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Challenges in early phase of implementing the 1-3-7 surveillance and response approach in malaria elimination setting:A field study from Myanmar

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Infectious Diseases of Poverty 2020年第1期9卷 100-100页

作者： Poe Poe aung Zaw Win Thein Zar Ni Min Hein kyaw thet aung Nwe Oo Mon Nay Yi Yi Linn aung Thi Khin thet Wai Thae Maung Maung Duke Global Health Institute Myanmar Program YangonMyanmar 不详

Background:The National Plan for Malaria Elimination(NPME)in Myanmar(2016–2030)aims to eliminate indigenous Plasmodium falciparum malaria in six states/regions of low endemicity by 2020 and countrywide by 2030.To achieve this goal,in 2016 the National Malaria Control Program(NMCP)implemented the“1-3-7”surveillance and response strategy.This study aims to identify the barriers to successful implementation of the NPME which emerged during the early phase of the“1-3-7”approach deployment.Methods:A mixed-methods study was conducted with basic health staff(BHS)and Vector Born Disease Control Program(VBDC)staff between 2017 and 2018 in six townships of six states/regions targeted for sub-national elimination by 2020.A self-administered questionnaire,designed to assess the knowledge required to implement the“1-3-7”approach,was completed by 544 respondents.Bivariate analysis was performed for quantitative findings and thematic analysis was conducted for qualitative findings using Atals.ti software.Results:Although 83%of participants reported performing the key activities in the“1-3-7”surveillance and response approach,less than half could report performing those activities within 3 days and 7 days(40 and 43%,respectively).Low proportion of BHS correctly identified six categories of malaria cases and three types of foci(22 and 26%,respectively).In contrast,nearly 80%of respondents correctly named three types of case detection methods.Most cited challenges included‘low community knowledge on health’(43%),‘inadequate supplies’(22%),and‘transportation difficulty’(21%).Qualitative data identified poor knowledge of key surveillance activities,delays in reporting,and differences in reporting systems as the primary challenges.The dominant perceived barrier to success was inability to control the influx of migrant workers into target jurisdictions especially in hard-to-reach areas.Interviews with township medical officers and the NMCP team leaders further highlighted the necessity of refresher training for every step in the“1-3-7

关键词： Malaria elimination 1-3-7 approach Surveillance and response Basic health staff Mixed methods Myanmar

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Differential Roles of Arabidopsis Dynamin-Related Proteins DRP3A,DRP3B,and DRP5B in Organelle Division

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Journal of Integrative Plant Biology 2012年第11期54卷 921-931页

作者： kyaw aung MSU-DOE Plant Research Laboratory and Plant Biology Department Michigan State UniversityEast LansingMI 48824USA

Dynaminrelated proteins （DRPs） are key components of the organelle division machineries, functioning as molecular scissors during the fission process. In Arabidopsis, DRP3A and DRP3B are shared by peroxisomal and mitochondrial division, whereas the structurallydistinct DRP5B （ARC5） protein is involved in the division of chloroplasts and peroxisomes. Here, we further investigated the roles of DRP3A, DRP3B, and DRP5B in organelle division and plant development. Despite DRP5B＇s lack of stable association with mitochondria, drp5B mutants show defects in mitochondrial division.

关键词： Arabidopsis dynamin-related protein mitochondria.

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Tetramethylammonium Iodide Additive for Enhancing the Charge Carrier Mobilities of Diketopyrrolopyrrole-Based Conju-gated Polymer in Ambipolar Organic Field-Effect Transistors

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Chinese Journal of Chemistry 2023年第9期41卷 1028-1036页

作者： Waner He Qian Liu Sultan Otep Hidetoshi Matsumoto Sergei Manzhos Prashant Sonar aung Ko Ko kyaw Tsuyoshi Michinobu Department of Materials Science and Engineering Tokyo Institute of TechnologyTokyo 152-8552Japan Guangdong University Key Laboratory for Advanced Quantum Dot Displays Department of Electrical and Electronic EngineeringSouthern University of Science and TechnologyShenzhenGuangdong 518055China Center for Materials Science School of Chemistry and PhysicsFaculty of ScienceQueensland University of TechnologyBrisbaneQLD 4000Australia School of Materials and Chemical Technology Tokyo Institute of TechnologyTokyo 152-8552Japan

Diketopyrrolopyrrole(DPP)is one of the most promising building blocks for constructing polymer semiconductors with high charge-carrier mobilities in organic field-effect transistors(OFETs).In this study,a novel DPP-based conjugated polymer,PDPPy-BDD,was designed and synthesized.The ambipolar field-effect transistor characteristics were realized with the average hole and electron mobilities of 3.5×10^(-3)and 3.07×10^(-2)cm^(2)V^(-1)s^(-1),respectively.Both the hole and electron mobilities could be successfully en-hanced by using a tetramethylammonium iodide(NMe4l)additive.Such an enhancement was attributed to the formation of stronger interchainπ-πstackings,the weakening of the face-on packing orientation in the thin film state,and the higher channel conductivi-ties in the OFETs.

关键词： Diketopyrrolopyrrole Pyridine Charge transport Conjugated polymers Organic field-effect transistors Semiconductors Tetramethylammonium iodide Thin films

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东喜马拉雅构造结快速隆升时期:来自缅甸中央盆地沉积学证据

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地球科学 2022年第7期47卷 2573-2585页

作者：鲁毅崔宇驰 Si Si Thu kyaw kyaw Khing Myo Min aung 朱伟林邵磊同济大学海洋地质国家重点实验室上海200092

东喜马拉雅构造结快速隆升时间以及雅鲁藏布江和伊洛瓦底江是否曾经相连已经争论了超过半个世纪.采用锆石U-Pb年代学等方法,对缅甸中央盆地新生代地层的“源-汇”路径开展研究.缅甸中央盆地始新统发育大量铬尖晶石、各坳陷的锆石年龄谱... 详细信息

东喜马拉雅构造结快速隆升时间以及雅鲁藏布江和伊洛瓦底江是否曾经相连已经争论了超过半个世纪.采用锆石U-Pb年代学等方法,对缅甸中央盆地新生代地层的“源-汇”路径开展研究.缅甸中央盆地始新统发育大量铬尖晶石、各坳陷的锆石年龄谱各不相同,表明该时期沉积物以盆地周边隆起为主要物源,不存在统一的源区;渐新世之后,源自区域变质岩的重矿物组合比例逐渐增加,盆地各坳陷碎屑锆石年龄谱特征趋于一致,均以40~70 Ma的主峰以及80~110 Ma次峰为特征,表明沉积物源区进入抹谷变质带,伊洛瓦底江雏形已经形成;由于缅甸中央盆地渐新统至下中新统完全没有喜马拉雅造山带信息,认为该时期雅鲁藏布江-伊洛瓦底江并未相连.晚中新世-更新世,喜马拉雅造山带特征组合十字石和蓝晶石以及110~130 Ma年龄峰的出现,表明伊洛瓦底江已经侵蚀到东喜马拉雅构造结,达到现今流域规模.因此,东喜马拉雅构造结快速隆升的时间大约在晚中新世.

关键词：青藏东南缘缅甸中央盆地河流演化锆石U-Pb定年重矿物物源分析地质年代学

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Esophago-gastro-duodenoscopy could be an important tool in the diagnostic dilemma inherent in perforated peptic ulcer: A case report

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Laparoscopic, Endoscopic and Robotic Surgery 2022年第2期5卷 82-84页

作者： Pankaj Prasoon Giridhar Hanumappa Devadasar Tun aung kyaw Mohd.Akthar Ansari Mulky Damodar Kamath Chean Leung Chong Department of General Surgery Suri Seri Begawan HospitalKuala Belait Negara Brunei DarussalamBrunei

Acute abdomen is a common and sometimes dramatic clinical condition,which can be fatal if diagnosis is not made in time.Perforated peptic ulcer is a cause of an acute abdomen,which can be diagnosed by imaging investigations.However,erect chest X-ray and CT scan may not always establish the diagnosis.Herein we report a case of a patient with acute abdomen,where radiological imaging and CT scan were not able to provide a clear diagnosis.The patient was diagnosed with perforated peptic ulcer by esophago-gastro-duodenoscopy,and underwent laparotomy to repair the anterior wall duodenal perforation with an omental patch.Early endoscopic evaluation seems to be an essential tool for upper gastrointestinal evaluation in acute abdomen cases with inconclusive imaging results.

关键词： Perforated peptic ulcer Esophago-gastro-duodenoscopy Acute abdomen

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Assessment of Farmer’s Practices on the Rubber Nursery Management Using Growing Medium and Varietal Selection in Mon State

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Agricultural Sciences 2022年第3期13卷 307-320页

作者： Khaing Hninn Soe kyaw Ngwe Yinn Mar Soe kyaw kyaw Win aung Naing Oo Department of Soil and Water Science Yezin Agricultural University Naypyitaw Myanmar Pro Rector (Admin.) Office Yezin Agricultural University Naypyitaw Myanmar Phyu Campus Yezin Agricultural University Naypyitaw Myanmar

Rubber is an economically important perennial crop in Myanmar for latex production. As the rubber plantation area increases yearly, the requirement of vigorous rubber seedlings for its establishment plays a central role. The success of rubber plantations depends on some farming practices such as using different compost or other materials in the potting soil-medium, varietal selection for stock and scion in the budding process, and fertilizer application methods. The objective of this study was to assess the farmer’s practices in the establishment of rubber nurseries in mostly rubber planted areas in Myanmar. The survey interviewed 60 respondents from three townships in Mon State, namely Mudon, Kyaikmaraw, and Thanbyuzayat. The response data were analyzed through the descriptive method. This survey exposed the potentially active operators (middle age of 30 - 60 years) in rubber nursery production. Local experienced farmers usually raised the budded seedlings with 15 cm × 23 cm polyethylene bag in all study regions. Most farmers selected multi-clonal seed for stock and BPM 24 for scion according to the local market demand and high latex yield. All survey areas used both organic and inorganic fertilizers for nutrient management. Compost is a chief component of growing medium in their nursery production. However, making compost and high demand of the compost were local constraints. Therefore, this survey suggested improving the proper composting method for rubber nursery establishment.

关键词： Compost Farmers’ Practices Nutrient Management Varietal Selection

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Predictors of malaria rapid diagnostic test positivity in a high burden area of Paletwa Township, Chin State in Western Myanmar

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Infectious Diseases of Poverty 2021年第1期10卷 26-35页

作者： Pyae Linn aung Myat Thu Soe Thit Lwin Oo aung Khin aungThi Yan Zhao Yarning Cao Liwang Cui Myat Phone kyaw Daniel M.Parker Myanmar Health Network Organization YangonMyanmar Myanmar Health Assistant Association YangonMyanmar Department of Public Health Ministry of Health and SportsNayPyiTawMyanmar Department of Immunology College of Basic Medical ScienceChina Medical UniversityShenyang 110122LiaoningChina Division of Infectious Diseases and International Medicine Department of Internal MedicineMorsani College of MedicineUniversity of South Florida3720 Spectrum BoulevardSuite 304TampaFL 33612USA Department of Population Health and Disease Prevention Department of EpidemiologyUniversity of CaliforniaIrvineUSA.

Background:Despite major reductions in malaria burden across Myanmar,clusters of the disease continue to persist in specific subregions.This study aimed to assess the predictors of test positivity among people living in Paletwa Township of Chin State,an area of persistently high malaria burden.Methods:Four villages with the highest malaria incidence from Paletwa Town ship were purposively selected.The characteristics of 1045 subjects seeking malaria diagnosis from the four assigned village health volunteers from January to December,2018 were retrospectively analyzed.Their household conditions and surroundings were also recorded using a checklist.Descriptive statistics and logistic regression models were applied to investigate potential associations between individual and household characteristics and malaria diagnosis.Results:In 2017,the Paletwa township presented 20.9%positivity and an annual parasite index of 46.9 cases per 1000 people.Plasmodium falciparum was the predominant species and accounted for more than 80.0%of all infections.Among 1045 people presenting at a clinic with malaria symptoms,31.1% were diagnosed with malaria.Predictors for test positivity included living in a hut[adjusted odds ratios(aOR):2.3,95%confidence intervals(CI ):1.2-4.6],owning farm animals(aOR:1.7,95% CI:1.1-3.6),using non-septic type of toilets(aOR:1.9,95%CI:1.1-8.4),presenting with fever(aOR:1.9,95%CI:1.1-3.0),having a malaria episode within the last year(aOR:2.9,95%CI:1.45.8),traveling outside the village in the previous 14 days (aOR:4.5,95%CI:1.5-13.4),and not using bed nets(aOR:3.4,95%CI:2.3-5.1).There were no statistically significant differences by age or gender in this present analysis.Conclusions:The results from this study,including a high proportion of P.falciparum infections,little difference in age,sex,or occupation,suggest that malaria is a major burden for these study villages.Targeted health education campaigns should be introduced to strengthen synchronous diagnosis-seeking behaviors,tighten treatment adheren ce,

关键词： Malaria Trend Risk Endemic area Myanmar

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Knowledge,access and utilization of bednets among stable and seasonal migrants in an artemisinin resistance containment area of Myanmar

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Infectious Diseases of Poverty 2017年第1期6卷 1227-1234页

作者： Wint Phyo Than Tin Oo Khin thet Wai aung Thi Philip Owiti Binay Kumar Hemant Deepak Shewade Rony Zachariah Regional Public Health Department Ministry of HealthBagoMyanmar Department of Medical Research Ministry of HealthYangonMyanmar National Malaria Control Program Ministry of HealthNaypyitawMyanmar Academic Model Providing Access to Healthcare(AMPATH) EldoretKenya GAVI the Vaccine Alliance GenevaSwitzerland International Union Against Tuberculosis and Lung Disease(The Union) South-East Asia Regional OfficeNew DelhiIndia Medecins Sans Frontieres Operational Research Unit(LuxOR)Luxembourg CityLuxembourg

Background:Myanmar lies in the Greater Mekong sub-region of South-East Asia faced with the challenge of emerging resistance to artemisinin combination therapies(ACT).Migrant populations are more likely than others to spread ACT resistance.A vital intervention to reduce malaria transmission,resistance spread and eliminate malaria is the use of bed nets.Among seasonal and stable migrants in an artemisinin resistance containment region of Myanmar,we compared a)their household characteristics,b)contact with health workers and information material,and c)household knowledge,access and utilization of bed nets.Methods:Secondary data from community-based surveys on 2484 migrant workers(2013 and 2014,Bago Region)were analyzed of which 37%were seasonal migrants.Bed net access and utilization were assessed using a)availability of at least one bed net per household,and b)one bed net per two persons,and c)proportion of household members who slept under abed net during the previous night(Indicator targets=100%).Results:Over 70%of all migrants were from unstable work settings with short transitory stays.Average household size was five(range 1-25)and almost half of all households had children under-five years.Roughly 10%of migrants were night-time workers.Less than 40%of households had contact with health workers and less than 30%had exposure to information education and communication(IEC)materials,the latter being significantly lower among seasonal migrants.About 70%of households were aware of the importance of insecticide-treated bed-nets/long-lasting insecticidal nets(ITNs/LLINs),but knowledge on insecticide impregnation and retreatment of ITNs was poor(<10%).Although over 95%of households had access to at least one bed net,the number with one bed net per two persons was grossly inadequate(13%for stable migrants and 9%for seasonal migrants,P=0.001).About half of all household members slept under a bed net during the previous night.Conclusions:This study reveals important short-falls in knowledge,access and utilization of bed n

关键词： Operational research Malaria Transmission Artemisinin Greater Mekong sub-region Mosquito

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Assessment of household ownership of bed nets in areas with and without artemisinin resistance containment measures in Myanmar

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Infectious Diseases of Poverty 2018年第1期7卷 199-205页

作者： Thae Maung Maung Tin Oo Khin thet Wai Thaung Hlaing Philip Owiti Binay Kumar Hemant Deepak Shewade Rony Zachariah aung Thi Department of Medical Research Ministry of Health and SportsYangonMyanmar Department of Public Health Ministry of Health and SportsNay Pyi TawMyanmar Academic Model Providing Access to Healthcare(AMPATH) EldoretKenya Gavi the Vaccine AllianceGenevaSwitzerland International Union Against Tuberculosis and Lung Disease(The Union) South-East Asia Regional OfficeNew DelhiIndia Medecins Sans Frontieres Brussels Operational CentreLuxembourg cityLuxembourg National Malaria Control Program Ministry of Health and SportsNay Pyi TawMyanmar

Background:Myanmar lies in the Greater Mekong Subregion where there is artemisinin-resistant Plasmodium falciparum malaria.As the artemisinin compound is the pillar of effective antimalarial therapies,containing the spread of artemisinin resistance is a national and global priority.The use of insecticide-treated bed nets/long-lasting insecticidal nets(ITNs/LLINs)is the key intervention for ensuring the reduction of malaria transmission and the spread of resistant strains,and for eventually eliminating malaria.This study aimed at assessing household ownership of,access to,and utilization of bed nets in areas of Myanmar with and without artemisinin resistance containment measures.Methods:Secondary data from a nationwide community-based malaria survey conducted by the National Malaria Control Program in 2014 were analyzed.Based on evidence of artemisinin resistance,Myanmar was divided into tiers 1,2,and 3:townships in tiers 1 and 2 were aggregated as the Myanmar Artemisinin Resistance Containment(MARC)areas and were compared with tier 3 townships,which were defined as non-MARC areas.The chi-square test was used to compare groups,and the level of significance was set at P≤0.05.Results:Of the 6328 households assessed,97.2%in both MARC and non-MARC areas had at least one bed net(any type),but only 63%of households had ITNs/LLINs.Only 44%of households in MARC areas and 24%in non-MARC areas had adequate numbers of ITNs/LLINs(one ITN/LLIN per two persons,P<0.001).Nearly 44%of household members had access to ITNs/LLINs.Regarding the utilization of ITNs/LLINs,45%of household members used them in MARC areas and 36%used them in non-MARC areas(P<0.001,desired target=100%).Utilization of ITNs/LLINs among children aged below five years and pregnant women(high malaria risk groups)was low,at 44%and 42%,respectively.Conclusions:This study highlights the nationwide shortfalls in the ownership of,access to,and utilization of ITNs/LLINs in Myanmar,which is of particular concern in terms of containing the spread of artemisinin resistan

关键词： Malaria Insecticide-treated bed nets Long-lasting insecticidal nets Myanmar artemisinin resistance containment Bed nets ownership Bed nets access Bed nets utilization Myanmar

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遥感在缅甸飓风灾害土地覆盖分类中的应用

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西南交通大学学报 2011年第4期46卷 701-705页

作者：陈晓勇刘波 aung kyaw TUN 东华理工大学测绘工程学院江西抚州344000 亚洲理工学院泰国曼谷12120

为探讨"纳尔吉斯(Nargis)"飓风对缅甸伊洛瓦底江三角洲地区的影响,利用该地区的遥感数据,用ISODATA非监督分类和贝叶斯最大似然监督分类方法对研究区土地覆盖进行分类,得到了纳尔吉斯飓风前后缅甸伊洛瓦底江三角洲地区土地覆盖的定量变... 详细信息

为探讨"纳尔吉斯(Nargis)"飓风对缅甸伊洛瓦底江三角洲地区的影响,利用该地区的遥感数据,用ISODATA非监督分类和贝叶斯最大似然监督分类方法对研究区土地覆盖进行分类,得到了纳尔吉斯飓风前后缅甸伊洛瓦底江三角洲地区土地覆盖的定量变化,并对纳尔吉斯飓风灾害与红树林面积和密度的关系进行了定量研究.结果表明,红树林面积越大,种植密度越高,对减小飓风灾害的作用越大.

关键词：遥感缅甸飓风灾害土地覆盖变化

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