luo Xueran kang Renwen Wan Fangqi Li Weiwei Lin Zhihua Han Beijie Qi Jinrong Lin Yaying Sun Jiebin Huang Yuzhen Xu Shiyi Chen Department of Sport Medicine Huashan HospitalFudan UniversityShanghaiChina Department of Orthopedic Surgery Hainan Province Clinical Medical CenterHaikou Affiliated Hospital of Central South University Xiangya School of MedicineHaikouHainan ProvinceChina Department of Basic Medicine Shanghai Jiao Tong University School of MedicineShanghai Jiao Tong UniversityShanghaiChina Department of Neurosurgery Second Affiliated Hospital of Zhejiang University School of MedicineZhejiang UniversityHangzhouZhejiang ProvinceChina Department of Orthopedics Shanghai General HospitalSchool of Medicine Shanghai Jiao Tong UniversityShanghaiChina Department of Infectious Diseases Children’s Hospital of Fudan UniversityNational Children’s Medical CenterShanghaiChina Department of Rehabilitation The Second Affiliated Hospital of Shandong First Medical UniversityTaianShandong ProvinceChina

Recent research has demonstrated the impact of physical activity on the prognosis of glioma patients,with evidence suggesting exercise may reduce mortality risks and aid neural *** role of the small ubiquitin-like modifier(SUMO)protein,especially post-exercise,in cancer progression,is gaining attention,as are the potential anti-cancer effects of *** used machine learning to create the exercise and SUMO-related gene signature(ESLRS).This signature shows how physical activity might help improve the outlook for low-grade glioma and other *** demonstrated the prognostic and immunotherapeutic significance of ESLRS markers,specifically highlighting how murine double minute 2(MDM2),a component of the ESLRS,can be targeted by *** underscores the intricate relationship between natural compounds such as nutlin-3 and immune *** comprehensive CRISPR screening,we validated the effects of specific ESLRS genes on low-grade glioma *** also revealed insights into the effectiveness of Nutlin-3a as a potent MDM2 inhibitor through molecular docking and dynamic ***-3a inhibited glioma cell proliferation and activated the p53 *** efficacy decreased with MDM2 overexpression,and this was reversed by Nutlin-3a or *** using a low-grade glioma mouse model highlighted the effect of physical activity on oxidative stress and molecular pathway ***,both physical exercise and Nutlin-3a administration improved physical function in mice bearing tumors derived from MDM2-overexpressing *** results suggest the potential for Nutlin-3a,an MDM2 inhibitor,with physical exercise as a therapeutic approach for glioma *** research also supports the use of natural products for therapy and sheds light on the interaction of exercise,natural products,and immune regulation in cancer treatment.

关键词： exercise and SUMO-related gene signatures(ESLRS) glioblastoma management low-grade glioma natural bioactives neural regeneration physical exercise

Liquid refractive index measurement method based on orthogonal polarization laser self-mixing interference

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Optoelectronics Letters 2025年

作者： ZHAO Yan WANG Haipeng DU Shengzhi TONG Jigang kang Jun School of Electrical Engineering and Automation， Tianjin University of Technology Tianjin Key Laboratory for Control Theory and Applications in Complicated Systems Department of Electrical Engineering， Tshwane University of Technology

In this paper， a novel method combining orthogonal polarization laser self-mixing interference is proposed. The method utilizes a rotating cuvette to measure the refractive index of liquids at different concentrations. The cuvette is filled with the liquid to be measured and rotated by a certain angle. The change in the number of interference fringes， caused by comparing an empty cuvette with a liquid-filled cuvette， is used to calculate the refractive index of the liquid. A four-fold logic subdivision algorithm is then used to improve measurement resolution. The experimental results show that for pure water and different NaCl and glucose solutions concentrations， the average relative errors are 0.47%， 0.59%， and 2.17%， respectively， with the maximum relative error within ±2.54%. The standard deviation of all solutions is less than 3.4%.

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Apocrine hidrocystoma of the conjunctiva

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International Journal of Ophthalmology(English edition) 2012年第2期5卷 247-248页

作者： Boyun Kim nam Yeo kang Department of Ophthalmology Bucheon St. Mary's Hospital College of Medicine The Catholic University of Korea Bucheon Kyunggi-do 420-717 Korea

Dear Sir, I am Dr. Boyun Kim, form the Department of Ophthalmology, Bucheon St. Mary’s Hospital, Bucheon, Korea. I write to present a case report of apocrine hidrocystoma on temporal bulbar conjunctiva. Apocrine hidrocystoma (AH) is a benign cutaneous cystic nodule arising from apocrine glands of Moll [1]. This lesion usually occurs on eyelids and canthus [1,2], ears, chest, shoulders in adults but its occurrence in conjunctiva [3] is

关键词： Figure Apocrine hidrocystoma of the conjunctiva

Extended X-ray absorption fine structure (EXAFS) of FAPbI_(3) for understanding local structure-stability relation in perovskite solar cells

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Journal of Energy Chemistry 2022年第4期31卷 549-554页

作者： Dong-Ho kang Yong-Jun Park Yun-Sung Jeon nam-Gyu Park School of Chemical Engineering and Center for Antibonding Regulated Crystals Sungkyunkwan UniversitySuwon 16419Korea

Perovskite solar cells (PSCs) employing formamidinium lead iodide (FAPbI_(3)) have shown high ***,operational stability has been issued due to phase instability of α phase FAPbI_(3) at ambient *** precursors in the perovskite precursor solution has been proposed to improve not only power conversion efficiency (PCE) but also device ***,there is a controversial issue on the beneficial effect on PCE and/or stability between excess FAI and excess PbI_(2).We report here extended X-ray absorption fine structure (EXAFS) of FAPbI_(3) to study local structural change and explain the effect of excess precursors on photovoltaic performance and *** films prepared from the precursor solution with excess PbI_(2)shows better stability than those from the one with excess FAI,despite similar PCE.A rapid phase transition from α phase to non-perovskite δ phase is observed from the perovskite film formed by excess ***,the (Pb-I) bond distance evaluated by the Pb L_(III)-edge EXAFS study is increased by excess FAI,which is responsible for the phase transition and poor device *** work can provide important insight into local structure-stability relation in the FAPbI_(3)-based PSCs.

关键词： Extended X-ray absorption fine structure EXAFS Excess precursor Local structure Stability Perovskite solar cells

Pulsed dynamic electrolysis enhanced PEMWE hydrogen production:Revealing the effects of pulsed electric fields on protons mass transport and hydrogen bubble escape

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Journal of Energy Chemistry 2025年第1期100卷 201-214页

作者： Xuewei Zhang Wei Zhou Yuming Huang Liang Xie Tonghui Li Huimin kang Lijie Wang Yang Yu Yani Ding Junfeng Li Jiaxiang Chen Miaoting Sun Shuo Cheng Xiaoxiao Meng Jihui Gao Guangbo Zhao School of Energy Science and Engineering Harbin Institute of Technology China Datang Technology Innovation Co. Ltd

The transition of hydrogen sourcing from carbon-intensive to water-based methodologies is underway,with renewable energy-powered proton exchange membrane water electrolysis （PEMWE） emerging as the preeminent pathway for hydrogen *** remarkable advancements in this field,confronting the sluggish electrochemical kinetics and inherent high-energy consumption arising from deteriorated mass transport within PEMWE systems remains a formidable *** impediment stems primarily from the hindered protons mass transfer and the untimely hydrogen bubbles *** address these challenges,we harness the inherent variability of electrical energy and introduce an innovative pulsed dynamic water electrolysis *** to constant voltage electrolysis (hydrogen production rate:51.6 m L h-1,energy consumption:5.37 kWh Nm-3H2),this strategy (hydrogen production rate:66 m L h-1,energy consumption:3.83 kWh Nm-3H2) increases the hydrogen production rate by approximately 27%and reduces the energy consumption by about 28%.Furthermore,we demonstrate the practicality of this system by integrating it with an off-grid photovoltaic （PV） system designed for outdoor operation,successfully driving a hydrogen production current of up to 500 mA under an average voltage of approximately 2 *** combined results of in-situ characterization and finite element analysis reveal the performance enhancement mechanism:pulsed dynamic electrolysis （PDE） dramatically accelerates the enrichment of protons at the electrode/solution interface and facilitates the release of bubbles on the electrode *** such,PDE-enhanced PEMWE represents a synergistic advancement,concurrently enhancing both the hydrogen generation reaction and associated transport *** promising technology not only redefines the landscape of electrolysis-based hydrogen production but also holds immense potential for broadening its application across a diverse spectrum of electrocatalytic endeavors.

关键词： Electrolysis

Mechanically reconfigurable architectured graphene for tunable plasmonic resonances

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Light(Science & Applications) 2018年第1期7卷 895-903页

作者： Pilgyu kang Kyoung-Ho Kim Hong-Gyu Park SungWoo nam Department of Mechanical Science and Engineering University of Illinois at Urbana-ChampaignUrbanaIL 61801USA Department of Mechanical Engineering George Mason UniversityFairfaxVA 22030USA Department of Physics Korea UniversitySeoul 02841Republic of Korea KU-KIST Graduate School of Converging Science and Technology Korea UniversitySeoul 02841Republic of Korea

Graphene nanostructures with complex geometries have been widely explored for plasmonic applications,as their plasmonic resonances exhibit high spatial confinement and gate ***,edge effects in graphene and the narrow range over which plasmonic resonances can be tuned have limited the use of graphene in optical and optoelectronic *** we present a novel approach to achieve mechanically reconfigurable and strongly resonant plasmonic structures based on crumpled *** calculations show that mechanical reconfiguration of crumpled graphene structures enables broad spectral tunability for plasmonic resonances from mid-to nearinfrared,acting as a new tuning knob combined with conventional electrostatic ***,a continuous sheet of crumpled graphene shows strong confinement of plasmons,with a high near-field intensity enhancement of~1×10^(4).Finally,decay rates for a dipole emitter are significantly enhanced in the proximity of finite-area biaxially crumpled graphene *** findings indicate that crumpled graphene provides a platform to engineer graphenebased plasmonics through broadband manipulation of strong plasmonic resonances.

关键词： plasmon figuration proximity

Activation-Tagged Suppressors of a Weak Brassinosteroid Receptor Mutant

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Molecular Plant 2010年第1期3卷 260-268页

作者： Bin kang Hao Wang Kyoung Hee nam Jiayang Li Jianming Li Department of Molecular Cellular and Developmental Biology University of Michigan 830 N. University Ann Arbor MI 48109-1048 USA Division of Biological Sciences Sookmyung Woman's University 52 Hyochangwon-gil Yongsan-gu Seoul 140-742 Korea State Key Laboratory of Plant Genomics and National Center for Plant Gene Research Institute of Genetics and Developmental Biology Chinese Academy of Sciences Beijing 100101 China

Brassinosteroids （BRs） are important plant hormones that act synergistically with auxin to regulate a variety of plant developmental and physiological processes. In the past decade, genetic and biochemical studies have revealed a linear signaling pathway that relies on protein phosphorylation to transmit the BR signal into the nucleus, altering ex- pression of hundreds of genes to promote plant growth. We conducted an activation-tagging based suppressor screen to look for Arabidopsis genes that, when overexpressed by inserted 35S enhancer elements, could suppress the dwarf phe- notype of a weak BR receptor mutant bril-301. This screen identified a total of six dominant activation-tagged bril sup- pressors （atbs-Ds）. Using a plasmid rescue approach, we discovered that the bril-301 suppression effect in four atbs-D mutants （atbs3-D to atbs6-D） was caused by overexpression of a YUCCA gene thought to be involved in tryptophan- dependent auxin biosynthesis. Interestingly, the three activation-tagged YUCCA genes belong to the YUCCA IIA subfamily that includes two other members out of 11 known Arabidopsis YUCCA genes. In addition, our molecular studies revealed a T-DNA insertion near a basic helix-loop-helix gene in atbsl-D and a T-DNA insertion in a region carrying a BR biosynthetic gene in atbs2-D. Further studies of these atbs-D mutants could lead to better understanding of the BR signaling process and the BR-auxin interaction.

关键词： Brassinosteroid BRI1 bril-301 auxin YUCCA.

Mechanical densification synthesis of single-crystalline Ni-rich cathode for high-energy lithium-ion batteries

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Journal of Energy Chemistry 2023年第4期79卷 562-568页

作者： Gwonsik nam Jaeseong Hwang Donghun kang Sieon Oh Sujong Chae Moonsu Yoon Minseong Ko Division of Convergence Materials Engineering Pukyong National UniversityBusan 48547Republic of Korea namyang R&D Center Hyundai Motor CompanyHwaseong 18280Republic of Korea Division of Industrial Chemistry and Polymer Engineering Pukyong National UniversityBusan 48547Republic of Korea Department of Nuclear Science and Engineering Massachusetts Institute of TechnologyCambridgeMA 02139USA

The intergranular microcracking in polycrystalline Ni-rich cathode particle is led by anisotropic volume change and stress corrosion along grain boundary,accelerating battery performance ***,we have suggested a simple but advanced solid-state method that ensures both uniform transition metal distribution and single-crystalline morphology for Ni-rich cathode synthesis without sophisticated ***-assisted mechanical densification(PAMD)process on solid-state precursor mixture enables the dynamic mass transfer through the increased solid-solid contact area which facilitates the grain growth during sintering process,readily forming micro-sized single-crystalline ***,the improved chemical reactivity by a combination of capillary effect and vacancyassisted diffusion provides homogeneous element distribution within each primary *** a result,single-crystalline Ni-rich cathode with PAMD process has eliminated a potential evolution of intergranular cracking,thus achieving superior energy retention capability of 85%over 150 cycles compared to polycrystalline Ni-rich particle even after high-pressure calendering process(corresponding to electrode density of~3.6 g cm^(-3))and high cut-off voltage *** work provides a concrete perspective on developing facile synthetic route of micron-sized single-crystalline Ni-rich cathode materials for high energy density lithium-ion batteries(LIBs).

关键词： Lithium-ion batteries Ni-rich cathode materials Mechanical densification Solid-state synthesis

Expert recommendation system based on analyzing expertise and networks of human resources in National Science & Technology Information Service

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Journal of Central South University 2013年第8期20卷 2212-2218页

作者： YANG Myung-seok kang nam-kyu KIM Yun-jeong KIM Jae-soo CHOI Kwang-nam KIM Young-kuk NTIS Center Korea Institute of Science and Technology Information Department Of Computer Science and Engineering Chungnam National University

This work aims to implement expert and collaborative group recommendation services through an analysis of expertise and network relations NTIS. First of all, expertise database has been constructed by extracting keywords after indexing national R＆D information in Korea （human resources, project and outcome） and applying expertise calculation algorithm. In consideration of the characteristics of national R＆D information, weight values have been selected. Then, expertise points were calculated by applying weighted values. In addition, joint research and collaborative relations were implemented in a knowledge map format through network analysis using national R＆D information.

关键词： human networks network analysis NTIS R&D information