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Incidence and predictors of upper gastrointestinal bleeding in patients receiving low-dose aspirin for secondary prevention of cardiovascular events in patients with coronary artery disease

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World Journal of Gastroenterology 2006年第18期12卷 2923-2927页

作者： William Ng Wai-Man Wong Wai-Hong Chen Hung-Fat Tse Pui-Yin Lee Kam-Chuen Lai Sheung-Wai Li Matthew Ng kwok-fai lam Xi Cheng Chu-Pak Lau Division of Cardiology University Department of Medicine Queen Mary Hospital Hong Kong SAR China Division of Gastroenterology University Department of Medicine Queen Mary Hospital Hong Kong SAR China Division of Rehabilitation Medicine University Department of Medicine Queen Mary Hospital Hong Kong SAR China Department of Statistics and Actuarial Science University of Hong Kong Hong Kong SAR China

AIM： The use of low-dose aspirin to prevent cardiovascular disease events is well established. However, the incidence and predictors of upper gastrointestinal bleeding （UGIB） with its use are unknown. We studied prospectively the incidence and outcome of peptic ulceration in low-dose aspirin users. METHODS： A total of 991 patients with coronary artery disease （CAD） on low-dose aspirin were prospectively followed-up for two years for the occurrence and clinical features of first hospitalized episode of UGIB. RESULTS： UGIB had a bimodal presentation with 45% occurring within four months of aspirin initiation and had an overall prevalence of 1.5% per year. There was no UGIB-related death. Hypertension （OR = 4.6, 95%CI 1.5 - 14.7, P = 0.009）, history of peptic ulceration （OR = 3.1, 95%CI 1.1 - 9.0, P = 0.039）, tertiary education （OR = 3.08, 95%CI 1.1 - 9.0, P = 0.039） and higher lean body mass （P = 0.016） were independent factors associated with UGIB. Use of nitrate did not reduce UGIB. CONCLUSION： The incidence of UGIB in patients with CAD on long-term low-dose aspirin is low, but is accompanied with significant morbidity. With prolonged use of aspirin, UGIB continues to be a problem for those with risk factors and especially in patients with a history of peptic ulcers, in which UGIB tends to occur early after aspirin therapy.

关键词： Coronary artery disease, Aspidn Gastrointestinal bleeding

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医疗卫生体系改革、针对医生的暴力伤害以及医务人员的工作满意度：中国东部地区浙江省的一项横断面调查

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英国医学杂志中文版 2015年第10期18卷 574-581页

作者： Dan Wu Yun Wang kwok fai lam Therese Hesketh 陈钟鸣肖月香港大学医学院家庭卫生和初级卫生保健学系香港大学社会科学学院自杀研究与预防中心香港大学社会科学学院统计与保险科学系伦敦大学学院全球卫生学会潍坊医学院管理学院国家卫生计生委卫生发展研究中心卫生政策与技术评估研究中心

目的研究新医疗卫生体系改革和医患关系恶化背景下医生工作满意度及士气的影响因素。设计运用自行设计的调查问卷进行横断面调查。地点调查开展于2012年3-5月，主要调查对象是中国浙江省的省级和县级医院以及基层医疗卫生机构。结果共调... 详细信息

目的研究新医疗卫生体系改革和医患关系恶化背景下医生工作满意度及士气的影响因素。设计运用自行设计的调查问卷进行横断面调查。地点调查开展于2012年3-5月，主要调查对象是中国浙江省的省级和县级医院以及基层医疗卫生机构。结果共调查202名医生。导致工作满意度低的主要原因是收入低、工作时间长。省级医院医生的满意度最低，基层医疗卫生机构医生的满意度最高。3％的医院医生以及27％的基层医疗卫生机构医生对工资满意。医院中仅有7％的医生对工作时间满意，基层医疗卫生机构中43％的医生对工作时间满意。医院只有不到10％的医生对带薪休假时间（3％）和带薪病假时间满意（5％），而基层医疗卫生机构人员对这两项的满意度则分别为38％和41％。总体而言，87％的医生表示患者投诉的可能性比以前更高了，针对医生的暴力事件不断增加。仅有4．5％的医生愿意自己的子女成为医生，在125个提供原因的医生中，34％表示因为收入太低，17％表示因为职业风险太高，9％考虑到患者暴力威胁和人身安全问题。结论总体而言医生的工作满意度较低。医生的招聘与保持成为中国医疗卫生系统的重大挑战。应采取相应的应对策略，以保障将来医生的招聘与保持。具体措施包括：减少医生的工作量，尤其是省级医院医生的工作量，可以通过鼓励患者到基层医疗卫生机构就诊来实现。提高医生工资以及有效的处理患者对医生的暴力伤害。

关键词：工作满意度体制改革医疗卫生暴力行为医疗行业横截面医生浙江

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A decomposition analysis to examine the change in the number of recipients in the comprehensive social security assistance(CSSA)system

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China Population and Development Studies 2021年第1期4卷 284-297页

作者： Paul Yip Milton Chan B.K.So K.P.Wat kwok fai lam Social Work and Social Administration The University of Hong KongHong Kong SARPeople’s Republic of China Center for Suicide Research and Prevention The University of Hong KongHong Kong SARPeople’s Republic of China Department of Mathematics Jilin UniversityChangChunPeople’s Republic of China Department of Statistics and Actuarial Science The University of Hong KongHong Kong SARPeople’s Republic of China

Social security is an important social and public policy measure to help address poverty in any contemporary *** Comprehensive Social Security Assistance(CSSA)system in Hong Kong provides a safety net for those aged children and adults below 65 years old who cannot support themselves *** is designed to bring their income up to a prescribed level to meet their basic *** rapid increase in social welfare expenditure in the last decade has become a concern to the Hong Kong SAR *** overall social welfare expenditure has accounted for nearly 15.6%of government expenditure in 2018,with the total amount increasing from$58 billion to$90 billion(an increase of 72.4%)for the period ***,the amount spent on CSSA only increased from$20.7 billion to$22.3 billion with an increase of 7.7%only for the same *** much slower magnitude of increase is related to the reduction in the number of CSSA recipients,which decreased from 237,501 to 185,528 over the period.A decomposition method was used to assess the changes in the number of people in the CSSA *** showed that the rate of arriving into the system has been decreasing due to a robust economy with a very low unemployment rate;whereas moving out of the system has also been decreasing in the past 5 *** phenomenon can be partly attributed to the widening of the income gap in the community in the *** the increase in population size,as long as employment conditions remain strong and the momentum of leaving the system can be maintained,the number of CSSA recipients will continue to ***,the results also suggested that a certain proportion of CSSA recipients will not be able to move out of the system and have been *** innovative methods to help them out of CSSA are *** view of the poor economic outlook arising from the COVID-19 pandemic,it is important for the Government to have effective measures to keep people in their *** the

关键词： Comprehensive Social Security Assistance(CSSA)system Social security Decomposition analysis

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A prospective cohort of men with localized prostate cancer on active surveillance protocol in Hong Kong,China:what did we learn?

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Asian Journal of Andrology 2024年第3期26卷 245-249页

作者： Xiaobo Wu Ivan Ching-Ho Ko Cindy Yeuk-lam Hong Samuel Chi-Hang Yee Jeremy Yuen-Chun Teoh Samson Yun-Sang Chan Ho-Man Tam Chi-kwok Chan Chi-fai Ng Peter Ka-Fung Chiu SH Ho Urology Centre Department of SurgeryFaculty of MedicineThe Chinese University of Hong KongHong KongChina

This study aimed to report the outcomes of active surveillance(AS)in the management of low-risk prostate cancer(PCa).It recruited87 men who were prospectively followed up according to the Prostate Cancer Research International Active Surveillance(PRIAS)protocol with local adaptation at SH Ho Urology Centre,Prince of Wales Hospital,Hong Kong,*** investigated the predictorsof disease progression and found that baseline prostate-specific antigen density(PSAD)and the presence of the highest ProstateImaging-Reporting and Data System(PI-RADS)score 5 lesion on magnetic resonance imaging(MRI)are significantly correlatedwith disease ***,men with PSAD>0.2 ng ml^(−2)or PI-RADS 4 or 5 lesions had significantly worse upgradingfree survival compared to those with PSAD≤0.2 ng ml−2 and PI-RADS 2 or 3 *** study concludes that AS is a safe andeffective management strategy for selected patients to defer radical treatment and that most disease progression can be detectedafter the first repeated *** combination of PSAD>0.2 ng ml^(−2)and PI-RADS 4 or 5 lesions may serve as a useful predictorof early disease progression and provide a guide to optimize follow-up protocols for men in different risk groups.

关键词： active surveillance cohort localized prostate cancer

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Ferroptosis and glaucoma: implications in retinal ganglion cell damage and optic nerve survival

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Neural Regeneration Research 2023年第3期18卷 545-546页

作者： Ming Yang kwok-fai So Wai-Ching lam Amy Cheuk Yin Lo Department of Ophthalmology School of Clinical MedicineLi Ka Shing Faculty of MedicineThe University of Hong KongHong Kong Special Administrative RegionChina State Key Laboratory of Brain and Cognitive Sciences The University of Hong KongHong Kong Special Administrative RegionChina GHM Institute of CNS Regeneration Jinan UniversityGuangzhouGuangdong ProvinceChina

Glaucoma and visual pathway degeneration:Glaucoma is the leading cause of irreversible blindness worldwide,which leads to a progressive loss of *** can be classified into two types:primary open-angle glaucoma and primary closed-angle *** open-angle glaucoma can be caused by the blockage of the trabecular meshwork,and this results in elevation of the intraocular pressure(IOP),leading to retinal ganglion cell(RGC)***,many glaucoma patients have normal IOP;this is known as normal-tension ***,excitotoxic damage and oxidative stress can also lead to RGC damage in normal-tension glaucoma(Almasieh et al.,2012).Glaucomatous genes such as TIGR,OPTN,and CYP1B1 have been suggested to contribute to the pathogenesis of ***,some glaucomatous patients may remain asymptomatic in the early,moderate,and late *** type of glaucoma is primary closed-angle *** this clinical condition,a relative pupillary block is contributed by the iris obstructing aqueous *** patients may suffer from corneal swelling,headache,nausea,and blurred vision during the acute phase.

关键词： glaucoma damage degeneration

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Multiomics approaches to uncover endometrial receptivity in embryo implantation:a mini-review

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Reproductive and Developmental Medicine 2024年第3期8卷 178-185页

作者： Sudini R.Fernando Yang Yan Manish Kumar Hoi-lam Lai Yin-Lau Lee Ernest H.Y.Ng William S.B.Yeung Kai-fai Lee Department of Obstetrics and Gynaecology Li Ka Shing Faculty of MedicineThe University of Hong KongPokfulamHong Kong SAR 999077China Department of Animal Science Faculty of Animal Science and Export AgricultureUva Wellassa UniversityBadullaSri Lanka Shenzhen Key Laboratory of Fertility Regulation The University of Hong Kong-Shenzhen HospitalFutian DistrictShenzhen 518053China

Successful implantation requires concerted interactions during the apposition,adhesion,and invasion of the embryo into a receptive ***,the embryo implantation rate for assisted reproduction remains low despite the transfer of good quality *** in endometrial transcriptomics,proteomics,lipidomics,and even microbiota all play important roles in embryo ***,the expression of steroid hormone-regulated adhesive and anti-adhesive molecules during the embryo implantation window is becoming an area of increasingly intense *** review(a)summarizes the different molecules expressed in the receptive endometrium and(b)proposes the use of surface protein markers to predict pregnancy outcomes from assisted reproduction.

关键词： Cell surface proteins Steroid regulation Endometrial receptivity Receptivity marker Infertility

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Acupuncture improves cognitive function A systematic review

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Neural Regeneration Research 2013年第18期8卷 1673-1684页

作者： Mason Chin Pang Leung Ka Keung Yip Chung Tsung lam Ka Shun lam Wai Lau Wing lam Yu Amethyst King Man Leung kwok-fai So Department of Rehabilitation Sciences the Hong Kong Polytechnic University Cambridge Regional College Department of Anatomy and the State Key Laboratory of Brain and Cognitive Science the University of Hong Kong Pokfulam Hong Kong Special Administrative Region China GHM Institute of CNS Regeneration Jinan University

BACKGROUND： Acupuncture has been used as a treatment for cognitive impairment. OBJECTIVE： This review assesses clinical evidence for or against acupuncture as a treatment for cognitive impairment. This review also discusses the proposed mechanism（s） that could link acupuncture to improved cognitive function. METHODS： We searched the literature using PolyUone search from its inception to January 2013, with full text available and language limited to English. Levels of evidence were examined using Oxford Centre for Evidence-based Medicine-Levels of Evidence （March, 2009）. RESULTS： Twelve studies met the inclusion criteria： 3 human studies and 9 animal studies. Levels of evidence ranged from level lb to level 5. CONCLUSION： Most animal studies demonstrated a positive effect of acupuncture on cognitive impairment. However, the results of human studies were inconsistent. Further high-quality human studies with greater statistical power are needed to determine the effectiveness of acupuncture and an optimal protocol.

关键词： neural regeneration dementia acupuncture electroacupuncture learning cognitive cognition memory neuroregeneration

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A Uniformly Robust Staggered DG Method for the Unsteady Darcy-Forchheimer-Brinkman Problem

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Communications on Applied Mathematics and Computation 2022年第1期4卷 205-226页

作者： Lina Zhao Ming fai lam Eric Chung Department of Mathematics The Chinese University of Hong KongHong Kong SARChina

In this paper,we propose and analyze a uniformly robust staggered DG method for the unsteady Darcy-Forchheimer-Brinkman *** formulation is based on velocity gradient-velocity-pressure and the resulting scheme can be flexibly applied to fairly general polygonal *** relax the tangential continuity for velocity,which is the key ingredi-ent in achieving the uniform *** present well-posedness and error analysis for both the semi-discrete scheme and the fully discrete scheme,and the theories indicate that the error estimates for velocity are independent of *** numerical experiments are presented to confirm the theoretical findings.

关键词： Staggered DG method Brinkman-Forchheimer General meshes Uniformly stable

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Late retroperitoneal recurrence of hepatocellular carcinoma 12 years after initial diagnosis

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World Journal of Gastroenterology 2010年第17期16卷 2187-2189页

作者： Tiffany Cho-lam Wong Ka-fai To Simon See-Ming Hou Sidney Kam-Hung Yip Chi-fai Ng Department of Surgery Prince of Wales HospitalThe Chinese University of Hong Kong Department of Anatomical and Cellular Pathology The Chinese University of Hong Kong

Hepatocellular carcinoma (HCC) is an aggressive tumor with poor long-term ***,we present an unusual patient with a solitary recurrence of HCC in the right kidney 12 years after the initial *** illustrates the importan... 详细信息

关键词： Hepatocellular carcinoma Late recurrence Metastasis Retroperitoneal

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Effect of Scutellariae Radix extract on experimental dextran-sulfate sodium-induced colitis in rats

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World Journal of Gastroenterology 2007年第42期13卷 5605-5611页

作者： Ho-lam Chung Grace Gar-Lee Yue Ka-fai To Ya-Lun Su Yu Huang Wing-Hung Ko Department of Physiology Faculty of MedicineThe Chinese University of Hong Kong Shatin Hong Kong China Institute of Chinese Medicine The ChineseUniversity of Hong Kong Shatin Hong Kong China Department of Anatomical and Cellular Pathology Faculty of Medicine The Chinese University of Hong KongShatin Hong Kong China Institute of Materia Medica Chinese Academy ofMedical Sciences and Peking Union Medical College Beijing100050 China Department of Physiology and LiKa Shing Institute of Health Sciences Faculty of Medicine TheChinese University of Hong Kong Shatin Hong Kong China

AIM： To investigate the effect of Scutellariae Radix extract （SRE） on ulcerative colitis （UC） in rats induced by dextran-sulfate sodium （DSS）. METHODS： Colitis was induced in male Sprague-Dawley （SD） rats （170-180 g） by 4% dextran sulfate sodium （DSS, wt/v, MW 54000） in drinking water for 8 d. The treated rats received 4% DSS and SRE orally （100 mg/kg per day）. Control rats received either tap water or SRE only. Macroscopic assessment which included body weight changes, fecal occult blood and stool consistency were determined daily. At the appointed time, the rats were sacrificed and the entire colons were removed. The colon length and the myeloperoxidase （MPO） activity were measured. The severity of colitis was graded by morphological and histological assessments. The ion transport activity of the colonic mucosa was assessed by electrophysiological technique. RESULTS： Rats treated with oral administration of 4% DSS regularly developed clinical and macroscopic signs of colitis. Treatment with SRE relieved the symptoms, including the reduction in body weight, shortening 2nd ulceration of the colon. Administration of SRE also significantly reduced the histological damage induced by DSS. Moreover, the Isc responses of the colonic mucosa to forskolin, were suppressed after the induction of colitis. The stimulated ion transport activity of DSS-rats treated with SRE displayed significant improvement in the secretory responsiveness. CONCLUSION： SRE was effective in treating acute DSS- induced ulcerative colitis, as gauged by reduced clinical disease, improved macroscopic and histological damage scores, and enhanced recovery of normal colonic secretory function.

关键词： Ulcerative colitis Scutellariae Radix Inflammatory bowel disease Colonic ion transport Traditional Chinese medicine

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