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Neural plasticity secondary to carpal tunnel syndrome: a pseudo-continuous arterial spin labeling study

Neural Regeneration Research 2021年第1期16卷 158-165页

作者： Xue Deng Phoebe Lai-Heung Chau Suk-Yee Chiu kwok-pui leung Yong Hu Wing-Yuk Ip Department of Orthopedics&Traumatology The University of Hong KongHong Kong Special Administrative RegionChina Clinical Neuro-diagnostic Unit Tung Wah HospitalHong Kong Special Administrative RegionChina Department of Medicine The University of Hong KongHong Kong Special Administrative RegionChina

Conventional neuroimaging techniques cannot truly reflect the change of regional cerebral blood flow in patients with carpal tunnel ***-continuous arterial spinning labeling(pCASL)as an efficient non-invasive neuroimaging technique can be applied to directly quantify the neuronal activities of individual brain regions that show the persistent symptoms owing to its better spatial resolution and increased signal-to-noise ***,this prospective observational study was conducted in 27 eligible female carpal tunnel syndrome,aged 57.7±6.51 *** tests,nerve conduction studies and pCASL neuroimaging assessment were *** results showed that the relevant activated brain regions in the cortical,subcrotical,and cerebral regions were correlated with numbness,pain,functionality,median nerve status and motor amplitude of median nerve(K=21–2849,r=–0.77–0.76,P<0.05).There was a tendency of pain processing which shifted from the nociceptive circuitry to the emotional and cognitive one during the process of chronic pain caused by carpal tunnel *** suggests the necessity of addressing the ignored cognitive or emotional state when managing patients with carpal tunnel *** for this study was obtained from the Institutional Review Board of The University of Hong Kong/Hospital Authority Hong Kong West,China(HKU/HA HKW IRB,approval ***17-129)on April 11,*** study was registered in Clinical Trial Registry of The University of Hong Kong,China(registration number:HKUCTR-2220)on April 24,2017.

关键词： Boston carpal tunnel questionnaire carpal tunnel syndrome cognitive nerve conduction studies pain principal component analysis pseudo-continuous arterial spin labeling

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Exploratory use of ultrasound to determine whether demyelination following carpal tunnel syndrome co-exists with axonal degeneration

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Neural Regeneration Research 2018年第2期13卷 317-323页

作者： Xue Deng Lai-Heung Phoebe Chau Suk-Yee Chiu kwok-pui leung Sheung-Wai Li Wing-Yuk Ip Department of Orthopedics & Traumatology The University of Hong Kong Clinical Electro-diagnostic Unit Tung Wah Hospital Department of Medicine The University of Hong Kong

Carpal tunnel syndrome （CTS） accompanied by secondary axonal degeneration cannot be clearly dis- criminated using the current cross-validated ultrasound severity classification system. This study aimed at exploring cut-off values of ultrasound parameters, including wrist cross-sectional area （W-CSA）, wrist perimeter （W-P）, ratio of cross-sectional area （R-CSA） and perimeter （R-P）, changes of CSA and P from wrist to one third distal forearm （△CSA＆AP） for differentiation. Seventy-three patients （13 male and 60 female） were assigned into group A （demyelination only, n = 40） and group B （demyelination with secondary axonal degeneration, n = 33） based on the outcomes of nerve conduction studies （NCS）. Receiver Operative Characteristics （ROC） curves were plotted to obtain sensitivity, specificity, and accuracy of cut- off values for all the ultrasound parameters. The overall identified cut-off values （W-CSA 12.0 mm2, W-P 16.27 mm, R-CSA 1.85, R-P 1.48, △CSA 6.98 mm2, △P 5.77 mm） had good sensitivity （77.1-88.6%）, fair specificity （40-62.2%） and fair-to-good accuracy （0.676-0.758）. There were also significant differences in demographics （age and severity gradation, P 〈 0.001）, NCS findings （wrist motor latency and conduction velocity, P 〈 0.0001; wrist motor amplitude, P 〈 0.05; distal sensory latency, P 〈 0.05; sensory amplitude, P 〈 0.001） and ultrasound measurements （W-CSA, W-P, R-CSA, R-P, △CSA＆△P, P 〈 0.05） between groups. These findings suggest that ultrasound can be potentially used to differentiate demyelinating CTS with sec- ondary axonal degeneration and provide better treatment guidance.

关键词： carpal tunnel syndrome nerve conduction studies ultrasound receiver operating characteristic curve peripheral nerve compression injury ultrasonography neural conduction axonal degeneration neural regeneration

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Erlotinib combination with a mitochondria-targeted ubiquinone effectively suppresses pancreatic cancer cell survival

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World Journal of Gastroenterology 2024年第7期30卷 714-726页

作者： pui-Yin leung Wenjing Chen Anissa N Sari Poojitha Sitaram pui-Kei Wu Susan Tsai Jong-In Park Department of Biochemistry Medical College of WisconsinMilwaukeeWI 53226United States Department of Surgery Medical College of WisconsinMilwaukeeWI 53226United States

BACKGROUND Pancreatic cancer is a leading cause of cancer-related *** activity of the epidermal growth factor receptor(EGFR)is often observed in pancreatic cancer,and the small molecule EGFR inhibitor erlotinib has been approved for pancreatic cancer therapy by the food and drug ***,erlotinib alone is ineffective and should be combined with other drugs to improve therapeutic *** previously showed that certain receptor tyrosine kinase inhibitors can increase mitochondrial membrane potential(Δψm),facilitate tumor cell uptake ofΔψm-sensitive agents,disrupt mitochondrial homeostasis,and subsequently trigger tumor cell *** has not been tested for this *** To determine whether erlotinib can elevateΔψm and increase tumor cell uptake ofΔψm-sensitive agents,subsequently triggering tumor cell ***Δψm-sensitive fluorescent dye was used to determine how erlotinib affectsΔψm in pancreatic adenocarcinoma(PDAC)cell *** viability of conventional and patient-derived primary PDAC cell lines in 2D-and 3D cultures was measured after treating cells sequentially with erlotinib and mitochondria-targeted ubiquinone(MitoQ),aΔψm-sensitive *** synergy between erlotinib and MitoQ was then analyzed using SynergyFinder *** preclinical efficacy of the twodrug combination was determined using immune-compromised nude mice bearing PDAC cell line *** Erlotinib elevatedΔψm in PDAC cells,facilitating tumor cell uptake and mitochondrial enrichment ofΔψm-sensitive *** triggered caspase-dependent apoptosis in PDAC cells in culture if used at high doses,while erlotinib pretreatment potentiated low doses of *** suggested that these drugs synergistically induced tumor cell *** with in vitro data,erlotinib and MitoQ combination suppressed human PDAC cell line xenografts in mice more effectively than single treatments of each *** Our findings suggest tha

关键词： Pancreatic cancer Erlotinib Mitochondria-targeted ubiquinone Mitochondria Combination therapy

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Cellular zinc metabolism and zinc signaling:from biological functions to diseases and therapeutic targets

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Signal Transduction and Targeted Therapy 2024年第2期9卷 401-441页

作者： Bonan Chen Peiyao Yu Wai Nok Chan Fuda Xie Yigan Zhang Li Liang Kam Tong leung kwok Wai Lo Jun Yu Gary M.K.Tse Wei Kang Ka Fai To Department of Anatomical and Cellular Pathology State Key Laboratory of Translational OncologyPrince of Wales HospitalThe Chinese University of Hong KongHong KongChina State Key Laboratory of Digestive Disease Institute of Digestive DiseaseThe Chinese University of Hong KongHong KongChina CUHK-Shenzhen Research Institute The Chinese University of Hong KongShenzhenChina Department of Pathology Nanfang Hospital and Basic Medical CollegeSouthern Medical UniversityGuangdong Province Key Laboratory of Molecular Tumor PathologyGuangzhouChina Institute of Biomedical Research Taihe HospitalHubei University of MedicineShiyanChina Department of Pediatrics The Chinese University of Hong KongHong KongChina Department of Medicine and Therapeutics The Chinese University of Hong KongHong KongChina

Zinc metabolism at the cellular level is critical for many biological processes in the body.A key observation is the disruption of cellular homeostasis,often coinciding with disease *** an essential factor in maintaining cellular equilibrium,cellular zinc has been increasingly spotlighted in the context of disease *** research suggests zinc’s involvement in promoting malignancy and invasion in cancer cells,despite its low tissue *** has led to a growing body of literature investigating zinc’s cellular metabolism,particularly the functions of zinc transporters and storage mechanisms during cancer *** transportation is under the control of two major transporter families:SLC30(ZnT)for the excretion of zinc and SLC39(ZIP)for the zinc ***,the storage of this essential element is predominantly mediated by metallothioneins(MTs).This review consolidates knowledge on the critical functions of cellular zinc signaling and underscores potential molecular pathways linking zinc metabolism to disease progression,with a special focus on *** also compile a summary of clinical trials involving zinc *** the main localization of zinc transporters at the cell membrane,the potential for targeted therapies,including small molecules and monoclonal antibodies,offers promising avenues for future exploration.

关键词： metabolism invasion involvement

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Immunomodulatory Effects of Esculetin(6,7-Dihydroxycoumarin)on Murine Lymphocytes and Peritoneal Macrophages

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Cellular & Molecular Immunology 2005年第3期2卷 181-188页

作者： kwok-nam leung Dr.kwok-nam leung pui-yinleung Lai-pingKong Po-kileung Department of Biochemistry The Chinese University of Hong KongShatinHong KongChina Corresponding Department of Biochemistry The Chinese University of Hong KongShatinHong KongChina.

Coumarins belong to a diverse group of naturally occurring non-nutrient phytochemicals known as benzo-α- pyrones. In this study, esculetin, a 6,7-dihydroxy derivative of coumarin with pleiotropic biological activities, was found to have no significant cytotoxic effect on normal murine macrophages, but it could increase the in vivo migration of the thioglycollate-elicited macrophages in a dose-dependent manner. Moreover, esculetin significantly increased the endocytic activity, and augmented the nitric oxide production and iNOS gene expression in LPS-treated macrophages. In addition, in vivo administration of esculetin into mice was shown to increase the mitogenesis of splenic lymphocytes towards Con A and LPS stimulations, and induced the LAK activity of splenic lymphocytes. Collectively, our results indicate that esculetin could exert immunomodulatory effects on murine macrophages and lymphocytes, both in vitro and in vivo, and this might be one of the possible mechanisms by which coumarins can exert their chemopreventive and anti-tumor activities in vivo. Cellular ＆ Molecular Immunology. 2005;2（3）： 181-188.

关键词： immunomodulatory esculetin coumarin murine macrophage LAK cell

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Genomics-driven derivatization of the bioactive fungal sesterterpenoid variecolin:Creation of an unnatural analogue with improved anticancer properties

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Acta Pharmaceutica Sinica B 2024年第1期14卷 421-432页

作者： Dexiu Yan Jemma Arakelyan Teng Wan Ritvik Raina Tsz Ki Chan Dohyun Ahn Vladimir Kushnarev Tsz Kiu Cheung Ho Ching Chan Inseo Choi pui Yi Ho Feijun Hu Yujeong Kim Hill Lam Lau Ying Lo Law Chi Seng leung Chun Yin Tong Kai Kap Wong Wing Lam Yim Nikolay S.Karnaukhov Richard Y.C.Kong Maria V.Babak Yudai Matsuda Department of Chemistry City University of Hong KongHong Kong SARChina iGEM Team“VarieCure” City University of Hong KongHong Kong SARChina Department of Biomedical Engineering City University of Hong KongHong Kong SARChina Moscow Clinical Research Center Named After A.S.Loginov Moscow 111123Russian Federation

A biosynthetic gene cluster for the bioactive fungal sesterterpenoids variecolin(1)and variecolactone(2)was identified in Aspergillus aculeatus ATCC *** production of 1 and 2 was achieved in Aspergillus oryzae by expressing the sesterterpene synthase VrcA and the cytochrome P450 ***,the replacement of VrcB with homologous P450s from other fungal terpenoid pathways yielded three new variecolin analogues(5-7).Analysis of the compounds’anticancer activity in vitro and in vivo revealed that although 5 and 1 had comparable activities,5 was associated with significantly reduced toxic side effects in cancer-bearing mice,indicating its potentially broader therapeutic *** study describes the first tests of variecolin and its analogues in animals and demonstrates the utility of synthetic biology for creating molecules with improved biological activities.

关键词： Animal studies Anticancer properties Biosynthesis Natural products Sesterterpenoids Synthetic biology Terpene synthases Variecolin

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Glial cells and glaucomatous neuropathy

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Chinese Medical Journal 2007年第4期120卷 326-335页

作者： ZHONG Yi-sheng Christopher Kai-shun leung Chi-pui Pang Department of Ophthalmology Ruijin Hospital Shanghai JiaotongUniversity Shanghai 200025 China Department of-Ophthalmology and Visual Sciences ChineseUniversity of Hong Kong Hong Kong China

Glaucomatous optic neuropathy is characterized by progressive loss of retinal ganglion cells associated with visual functional deficits. As the ganglion cells die in glaucoma, there is a progressive thinning of the nerve fibre layer （NFL）.l The underlying pathophysiological mechanisms, however, remain unclear. Many mechanisms are involved in the initiation and process of irreversible ganglionic cell death in glaucoma. These include reduced axoplasmic transport, accumulation of toxic levels of neurotransmitter, increased nitric oxide and endothelin syntheses, and remodelling of the extracellular matrix, among others.

关键词： OPTIC-NERVE HEAD RETINAL GANGLION-CELLS NITRIC-OXIDE SYNTHASE NECROSIS-FACTOR-ALPHA OPEN-ANGLE GLAUCOMA CILIARY NEUROTROPHIC FACTOR ASTROCYTE PRECURSOR CELLS MULLER CELLS IN-VITRO REACTIVE ASTROCYTES

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Awareness and knowledge of hepatitis B infection and prevention and the use of hepatitis B vaccination in the Hong Kong adult Chinese population

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Chinese Medical Journal 2012年第3期125卷 422-427页

作者： Wah, Chung pui Hung, Suen Sik Ka, Chan Oi Hsi, Lao Tzu Yeung, leung Tak Chinese Univ Hong Kong Prince Wales Hosp Dept Obstet & Gynecol Shatin Hong Kong Peoples R China

Background Hepatitis B virus （HBV） infection remains a global public health problem and it is an important cause of acute,chronic and fulminant hepatitis,liver cirrhosis and hepatocellular *** prevalence of HBV infection in Hong Kong over the past decade remained unchanged at 10%,despite the implementation of universal neonatal and availability of adult *** suspect that the current state of affairs is attributable to inadequate awareness and knowledge of HBV transmission and prevention in the general population,resulting in a low rate of uptake of HBV vaccination by the lay ***,we have embarked in this study to evaluate the awareness and knowledge on HBV infection in our local Chinese population,their attitude on the prevention of horizontal transmission of HBV,and the use of HBV vaccination,especially in those who were born before the era of universal neonatal *** The factors associated with HBV screening,vaccination uptake,and knowledge were examined in a face-to-face questionnaire survey on a group of adult Chinese in Hong *** Within this group,14% was considered to have good knowledge for HBV infection,and 26% had HBV ***,occupation,having children,and family monthly income,are independent factors associated with *** This study suggests insufficient public awareness of HBV infection in the Hong Kong Adult Chinese population.

关键词： hepatitis B infection prevention awareness Hong Kong

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Clinical features and treatment outcomes of endogenous Klebsiella endophthalmitis:a 12-year review

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International Journal of Ophthalmology(English edition) 2020年第12期13卷 1933-1940页

作者： Chun Yue Mak Mary Ho Lawrence pui-leung Iu Helena pui-yee Sin Li Jia Chen Grace Lui Marten Erik Brelen Alvin Lerrmann Young Department of Ophthalmology and Visual Sciences Prince of Wales HospitalNew TerritoriesHong KongChina Department of Ophthalmology and Visual Sciences the Chinese University of Hong KongNew TerritoriesHong KongChina Division of Infectious Diseases Department of Medicine and Therapeuticsthe Chinese University of Hong KongNew TerritoriesHong KongChina

AIM:To identify the clinical features and treatment outcomes of endogenous Klebsiella pneumoniae endophthalmitis and investigate prognostic factors of poor visual ***:The clinical records of all patients diagnosed with endogenous Klebsiella endophthalmitis between January 2007 to December 2018 in Prince of Wales Hospital,Hong Kong,China were retrospectively *** ophthalmological examination findings were recorded in the case note,including visual acuity testing,slit-lamp examination,indirect ophthalmoscopy and B-scan ultrasonography if media opacity precluded fundus ***:A total of 18 eyes in 14 patients were *** involvement was noted in 4 patients(28.6%).Hepatobiliary sepsis was the source in 9 patients(64.3%).Culture of intraocular fluid was positive in 5 out of 18 eyes(27.8%).Mortality was noted in 2 patients(14.3%).Mean final visual acuity was 20/*** out of 16 eyes had total loss of sight(37.5%)and 3 eyes required evisceration(18.8%).Multivariate linear regression revealed poor presenting visual acuity(P=0.031)and lack of fundus view due to vitritis(P=0.02)as prognostic factors of poor visual ***:Visual outcome of endogenous Klebsiella endophthalmitis is *** presenting visual acuity and lack of fundus view predict poor visual *** index of suspicion for endophthalmitis is important in Klebsiella sepsis patients with complaints of ocular *** screening is recommended in noncommunicable patients with Klebsiella sepsis.

关键词： Klebsiella pneumoniae endogenous endophthalmitis screening liver abscess sepsis

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Traditional Chinese medicine poisoning in the emergency departments in Hong Kong: Trend, clinical presentation and predictors for poor outcome

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World Journal of Emergency Medicine 2021年第2期12卷 143-150页

作者： Rex pui Kin Lam Eric Ho Yin Lau Wai Lam Yip Joe Kai Shing leung Matthew Sik Hon Tsui Emergency Medicine Unit Li Ka Shing Faculty of Medicinethe University of Hong KongHong KongChina Accident and Emergency Department Queen Mary HospitalHong KongChina Accident and Emergency Department Pamela Youde Nethersole Eastern HospitalHong KongChina School of Public Health Li Ka Shing Faculty of Medicinethe University of Hong KongHong KongChina

Dear editor,Traditional Chinese medicine (TCM) is popular in many countries,especially in the Chinese population.^([1,2]) In Hong Kong,it has been estimated that around 15%of the population consumed Chinese medicine products/herbs in the preceding *** reasons for consumption include regulating bodily functions,curing disease,and building up health.

关键词： has editor curing

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