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Exploratory use of ultrasound to determine whether demyelination following carpal tunnel syndrome co-exists with axonal degeneration

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Neural Regeneration Research 2018年第2期13卷 317-323页

作者： Xue Deng Lai-Heung Phoebe Chau Suk-Yee Chiu kwok-Pui leung Sheung-Wai Li Wing-Yuk Ip Department of Orthopedics & Traumatology The University of Hong Kong Clinical Electro-diagnostic Unit Tung Wah Hospital Department of Medicine The University of Hong Kong

Carpal tunnel syndrome （CTS） accompanied by secondary axonal degeneration cannot be clearly dis- criminated using the current cross-validated ultrasound severity classification system. This study aimed at exploring cut-off values of ultrasound parameters, including wrist cross-sectional area （W-CSA）, wrist perimeter （W-P）, ratio of cross-sectional area （R-CSA） and perimeter （R-P）, changes of CSA and P from wrist to one third distal forearm （△CSA＆AP） for differentiation. Seventy-three patients （13 male and 60 female） were assigned into group A （demyelination only, n = 40） and group B （demyelination with secondary axonal degeneration, n = 33） based on the outcomes of nerve conduction studies （NCS）. Receiver Operative Characteristics （ROC） curves were plotted to obtain sensitivity, specificity, and accuracy of cut- off values for all the ultrasound parameters. The overall identified cut-off values （W-CSA 12.0 mm2, W-P 16.27 mm, R-CSA 1.85, R-P 1.48, △CSA 6.98 mm2, △P 5.77 mm） had good sensitivity （77.1-88.6%）, fair specificity （40-62.2%） and fair-to-good accuracy （0.676-0.758）. There were also significant differences in demographics （age and severity gradation, P 〈 0.001）, NCS findings （wrist motor latency and conduction velocity, P 〈 0.0001; wrist motor amplitude, P 〈 0.05; distal sensory latency, P 〈 0.05; sensory amplitude, P 〈 0.001） and ultrasound measurements （W-CSA, W-P, R-CSA, R-P, △CSA＆△P, P 〈 0.05） between groups. These findings suggest that ultrasound can be potentially used to differentiate demyelinating CTS with sec- ondary axonal degeneration and provide better treatment guidance.

关键词： carpal tunnel syndrome nerve conduction studies ultrasound receiver operating characteristic curve peripheral nerve compression injury ultrasonography neural conduction axonal degeneration neural regeneration

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纪恩绵泽圆明园的建筑与亲情

紫禁城 2024年第4期351卷 94-113页

作者：梁慧淇香港故宫文化博物馆

圆明园原是康熙帝玄烨赐给其子胤禛的园林。胤禛继位后,圆明园升格为御园,历经雍正、乾隆、嘉庆、道光、咸丰五朝皇帝经营。在一百五十余年中,君臣父子的事迹在园内一再上演,通过艺术及文学创作,流传后世。

关键词：胤禛玄烨圆明园康熙帝咸丰雍正嘉庆

An Evaluation of Tropical Cyclone Genesis Forecast over the Western North Pacific and the South China Sea from the CMA-TRAMS

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Journal of Tropical Meteorology 2024年第1期30卷 20-28页

作者：李梦婕陈子通戴光丰田群梁卓轩林青张艳霞 Guangzhou Institute of Tropical and Marine Meteorology/Guangdong Provincial Key Laboratory of Regional Numerical Weather Prediction CMAGuangzhou 510641 China State Key Laboratory of Severe Weather Chinese Academy of Meteorological SciencesBeijing 100081 China Guangdong Meteorological Observatory Guangzhou 510641 China

Tropical cyclone(TC) genesis forecasting is essential for daily operational practices during the typhoon *** updated version of the Tropical Regional Atmosphere Model for the South China Sea(CMA-TRAMS) offers forecasters reliable numerical weather prediction(NWP) products with improved configurations and fine resolution. While traditional evaluation of typhoon forecasts has focused on track and intensity, the increasing accuracy of TC genesis forecasts calls for more comprehensive evaluation methods to assess the reliability of these predictions. This study aims to evaluate the effectiveness of the CMA-TRAMS for cyclogenesis forecasts over the western North Pacific and South China Sea. Based on previous research and typhoon observation data over five years, a set of localized, objective criteria has been proposed. The analysis results indicate that the CMA-TRAMS demonstrated superiority in cyclogenesis forecasts, predicting 6 out of 22 TCs with a forecast lead time of up to 144 h. Additionally, over 80% of the total could be predicted 72 h in advance. The model also showed an average TC genesis position error of 218.3 km, comparable to the track errors of operational models according to the annual evaluation. The study also briefly investigated the forecast of Noul(2011). The forecast field of the CMA-TRAMS depicted thermal and dynamical conditions that could trigger typhoon genesis, consistent with the analysis field. The 96-hour forecast field of the CMA-TRAMS displayed a relatively organized threedimensional structure of the typhoon. These results can enhance understanding of the mechanism behind typhoon genesis,fine-tune model configurations and dynamical frameworks, and provide reliable forecasts for forecasters.

关键词： CMA-TRAMS cyclogenesis numerical weather prediction tropical cyclone

Genomics-driven derivatization of the bioactive fungal sesterterpenoid variecolin:Creation of an unnatural analogue with improved anticancer properties

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Acta Pharmaceutica Sinica B 2024年第1期14卷 421-432页

作者： Dexiu Yan Jemma Arakelyan Teng Wan Ritvik Raina Tsz Ki Chan Dohyun Ahn Vladimir Kushnarev Tsz Kiu Cheung Ho Ching Chan Inseo Choi Pui Yi Ho Feijun Hu Yujeong Kim Hill Lam Lau Ying Lo Law Chi Seng leung Chun Yin Tong Kai Kap Wong Wing Lam Yim Nikolay S.Karnaukhov Richard Y.C.Kong Maria V.Babak Yudai Matsuda Department of Chemistry City University of Hong KongHong Kong SARChina iGEM Team“VarieCure” City University of Hong KongHong Kong SARChina Department of Biomedical Engineering City University of Hong KongHong Kong SARChina Moscow Clinical Research Center Named After A.S.Loginov Moscow 111123Russian Federation

A biosynthetic gene cluster for the bioactive fungal sesterterpenoids variecolin(1)and variecolactone(2)was identified in Aspergillus aculeatus ATCC *** production of 1 and 2 was achieved in Aspergillus oryzae by expressing the sesterterpene synthase VrcA and the cytochrome P450 ***,the replacement of VrcB with homologous P450s from other fungal terpenoid pathways yielded three new variecolin analogues(5-7).Analysis of the compounds’anticancer activity in vitro and in vivo revealed that although 5 and 1 had comparable activities,5 was associated with significantly reduced toxic side effects in cancer-bearing mice,indicating its potentially broader therapeutic *** study describes the first tests of variecolin and its analogues in animals and demonstrates the utility of synthetic biology for creating molecules with improved biological activities.

关键词： Animal studies Anticancer properties Biosynthesis Natural products Sesterterpenoids Synthetic biology Terpene synthases Variecolin

Effect of Lycium barbarum Polysaccharides on the expression of endothelin-1 and its receptors in an ocular hypertension model of rat glaucoma

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Neural Regeneration Research 2012年第9期7卷 645-651页

作者： Xue-Song Mi Kin Chiu Geoffrey Van Justin Wai Chung leung Amy Cheuk Yin Lo SookjaKim Chung Raymond Chuen-Chung Chang kwok-Fai So Department of Anatomy and the State Key Laboratory of Brain and Cognitive Science Li Ka Shing Faculty of MedicineThe University of Hong KongPokfulamHong Kong Special Administrative RegionChina Eye Institute Li Ka Shing Faculty of MedicineThe University of Hong KongPokfulamHong Kong Special Administrative RegionChina Research Centre of Heart BrainHormone and Healthy AgingLi Ka Shing Faculty of MedicineThe University of Hong KongPokfulamHong Kong Special Administrative RegionChina The Joint Laboratory for Brain Function and Health （BFAH） Jinan University and The University of Hong Kong Guangzhou 510632Guangdong Province China

Lycium barbarum, a traditional Chinese anti-aging herb, has been shown to protect retinal ganglion cells （RGCs） in a rat chronic ocular hypertension （COH） model. Here, we investigated the expression of endothelin-1 （ET-1）, a strong vasoconstrictor, and its receptors, ETA and ETB, in the COH model and assessed the effects of Lycium barbarum on the ET-1 axis. Elevated intraocular pressure （IOP） was induced in the right eye of SD rats using argon laser photocoagulation. （1） The expression of ET-1, ETA and ETB in normal and COH retinas was studied. （2） Some COH rats were fed daily with Lycium barbarum Polysaccharides （LBP） using 1 mg/kg or phosphate-buffered saline （PBS） for 3 weeks （started 1 week before photocoagulation）. The effects of LBP on the expression of ET-1 and its receptors, ETA and ETB, in COH retina were evaluated. A semi-quantitative analysis of staining intensity was used to evaluate the expression levels of ET-1, ETA and ETB in retinal vasculature. We found that （1） Under COH condition, the immunoreactivity of ET-1 was increased in retina associated with an increase of ETB receptor immunoreactivity and a decrease of ETA receptor immunoreactivity. （2） After feeding COH rats with LBP, the expression of ET-1 was decreased with an increase of ETA expression and a decrease of ETB expression in the retina, especially in RGCs. （3） By comparing the staining intensity in the vasculature of COH retina in LBP-fed group with PBS-fed group, there was a decrease in the expression of ET-1 and ETA and an increase in ETB. In summary, ET-1 expression was up-regulated in the retina in COH model. LBP could decrease the expression of ET-1 and modulate the expression of its receptors, ETA and ETB, under the condition of COH. The neuroprotective effect of LBP on RGCs might be related to its ability to regulate the ET-1-mediated biological effects on RGCs and retinal vasculature.

关键词： retinal ganglion cell Lycium barbarum Polysaccharides glaucoma endothelin-1

Modelling for registration of remotely sensed imagery when reference control points contain error

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Science China Earth Sciences 2006年第7期49卷 739-746页

作者： leung Yee The Department of Geography and Resource Management The Chinese University of Hong Kong Shatin Hong Kong China

Reference control points (RCPs) used in establishing the regression model in the regis-tration or geometric correction of remote sensing images are generally assumed to be “perfect”. That is, the RCPs, as explanatory variables in the regression equation, are accurate and the coordinates of their locations have no errors. Thus ordinary least squares (OLS) estimator has been applied exten-sively to the registration or geometric correction of remotely sensed data. However, this assumption is often invalid in practice because RCPs always contain errors. Moreover, the errors are actually one of the main sources which lower the accuracy of geometric correction of an uncorrected image. Under this situation, the OLS estimator is biased. It cannot handle explanatory variables with errors and cannot propagate appropriately errors from the RCPs to the corrected image. Therefore, it is essential to develop new feasible methods to overcome such a problem. This paper introduces a consistent adjusted least squares (CALS) estimator and proposes relaxed consistent adjusted least squares (RCALS) estimator, with the latter being more general and flexible, for geometric correction or regis-tration. These estimators have good capability in correcting errors contained in the RCPs, and in propagating appropriately errors of the RCPs to the corrected image with and without prior information. The objective of the CALS and proposed RCALS estimators is to improve the accuracy of measure-ment value by weakening the measurement errors. The conceptual arguments are substantiated by a real remotely sensed data. Compared to the OLS estimator, the CALS and RCALS estimators give a superior overall performance in estimating the regression coefficients and variance of measurement errors.

关键词： error modelling, registration, ordinary least squares, relaxed consistent adjusted least squares, remote sensing images.

Effects of Risk Perception on Disaster Preparedness Toward Typhoons:An Application of the Extended Theory of Planned Behavior

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International Journal of Disaster Risk Science 2022年第1期13卷 100-113页

作者： Sai leung Ng Graduate Institute of Earth Science Chinese Culture UniversityTaipei 11114TaiwanChina

This study adopted an extended theory of planned behavior to understand how risk perception affected disaster preparedness *** intercept survey(N=286)was conducted at a typhoon-prone district of Hong Kong,China in 2019,then the data were analyzed using structural equation *** results indicated that risk perception and intention of preparedness were predictors of disaster preparedness *** perception significantly affected intention of preparedness and the effect was partially mediated by subjective *** perception also significantly affected attitude and perceived behavioral control,but attitude and perceived behavioral control were not significantly correlated with intention of *** only may this study supplement the existing literature of disaster preparedness toward typhoons,but also it provides insights for the planning and management of natural hazards and disaster risk reduction in Hong Kong,China.

关键词： Disaster preparedness behaviour Hong Kong,China Risk perception Structural equation modelling Theory of planned behaviour Typhoon preparedness

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设计思维

人类居住 2024年第2期 54-57页

作者：梁鹤年加拿大女王大学城市与区域规划学院

"Design"一词来自文艺复兴时期意大利建筑界所用的拉丁语"disegno"——通过绘图把形状加诸建筑物.之前,设计一词其实有更广、更抽象的意义,包括字面上和物质意义上的"描图"(tracing);战术(tactics)意义上的"设法"(contrive)和达到目的(a... 详细信息

"Design"一词来自文艺复兴时期意大利建筑界所用的拉丁语"disegno"——通过绘图把形状加诸建筑物.之前,设计一词其实有更广、更抽象的意义,包括字面上和物质意义上的"描图"(tracing);战术(tactics)意义上的"设法"(contrive)和达到目的(achieve a goal);组织和体制意义上的任命、指派(designate).这些"意义"都包含着一种"把形状加诸世界"(impose shape on the world)的味道.

关键词：设计思维 tactics racing

以住房抵押贷款保险,保障房地产市场的长远稳定发展

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人类居住 2024年第1期 50-53页

作者：梁鹤年加拿大女王大学城市与区域规划学院

小康社会的标签是“丰衣足食”;富裕社会的标签是“家有恒产”。恒产就是“固定的产业”。对一般老百姓来说,就是房子。有了稳定的居所才可以对社会作稳定的贡献。可以说,安居才会乐业。人民有“置业”的愿望,国家有帮助人民置业的责任... 详细信息

小康社会的标签是“丰衣足食”;富裕社会的标签是“家有恒产”。恒产就是“固定的产业”。对一般老百姓来说,就是房子。有了稳定的居所才可以对社会作稳定的贡献。可以说,安居才会乐业。人民有“置业”的愿望,国家有帮助人民置业的责任。人民有房,不单是“民安”的保证,同时也是“国泰”(经济发展)的基础。建房,包括进住所需的装修、家具和后续的维修、保养都是国家经济和国民就业的一大支柱。买房更是人民储蓄转向生产投资的一大渠道。

关键词：房地产市场小康社会住房抵押贷款保险恒产富裕社会储蓄标签