检索结果-南通市图书馆

Pre-operative visceral adipose tissue radiodensity is a potentially novel prognostic biomarker for early endoscopic post-operative recurrence in Crohn’s disease

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Surgery 2024年第3期16卷 740-750页

作者： Phillip Gu Shishir Dube Norman Gellada So Yung Choi Susan win Yoo Jin Lee Shaohong Yang Talin Haritunians Gil Y Melmed Eric A Vasiliauskas Niru Bonthala Gaurav Syal Andres J Yarur David Ziring Shervin Rabizadeh Phillip Fleshner Cindy Kallman Suzanne Devkota Stephan R Targan Dalin Li Dermot PB McGovern Department of Medicine Cedars-Sinai Medical CenterLos AngelesCA 90048United States Department of Imaging Cedars-Sinai Medical CenterLos AngelesCA 90048United States Department of Biostatistics Shared Resource Cedars-Sinai Medical CenterLos AngelesCA 90048United States Department of Internal Medicine Keimyung University School of MedicineDaegu 42601South Korea Department of Medicine University of California at Los AngelesLos AngelesCA 90095United States Department of Medicine University of California at San DiegoSan DiegoCA 92093United States Department of Pediatrics Cedars-Sinai Medical CenterLos AngelesCA 90048United States Department of Surgery Cedars-Sinai Medical CenterLos AngelesCA 90048United States

BACKGROUND Evidence suggests inflammatory mesenteric fat is involved in post-operative recurrence(POR)of Crohn’s disease(CD).However,its prognostic value is INTRODUCTION Crohn’s disease(CD)is a debilitating chronic immune-mediated inflammatory disease(IMID)of the gastrointestinal tract that is increasing in incidence and prevalence globally[1].CD patients often undergo surgery for disease-related complic-ations and/or medically refractory ***,surgery is not curative,and many patients develop post-operative recurrence(POR)of CD with a significant proportion eventually requiring additional *** advances in early detection and therapeutics,the contemporary 10-year risk of surgery has improved from 50%to 26%,but the risk of recurrent surgery has remained unchanged at 30%,suggesting a need to improve post-operative management strategies[2].Presently,there are two accepted strategies to mitigate POR,but each have potential ***,patients start early post-operative pharmacologic prophylaxis within 4-6 wk after *** strategy can potentially overtreat a subset of patient who may not develop long-term disease recurrence off ***,these patients are at risk of medication-related adverse events and the direct and indirect costs associated with therapy with little or no benefit[3].The second strategy is performing early colonoscopy within 6-12 months after surgery and escalating therapy based on FOOTNOTES Author contributions:Gu P is the guarantor of the article and was involved in concept and design,data collection,statistical analysis,drafting of manuscript,and final approval of manuscript;Dube S and Choi SY were involved in statistical analysis,drafting of the manuscript,and final approval of manuscript;Gellada N,win S,Lee YJ and Yang S were involved in the data collection,drafting of the manuscript,and final approval of manuscript;Haritunians T and Li D were involved in data analysis and interpretation,drafting

关键词： Crohn’s disease Surgery Visceral adipose tissue Mesenteric adipose tissue Creeping fat Computed tomography

Is prostate cancer a Lynch syndrome cancer？

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Journal of Andrology 2013年第5期15卷 588-589页

作者： Aung Ko win Centre for Molecular Environmental Genetic andAnalytic Epidemiology Melbourne School of Populationand G oba Heath Parkv e Vc. 3010 Austra a

The question of whether men with an inherited genetic condition called Lynch syndrome have an increased risk of developing prostate cancer has been controversial. It is important to answer this question, for understanding the role of DNA mismatch repair in carcinogenesis of prostate as well as for clinical implications for screening.

关键词： prostate cancer Lynch syndrome cancer

MOF负载Weel抑制剂实现p53突变胆囊癌的合成致死靶向治疗

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science Bulletin 2024年第9期69卷 1286-1301页

作者：郦仕杰 Sarun Juengpanich win Topatana 谢天傲侯丽丹朱怡远陈佳东单煜凯韩依纳陆子毅陈天恩 Charlie Topatana 张斌曹佳胜胡家豪严加费陈迎鑫顾臻俞计成蔡秀军陈鸣宇 Department of General Surgery Sir Run-Run Shaw HospitalZhejiang UniversityHangzhou 310016China School of Medicine Zhejiang UniversityHangzhou 310058China National Engineering Research Center of Innovation and Application of Minimally Invasive Instruments Sir Run-Run Shaw HospitalZhejiang UniversityHangzhou 310016China School of materials Science and Engineering Zhejiang UniversityHangzhou 310058China Department of Chemistry Zhejiang UniversityHangzhou 310016China Department of Pathology Sir Run-Run Shaw HospitalZhejiang UniversityHangzhou 310016China International College Zhejiang UniversityHangzhou 310058China Institute of Advanced magnetic materials and International Research Center for EM Metamaterials College of Materials&Environmental EngineeringHangzhou Dianzi UniversityHangzhou 310018China Zhejiang Provincial Key Laboratory for Advanced Drug Delivery Systems College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China National Key Laboratory of Advanced Drug Delivery and Release Systems Zhejiang UniversityHangzhou 310058China Liangzhu Laboratory Zhejiang UniversityHangzhou 311121China Jinhua Institute of Zhejiang University Jinhua 321299China MOE Key Laboratory of macromolecular Synthesis and Functionalization Department of Polymer Science and EngineeringZhejiang UniversityHangzhou 310027China

Adavosertib(ADA)is a WEE1 inhibitor that exhibits a synthetic lethal effect on p53-mutated gallbladder cancer(GBC).However,drug resistance due to DNA damage response compensation pathways and high toxicity limits further ***,estrone-targeted ADA-encapsulated metal–organic frameworks(ADA@MOF-EPL)for GBC synthetic lethal treatment by inducing conditional factors are *** high expression of estrogen receptors in GBC enables ADA@MOF-EPL to quickly enter and accumulate near the cell nucleus through estrone-mediated endocytosis and release ADA to inhibit WEE1 upon entering the acidic tumor *** irradiation induces ADA@MOF-EPL to generate reactive oxygen species(ROS),which leads to a further increase in DNA damage,resulting in a higher sensitivity of p53-mutated cancer cells to WEE1 inhibitor and promoting cell death via conditional synthetic *** conditional factor induced by ADA@MOF-EPL further enhances the antitumor efficacy while significantly reducing systemic ***,ADA@MOF-EPL demonstrates similar antitumor abilities in other p53-mutated solid tumors,revealing its potential as a broad-spectrum antitumor drug.

关键词： Synthetic lethality Nanomedicine Sonodynamic therapy Gallbladder cancer Metal-organic frameworks DNA damage response

Effects of platinum content on tribological properties of platinum/nitrogen doped diamond-like carbon thin films deposited via magnetron sputtering

在线全文

学校读者我要写书评

暂无评论

Friction 2014年第1期2卷 64-72页

作者： Nay win KHUN Erjia LIU School of Mechanical and Aerospace Engineering Nanyang Technological University50 Nanyang AvenueSingapore 639798Singapore

Platinum(Pt)and nitrogen(N)were co-incorporated in diamond-like carbon(DLC)thin films using a magnetron sputtering system to form PtN-DLC thin films for tribological *** Pt content in the PtN-DLC films prepared on Si substrates was controlled by varying RF power applied to a Pt target at a fixed N2 flow *** tribological properties of the PtN-DLC films were investigated with respect to the Pt content in the *** uncoated Si substrate surface tested against a steel ball of 6 mm in diameter had significant abrasive and fatigue wear,while no significant wear was found on the N-DLC coated sample surface,indicating that the N-DLC film effectively prevented its underlying Si substrate from ***,the incorporation of Pt in the N-DLC films reduced the wear resistance of the films by degrading sp3-bonded cross-linking structures of the films so that significant wear tracks were found on the surfaces of the PtN-DLC ***,the increased radio frequency(RF)power applied to the Pt target decreased the wear resistance of the PtN-DLC films as a result of the increased Pt content.

关键词： diamond-like carbon(DLC)film Pt and N doping friction wear

Tribological properties of platinum/ruthenium/nitrogen doped diamond-like carbon thin films deposited with different negative substrate biases

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Friction 2014年第4期2卷 317-329页

作者： Nay win KHUN Erjia LIU School of Mechanical and Aerospace Engineering Nanyang Technological University50 Nanyang AvenueSingapore 639798Singapore

The platinum/ruthenium/nitrogen doped diamond‐like carbon(PtRuN‐DLC)thin films were deposited on Si substrates via DC magnetron sputtering by varying negative substrate *** tribological performance of the PtRuN‐DLC films was systematically investigated using ball‐on‐disc microtribological *** Raman results showed that the increased negative substrate bias significantly increased the number of sp3 bonds in the PtRuN‐DLC films as a result of the increased kinetic energies of impinging *** adhesion strength of the PtRuN‐DLC films apparently decreased with increased negative substrate bias due to the promoted residual stress in the *** tribological results clearly revealed that the increased negative substrate bias decreased the friction and wear of the PtRuN‐DLC films by improving the sp3 bonded cross‐linking structures of the *** can be concluded that the PtRuN‐DLC films could effectively prevent their underlying Si substrates from wear as the negative substrate bias had a significant influence on the tribological properties of the PtRuN‐DLC films.

关键词： DC magnetron sputtering PtRuN‐DLC film adhesion friction wear

Development of synthetic lethality in cancer:molecular and cellular classification

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2020年第1期5卷 434-447页

作者： Shijie Li win Topatana Sarun Juengpanich Jiasheng Cao Jiahao Hu Bin Zhang Diana ma Xiujun Cai Mingyu Chen Department of General Surgery Sir Run-Run Shaw HospitalZhejiang University School of Medicine310016 HangzhouChina School of Medicine Zhejiang University310058 HangzhouChina Key Laboratory of Laparoscopic Technology of Zhejiang Province 310016 HangzhouChina Zhejiang Minimal Invasive Diagnosis and Treatment Technology Research Center of Severe Hepatobiliary Disease 310016 HangzhouChina Zhejiang Research and Development Engineering Laboratory of Minimally Invasive Technology and Equipment 310016 HangzhouChina Zhejiang University Cancer Center 310000 HangzhouChina

Recently,genetically targeted cancer therapies have been a topic of great *** lethality provides a new approach for the treatment of mutated genes that were previously considered unable to be targeted in traditional genotype-targeted *** increasing researches and applications in the clinical setting made synthetic lethality a promising anticancer treatment ***,the current understandings on different conditions of synthetic lethality have not been systematically assessed and the application of synthetic lethality in clinical practice still faces many ***,we propose a novel and systematic classification of synthetic lethality divided into gene level,pathway level,organelle level,and conditional synthetic lethality,according to the degree of specificity into its biological *** preclinical findings of synthetic lethality in recent years will be reviewed and classified under these different ***,synthetic lethality targeted drugs in clinical practice will be briefly ***,we will explore the essential implications of this classification as well as its prospects in eliminating existing challenges and the future directions of synthetic lethality.

关键词： specificity drugs synthetic

Turandot in the Forbidden City

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

China Today 1999年第3期48卷 29-30页

作者： ma win

Focuses on the Chinese opera `Turandot' staged in the Forbidden City in China by the Florence Opera House company and directed by Chinese film director Zhang Yimou. Summary outline; Use of Chinese folk melody `Jasmine... 详细信息

关键词： Turandot in the Forbidden City

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中国地表水环境微塑料赋存特征及驱动因素

中国环境科学 2024年第8期44卷 4599-4609页

作者：陈钦威王鹏丁明军张华聂明华黄高翔江西师范大学地理与环境学院鄱阳湖湿地与流域研究教育部重点实验室江西南昌330022

为阐明中国地表水环境微塑料(MPs)的赋存特征及驱动因素,基于已发表文献,收集了1944个采样点的MPs特征,分析地理环境和实验方法对MPs特征的影响.研究表明:中国地表水环境中MPs的丰度范围为水体0~204183items/m^(3),平均值为5465.26items... 详细信息

为阐明中国地表水环境微塑料(MPs)的赋存特征及驱动因素,基于已发表文献,收集了1944个采样点的MPs特征,分析地理环境和实验方法对MPs特征的影响.研究表明:中国地表水环境中MPs的丰度范围为水体0~204183items/m^(3),平均值为5465.26items/m^(3),沉积物0~79931items/kg,平均值为1374.51items/kg.中国地表水环境中MPs丰度呈现显著的空间异质性;水体中,内陆河流域MPs平均丰度最高(13185.77items/m^(3)),东南诸河流域(2678.07items/m^(3))的平均丰度最低.沉积物中,淮河流域的MPs平均丰度(2145.61items/kg)最高,而海河流域(294.82items/kg)最低.水体和沉积物中MPs的形态主要以纤维状(58.29%/47.21%)､碎块状(23.20%/30.03%)为主.粒径以小型MPs(<0.5mm)(59.61%/62.76%)为主.颜色以透明(30.18%/28.17%)为主.微塑料材质主要为聚乙烯(PE)(25.49%/27.78%)､聚丙烯(PP)(25.36%/22.69%)等.水体微塑料特征主要受自然环境因素影响,丰度、形状和颜色特征均与自然环境因子(气温,降水)显著相关.沉积物MPs特征主要受社会经济因素影响,丰度、形状和粒径特征与社会经济环境因子(GDP､夜光强度､人口密度)显著相关.不同实验处理下的MPs特征,包括丰度、形态、颜色和聚合物类型均有显著差异;偏最小二乘路径分析显示,实验处理过程对MPs特征的影响与地理环境相当;缺乏标准化的实验方法使得不同实验结果难以比较和验证,因此,迫切需要制定标准化的实验过程,减少实验处理对MPs观测特征的影响.

关键词：地表水环境微塑料特征赋存特征驱动因素地理环境实验过程

在线全文

学校读者我要写书评

暂无评论

中国式现代化的独特优势及其拓展路径探析

江苏行政学院学报 2024年第5期 75-83页

作者：燕连福马璐西安交通大学马克思主义学院西安710049

中国式现代化从领导力量、规模体量、发展布局、世界意蕴等维度破解了西方现代化发展的桎梏,形成了具有领导力量的先进性、受益群体的广泛性、发展方式的系统性、发展道路的包容性等独特优势。中国式现代化独特优势的生成,源于我们始终... 详细信息

中国式现代化从领导力量、规模体量、发展布局、世界意蕴等维度破解了西方现代化发展的桎梏,形成了具有领导力量的先进性、受益群体的广泛性、发展方式的系统性、发展道路的包容性等独特优势。中国式现代化独特优势的生成,源于我们始终坚持马克思主义现代化理论的基本原理,坚持对中国式现代化新道路的实践探索,坚持人民性这一中国式现代化发展的本质属性,坚持对西方现代化的批判、借鉴与超越。新时代新征程,必须聚焦发展实际,把握发展态势,在中国式现代化的方向性、协调性、开放性、创新性上下功夫,不断拓展中国式现代化的独特优势,开辟中国式现代化发展的新境界。

关键词：中国式现代化独特优势拓展路径人类文明新形态