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Pan-TRk positive uterine sarcoma in immunohistochemistry without neurotrophic tyrosine receptor kinase gene fusions:A case report

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World Journal of Clinical Cases 2025年第2期13卷 39-49页

作者： Seungmee Lee Yu-Ra Jeon Changmin Shin Sun-Young kwon Sojin Shin Department of Obstetrics and Gynecology Keimyung University School of MedicineDaegu 42601South Korea Department of Pathology and institute for Cancer Research Keimyung University School of MedicineDaegu 42601South Korea

BACkGROUND The classification of uterine sarcomas is based on distinctive morphological and immunophenotypic characteristics,increasingly supported by molecular genetic *** on neurotrophic tyrosine receptor kinase(NTRk)gene fusionpositive uterine sarcoma,potentially aggressive and morphologically similar to fibrosarcoma,are limited due to its recent ***-TRk immunohistochemistry(iHC)analysis serves as an effective screening tool with high sensitivity and specificity for NTRk-fusion *** SUMMARY We report a case of a malignant mesenchymal tumor originating from the uterine cervix,which was pan-TRk iHC-positive but lacked NTRk gene fusions,accompanied by a brief literature review.A 55-year-old woman presented to the emergency department with abdominal pain and distension,exhibiting significant ascites and multiple solid pelvic *** examination revealed a tumor encompassing the uterine cervix,extending to the vagina and uterine corpus.A punch biopsy of the cervix indicated NTRk sarcoma with positive immunochemical pan-TRk ***,subsequent next generation sequencing revealed no NTRk gene fusion,leading to a diagnosis of poorly differentiated,advanced-stage *** The clinical significance of NTRk gene fusion lies in potential treatment with TRk inhibitors for positive *** such rare tumors is crucial due to the potential applicability of tropomyosin receptor kinase inhibitor treatment.

关键词： Uterine sarcoma Cervical sarcoma Neurotrophic tyrosine receptor kinase gene fusion Next generation sequencing Case report

The Effect of Non-equilibrium Condensation on the Drag Coefficient in a Transonic Airfoil Flow

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Journal of Thermal Science 2012年第6期21卷 518-524页

作者： i.W.kim M.M.A.Alam S.J.Lee Y.D.kwon S.B.kwon School of Mechanical Engineering Kyungpook Nat.Uni.1370Sankyuk-dongDaegu 702-701Korea Dept.of Advanced & Control Eng.Saga Uni.Japan

in this study, a transonic flow past NACA0012 profile at angle of attack α=0^0 whose aspect ratio AR is 1.0 with non-equilibrium condensation is analyzed by numerical analysis using a TVD scheme and is investigated using an intermittent indraft type supersonic wind tunnel. Transonic flows of 0.78-0.90 in free stream Mach number with the variations of the stagnation relative humidity（φ0） are tested. For the same free stream Mach number, the increase in φ0 causes decrease in the drag coefficient of profile which is composed of the drag components of form, viscous and wave. in the case of the same Moo and To, for more than φ0=30%, despite the irreversibility of process in non-equilibrium condensation, the drag by shock wave decreases considerably with the increase of φ0. On the other hand, it shows that the effect of condensation on the drag coefficients of form and viscous is negligible. As an example, the decreasing rate in the drag coefficient of profile caused by the influence of non-equilibrium condensation for the case of M∞=0.9 and φ0 =50% amounts to 34%. Also, it were turned out that the size of supersonic bubble （that is, the maximum height of supersonic zone） and the deviation of pressure coefficient from the value for M=1 decrease with the increase of φ0 for the same M∞.

关键词： Non-equilibrium condensation Transonic Moist air Drag coefficient Pressure coefficient

高温干燥生产的潜在多微生物益生素和抗生素对断奶仔猪生产性能的影响

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饲料博览 2011年第11期21卷 13-13页

作者： Choi J Y kim J S ingale S L kim k H Shinde P L kwon i k Chae B J 张树金不详

试验旨在研究接受高温干燥对潜在多微生物益生素的影响。潜在多微生物益生素通过固体基质发酵生产,在低温（LT,40℃72h）或高温（HT,70℃36h）下干燥。试验1,288头断奶仔猪（体重6.43±0.68kg）根据体重分配给4个处理（每个处理4个猪圈... 详细信息

试验旨在研究接受高温干燥对潜在多微生物益生素的影响。潜在多微生物益生素通过固体基质发酵生产,在低温（LT,40℃72h）或高温（HT,70℃36h）下干燥。试验1,288头断奶仔猪（体重6.43±0.68kg）根据体重分配给4个处理（每个处理4个猪圈,每个猪圈18头猪）。日粮处理为负对照组（NC组,不添加抗菌剂的基础日粮）、正对照组（PC组,基础日粮＋金霉素0.1%）、含LT益生素0.03%的基础日粮、含HT益生素0.03%的基础日粮。日粮分两个阶段饲喂,0~14d为第1阶段,15~28d为第2阶段。评估猪的生长性能、总消化道养分表观消化率（ATTD,第28天）和粪便微生物区系（第14和28天）。试验结果表明,在28d试验期中,与饲喂NC组日粮的猪只比较,饲喂PC组和益生素日粮的猪只有较高的平均日增重（P〈0.001）、酸性洗涤纤维进食量（P〈0.05）和饲料转化率（P〈0.01）。与饲喂NC组日粮的猪只比较,饲喂益生素日粮猪只干物质的ATTD和总能较高（P〈0.05）。第28天,与饲喂NC组日粮的猪只比较,饲喂PC组和益生素日粮猪只粪便中发现较少的梭状芽胞杆菌（P〈0.01）,不过,饲喂LT益生素和HT益生素日粮猪只之间的生长性能、干物质ATTD和总能及粪便梭状芽胞杆菌菌群相似。试验2,288头断奶仔猪（起始体重5.84±0.18kg）根据体重以2×2因子设计分为4个处理,研究添加或不添加抗生素（金霉素,0、0.1%）的2个HT（0.30、0.60%）益生素水平对生产性能、ATTD、小肠形态学及粪便与肠道菌群的影响。试验结果表明,饲喂HT益生素0.60%日粮的仔猪改善了总平均日增重、干物质ATTD、总能及粪便和肠道中的乳酸菌菌群,降低粪便和回肠中梭状芽胞杆菌和大肠杆菌群（第14天）（P〈0.05）。抗生素的加入改善了总的平均日增重、酸性洗涤纤维进食量和干物质ATTD（第14天）,降低粪便梭状芽胞杆菌菌群数量（第28天）（P〈0.05）。在饲喂HT益生素0.60%和抗生素日粮的猪只中,观察到空肠和回肠绒毛高度、回肠绒毛高度与腺窝深度的比值增加（P〈0.05）。试验结果表明,较高的干燥温度对潜在多微生物益生素的功效无影响。不过,高温干燥益生素以0.60%比例加入日粮时更有效,而抗生素的加入可改善猪只的生产性能,但是抗生素与益生素之间无交互作用。

关键词：抗生素总消化道养分表观消化率生长性能肠道形态学潜在多微生物益生素断奶仔猪

人工合成抗菌肽-A3和P5对断奶仔猪的生长性能、消化道内营养物质表观消化率、粪便和肠道内菌群和肠道形态的影响

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饲料博览 2014年第4期24卷 8-8页

作者： Yoon J H ingale S L kim J S kim k H Lee S H Park Y k Lee S C kwon i k Chae B J

研究旨在探讨人工合成抗菌肽-A3和P5(AMP-A3和P5)对断奶仔猪的生长性能、消化道内营养物质表观消化率(ATTD)、粪便和肠道内菌群、免疫球蛋白和肠道形态的影响。根据初始体重将猪(n=240,长白×大白×杜洛克,初始体重为5.9±0.56 kg)随机... 详细信息

研究旨在探讨人工合成抗菌肽-A3和P5(AMP-A3和P5)对断奶仔猪的生长性能、消化道内营养物质表观消化率(ATTD)、粪便和肠道内菌群、免疫球蛋白和肠道形态的影响。根据初始体重将猪(n=240,长白×大白×杜洛克,初始体重为5.9±0.56 kg)随机分为4个处理,每个处理4个重复,每个重复15头猪。阴性对照组(NC,基础饲粮不添加任何抗菌生长促进剂)、阳性对照组(PC,基础日粮+阿维霉素150 mg·kg-1基础饲粮)、添加AMP-A3 60 mg·kg-1基础饲粮(A3)和AMP-P560 mg·kg-1基础饲粮(P5)。试验期为28 d。与NC组相比,整个试验阶段PC、A3和P5组的日增重、料重比均显著提高(P0.05)。与NC组相比PC、A3和P5组的营养物质表观消化率的总能、粗蛋白质(Ⅰ期和Ⅱ期)和干物质(Ⅱ期)显著增加(PigG、igA、igM)无显著影响(P>0.05)。研究表明,AMP-A3和P5可以提高断奶仔猪的生长性能、营养物质的表观消化率,改善肠道形态和降低致病菌。由于试验测定的指标较低,因此需要进一步的研究来证实目前的结果。

关键词：表观消化率断奶仔猪肠道形态生长性能人工合成营养物质抗菌肽消化道

Nearly-complete labial adhesions diagnosed with repetitive cystitis in postmenopausal women:A case report

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World Journal of Clinical Cases 2022年第35期10卷 12990-12995页

作者： Hyejin kwon Department of Obstetrics and Gynecology Won Kwang University Sanbon HospitalWon Kwang University School of MedicineGunpo-si15865Gyeonggi-doSouth Korea

BACkGROUND Nearly-complete labial adhesions diagnosed with repetitive cystitis in postmenopausal women:A case report CASE SUMMARY The case of an 83-year-old woman who presented with dysuria,urination disorders,recurrent cystitis,and bacteriuria and was admitted to a private hospital after 1 mo of antibiotic treatment without improvement of her *** examination,labial adhesions were observed with nearly-complete labial fusion with a pinpoint *** was detected in urine analysis,and the urine culture test was positive for Escherichia ***,a parenteral antibiotic(Fosfomycin)and topical estrogen cream were ***,since the adhesion did not separate after 2 wk of treatment,surgical correction was ***,adhesiolysis was conducted with a blunt ***,hysteroscopy and cystoscopy were *** findings showed no abnormalities of the endometrium and endocervix,and the cystoscopic results were also ***,labiaplasty was completed to prevent adhesion *** month after the surgery,the discomfort while urinating was eliminated and the adhesion did not *** Labial adhesions in postmenopausal women cannot be successfully treated with estrogen creams,and surgical treatment should be considered.

关键词： Post menopause Genitalia,female Cystitis Gynecologic Surgical Procedures Atrophy Urinary Retention Case report

A metabolite of the gut microbiota:a facilitator of chemotherapy efficacy in cancer

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Signal Transduction and Targeted Therapy 2023年第7期8卷 3189-3191页

作者： Byungsuk kwon School of Biological Sciences University of UlsanUlsanRepublic of Korea

A recent study has identified a surprising metabolic connection between the gut microbiota and intratumoral neutrophils that impairs the oxidative stress adaptation response to chemotherapy in pancreatic cancer.1 This finding suggests that a microbiota metabolite might be used as an additive in improving chemotherapeutic efficacy for cancer patients.

关键词： chemotherapy cancer additive

Changes in brain activation patterns according to cross-training effect in serial reaction time task An functional MRi study

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Neural Regeneration Research 2013年第7期8卷 639-646页

作者： Yong Hyun kwon Jung Won kwon Ji Won Park Department of Physical Therapy Yeungnam College of Science & Technology Department of Physical Therapy College of Health Science Catholic University of Daegu

Cross-training is a phenomenon related to motor learning, where motor performance of the untrained limb shows improvement in strength and skill execution following unilateral training of the homologous contralateral limb. We used functional MRi to investigate whether motor performance of the untrained limb could be improved using a serial reaction time task according to motor sequential learning of the trained limb, and whether these skill acquisitions led to changes in brain activation patterns. We recruited 20 right-handed healthy subjects, who were randomly allocated into training and control groups. The training group was trained in performance of a serial reaction time task using their non-dominant left hand, 40 minutes per day, for 10 days, over a period of 2 weeks. The control group did not receive training. Measurements of response time and percentile of response accuracy were performed twice during pre- and post-training, while brain functional MRi was scanned during performance of the serial reaction time task using the untrained right hand. in the training group, prominent changes in response time and percentile of response accuracy were observed in both the untrained right hand and the trained left hand between pre- and post-training. The control group showed no significant changes in the untrained hand between pre- and post-training. in the training group, the activated volume of the cortical areas related to motor function （i.e., primary motor cortex, premotor area, posterior parietal cortex） showed a gradual decrease, and enhanced cerebellar activation of the vermis and the newly activated ipsilateral dentate nucleus were observed during performance of the serial reaction time task using the untrained right hand, accompanied by the cross-motor learning effect. However, no significant changes were observed in the control group. Our findings indicate that motor skills learned over the 2-week training using the trained limb were transferred to the opposi

关键词： neural regeneration neuroimaging cross-training effects motor skill learning cortical activation cerebellar activation serial reaction time task functional MRi response time response accuracy primary motor cortex dentate nucleus vermis grants-supported paper photographs-containingpaper neuroregeneration

Novel Rifle Number Recognition Based on improved YOLO in Military Environment

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Computers, Materials & Continua 2024年第1期78卷 249-263页

作者： Hyun kwon Sanghyun Lee Department of Artificial intelligence and Data Science Korea Military AcademySeoulKorea Graduate School of information Security Korea Advanced Institute of Science and TechnologyDaejeonKorea

Deep neural networks perform well in image recognition,object recognition,pattern analysis,and speech *** military applications,deep neural networks can detect equipment and recognize *** military equipment,it is necessary to detect and recognize rifle management,which is an important piece of equipment,using deep neural *** have been no previous studies on the detection of real rifle numbers using real rifle image *** this study,we propose a method for detecting and recognizing rifle numbers when rifle image data are *** proposed method was designed to improve the recognition rate of a specific dataset using data fusion and transfer *** the proposed method,real rifle images and existing digit images are fusedas trainingdata,andthe final layer is transferredto theYolov5 *** detectionand recognition performance of rifle numbers was improved and analyzed using rifle image and numerical *** used actual rifle image data(k-2 rifle)and numeric image datasets,as an experimental *** was used as the machine learning *** results show that the proposed method maintains 84.42% accuracy,73.54% precision,81.81% recall,and 77.46% F1-score in detecting and recognizing rifle *** proposed method is effective in detecting rifle numbers.

关键词： Machine learning deep neural network rifle number recognition detection

kinematic Analysis of the Neck and Upper Extremities During Walking in Healthy Young Adults

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Journal of Bionic Engineering 2011年第3期8卷 305-312页

作者： kwon Son Junghong Park Seonghun Park School of Mechanical Engineering Pusan National University Busan 609-735 Republic of Korea

The objective of this paper is to quantify the local stabilities of the neck and upper extremities （right/left shoulders and right/left elbows）, and investigate differences between linear and nonlinear measurements of the associated joint motions and differences in the local stability between the upper and lower extremities. This attempt involves the calculation of a nonlinear parameter, Lyapunov Exponent （LE）, and a linear parameter, Range of Motion （ROM）, during treadmill walking in conj unction with a large population of healthy subjects. Joint motions of subjects were captured using a three-dimensional motion-capture system. Then mathematical chaos theory and the Rosenstein algorithm were employed to calculate LE of joints as the extent of logarithmic divergence between the neighboring state-space trajectories of flexion-extension angles. LEs computed over twenty males and twenty females were 0.037~0.023 for the neck, 0.043＋0.021 for the right shoulder, 0.045i0.030 for the left shoulder, 0.032i0.021 for the right elbow, and 0.034~0.026 for the left elbow. Although statistically significant difference in the ROM was observed between all pairs of the neck and upper extremity joints, differences in the LE between all pairs of the joints as well as between males and females were not statistically significant. Between the upper and lower extremities, LEs of the neck, shoulder, and elbow were significantly smaller than those of the hip （-0.064） and the knee （-0,062）. These results indicate that a statistical difference in the local stability between the upper extremity joints is not significant. However, the different result between the ROM and LE gives a strong rationale for applying both linear and nonlinear tools together to the evaluation of joint movement. The LEs of the joints calculated from a large population of healthy subjects could provide normative values for the associated joints and can be used to evaluate the recovery progress of patients with joint rel

关键词： kinematic analysis Lyapunov exponent range of motion chaos theory upper extremities