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Science China(Life Sciences) 2017年第4期60卷 386-396页

作者： Peng Lyu Shu-Dong Zhang Hiu-fung Yuen Cian M.McCrudden Qing Wen kwok-wah Chan Hang Fai kwok Faculty of Health Sciences University of Macao Avenida de Universidade Macao 999078 China Northern Ireland Centre for Stratified Medicine C-TRIC Building Altnagelvin Hospital Campus Ulster University Londonderry BT47 6SB UK Institute of Molecular and Cellular Biology Agency for Science Technology and Reseach Singapore 138673 Singapore School of Pharmacy Queen's University of Belfast Belfast BT9 7BL UK Centre for Cancer Research & Cell Biology School of Medicine Dentistry and Biomedical Sciences Queen's University Belfast Belfast BT9 7BL UK Department of Pathology Queen Mary Hospital University of Hong Kong Hong Kong 999077 China

Prostate cancer is one of the most common cancers in men worldwide, and the number of diagnosed patients has dramatically increased in recent years. Currently, the clinical parameters used to diagnose prostate cancer, such as Gleason score, pathological tumor staging, and prostate-specific antigen(PSA) expression level, are considered insufficient to inform recommendation to guide clinical practice. Thus, identification of a novel biomarker is necessary. TWIST is one of the well-studied targets and is correlated with cancer invasion and metastasis in several human cancers. We have investigated two largest prostate cancer patient cohorts available in GEO database and found that TWIST expression is positive correlated with Gleason score and associated with poorer survival. By using a prostate cancer cohort and a prostate cancer cell line dataset, we have identified three potential downstream targets of TWIST, PPM1 A, SRP72 and TBCB. TWIST's prognostic capacity is lost when the gene is mutated. Further investigation in the prostate cancer cohort revealed that gene expression of SERPINA, STX7, PDIA2, FMP5, GP1 BB, VGLL4,KCNMA1, SHMT2, SAA4 and DIDO1 influence the prognostic significance of TWIST and vice versa. Importantly, eight out of these ten genes are prognostic indicator by itself. In conclusion, our study has further confirmed that TWIST is a prognostic marker in prostate cancer, identified its potential downstream targets and genes that could possibly give additional prognostic value to predict TWIST-mediated prostate cancer progression.

关键词： Gleason prognostic staging cohort progression invasion downstream metastasis biomarker interacting

Multi-limb necrotizing fasciitis in a patient with rectal cancer

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World Journal of Gastroenterology 2006年第32期12卷 5256-5258页

作者： Shirley Yuk wah Liu Simon Siu Man Ng Janet fung Yee Lee Department of Surgery Prince of Wales Hospital 30-32 Ngan Shing StreetShatinN.T.Hong KongChina

Necrotizing fasciitis is a devastating soft tissue infection affecting fascias and subcutaneous soft tissues. Literature reviews have identified several related risk factors, including malignancy, alcoholism, malnutrition, diabetes, male gender and old age. There are only scanty case reports in the literature describing its rare association with colorectal malignancy. All published cases are attributed to bowel perforation resulting in necrotizing fasciitis over the perineal region. Isolated upper or lower limb diseases are rarely identified. Simultaneous upper and lower limb infection in colorectal cancer patients has never been described in the literature. We report an unusual case of multi-limb necrotizing fasciitis in a patient with underlying non-perforated rectal carcinoma.

关键词： Necrotizing fasciitis Soft tissue infection Colorectal cancer Malignancy Group G streptococcus

A Current Bleeding CMOS Mixer Featuring <i>LO</i>Amplification Based on Current-Reused Topology

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Circuits and Systems 2013年第1期4卷 58-66页

作者： wah Ching Lee Kim fung Tsang Yi Shen kwok Tai Chui Department of Electronic & Information Engineering The Hong Kong Polytechnic University Hong Kong China&Department of Electronic Engineering City University of Hong Kong Hong Kong China Department of Electronic Engineering City University of Hong Kong Hong Kong China

A double balanced Gilbert-cell class-A amplifier bleeding mixer (DBGC CAAB mixer) is proposed and implemented. The injection current is utilized to amplify the local oscillator (LO) signal to improve the performance of the transconductor stage. The DBGC CAAB mixer achieves a conversion gain of 17.5 dB at -14 dBm LO power, and the noise figure is suppressed from 45 dB to 10.7 dB. It is important to stress that the new configuration will not drain additional power in contrast to the former current bleeding mixers. This topology dramatically relieves the requirement of the LO power. The DBGC CAAB mixer is implemented by using 0.18-μm RFCMOS technology and operates at the 2.4 GHz ISM application with 10 MHz intermediate frequency. The power consumption is 12 mA at 1.5 V supply voltage. The DBGC CAAB mixer features the highest FOM figure within a wide range of LO power.

关键词： Mixer Gilbert-Cell Current Bleeding Noise Conversion Gain Current-Reuse Class-A Amplifier

Learning English Idioms

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教学研究 1978年第2期 129-155页

作者： fung Chui wah

'English idioms are so difficult to master.' Most Chinese students of English complain about this some time or other in their course of study,and even the abler ones are no *** is not very surprising,for the idio(?)at... 详细信息

关键词：工工 Learning English Idioms 土口上七

Revisiting an Old Surgical Approach to the Management of Tophaceous Gout

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Surgical Science 2017年第10期8卷 436-443页

作者： Lok wah Noah So Margaret Woon Man Fok Kenny Yat Hong Kwan kwok Keung Boris fung Department of Orthopaedics and Traumatology Queen Mary Hospital Hong Kong China The University of Hong Kong Hong Kong China

The management of gouty tophi has generally shifted from surgical excision to conservative therapy due to surgery’s traditional association with high wound complication rate. Yet there are still patients who are indicated for surgical excision of gouty tophi, including for functional or cosmetic reasons. We describe our surgical technique and clinical outcomes in patients who underwent gouty tophi excision. This technique includes near complete excision of non-infected gouty tophi with preservation of important soft tissue structures. We have performed 44 elective tophi excision surgery in ten patients with an average follow-up of 29 months. The overall patients’ satisfaction rate was 90%. Only one post-operative infection was noted. No recurrence was observed. Our results suggested that this technique is a safe and effective option for a selected group of patients suffering from tophaceous gout.

关键词： Gout Tophus Surgical Procedures

A WiFi-ZigBee Building Area Network Design of High Traffics AMI for Smart Grid

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Smart Grid and Renewable Energy 2012年第4期3卷 324-333页

作者： Hoi Yan Tung Kim fung Tsang Hoi Ching Tung Veseline Rakocevic kwok Tai Chui Yat wah Leung 1Department of Electronic Engineering City University of Hong Kong Hong Kong China Department of Electronic Engineering City University of Hong Kong Hong Kong China Department of SEEM City University of Hong Kong Hong Kong China. School of Engineering & Mathematical Science City University London London UK

A WiFi-ZigBee hybrid BAN solution, namely WiZBAN, is proposed and implemented to cater for the development of high traffic AMI for smart grid application. It is important to highlight that the major challenge of WiZBAN is to handle the high density environment which results in heavy traffic loading and weak signal propagation. To overcome the captioned problem, Vertical Backbone Communication (VBC) and Horizontal Floor Communication (HFC) are defined for WiZBAN. The WiZBAN consists of WiZBAN Gateway (WiZGW), WiZBAN Meter Hub (WiZBAN) and WiZBAN In Home Display (WiZIHD) which caters for the smart grids services including smart metering and demand response. The WiZGW is the entrance of WiZBAN and connects WiZBAN to utilities. The WiZGW also teams up with WiZMH to enables VBC. On the other hand, WiZMH serves as the interception point of VBC and HFC. It interacts with smart meters and sets up the HFC together with WiZIHD to provide the user interface for end users. To shorten the transmission time, WiFi is adopted for VBC while ZigBee is applied to HCF to overcome the weak signal propagation. To investigate the performance of WiZBAN, a case study has been conducted based on an existing 23 floor residential building. From the measured and simulated results, the average round trip delay of demand response and smart metering are found to be 0.6 s and 9 s respectively.

关键词： Advance Metering Infrastructure Building Area Network WiFi ZigBee Delay

Profiles and removal efficiency of polycyclic aromatic hydrocarbons by two different types of sewage treatment plants in Hong Kong

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Journal of Environmental Sciences 2017年第3期29卷 196-206页

作者： Yu Bon Man Ka Lai Chow Zhang Cheng Wing Yin Mo Yung Hau Chan James Chung wah Lam Frankie Tat Kwong Lau Wing Cheong fung Ming Hung Wong Consortium on Health EnvironmentEducation and Research(CHEER)and Department of Science and Environmental StudiesThe Education University of Hong KongTai PoHong KongChina Department of Environmental Engineering Jinan UniversityGuangzhou 510630China State Key Laboratory in Marine Pollution Croucher Institute for Environmental SciencesHong Kong Baptist University and City University of Hong KongKowloon TongHong KongChina Department of Geography Hong Kong Baptist UniversityKowloon TongHong KongChina College of Environment Sichuan Agricultural UniversityChengdu 611130China State Key Laboratory in Marine Pollution and Research Centre for the Oceans and Human Health City University of Hong KongKowioon TongHong KongChina The Drainage Services Department The Government of the Hong Kong Special Administrative RegionHong KongChina

Sewage discharge could be a major source of polycyclic aromatic hydrocarbons （PAHs） in the coastal waters. Stonecutters Island and Shatin Sewage Treatment Works （SCISTW and STSTW） in Hong Kong, adopted chemically enhanced primary treatment and biological treatment, respectively. This study aimed at （1） determining the removal efficiencies of PAHs, （2） comparing the capabilities in removing PAHs, and （3） characterizing the profile of each individual PAHs, in the two sewage treatment plants （STPs）. Quantification of 16 PAHs was conducted by a Gas Chromatography. The concentrations of total PAHs decreased gradually along the treatment processes （from 301 ± 255 and 307 ± 217 ns/L to 14.9 ± 12.1 and 63.3 ± 54.1 ng/L in STSTW and SCISTW, respectively）. It was noted that STSTW was more capable in removing total PAHs than SCISTW with average total removal effidency 94.4% ± 4.12% us. 79.2% ± 7.48% （p 〈 0.05）. The removal of PAHs was probably due to sorption in particular matter, confirmed by the higher distribution coefficient of individual and total PAHs in solid samples （dewatered sludge contained 92.5% and 74.7% of total PAHs in SCISTW and STSTW, respectively） than liquid samples （final efffluent-total contained 7.53% and 25.3% of total PAHs in STSTW and SCISTW, respectively）. Despite the impressive capability of STSTW and SCISTW in removing PAHs, there was still a considerable amount of total PAHs （1.85 and 39.3 ks/year, respectively for the two STPs） being discharged into Hone Kon coastal waters, which would be an environmental concern.

关键词： Sewage treatment plantsPAHsRemoval efficiencySludgeSewage

Inhibition of angiogenesis and HCT-116 xenograft tumor growth in mice by kallistatin

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World Journal of Gastroenterology 2007年第34期13卷 4615-4619页

作者： Yong Diao Jian Ma Wei-Dong Xiao Jia Luo Xin-Yan Li Kin-wah Chu Peter WC fung Nagy Habib Farzin Farzaneh Rui-An Xu Molecular Medicine Engineering Research Center of the Ministry of Education Institute of Molecular Medicine Huaqiao University Quanzhou362021 Fujian Province China Department of Medicine Hong Kong University Hong Kong China Department of Pharmacy Chicago UniversityUnited States Department of Transplantation Imperial College London United Kingdom Department of Haematological & Molecular Medicine King's College London London SE5 9NUUnited Kingdom

AIM： TO investigate the inhibitory effect of kallistatin （KAL） on angiogenesis and HCT-116 xenograft tumor growth.METHODS： Heterotopic subcutaneous injection of 2 Seven days later, 2 x 1011 injected intratumorally （n tumors were induced by x 106 HCT-11 cells in mice. rAAV-GFP or rAAV-KAL was = 5 for each group）. The mice were sacrificed at d 28, by which time the tumors in the rAAV-GFP group had grown to beyond 5% of the total body weight. Tumor growth was measured by calipers in two dimensions. Tumor angiogenesis was determined with tumor microvessel density （MVD） by immunohistology. Tumor cell proliferation was assessed by Ki-67 staining.RESULTS： Intratumor injection of rAAV-KAL inhibited tumor growth in the treatment group by 78% （171 ＋ 52 mm^3） at d 21 after virus infection compared to the control group （776 ＋ 241 mm^3）. Microvessel density was significantly inhibited in tumor tissues treated with rAAV-KAL, rAAV-KAL also decreased the proportion of proliferating cells （Ki-67 positive cells） in tumors compared with the control group.CONCLUSION： rAAV-mediated expression of KAL inhibits the growth of colon cancer by reducing angiogenesis and proliferation of tumor cells, and may provide a promising anti-angiogenesis-based approach to the treatment of metastatic colorectal cancer.

关键词： Kallistatin Adeno-associated virus Angiogenesis inhibitors Colon Neoplasm

Does Topical Agent Help Fracture Healing? A Pilot Study Using a Herbal Patch

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Open Journal of Therapy and Rehabilitation 2015年第2期3卷 35-39页

作者： Lung-fung Tse Hi-Shan Cheng Chi-Yin Tso Yuk-wah Hung Leung-Kim Hung Jing-Zhou Chen Xue-Lin Zhou Chak-Hei fung Ellie Suet-Yee Pang King-Fai Cheng Chun-kwok Wong Ping-Chung Leung Department of Orthopaedics & Traumatology Prince of Wales Hospital Hong Kong China Department of Orthopaedics & Traumatology The Chinese University of Hong Kong Hong Kong China Institute of Chinese Medicine The Chinese University of Hong Kong Hong Kong China State Key Laboratory of Phytochemistry and Plant Resources in West China The Chinese University of Hong Kong Hong Kong China Department of Chemical Pathology The Chinese University of Hong Kong Hong Kong China

To observe the safety and effectiveness of a topical herbal agent used to promote fracture healing, a herbal patch containing extracts of three herbs, viz., Flos Carthami, Radix Dipsaci, Rhizoma Rhei and Borneolum Syntheticum (an enhancer) was applied on ten subjects with un-displaced fifth metatarsal fractures. Pain scores, foot and ankle function questionnaires and regional swelling were carefully assessed and recorded. Peripheral blood was taken to measure the inflammation cytokines. Assessment checks were performed biweekly to enforce effective patch application and compliance. The results showed that pain improved after two weeks and fracture sites swelling had 20% reduction in thickness when measured with an ultrasonic tool. Foot and ankle functional scores markedly improved after six weeks. Radiological examinations revealed early perfect fracture unions. The topical herbal patch was effective in promoting fracture healing. It was well tolerated by the fracture patients. Larger randomized controlled trials would be indicated.

关键词： Fracture Traditional Chinese Medicine Topical Agent Herbal Treatment