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Dieckol isolated from Eisenia bicyclis extract suppresses RANKL-induced osteoclastogenesis in murine RAW 264.7 cells

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Asian Pacific Journal of Tropical Biomedicine 2022年第6期12卷 262-269页

作者： Su-Hyeon Cho Tae-Hyung kwon Hoibin jeong Jin Sook Kim Song-Rae Kim Myeong Seon jeong SeonJu Park Miri Choi Jung-Hee Woo Juhee Ahn Kil-Nam Kim Chuncheon Center Korea Basic Science InstituteChuncheon 24341Republic of Korea Department of Medical Biomaterials Engineering College of Biomedical SciencesKangwon National UniversityChuncheon 24341Republic of Korea Department of Research and Development Chuncheon Bio-industry FoundationChuncheonRepublic of Korea Marine Industry Research Institute for East se rim Uljin-gunGyeongsangbuk-doRepublic of Korea Department of Bio-analysis Science University of Science&TechnologyDaejeon34113Republic of Korea

Objective:To demonstrate the effect of dieckol from Eisenia bicyclis on osteoclastogenesis using RAW 264.7 ***:Murine macrophage RAW 264.7 cells were subjected to dieckol treatment,followed by treatment with receptor activator of nuclear factor kappa-B ligand(RANKL)to induce ***-resistant acid phosphatase(TRAP)activity was examined using a TRAP activity *** blotting analysis was conducted to examine the level of osteoclast-related factors,including TRAP and calcitonin receptor(CTR),transcriptional factors,including c-Fos,c-Jun,and nuclear factor of activated T cells cytoplasmic 1(NFATc1),nuclear factor kappa-B(NF-κB),extracellular signal-regulated kinase(ERK),and c-Jun N-terminal kinase(JNK).Immunofluorescence staining was conducted to examine the expression of c-Fos,c-Jun,and ***:Among the four phlorotannin compounds present in Eisenia bicyclis,dieckol significantly hindered osteoclast differentiation and expression of RANKL-induced TRAP and *** addition,dieckol downregulated the expression levels of c-Fos,c-Jun,NFATc1,ERK,and JNK,and suppressed NF-κB ***:Dieckol can suppress RANKL-induced ***,it has therapeutic potential in treating osteoclastogenesis-associated diseases.

关键词： Eisenia bicyclis Dieckol Osteoclasts ERK JNK NF-κB RANKL TRAP Calcitonin receptor NFATc1 RAW 264.7 cell

An XPath-based OWL storage model for effective ontology management in Semantic Web environment

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2009年第6期10卷 843-857页

作者： Jinhyung KIM Dongwon jeong Doo-kwon BAIK Department of Computer Science and Engineering Korea University Department of Informatics and Statistics Kunsan National University

With the rapid growth of the Web, the volume of information on the Web is increasing exponentially. However, information on the current Web is only understandable to humans, and this makes precise information retrieval difficult. To solve this problem, the Semantic Web was proposed. We must use ontology languages that can assign data the semantics for realizing the Semantic Web. One of the representative ontology languages is the Web ontology language OWL, adopted as a recommen-dation by the World-Wide Web Consortium (W3C). OWL includes hierarchical structural information between classes or prop-erties. Therefore, an efficient OWL storage model that considers a hierarchical structure for effective information retrieval on the Semantic Web is required. In this paper we suggest an XPath-based OWL storage (XPOS) model, which includes hierarchical information between classes or properties in XPath form, and enables intuitive and effective information retrieval. Also, we show the comparative evaluation results for the performance of the XPOS model, Sesame, and the XML file system-based storage (XFSS) model, in terms of query processing and ontology updating.

关键词：语义Web XPath 存储模式本体论 Web环境有效管理 Web本体语言信息网络

VQT:value cardinality and query pattern based R-schema to XML schema translation with implicit referential integrity

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2008年第12期9卷 1694-1707页

作者： Jinhyung KIM Dongwon jeong Doo-kwon BAIK Department of Computer Science and Engineering Korea UniversitySeoul 136-713Korea Department of Informatics and Statistics Kunsan National UniversityKunsan 573-701Korea

In this paper,we propose a new relational schema (R-schema) to XML schema translation algorithm, VQT, which analyzes the value cardinality and user query patterns and extracts the implicit referential integrities by using the cardinality property of foreign key constraints between columns and the equi-join characteristic in user queries. The VQT algorithm can apply the extracted implied referential integrity relation information to the R-schema and create an XML schema as the final result. Therefore, the VQT algorithm prevents the R-schema from being incorrectly converted into the XML schema, and it richly and powerfully represents all the information in the R-schema by creating an XML schema as the translation result on behalf of the XML DTD.

关键词：询问模式相关计划 XML 计算机技术

Degradable and Tunable Keratin-fibrinogen Hydrogel as Controlled Release System for Skin Tissue Regeneration

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Journal of Bionic Engineering 2023年第3期20卷 1049-1059页

作者： Sung Jun Min Jae Seo Lee Haram Nah Ho-Jin Moon Sang Jin Lee Hyeon jeong Kang Yu-Shik Hwang Il Keun kwon Dong Nyoung Heo Department of Dentistry Graduate SchoolKyung Hee University26 Kyungheedae-RoDongdaemun-GuSeoul02447Republic of Korea Biofriends Inc 26 Kyungheedae-RoDongdaemun-GuSeoul02447Republic of Korea Department of Dental Materials School of DentistryKyung Hee University26 Kyungheedae-RoDongdaemun-GuSeoul02447Republic of Korea Department of Maxillofacial Biomedical Engineering and Institute of Oral Biology School of DentistryKyung Hee UniversitySeoul02447Korea Kyung Hee University Medical Science Research Institute Kyung Hee University23 Kyungheedae-RoDongdaemun-GuSeoul02447Republic of Korea

Biodegradable hydrogels are promising biomaterials for use in controlled-release systems for skin tissue regeneration. Controlled delivery systems constitute an important aspect of tissue engineering because they can modulate various physiological responses, including early immune response, tissue remodeling, and cell proliferation and maturation in the wound-healing process. Hydrogels composed of various biomaterials have been developed to overcome the limitations of conventional drug- or protein-delivery systems, such as limited targeting ability, low stability, and the induction of drug resistance. Hydrogels based on keratin, a natural polymer extracted from human hair, can provide adequate cell support and control homeostasis. Consequently, they can be applied for skin tissue engineering. In this study, we prepared degradable, tunable, and biocompatible hydrogels for controllable protein delivery. We synthesized keratin-fibrinogen (KER-FBG) by the chemical coupling reaction and prepared hydrogels through polymerization with thrombin. The structures and morphologies of the KER-FBG hydrogels were confirmed. Furthermore, the mechanical properties, swelling ratio, degradation, release behavior, and biocompatibility were investigated. The KER-FBG hydrogels presented promising biological performance, indicating that the material is suitable as a controlled protein delivery carrier.

关键词： Keratin Fibrinogen Hydrogel Drug delivery Degradable

墨西哥青少年心理健康教育和社会服务体系研究

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基础教育参考 2024年第2期 60-70页

作者：吴蒙闫嵘高琳婷 Yu jeong Jin 谭翎王永丽西交利物浦大学未来教育学院江苏苏州215123 西交利物浦大学语言学院江苏苏州215123 教育部教育管理信息中心研究处北京100816

儿童和青少年的心理健康一直是墨西哥政府和社会高度关注的热点问题。文章在概括墨西哥儿童和青少年心理健康状况与政策基础上,重点介绍了墨西哥儿童和青少年心理健康服务的实施策略和路径,包括开展社会情感培训,提升教师心理健康素养,... 详细信息

儿童和青少年的心理健康一直是墨西哥政府和社会高度关注的热点问题。文章在概括墨西哥儿童和青少年心理健康状况与政策基础上,重点介绍了墨西哥儿童和青少年心理健康服务的实施策略和路径,包括开展社会情感培训,提升教师心理健康素养,以及开展家庭教育指导和多种社会心理健康支持等。总的来说,墨西哥通过政府、社会、学校和家庭等多个层面提升了心理健康服务的普及性和有效性,并为全球其他国家在心理健康服务领域的实践提供了宝贵的经验和案例。

关键词：墨西哥儿童和青少年心理健康服务学校心理健康家庭教育指导

Genetic algorithm tuned PI controller on PMSM simplified vector control

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Journal of Central South University 2013年第11期20卷 3042-3048页

作者： WIBOWO Wahyu Kunto jeong Seok-kwon Mechatronics Engineering Pukyong National University Refrigeration and Air-Conditioning Engineering Pukyong National University

A simple control structure in servo system is occasionally needed for simple industrial application which precise and high control performance is not exessively important so that the cost production can be reduced *** vector control,which has simple control structure,is utilized as the permanent magnet synchronous motor control algorithm and genetic algorithm is used to tune three PI controllers used in simplified vector *** control performance is obtained from simulation and investigated to verify the feasibility of the algorithm to be applied in the real *** results show that the speed and torque responses of the system in both continuous time and discrete time can achieve good ***,simplified vector control combined with genetic algorithm has a similar performance with conventional field oriented control algorithm and possible to be realized into the real simple application in the future.

关键词：永磁同步电机 PI控制器遗传算法矢量控制调整控制性能工业应用控制结构

Safety of acupotomy in a real-world setting:A prospective pilot and feasibility study

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Journal of Integrative Medicine 2022年第6期20卷 514-523页

作者： Sang-Hoon Yoon Chan-Young kwon Hee-Geun Jo Jae-Uk Sul Hyangsook Lee Jiyoon Won Su Jin jeong Jun-Hwan Lee Jungtae Leem Chung-Yeon Korean Medicine Clinic Gangnam-guSeoul 06224Republic of Korea Department of Oriental Neuropsychiatry Dong-eui University College of Korean MedicineBusanjin-guBusan 47340Republic of Korea Department of Herbal Pharmacology College of Korean MedicineGachon University1342 Seongnamdae-roSujeong-guSeongnam 13120Republic of Korea Department of Korean Rehabilitation Medicine Dongshin University Korean Medicine HospitalGwangju 61619Republic of Korea Acupuncture and Meridian Science Research Center Kyung Hee UniversityDongdaemun-guSeoul 02447Republic of Korea Department of Science in Korean Medicine Graduate SchoolKyung Hee UniversityDongdaemun-guSeoul 02447Republic of Korea KM Science Research Division Korea Institute of Oriental MedicineDaejeon 34054Republic of Korea Department of Statistics Support Medical Science Research InstituteKyung Hee University Medical CenterDongdaemun-guSeoul 02447Republic of Korea Clinical Medicine Division Korea Institute of Oriental MedicineYuseong-guDaejeon 34054Republic of Korea Korean Medicine Life Science University of Science&Technology(UST)Campus of Korea Institute of Oriental MedicineYuseong-guDaejeon 34054Republic of Korea College of Korean Medicine Wonkwang UniversityIksanJeollabuk-do54538Republic of Korea

Objective:Acupotomy is a modern acupuncture method that includes modern surgical *** acupotomy is relatively more invasive than filiform acupuncture treatment,it is important to establish the safety profile of this *** justify further large-scale prospective observational studies,this preliminary study was performed to assess the feasibility of the approach and investigate the safety profile and factors potentially associated with adverse events(AEs).Methods:This was a prospective pilot study that assessed the feasibility of a large-scale forthcoming safety study on acupotomy treatment in a real-world *** feasibility(call response rate,dropout rate,response rate for each variable and recruitment per month)and safety profile(incidence,type,severity and causality of AEs,and factors potentially associated with AEs)were ***:A total of 28 participants joined the study from January to May 2018.A follow-up assessment was achieved in 258(1185 treatment points)out of 261 sessions(1214 treatment points).The response rate via telephone on the day after treatment was 87.3%.There were 8 systemic AEs in all the sessions(8/258;3.11%)and 27 local AEs on the total points treated(27/1185;2.28%).Severe AEs did not *** AE and local AE occurrence were associated with blade width and the number of needle stimulations per treatment ***:The findings suggest that it could be feasible to analyze the safety of acupotomy in a realworld ***,the primary data on some relevant AEs could be *** are planning large-scale prospective studies based on these *** registration:Clinical Research Information Service(CRIS)KCT0002849(https://***/cris/search/***/11487).

关键词： Acupotomy Acupuncture Safety Adverse effects Observational study Traditional Chinese medicine

Humidity-induced synaptic plasticity of ZnO artificial synapses using peptide insulator for neuromorphic computing

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Journal of Materials Science & Technology 2022年第24期119卷 150-155页

作者： Min-Kyu Song Hojung Lee jeong Hyun Yoon Young-Woong Song Seok Daniel Namgung Taehoon Sung Yoon-Sik Lee Jong-Seok Lee Ki Tae Nam Jang-Yeon kwon School of Integrated Technology Yonsei UniversityIncheon 21983South Korea Department of Materials Science and Engineering Seoul National UniversitySeoul 08826South Korea Soft Foundry Seoul National UniversitySeoul 08826South Korea School of Chemical and Biological Engineering Seoul National UniversitySeoul 08826South Korea

Neuromorphic devices inspired by the human brain have attracted significant attention because of their excellent ability for cognitive and parallel *** study presents ZnO-based artificial synapses with peptide insulators for the electrical emulation of biological *** demonstrated the dynamic responses of the device under various environmental *** proton-conducting property of the tyrosine-rich peptide enables time-dependent responses under ambient conditions such that various aspects of synaptic behaviors are emulated by the *** transition from short-term memory to longterm memory is achieved via electrochemical doping of ZnO by ***,we demonstrate an image classification simulation using a multi-layer perceptron model to evaluate the potential of the device for use in neuromorphic *** neural network based on our device achieved a recognition accuracy of 87.47% for the MNIST handwritten digit *** work proposes a novel device platform inspired by biosystems for brain-mimetic hardware systems.

关键词： Artificial synapse Neuromorphic computing Oxide semiconductor Proton conductor Artificial neural network

Tyrosine-mediated analog resistive switching for artificial neural networks

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Nano Research 2023年第1期16卷 858-864页

作者： Min-Kyu Song Seok Daniel Namgung Hojung Lee jeong Hyun Yoon Young-Woong Song Kang Hee Cho Yoon-Sik Lee Jong-Seok Lee Ki Tae Nam Jang-Yeon kwon School of Integrated Technology Yonsei UniversityIncheon 21983Republic of Korea Department of Mechanical Engineering Massachusetts Institute of TechnologyMA 02139USA Research Laboratory of Electronics Massachusetts Institute of TechnologyMA 02139USA Department of Materials Science and Engineering Seoul National UniversitySeoul 08826Republic of Korea Soft Foundry Seoul National UniversitySeoul 08826Republic of Korea School of Chemical and Biological Engineering Seoul National UniversitySeoul 08826Republic of Korea

The fourth industrial revolution indispensably brings explosive data processing and storage;thus,a new computing paradigm based on artificial intelligence-enabling device structure is urgently *** have received considerable attention in this regard because of their ability to process and store data at the same ***,fundamental problems with abrupt switching characteristics limit their practical *** address this problem,we utilized the concept of metaplasticity inspired by biosystems and observed gradual switching in the peptide-based memristor at high proton *** unexpectedly high slope value>1.7 in the logI–V curve at low voltage(≤400 mV)was considered the main origin,and it might arise from the modulatory response of proton ions on the threshold of Ag ion migration in the peptide *** the obtained gradual switching property at high proton conductivity,the device showed significantly increased accuracy of image recognition(~82.5%).We believe that such a demonstration not only contributes to the practical application of neuromorphic devices but also expands the bioinspired functional synthetic platform.

关键词： artificial synapse neuromorphic computing proton conductor peptide materials artificial neural network