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Application of physics-informed neural network in the analysis of hydrodynamic lubrication

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Friction 2023年第7期11卷 1253-1264页

作者： Yang ZHAO Liang GUO Patrick Pat lam WONG School of Automotive and Transportation Engineering Shenzhen PolytechnicShenzhen 518055China School of Mechatronic Engineering and Automation Shanghai UniversityShanghai 200444China Department of Mechanical Engineering City University of Hong KongHong KongChina

The last decade has witnessed a surge of interest in artificial neural network in many different areas of scientific *** the rapid expansion in the application of neural networks,few efforts have been carried out to introduce such a powerful tool into lubrication ***,this work aims to apply the physics-informed neural network(PINN)to the hydrodynamic lubrication *** 2D Reynolds equation is *** PINN is a meshless method and does not require big data for network training compared with classical *** results are consistent with those obtained by experiments and the finite element ***,we envision that the PINN method will have great application potential in lubrication and bearing research.

关键词： physics-informed neural network hydrodynamic lubrication slider bearing

Spray freeze drying of small nucleic acids as inhaled powder for pulmonary delivery

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Asian Journal of Pharmaceutical Sciences 2018年第2期13卷 163-172页

作者： Wanling Liang Alan Y.L.Chan Michael Y.T.Chow Fiona F.K.Lo Yingshan Qiu Philip C.L.kwok Jenny K.W.lam Department of Pharmacology and Pharmacy Li Ka Shing Faculty of Medicine The University of Hong Kong Advanced Drug Delivery Group Faculty of Pharmacy The University of Sydney

The therapeutic potential of small nucleic acids such as small interfering RNA(siRNA) to treat lung diseases has been successfully demonstrated in many in vivo studies. A major barrier to their clinical application is the lack of a safe and efficient inhaled *** this study, spray freeze drying was employed to prepare dry powder of small nucleic *** and herring sperm DNA were used as bulking agent and model of small nucleic acid therapeutics, respectively. Formulations containing different solute concentration and DNA concentration were produced. The scanning electron microscope(SEM) images showed that the porosity of the particles increased as the solute concentration decreased. Powders prepared with solute concentration of 5% w/v were found to maintain a balance between porosity and robustness. Increasing concentration of DNA improved the aerosol performance of the formulation. The dry powder formulation containing 2% w/w DNA had a median diameter of 12.5 μm, and the aerosol performance study using next generation impactor(NGI) showed an emitted fraction(EF) and fine particle fraction(FPF) of 91% and 28% respectively. This formulation(5% w/v solute concentration and 2% w/w nucleic acid) was adopted subsequently to produce siRNA powder. The gel retardation and liquid chromatography assays showed that the siRNA remained intact after spray freeze drying even in the absence of delivery vector. The siRNA powder formulation exhibited a high EF of 92.4%and a modest FPF of around 20%. Further exploration of this technology to optimise inhaled siRNA powder formulation is warranted.

关键词： Inhalation Pulmonary delivery Small interfering RNA Spray freeze drying

Novel biomarkers GEP/ABCB5 regulate response to adjuvant transarterial chemoembolization after curative hepatectomy for hepatocellular carcinoma

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Hepatobiliary & Pancreatic Diseases International 2018年第6期17卷 524-530页

作者： Charing Ching-Ning Chong Siu Tim Cheung Yue-Sun Cheung Anthony Wing-Hung Chan Stephen lam Chan Simon Chun-ho Yu Paul Bo-San Lai Department of Surgery Prince of Wales HospitalThe Chinese University of Hong Kong4/F Clinical Science Building30-32 Ngan Shing StreetShatinHong KongChina Department of Anatomical and Cellular Pathology State Key Laboratory in Oncology in South ChinaPrince of Wales HospitalThe Chinese University of Hong Kong30-32 Ngan Shing StreetShatinHong KongChina Department of Clinical Oncology Prince of Wales HospitalThe Chinese University of Hong Kong30-32 Ngan Shing StreetShatinHong KongChina Department of Imaging and Interventional Radiology Prince of Wales HospitalThe Chinese University of Hong Kong30-32 Ngan Shing StreetShatinHong KongChina

Background: Transarterial chemoembolization(TACE) is the most commonly used adjuvant therapy for hepatocellular carcinoma(HCC) after curative resection. Responses to TACE are variable due to tumor and patient heterogeneity. We had previously demonstrated that expression of Granulin-epithelin precursor(GEP) and ATP-dependent binding cassette(ABC)B5 in liver cancer stem cells was associated with chemoresistance. The present study aimed to evaluate the association between GEP/ABCB5 expression and response to adjuvant TACE after curative resection for HCC. Methods: Patients received adjuvant TACE after curative resection for HCC and patients received curative resection alone were identified from a prospectively collected database. Clinical samples were retrieved for biomarker analysis. Patients were categorized into 3 risk groups according to their GEP/ABCB5 status for survival analysis: low(GEP-/ABCB5-), intermediate(either GEP +/ABCB5-or GEP-/ABCB5 +) and high(GEP +/ABCB5 +). Early recurrence(recurrence within 2 years after resection) and disease-free survival were analyzed. Results: Clinical samples from 44 patients who had followed-up for more than 2 years were retrieved for further biomarker analysis. Among them, 18 received adjuvant TACE and 26 received surgery alone. Patients with adjuvant TACE in the intermediate risk group was associated with significantly better overall survival and 2-year disease-free survival than those who had surgery alone( P = 0.036 and P = 0.011, respectively). Adjuvant TACE did not offer any significant differences in the early recurrence rate, 2-year disease-free survival and overall survival for patients in low and high risk groups. Conclusions: Adjuvant TACE can only provide survival benefits for patients in the intermediate risk group(either GEP +/ABCB5-or GEP-/ABCB5 +). A larger clinical study is warranted to confirm its role in patient selection for adjuvant TACE.

关键词： Adjuvant therapy Hepatocellular carcinoma Drug transporter Transarterial chemoembolisation Granulin-epithelin precursor

Comparing the effectiveness of pattern differentiation treatment and fixed formula treatment for perimenopausal syndrome with Chinese herbal medicine:A study protocol

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Journal of Traditional Chinese Medical Sciences 2023年第3期10卷 331-338页

作者： Wingsze Hsu Manhon Chan Sirong Zheng Kingchung Li Kamyin Chan hoiyi lam Tammy Tinyan Chu Siufung Chan Yingching kwok Linda LD.Zhong HKFTU Workers’Medical Clinics Hong Kong Baptist University Chinese Medicine Clinic cum Training and Research Centre(North District)Hong KongChina School of Chinese Medicine Hong Kong Baptist UniversityHong KongChina School of Biological Sciences Nanyang Technological University637551Singapore

Objective:To further understand and compare the effectiveness of pattern differentiation treatment and fixed prescription treatment in perimenopausal ***:The study will be conducted in the hong Kong Federation of Trade Unions Workers'Medical Clinics,hong Kong Baptist University Chinese Medicine Clinic cum Training and Research Centre(hong Kong,China).One hundred Chinese women,aged 45-55 years,will be *** participants will be randomized into 2 *** intervention group will be administered medication,based on pattern differentiation,by qualified traditional Chinese medicine(TCM)*** each evaluation,TCM practitioners will evaluate and revise the prescription,based on the participants'*** control group will be given the standard formula,i.e.,the Erxian decoction,which contains 6 *** treatment period and the follow-up period will be 8 weeks *** primary assessment outcome measure will be the Kupperman Index,and the secondary outcome measure will be the Menopause-specific Quality of Life Questionnaire ***:Pattern-differentiated treatment is the basic principle of TCM to understand and treat *** study will show the pattern-differentiated treatment is effectiveness than the fixed prescription.

关键词： Pattern differentiation treatment Perimenopausal Chinese herbal medicine Kupperman index Menopause-specific quality of life

A Simple Approach to Bioconjugation at Diverse Levels: Metal-Free Click Reactions of Activated Alkynes with Native Groups of Biotargets without Prefunctionalization

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Research 2018年第1期2018卷 172-183页

作者： Xianglong Hu Xueqian Zhao Benzhao He Zheng Zhao Zheng Zheng Pengfei Zhang Xiujuan Shi Ryan T.K.kwok Jacky W.Y.lam Anjun Qin Ben Zhong Tang Department of Chemistry Hong Kong Branch of Chinese National EngineeringResearch Center for Tissue Restoration and ReconstructionInstitute of Advanced StudyState Key Laboratory of Molecular NanoscienceDivision of Life Science and Diversion of Biomedical EngineeringTe Hong Kong University of Science and TechnologyClear Water BayKowloonHong KongChina Ministry of Education Key Laboratory of Laser Life Science&Institute of Laser Life Science College of BiophotonicsSouth China Normal UniversityGuangzhou 510631China HKUST-Shenzhen Research Institute Shenzhen 518057China NSFC Center for Luminescence from Molecular Aggregates SCUT-HKUST Joint Research InstituteState Key Laboratory of Luminescent Materials and DevicesSouth China University of TechnologyGuangzhou 510640China

Te efcient bioconjugation of functional groups/molecules to targeted matrix and bio-related species drives the great development of material science and biomedicine,while the dilemma of metal catalysis,uneasy premodifcation,and limited reaction efciency in traditional bioconjugation has restricted the booming development to some ***,we provide a strategy for metal-free click bioconjugation at diverse levels based on activated *** a proof-of-concept,the abundant native groups including amine,thiol,and hydroxyl groups can directly react with activated alkynes without any modifcation in the absence of metal *** this strategy,high-efcient modifcation and potential functionalization can be achieved for natural polysaccharide,biocompatible polyethylene glycol(PEG),synthetic polymers,cell penetrating peptide,protein,fast whole-cell mapping,and even quick diferentiation and staining of Gram-positive bacteria,***,current metal-free click bioconjugation strategy based on activated alkynes is promising for the development of quick fuorescence labeling and functional modifcation of many targets and can be widely applied towards the fabrication of complex biomaterials and future in vivo labeling and detection.

关键词： proof catalysis biomaterials

Metastatic Colorectal Cancer: Optimizing Treatment with Anti-EGFR Monoclonal Antibody

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Journal of Cancer Therapy 2012年第6期3卷 902-911页

作者： Ka-On lam Victor ho-Fun Lee Department of Clinical Oncology Li Ka Shing Faculty of Medicine The University of Hong Kong Hong Kong China.

Colorectal cancer remains a major cause of morbidity and mortality worldwide despite substantial improvement in the standard of care. Although surgical resection in selected patients may potentially be curative, systemic therapy is the only choice of treatment for most patients with metastatic colorectal cancer. Anti-epidermal growth factor receptor (anti-EGFR) monoclonal antibody has established its role in the systemic therapy of metastatic colorectal cancer through multiple well-designed clinical trials and yet, the optimal use of anti-EGFR monoclonal antibody is undefined. This article serves to review the available evidence for anti-EGFR monoclonal antibodies and to speculate optimal strategy for their uses.

关键词： Colorectal Cancer Epidermal Growth Factor Receptor Cetuximab Panitumumab Strategy

Playing Tic-Tac-Toe Using Genetic Neural Network with Double Transfer Functions

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Journal of Intelligent Learning Systems and Applications 2011年第1期3卷 37-44页

作者： Sai ho Ling Hak Keung lam 不详

Computational intelligence is a powerful tool for game development. In this paper, an algorithm of playing the game Tic-Tac-Toe with computational intelligence is developed. This algorithm is learned by a Neural Network with Double Transfer functions (NNDTF), which is trained by genetic algorithm (GA). In the NNDTF, the neuron has two transfer functions and exhibits a node-to-node relationship in the hidden layer that enhances the learning ability of the net-work. A Tic-Tac-Toe game is used to show that the NNDTF provide a better performance than the traditional neural network does.

关键词： Game Genetic Algorithm Neural Network

Non-conventional modeling of extreme significant wave height through random sets

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Acta Oceanologica Sinica 2014年第7期33卷 125-130页

作者： ZHANG Yi lam Jasmine Siu Lee Division of Infrastructure Systems and Maritime Studies School of Civil and Environmental EngineeringN1-B1a-25 Nanyang Technological UniversitySingapore Division of Infrastructure Systems and Maritime Studies School of Civil and Environmental EngineeringN1-01b-43 Nanyang Technological UniversitySingapore

The analysis and design of offshore structures necessitates the consideration of wave loads. Realistic modeling of wave loads is particularly important to ensure reliable performance of these structures. Among the available methods for the modeling of the extreme significant wave height on a statistical basis, the peak over threshold method has attracted most attention. This method employs Poisson process to character- ize time-varying properties in the parameters of an extreme value distribution. In this paper, the peak over threshold method is reviewed and extended to account for subjectivity in the modeling. The freedom in selecting the threshold and the time span to separate extremes from the original time series data is incorpo- rated as imprecision in the model. This leads to an extension from random variables to random sets in the probabilistic model for the extreme significant wave height. The extended model is also applied to different periods of the sampled data to evaluate the significance of the climatic conditions on the uncertainties of the parameters.

关键词： offshore engineering extreme value distribution wave height peak over threshold randomset Pareto distribution

Salt Tolerance in Soybean

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Journal of Integrative Plant Biology 2008年第10期50卷 1196-1212页

作者： Tsui-Hung Phang hon-Ming lam Department of Biology The Chinese University of Hong KongShatinHong Kong China State Key Laboratory for Agrobiotechnology The Chinese University of Hong KongShatinHong Kong China

Soybean is an important cash crop and its productivity is significantly hampered by salt stress. High salt imposes negative impacts on growth, nodulation, agronomy traits, seed quality and quantity, and thus reduces the yield of soybean. To cope with salt stress, soybean has developed several tolerance mechanisms, including：（i） maintenance of ion homeostasis; （ii） adjustment in response to osmotic stress; （iii） restoration of osmotic balance; and （iv） other metabolic and structural adaptations. The regulatory network for abiotic stress responses in higher plants has been studied extensively in model plants such as Arabidopsis thaliana. Some homologous components involved in salt stress responses have been identified in soybean. In this review, we tried to integrate the relevant works on soybean and proposes a working model to describe its salt stress responses at the molecular level.

关键词： abiotic stress Glycine max ion homeostasis osmotic adjustment reactive oxygen species scavenging salt tolerance soybean.