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A Hidden Threat: Subungual Melanoma in Hand

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Surgical Science 2012年第2期3卷 78-83页

作者： Chris Y. K. Tang boris kwok-keung fung C. P. Lung Department of Orthopaedics and Traumatology University of Hong Kong Medical Centre Queen Mary Hospital Hong Kong (China)

Subungual melanoma, a relatively uncommon disease, has a worse prognosis than cutaneous melanoma in other sites. Both this life-threatening disease and its treatment cause cosmetic and functional impairment to the patient. The diagnosis is often delayed and resulting an advanced disease at presentation. The important clinical manifestation, diagnosis and latest treatments for subungual melanoma are reviewed. Electronic databases of Medline, PubMed, and the Cochrane library were searched with the key word “subungual melanoma”. A clinical scoring system is proposed by the authors to stratify patients to undergo biopsy, making earlier diagnosis of this disease possible. The latest trend of treatment involves wide local excision at a more distal level of the affected digit, in contrast to radical amputation of the digit in the past. Studies have shown that this does not decrease the survival nor increase local recurrence, but reduces the functional impairment for the patient. This review aims to summarise the approach to subungual melanoma for clinicians, so that they can recognise and diagnose this disease early and generate the best functional and cosmetic outcome for the patients.

关键词： Subungual Melanoma Hand

A Retrospective Study of Radiographic Anatomy of Wrist in Chinese Population

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E-Health Telecommunication Systems and Networks 2018年第3期7卷 57-65页

作者： Chris Yuk Kwan Tang fung kwok keung boris Fok Margaret Woon Man Lee Juliana Tsz Yan Aslam Muhammad Zeeshan Fang Benjamin Wong Joyce Yeung Kelvin Department of Orthopaedics and Traumatology University of Hong Kong Medical Centre Queen Mary Hospital Hong Kong China Department of Radiology Queen Mary Hospital Hong Kong China

In wrist pathology, there is a need to establish the normal range of radiographic measurement parameters. Previous study showed that the contralateral wrist might not be valid as a reference for all parameters. There is a lack of literature describing the normal range of wrist radiographic parameters in literature. As a result, a retrospective study was carried out. Patients who underwent standard wrist x-rays during the period February 2012 to February 2013 (one single year) were retrospectively reviewed. 71 patients were included. Scapholunate angle was 54.7° (±6.5°). Scapholunate interval was 2.0 mm (±0.4 mm). Ulnar variance was +1.0 mm (±1.8 mm). Carpal height was 31.8 mm (±3.0 mm). Radial inclination was 25.1° (±2.1°). All 71 patients had 1 sesamoid bone at first metacarpal. 16.9% (12 out of 71) patients had positive cortical ring signs. All these parameters are valuable clinically, especially in monitoring of the wrist disease progression, in the design of wrist implants and for future clinical research.

关键词： Radiographic Anatomy Wrist Chinese

Gastrointestinal stromal tumors in a cohort of Chinese patients in Hong Kong

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World Journal of Gastroenterology 2006年第14期12卷 2223-2228页

作者： Kam Hoi Chan Chun Wing Chan Wai Hung Chow Wai keung Kwan Chi Kwan Kong Ka fung Mak Miu Yi Leung Lin Kiu Lau Department of Medicine Yan Chai Hospital Tsuen Wan Hong Kong SAR China Department of Surgery Yan Chai Hospital Tsuen Wan Hong Kong SAR China Department of Radiology Yah Chai Hospital Tsuen Wan Hong Kong SAR Chin Department of Pathology Yah Chai Hospital Tsuen Wan Hong Kong SAR China

AIM： To investigate the prevalence and clinical pattern of gastrointestinal stromal tumors （GISTs） in Hong Kong Chinese, and to assess the impact of introduction of CD117 on the disease incidence. METHODS： From the database of the Department of Pathology of Yan Chai Hospital, 47 patients, with GISTs from September 1995 to December 2003 were included in this study. Ten GISTs were diagnosed before the introduction of CD117. The clinical features, tumor characteristics, and treatment were analyzed. Factors predicting tumor related death or recurrence were studied with Cox proportional hazard model. RESULTS： The patients included 26 males and 21 females, with a mean age of 66.6 years （SD 13.1, range 29-87 years）. The estimated prevalence of GISTs was 13.4-15.6 per 100 000 people, with an annual inddence of 1.68-1.96 per 100 000 people. The annual incidence of GISTs before and after the introduction of CD117 was 1.1 per 100 000 people and 2.1 per 100 000 people respectively. Stomach （34 patients, 72.3%） was the most common location for the tumor, followed by the small intestine （8 patients, 17.0%）, esophagus （2 patients, 4.3%）, omentum （2 patients, 4.3%） and colon （1 patient, 2.1%）. Thirty-one patients （66%） had complete tumor resection. Eleven out of 16 deaths （23%） were tumor-related. The median survival time was 26 too. Five-year survival rate was 61.3%. The significant factors associated with tumor-related death or recurrence were incomplete resection, tumor size 5 cm or above, invasion to the adjacent organ or presence of metastasis, CONCLUSION： The incidence of GIST in Hong Kong is comparable to that in the United States but lower than that in Finland. The true incidence of GISTs could be underestimated before the introduction of CD117. Incomplete resection, tumor size 5 cm or above, invasion to the adjacent organ or presence of metastasis are factors predicting tumor-related death or recurrence.

关键词： Gastrointestinal tumor GIST Prognostic factors, Clinical features Incidence

Applying Analytical Hierarchy Process to a WiMAX Performance Evaluation Model

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ZTE Communications 2010年第3期8卷 50-55页

作者： Ronald Shiu keung Kwan Kim fung Tsang Department of MEEM City University of Hong Kong Department of Electronic Engineering City University of Hong Kong

Evaluating performance of individual features of WiMAX technology is a topic of widespread discussion. Currently, there is no quantitative way of measuring WiMAX technology so that wireless operators can meet their design objectives. This paper outlines a set of design criteria for WiMAX and provides a decision-making aid that ranks the importance of criteria using Analytic Hierarchy Process （AHP）. This ranking should sufficiently reflect market expectations of the relative importance of various design criteria. A model integrating AHP priorities with enhanced Data Envelopment Analysis （DEA） is the basis for formulating a technological value in simple, comparable format. A case study is provided to show how this technological value is used to evaluate a three year network deployment plan. In the future, this model could be extended to WiMAX equipment suppliers for the purpose of validating performance targets of individual criteria, and enhancing supplier roadmaps for future network development.

关键词： WiMAX Applying Analytical Hierarchy Process to a WiMAX Performance Evaluation Model

Application of hematopoietic growth factor TPO to the protection and repair of the central nervous system

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Application of hematopoietic growth factor TPO to the protec...

Red organic light-emitting diodes based photobiomodulation therapy enabling prominent hair growth

第10届全国实验血液学会议

作者： Margaret HL Ng Nga Hin Pong Ki Wai Chik Ho keung Ng kwok Pui fung Tai Fai Fok Department of Anatomical and Cellular Pathology The Chinese University of Hong Kong Hong Kong Department of Paediatrics The Chinese University of Hong Kong Hong Kong Department of Paediatrics The Chinese University of Hong Kong Hong Kong Department of Anatomical and Cellular Pathology The Chinese University of Hong Kong Hong Kong The Institute of Chinese Medicine The Chinese University of Hong Kong Hong Kong Department of Paediatrics The Chinese University of Hong Kong Hong Kong

＜正＞The infusion of bone marrow cells into the damaged brain has been proposed as a new clinical practice for this disorder. Alternatively, hematopoietic growth factors may have a direct role on neural protection or have a mobilizing effect on bone marrow stem/progenitor cells to circulation for brain repair. Based on our previous findings, there are many similarities between megakaryocytes and neurons on functions and antigen expression such as neural marker MAP2, GFAP and Tau, 5 - HT2A,2B and 2C receptors, dopamine D1 and D2 receptors. Thrombopoietin （TPO） is a growth factor for the megakary-ocytic lineage. We postulate that TPO may play a role on neural protection or regeneration. The effect

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Nano Research 2023年第5期16卷 7164-7170页

作者： Shuang-Qiao Sun Jing-Jing Shen Yu-Fei Wang Yu-Tong Jiang Lin-Fu Chen Hua Xin Jiang-Nan Wang Xiao-Bo Shi Xiao-Zhao Zhu Qi Sun Liang-Sheng Liao Qian Chen Man-keung fung Shuit-Tong Lee Institute of Functional Nano&Soft Materials(FUNSOM) Jiangsu Key Laboratory for Carbon-Based Functional Materials&DevicesSoochow University199 Ren'ai RoadSuzhou 215123China Macao Institute of Materials Science and Engineering(MIMSE) MUST-SUDA Joint Research Center for Advanced Functional MaterialsZhuhai MUST Science and Technology Research InstituteMacao University of Science and TechnologyTaipa 999078MacaoChina 3 Institute of Organic Optoelectronics Jiangsu Industrial Technology Research Institute(JITRI)1198 Fenhu DadaoWujiangSuzhou 215200China

Hair loss can cause psychological ***,red organic light-emitting diode(OLED)light source is first introduced as the photobiomodulation therapy(PBMT)for hair growth and demonstrated as a promising and non-invasive therapeutic modality for *** exhibits unique advantages of homogeneous irradiation,flexible in form factor,less heat *** features enable OLED to be an ideal candidate for wearable PBMT light sources.A systematic study of using red OLEDs to facilitate hair growth was *** results show that OLEDs excellently promote hair *** irradiation can increase the length of the hair by a factor of 1.5 as compared to the control,the hair regrowth area is enlarged by over 3 times after 20 days of ***,the mechanism of OLED that stimulates hair follicle regeneration is investigated invivo by conducting a systematic controlled experiments on mice with or without OLED *** on the comprehensive histological and immunofluorescence staining studies,two key factors are identified for red OLEDs to facilitate hair follicle regeneration:(i)increased autophagy during the anagen phase of the hair growth cycle;(ii)increased blood oxygen content promoted by the accelerated microvascular blood flow.

关键词： red organic light-emitting diode(OLED) light therapy hair growth autophagy oxygen saturation

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高效大面积有机白光照明研究及其展望

影像科学与光化学 2017年第1期35卷 26-33页

作者：樊健冯敏强唐建新廖良生苏州大学功能纳米与软物质研究院江苏省碳基功能材料与器件重点实验室江苏苏州215123

白光有机发光二极管(OLED)是新一代健康节能照明光源,光效性能已超过荧光灯水平。自从OLED技术问世以来,研究人员陆续开展了关于OLED照明的研究工作。本文介绍了OLED照明的特点,以及国内外OLED照明发展现状,讨论了发展OLED照明技术和装... 详细信息

白光有机发光二极管(OLED)是新一代健康节能照明光源,光效性能已超过荧光灯水平。自从OLED技术问世以来,研究人员陆续开展了关于OLED照明的研究工作。本文介绍了OLED照明的特点,以及国内外OLED照明发展现状,讨论了发展OLED照明技术和装备国产化所亟待解决的重大难题和面临的挑战,重点论述了发展高效大面积OLED照明器件制备技术及推动OLED照明产业化的重要意义。

关键词：有机光电高效大面积OLED照明装备国产化节能

螺芴对含三齿磷配体的铱配合物光电性能的影响

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无机化学学报 2020年第3期36卷 494-502页

作者：陈熳王月周跃跃王平童碧海冯敏强王松安徽工业大学冶金工程学院分子工程与应用化学研究中心冶金减排与资源综合利用教育部重点实验室马鞍山243002 苏州大学功能纳米与软物质研究院苏州大学纳米协同创新中心江苏省碳基功能材料重点实验室苏州215123 湖北文理学院湖北省低维光电材料与器件重点实验室襄阳441053

合成了一种含4,5-二氮-9,9-螺二芴(sb)配体的三齿磷铱配合物Ir(tpit)(sb)Cl(tpitH2=亚磷酸三苯基酯),通过核磁共振氢谱和磷谱及高分辨质谱对其结构进行了确定。X射线单晶衍射分析表明,sb配体的存在扭曲了分子结构,有助于降低分子聚集及... 详细信息

合成了一种含4,5-二氮-9,9-螺二芴(sb)配体的三齿磷铱配合物Ir(tpit)(sb)Cl(tpitH2=亚磷酸三苯基酯),通过核磁共振氢谱和磷谱及高分辨质谱对其结构进行了确定。X射线单晶衍射分析表明,sb配体的存在扭曲了分子结构,有助于降低分子聚集及发光淬灭。与存在分子内π-π堆积的模型配合物Ir(tpit)(bpy)Cl(bpy=2,2′-联吡啶)对比进行了光电性能的研究。结果表明在聚甲基丙烯酸甲酯(质量分数1%)中配合物Ir(tpit)(sb)Cl的发光波长为512 nm,相对配合物Ir(tpit)(bpy)Cl的波长(520 nm)有了8 nm蓝移。配合物Ir(tpit)(sb)Cl的发光量子效率为30%,与配合物Ir(tpit)(bpy)Cl的94%相比有明显降低,说明了分子内π-π堆积作用在降低柔性基团非辐射跃迁率方面的重要作用。基于配合物Ir(tpit)(sb)Cl的有机电致发光器件,最大电流效率和外量子效率分别为14 cd·A-1和4.5%。而由于分子内π-π堆积作用,基于配合物Ir(tpit)(bpy)Cl器件的最大电流效率和外量子效率分别高达60 cd·A-1和18.2%。

关键词：环金属铱(Ⅲ)髥配合物三齿磷配体有机电致发光磷光螺芴

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辅助配体对噌啉类铱配合物光电性能的影响

无机化学学报 2018年第4期34卷 627-632页

作者：潘淼李思华程茂玲胡媛媛时鹏徐靖宇童碧海冯敏强张千峰安徽工业大学冶金工程学院分子工程与应用化学研究中心冶金减排与资源综合利用教育部重点实验室马鞍山243002 苏州大学功能纳米与软物质研究院苏州大学纳米协同创新中心江苏省碳基功能材料重点实验室苏州215123

合成了2种新的噌啉类铱配合物(dpci)_2Ir(paz)和(dpci)_2Ir(taz)(dpci=3,4-二苯基噌啉,paz H=5-(2′-吡啶基)-3-三氟甲基-吡唑,taz H=5-(2′-吡啶基)-3-三氟甲基-1,2,4-三唑),通过核磁共振氢谱和氟谱及高分辨质谱对其结构进行了确定,同... 详细信息

合成了2种新的噌啉类铱配合物(dpci)_2Ir(paz)和(dpci)_2Ir(taz)(dpci=3,4-二苯基噌啉,paz H=5-(2′-吡啶基)-3-三氟甲基-吡唑,taz H=5-(2′-吡啶基)-3-三氟甲基-1,2,4-三唑),通过核磁共振氢谱和氟谱及高分辨质谱对其结构进行了确定,同时对其光电性能进行了表征。结果表明在聚甲基丙烯酸甲酯(1%,w/w)中(dpci)_2Ir(paz)和(dpci)_2Ir(taz)的发光波长分别为616和612 nm,相对参比铱配合物(dpci)_2Ir(pic)的波长(625 nm)有了较大蓝移,发光量子效率也由16.1%提高到了51.9%和32.5%。改进辅助配体后,材料的稳定性明显提高,使其能用蒸镀法制备有机电致发光器件。基于(dpci)_2Ir(paz)的器件发光为纯红光,CIE色坐标为(0.66,0.34),最大亮度为2 054 cd·m^(-2),最大电流效率为8.5 cd·A^(-1)。基于(dpci)_2Ir(taz)的器件最大亮度为2 931 cd·m^(-2),最大电流效率为14.5 cd·A^(-1)。

关键词：环金属铱価配合物苯基噌啉有机电致发光磷光辅助配体