检索结果-南通市图书馆

Monogenic features of urolithiasis: A comprehensive review

Asian Journal of Urology 2024年第2期11卷 169-179页

作者： Kyo Chul Koo Abdulghafour Halawani Victor K.F.wong Dirk Lange Ben H.Chew Department of Urology Yonsei University College of MedicineSeoulRepublic of Korea Department of Urology King Abdulaziz UniversityJeddahSaudi Arabia Department of Urological Sciences University of British ColumbiaStone Centre at Vancouver General HospitalVancouverBritish ColumbiaCanada

Objective: Urolithiasis formation has been attributed to environmental and dietary factors. However, evidence is accumulating that genetic background can contribute to urolithiasis formation. Advancements in the identification of monogenic causes using high-throughput sequencing technologies have shown that urolithiasis has a strong heritable ***: This review describes monogenic factors implicated in a genetic predisposition to urolithiasis. Peer-reviewed journals were evaluated by a PubMed search until July 2023 to summarize disorders associated with monogenic traits, and discuss clinical implications of identification of patients genetically susceptible to urolithiasis ***: Given that more than 80% of urolithiases cases are associated with calcium accumulation, studies have focused mainly on monogenetic contributors to hypercalciuric urolithiases, leading to the identification of receptors, channels, and transporters involved in the regulation of calcium renal tubular reabsorption. Nevertheless, available candidate genes and linkage methods have a low resolution for evaluation of the effects of genetic components versus those of environmental, dietary, and hormonal factors, and genotypes remain undetermined in the majority of urolithiasis ***: The pathophysiology underlying urolithiasis formation is complex and multifactorial, but evidence strongly suggests the existence of numerous monogenic causes of urolithiasis in humans.

关键词： Gene Genetic expression Inheritance pattern Urolithiasis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cascade Catalysts Based on Colloidal Engineering

引用

CCS Chemistry 2024年第9期6卷 2150-2161页

作者： Chen Chen Chin Ken wong Hui Chen Nicole Janoszka Giada Quintieri AndréH.Gröschel School of Chemistry and Chemical Engineering Shanghai Jiao Tong University200240 Shanghai School of Chemistry University of New South Wales(UNSW)SydneySydney NSW 2052 Physical Chemistry and Center for Soft Nanoscience University of MünsterCorrensstraße 28-3048149 Münster

We see significant progress in the preparation of nanoreactors that host incompatible catalysts for cascade reactions,yet their preparation typically requires specialized,multistep synthetic ***,we utilize core-satellite microparticles as a versatile strategy for the site isolation of catalysts in core and *** core-satellite clusters are prepared by mixing specific amounts of negatively charged core microparticles(e.g.,acid catalyst)with positively charged satellites(e.g.,base catalyst).Core and satellite are made from incompatible polymers allowing solvent-annealing of clusters into different morphologies(raspberry,patchy,and core-shell)while maintaining site isolation of the *** core-satellite microparticles show very good catalytic activity in a model one-pot acid/base cascade reaction with subtle differences regarding particle *** microparticles thereby demonstrated the highest reaction rate and yield,likely due to an alleviated diffusion pathway for the ***,we show that this colloidal engineering strategy can be extended to multifunctional microparticles suitable to perform multistep cascade reactions in one pot.

关键词： cascade catalysts compartmentalization colloidal engineering emulsion polymerization multifunctional particles

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Sarcopenia and metabolic dysfunction associated steatotic liver disease:Time to address both

引用

World Journal of Hepatology 2024年第6期16卷 871-877页

作者： Rochelle wong Li-Yun Yuan Division of Gastrointestinal and Liver Diseases Keck School of Medicine of University of Southern CaliforniaLos AngelesCA 90033United States

Sarcopenia and metabolic dysfunction associated steatotic liver disease(MASLD)are closely ***,traditionally a disease of the older adult and chronic disease population,has been closely studied as one of the pathophysiologic conditions at play in the development of *** share similar risk factors of insulin resistance and physical *** similar pathophysiology along the liver-muscle axis,sarcopenia has been studied as a risk factor for MASLD,and vice *** research suggests a bidirectional *** the chronicity of MASLD as a chronic inflammatory liver disease,it can break down muscle mass and lead to sarcopenia,while sarcopenia promotes intramuscular lipid accumulation that releases cytokines that can aggravate inflammation in the ***,for the longest time,a lack of consensus definition for MASLD and sarcopenia made it difficult to study their relationship and outcomes.A recent nomenclature update to diagnosing MASLD has made it easier for researchers to identify cohorts for ***,no gold standard technique to measure muscle mass or consensus sarcopenia definition has been identified *** studies are needed to reach a consensus and reduce diagnostic *** similar pathophysiology and shared risk factors between the two diseases,future research may also identify potential therapeutic targets along the liver-muscle axis that would benefit both sarcopenia and MASLD in order to maximize their outcomes.

关键词： Sarcopenia Steatotic liver disease Metabolic dysfunction Insulin resistance Liver-muscle axis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Low phase noise K-band signal generation using polarization diverse single-soliton integrated microcombs

引用

Photonics Research 2024年第6期12卷 1175-1185页

作者： ALWALEED ALDHAFEERI HSIAO-HSUAN CHIN TRISTAN MELTON DONG IL LEE ALLEN CHU WENTING WANG MINGBIN YU PATRICK GUO-QIANG LO DIM-LEE Kwong CHEE WEI wong Fang Lu Mesoscopic Optics and Quantum Electronics Laboratory University of CaliforniaLos AngelesCalifornia 90095USA Institute of Microelectronics A*STARSingapore 117865Singapore State Key Laboratory of Functional Materials for Informatics Shanghai Institute of Microsystem and Information Technologyand Shanghai Industrial Technology Research InstituteShanghai 200050China

Frequency microcombs with microwave and millimeter-wave repetition rates provide a compact solution for coherent communication and information *** implementation of these microcombs using a CMOS-compatible platform further paves the way for large-scale photonic integration and ***,we demonstrate free-running soliton microcombs with K-band repetition rates with very low phase noise over a 4 GHz pump detuning range reaching−117(−123)dBc/Hz at 10 kHz offset for a 19.7(10)GHz carrier without active pump stabilization,exceeding commercial electronic microwave oscillators at frequency offsets above 40 *** minimum laser noise to soliton microwave signal transduction factor observed is−*** noise performance is achieved using a hybridized dual-mode for soliton generation to achieve passive thermal stabilization and minimal soliton spectrum shift from prior Raman scattering and dispersive wave *** further examine the locking of the repetition rate to an external ultrastable photonic oscillator to illustrate the feasibility of phase noise suppression below the thermorefractive noise limits of microresonator frequency combs.

关键词： pump polarization millimeter

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Solitary extraovarian primary peritoneal carcinoma with direct invasion into the liver,diaphragm and lung without peritoneal dissemination or distant metastasis

引用

Hepatobiliary & Pancreatic Diseases International 2024年第3期23卷 322-325页

作者： Billy Ho Hung Cheung wong Hoi She Siu Lun Ho Albert Chi Yan Chan Chung Mau Lo Tan To Cheung Department of Surgery The University of Hong KongHong KongChina Department of Pathology The University of Hong KongHong KongChina

To the Editor:Extraovarian primary peritoneal carcinoma(EOPPC)is an uncommon malignancy with many similarities to epithelial ovarian carcinoma in histological,clinical,and etiological aspects[1].This phenomenon is explained by their common embryonal origin,in which both develop from the coelomic epithelium in the early embryological *** their similarities,the incidence of EOPPC is significantly lower than that of epithelial ovarian carcinoma(6.78 cases per million vs.120.5 cases per million)[1].

关键词： peritoneal invasion metastasis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Indications of pro-inflammatory cytokines in laparoscopic and open liver resection for early-stage hepatocellular carcinoma

引用

Hepatobiliary & Pancreatic Diseases International 2024年第3期23卷 257-264页

作者： Kevin Tak-Pan Ng Li Pang Jia-Qi Wang wong Hoi She Simon Hing-Yin Tsang Chung Mau Lo Kwan Man Tan To Cheung Department of Surgery HKU-SZH&School of Clinical MedicineLi Ka Shing Faculty of MedicineThe University of Hong KongHong KongChina State Key Laboratory of Liver Research The University of Hong KongHong KongChina

Background:Our clinical practice of laparoscopic liver resection(LLR)had achieved better short-term and long-term benefits for patients with hepatocellular carcinoma(HCC)over open liver resection(OLR),but the underlying mechanisms are not *** study was to find out whether systemic inflammation plays an important ***:A total of 103 patients with early-stage HCC under liver resection were enrolled(LLR group,n=53;OLR group,n=50).The expression of 9 inflammatory cytokines in patients at preoperation,postoperative day 1(POD1)and POD7 was quantified by Luminex Multiplex *** relationships of the cytokines and the postoperative outcomes were compared between LLR and ***:Seven of the circulating cytokines were found to be significantly upregulated on POD1 after LLR or OLR compared to their preoperative *** to OLR,the POD1 levels of granulocytemacrophage colony-stimulating factor(GM-CSF),interleukin-6(IL-6),IL-8,and monocyte chemoattractant protein-1(MCP-1)in the LLR group were significantly *** POD1 levels of these cytokines were significantly correlated with longer operative time and higher volume of blood loss during *** levels of these cytokines were positively associated with postoperative liver injury,and the length of hospital ***,a high level of IL-6 at POD1 was a risk factor for HCC recurrence and poor disease-free survival after liver ***:Significantly lower level of GM-CSF,IL-6,IL-8,and MCP-1 after liver resection represented a milder systemic inflammation which might be an important mechanism to offer better short-term and long-term outcomes in LLR over OLR.

关键词： Laparoscopic liver resection Open liver resection Hepatocellular carcinoma Postoperative cytokines Inflammatory responses

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Letter from the Editor-in-Chief

引用

Neural Regeneration Research 2025年第1期20卷 5-5页

作者： kwok-Fai So Neural Regeneration Research

Greetings esteemed readers,As we embark on a new year filled with promise and innovation,it is my pleasure to reflect on the remarkable achievements and advancements in the journal Neural Regeneration Research(NRR)showcased throughout ***,the 2024 International Neural Regeneration Symposium(INRS2024)and the 15^(th) Asia Pacific Symposium on Neural Regeneration(APSNR),held from April 12^(th) to 14^(th) in Guangzhou,China,stand as shining examples of collaboration,knowledge exchange,and scientific excellence.

关键词： Regeneration filled journal

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

基于先进绝热压缩空气储能站的电-热综合能源系统优化运行方法

引用

电测与仪表 2024年第2期61卷 25-33页

作者：时帅刘杰米阳 kwok Lun Lo 林哲敏上海电力大学电气工程学院上海200090 斯特拉斯克莱德大学电子与电气工程系格拉斯哥安徽电力交易有限公司合肥230061

为加强先进绝热压缩空气储能(Advanced Adiabatic Compressed Air Energy Storage,AA-CAES)与综合能源系统(Integrated Energy Systems,IES)的多能互补协同,提高系统运行效率,文中提出了一种含AA-CAES能源站的电-热综合能源系统优化运行方法。构建了含AA-CAES能源站的IES基本调度架构,详细分析了AA-CAES装置在压缩和膨胀工况下的储热、换热及供热等特性,建立了AA-CAES电热联供联储运行模型;基于热网管道传热延迟和损耗等动态特性,建立了考虑供热网储热惯性的热网方程;在此基础上,考虑了用户侧可调度资源,提出了计及综合需求响应的含AA-CAES能源站的IES日前优化运行模型;在修改的IEEE 33节点配电网和巴厘岛32节点区域供热网进行算例分析。仿真结果表明,所提方法可有效降低IES运行成本,提高IES可再生能源消纳能力。

关键词：先进绝热压缩空气储能综合能源系统优化运行供热网储热可再生能源消纳

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

基于深度强化学习的RIS辅助通感融合网络:挑战与机遇

引用

电子与信息学报 2024年第9期46卷 3467-3473页

作者：陈真杜晓宇唐杰 wong Kat-Kit 香港城市大学电子工程系中国香港999077 华南理工大学电子与信息学院广州510000 伦敦大学学院电子与电气工程系伦敦(英国)W128LP

随着深度强化学习(DRL)技术的广泛应用,基于DRL的可重构智能表面(RIS)辅助的通信感知一体化(ISAC)展现出巨大的潜力。然而,由于数据卸载和模型训练的高成本,基于现有ISAC框架实现网络智能仍面临着巨大的挑战。为了克服该问题,该文深入... 详细信息

随着深度强化学习(DRL)技术的广泛应用,基于DRL的可重构智能表面(RIS)辅助的通信感知一体化(ISAC)展现出巨大的潜力。然而,由于数据卸载和模型训练的高成本,基于现有ISAC框架实现网络智能仍面临着巨大的挑战。为了克服该问题,该文深入分析了DRL技术在ISAC领域的应用,探讨了RIS辅助的ISAC建模及其解决方案,该技术能够解决覆盖区域受限、算法复杂度高以及高频传输等问题。为了推动这些技术的实施,该文进一步讨论了RIS辅助ISAC网络中DRL技术的未来发展趋势,包括潜在的应用和需要解决的问题。

关键词：深度强化学习可重构智能表面通信感知一体化

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Dual innervation method to preserve erectile function following prostatectomy

引用

Chinese Journal of Plastic and Reconstructive Surgery 2024年第3期6卷 159-160页

作者： Nadia Hui Shan Sim Allen Sim Dayna Sim Bien-Keem Tan Allen Wei-Jiat wong Plastic Reconstructive and Aesthetic Surgery ServiceSengkang General Hospital544886Singapore Department of Urology Mount Alvernia Hospital Singapore574623Singapore Department of General Surgery Sengkang General Hospital544886Singapore Department of Plastic Reconstructive and Aesthetic SurgerySingapore General Hospital169608Singapore

Prostate cancer is the second most prevalent cancer in ***-assisted radical prostatectomy(RARP)has altered the landscape of prostate cancer *** the excellent oncological outcomes associated with RARP,the rate of erectile dysfunction(ED)remains *** repair of disrupted cavernous nerves with interpositional nerve grafts has been described;however,the outcomes have been *** hypothesize that this is attributed to Schwann cell atrophy and axonal regeneration limitations caused by long nerve *** proposed the use of nerve transfer to support axonal regrowth via an inter-positional graft with additional donor axons.A cadaveric study was performed to evaluate the anatomical feasibility of a vastus lateralis nerve(VLN)transfer to the distal recipient cavernous nerve *** VLN is long with multiple branching patterns that allow tension-free coaptation of the cavernous *** postulate that a dual innervation method using VLN nerve transfer together with interpositional nerve graft repair of the transacted cavernous nerves may improve the outcomes of ED post-RARP.

关键词： Erectile dysfunction Prostatectomy Interposition nerve graft Nerve transfer Vastus lateralis nerve

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：