检索结果-南通市图书馆

Decreased Expression of TRPM3 and mAChRM3 in the Small Intestine in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis

引用

International Journal of Clinical Medicine 2018年第5期9卷 467-480页

作者： Sonya Marshall-Gradisnik Marshall Fretel Natalie Eaton Helene Cabanas Cassandra Balinas Vinod Gopalan Daniel Petersen Rachel Passmore Kevin Tang Mazhar Haque Alfred lam Donald Staines School of Medical Science Griffith University Brisbane Australia The National Centre for Neuroimmunology and Emerging Diseases Menzies Health Institute Queensland Griffith University Brisbane Australia Gold Coast University Hospital Parklands Australia Mater Hill Gastroenterology South Brisbane Australia

Introduction: Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME) is often associated with gastrointestinal disturbance and inflammatory markers;however, there have been no histological studies performed in the small intestine from CFS/ME patients. The aim of this investigation was to assess the expression of certain inflammatory markers and inflammatory receptors, namely transient receptor potential melastin 3 (TRPM3) ion channels and muscarinic acetylcholine M3 (mAChRM3) receptors, in small intestinal tissues in a case controlled study comprising a CFS/ME patient and a healthy non-fatigued control. Method: Immunohistochemistry was performed on a small intestinal biopsy from a CFS/ME patient (age = 50;female) with self-reported symptoms of gastrointestinal disturbance and a non-fatigued control (NFC), (age = 28;female). Semi-quantitative analysis of expression was undertaken for interferon-gamma (IFNy), interleukin-1 alpha (IL-1α), tumour necrosis factor-alpha (TNFα), TRPM3 ion channels and mAChRM3 acetylcholine receptors. Results: There was significantly decreased expression of TRPM3 in the CFS/ME patient (35% ±9%) and a significant decrease in mAChRM3 in the CFS/ME patient (54% ±9%). There was no difference in IL-1α between CFS/ME patient and NFC, however;there was an increase in IFNy (13% ±6%) in the CFS/ME patient compared to NFC. There was a difference observed in TNFα in CFS/ME compared to NFC. Conclusion: Differences were noted in the expression of specific TRP ion channels and cholinergic receptors in CFS/ME compared with NFC, with CFS/ME demonstrating decreased TRPM3 and mAChRM3. Further, IFNy was increased, and TNFα decreased, in the small intestine of the CFS/ME patient with reported gastrointestinal disturbance.

关键词： Chronic Fatigue Syndrome/Myalgic Encephalomyelitis Irritable Bowel TRPM3 mAChRM3 Small Intestine Inflammation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

剩余油测定方法的评价与对比

引用

石油勘探开发情报 1992年第2期 104-112页

作者： chan.,MM 冯为民

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

“好意施惠关系”中的责任承担——从《楼上楼下》的个案角度分析

引用

法学论坛 2005年第1期20卷 120-126页

作者：杨婵南京大学法学院江苏南京210093

《今日说法》中播出的真实案例《楼上楼下》是日常生活中常见的好人好事引起的纠纷。以该真实案例为模型 ,作者对其进行理论上的分析和研讨 ,系统地分析了“好意施惠关系”在法律上的认定以及施惠人承担责任的请求权基础。

关键词：合同好意施惠关系违法过错因果关系

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Extremely high prevalence of Helicobacter pylori infection in Bhutan

引用

World Journal of Gastroenterology 2013年第18期19卷 2806-2810页

作者： Ratha-korn Vilaichone Varocha Mahachai Seiji Shiota Tomohisa Uchida Thawee Ratanachu-ek Lotay Tshering Nguyen lam Tung Toshio Fujioka Masatsugu Moriyama Yoshio Yamaoka Gastroenterology Unit Department of Medicine Thammasat University Hospital Pathumthani 12120 Thailand GI and Liver Center Bangkok Medical Center Bangkok 10310 Thailand Department of Environmental and Preventive Medicine Oita University Faculty of Medicine Yufu 879-5593 Japan Department of Molecular Pathology Oita University Faculty of Medicine Yufu 879-5593 Japan Department of Surgery Rajavithi Hospital Bangkok 10400 Thailand Department of Surgery Jigme Dorji Wangchuk National Referral Hospital Thimphu Bhutan Department of Gastroenterology 108 Hospital Hanoi 12771 Vietnam Department of Gastroenterology Oita University Faculty of Medicine Yufu 879-5593 Japan Department of Gastroenterology and Hepatology Baylor College of Medicine and Michael DeBakey Veterans Affairs Medical Center Houston TX 77030 United States

AIM: To revealed the prevalence of Helicobacter pylori (H. pylori ) infection in the Bhutanese population. METHODS: We recruited a total of 372 volunteers (214 females and 158 males; mean age of 39.6 ± 14.9 years) from three Bhutanese cities (Thimphu, Punaka, and Wangdue). The status of H. pylori infection was determined based on five different tests: the rapid urease test (CLO test), culture, histology, immunohistochemistry (IHC), and serum anti H. pylori -antibody. RESULTS: The serological test showed a significantly higher positive rate compared with the CLO test, culture, histology and IHC (P < 0.001, P < 0.001, P=0.01, and P=0.01, respectively). When the subjects were considered to be H. pylori positive in the case of at least one test showing a positive result, the overall prevalence of H. pylori infection in Bhutan was 73.4%. The prevalence of H. pylori infection significantly decreased with age (P < 0.01). The prevalence of H. pylori infection was lower in Thimphu than in Punakha and Wangdue (P=0.001 and 0.06, respectively). The prevalence of H. pylori infection was significantly higher in patients with peptic ulcers than in those with gastritis (91.4% vs 71.3%, P=0.003). CONCLUSION: The high incidence of gastric cancer in Bhutan may be attributed to the high prevalence of H. pylori infection.

关键词： Helicobacter pylori Bhutan Prevalence

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

基于邻域组合测度的属性约简方法

引用

控制与决策 2016年第7期31卷 1225-1230页

作者：何松华康婵娟鲁敏滕书华湖南大学信息科学与工程学院长沙410082 国防科技大学自动目标识别重点实验室长沙410073

属性约简是机器学习和知识发现的研究热点,而属性重要性度量则是构建属性约简算法的关键环节.针对不完备的混合型信息系统,在邻域关系下定义了一种新的属性集成重要性度量—–邻域组合测度,并据此提出一种基于邻域组合测度的属性约简(NC... 详细信息

属性约简是机器学习和知识发现的研究热点,而属性重要性度量则是构建属性约简算法的关键环节.针对不完备的混合型信息系统,在邻域关系下定义了一种新的属性集成重要性度量—–邻域组合测度,并据此提出一种基于邻域组合测度的属性约简(NCMAR)算法.通过多个UCI数据集上的实验表明,NCMAR算法不仅能够直接处理符号和数值属性共存的混合信息系统,而且适用于不完备信息系统,在获得较小约简结果的同时,能够保证较高的分类精度.

关键词：粗糙集属性约简不确定性度量不完备信息系统混合数据

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Discovery of Tanichthys albonubes Lin 1932 (Cyprinidae) on Hainan Island,and Notes on Its Ecology

引用

Zoological Research 2009年第2期30卷 209-214页

作者：陈辈乐陈湘粦嘉道理农场暨植物园华南师范大学生命科学学院广州510631

A wild population of the globally restricted and highly threatened freshwater fish Tanichthys albonubes Lin was recently discovered on Hainan Island, China. Prior to the present study, native populations were only known from isolated pockets in Guangdong Province of China and Quang Ninh Province of Vietnam; the Hainan record thus represents the first insular and southernmost distribution of this little-known species. Thus far it is known only from a single site in Hainan, despite repeated surveys of similar habitats throughout the island. The Hainan population occurs in a clean, sluggish coastal stream with abundant hydrophytes, and is sympatric with 20 fish species. Due to the unique geographic distribution of the Hainan population, and the conservation significance of the species, studies of its phylogenetic relationships with conspecifics populations elsewhere are underway. The exact locality of the newly discovered Hainan population cannot be revealed, but relevant government authorities have been notified and we are working to protect the site.

关键词： Tanichthys albonubes Freshwater fish New record Ecology Hainan China

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Evaluation of the Surface of Nitinol after MR Polishing Process

引用

Journal of Applied Mathematics and Physics 2015年第2期3卷 208-217页

作者： Byung-chan Kim Jung-Won Lee Seok-Jae Ha Yong-Kyu Cho Dong-Sung Kang Myeong-Woo Cho Department of Mechanical Engineering Inha University Incheon Republic of Korea WISYS Gunpo-si Republic of Korea

Nitinol is used in various industries, especially for biomaterials. Generally, the surface integrity of sub-micron level and non-surface flaw is required in nitinol for biomaterial. However, surface flaws, such as scratches, pits, and residual stress, can occur on the polished surface, and it is difficult to remove these surface flaws. The corrosion is accelerated continuously and causes bad influence in the body. Therefore, in this study, conventional polishing and MR polishing were used to minimize the corrosion and residual stress when the nitinol is used as biomaterial. X-ray diffraction and Tafel extrapolation were used to investigate the residual stress and the corrosion, and the strain hardening was investigated by nanoindentation. Surface integrities were also evaluated by SEM image and surface roughness results. As a result, the increased residual stress in conventional polishing was decreased by MR polishing. The result of corrosion test was improved from ?301 mV to ?280 mV. The residual stress was improved from ?38.18 MPa to ?31.17 MPa. Finally, it is certified that MR polishing can be used to minimize surface flaws and to improve the corrosion properties.

关键词： Nitinol MR Polishing Corrosion Test Residual Stress Strain Hardening

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

本科生工程领导力培养模式及开发路径——基于7个案例的扎根分析

引用

高等工程教育研究 2023年第4期 73-78页

作者：宋扬陈婵李拓宇浙江大学公共管理学院浙江大学政策研究室

“卓越工程师”是人才强国重要组成部分,也是应对全球挑战、赢得国际竞争优势的骨干力量。工程团队实现“工程愿景”能力的工程领导力,受重视程度日渐提升。现有高校多聚焦领导力培养在工程上的发展和丰富,鲜有工程领导力的内涵剖析和... 详细信息

“卓越工程师”是人才强国重要组成部分,也是应对全球挑战、赢得国际竞争优势的骨干力量。工程团队实现“工程愿景”能力的工程领导力,受重视程度日渐提升。现有高校多聚焦领导力培养在工程上的发展和丰富,鲜有工程领导力的内涵剖析和模式识别。基于“MIT戈登工程领导力培养计划”等7个案例,扎根分析提炼41项工程领导力培养模式要素,从培养目标、计划框架、课程结构、实训环节、组织机构、经费支持、过程管理、评估选拔等8个维度,构建工程领导力培养模式AT3泛用模型。立足新业态、新场景及新工科建设要求,提出了卓越工程师领导力研究与实践的若干启示。

关键词：工程领导力培养模式开发路径扎根理论

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

基于微型机的汽车发动机分析器

引用

国外微计算机 1989年第3期 8-13页

作者： chan.,FH 范伟光

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

成功的并购使企业更强大

引用

新理财（公司理财） 2023年第2期 90-93页

作者： Jeremy chan(文) Gianfranco Bonadies(图) 不详

成功的并购可使企业实现潜在增长、扩大市场份额,并有效提升业务数量。因其过程充满挑战,所以企业需要会计师等专家为其制定最佳方案。本文主要探讨如何在此过程中创造价值,在相关范畴取得成功需要什么技能,以及中国香港为何能长期维持... 详细信息

成功的并购可使企业实现潜在增长、扩大市场份额,并有效提升业务数量。因其过程充满挑战,所以企业需要会计师等专家为其制定最佳方案。本文主要探讨如何在此过程中创造价值,在相关范畴取得成功需要什么技能,以及中国香港为何能长期维持其并购热点地区的地位。对一家公司而言,合并与收购(M&A)的重要性几乎超过其他任何决策。

关键词：并购潜在增长最佳方案市场份额会计师中国香港热点地区相关范畴

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：