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Earthquake Engineering and Engineering Vibration 2023年第4期22卷 937-950页

作者： Jae-Kyoung lee Innovation Center for Engineering Education Daejin UniversityPocheon-siGyeonggi-do487-711Republic of Korea

Following the Pohang and Gyeongju earthquakes and their aftershocks,there is no longer any zone that is safe from earthquake-related disasters in the Korean *** order to monitor and predict earthquakes,correlation analysis of earthquakes and hydro-environmental factors are insufficient,and the development and application of hydro-environmental factor measurement equipment is still in the early *** study developes and verifies a more precise radon measurement *** specific earthquake cases(2019–2020)were selected,and the correlation of the analyses of the earthquakes and hydro-environmental factors(radon,electric conductivity(EC),water-level(WL),and water-temperature(WT))was conducted at the three specific groundwater ***,was confirmed that four factors are affected by earthquakes or seismic ***,the variability of the EC showed an identical tendency for a certain period before an earthquake occurred,and,in particular,the variability trends for radon,WL,and EC coincided at the time of the earthquake′s occurrence.

关键词： variability analysis earthquake radon hydro-environmental factor

Unveiling anomalous lattice shrinkage induced by Pi-backbonding in Prussian blue analogues

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Journal of Energy Chemistry 2022年第7期31卷 121-128,I0004页

作者： Ju-Hyeon lee Jin-Gyu Bae Hyeon Jeong lee Ji Hoon lee School of Materials Science and Engineering Kyungpook National UniversityDaegu 41566Republic of Korea Department of Materials University of OxfordOxford OX13PHUnited Kingdom

Transition-metal(TM)-based Prussian blue and its analogues(TM-PBAs) have attracted considerable attention as cathode materials owing to their versatile ion storage capability with tunable working voltages. TM-PBAs with different crystal structures, morphologies, and TM combinations can exhibit excellent electrochemical properties because of their unique and robust host frameworks with well-defined ionic diffusion channels. Nonetheless, there is still a lack of understanding regarding the performance dependence of TM-PBAs on structural changes during charging/discharging processes. In this study, in situ X-ray diffraction and X-ray absorption fine structure analyses elucidate the TMdependent structural changes in a series of TM-PBAs during the charging and discharging *** the discharging process, the lattice volume of Fe-PBA increased while those of Ni-and Cu-PBAs decreased. This discrepancy is attributed to the extent of size reduction of the cyanometallate complex([Fe(CN)_(6)]) via pi-backbonding from Fe to C due to redox flips of the low-spin Fe^(3+/2+) ion. This study presents a comprehensive understanding of how TM selection affects capacity acquisition and phase transition in TM-PBAs, a promising class of cathode materials.

关键词： Prussian blue analogues X-ray diffraction X-ray absorption fine structure Pi-backdonation Cyanides

Medical oncology management of advanced hepatocellular carcinoma 2019: a reality check

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Frontiers of Medicine 2020年第3期14卷 273-283页

作者： Amy lee Fa-Chyi lee Department of Biology University of California San DiegoSan DiegoCA 92093USA Division of Hematology/Oncology Department of Internal MedicineUniversity of California IrvineOrangeCA 92868USA

In terms of global cancer-related deaths,hepatocellular carcinoma (HCC) has the fourth highest mortality *** until 2017,treatment of advanced HCC was largely limited to sorafenib,an oral tyrosine kinase inhibitor,with little to no success in the development of alternative treatment ***,in the past two years,there has been an unprecedented increase in both the number and type of treatment options available for *** of 2019,the US FDA has approved four oral tyrosine kinase inhibitors,two immune checkpoint inhibitors,and one anti-angiogenesis antibody for the treatment of *** with this new variety,systemic treatment of advanced HCC remains largely unsatisfactory,and the median survival rate stands at approximately one *** expected breakthrough of using immune checkpoint inhibitors in advanced HCC did not materialize in *** use of immune checkpoint inhibitors in conjunction with oral tyrosine kinase inhibitors or antiangiogenesis medications is the current clinical research trend,the results of which are eagerly *** limited progress in survival,HCC research is currently experiencing a period of growth and innovation,and there is hope for significant advances in the treatment of advanced HCC as the field continues to develop.

关键词： hepatocellular carcinoma tyrosine kinase inhibitor check point inhibitor anti-angiogenesis

2022年中国新生儿协作网极早产儿红细胞输注现况分析

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中华儿科杂志 2025年第1期63卷 55-61页

作者：莫艳钱爱民白瑞苗李淑涓玉小清王瑾 lee Shoo K. 蒋思远韦秋芬周文浩国家儿童医学中心复旦大学附属儿科医院新生儿科上海南京医科大学附属儿童医院新生儿医疗中心南京西北妇女儿童医院新生儿科西安广西壮族自治区妇幼保健院新生儿医疗中心南宁加拿大西奈山医院母婴健康研究中心多伦多M5GX 广州市妇女儿童医疗中心新生儿医学中心广州

目的分析2022年中国新生儿协作网(CHNN)各单位极早产儿(出生胎龄<32周)红细胞输注治疗的状况。方法基于CHNN极早产儿队列的横断面研究, 纳入2022年生后24 h内收入CHNN 89家单位的6 985例极早产儿。排除合并严重先天畸形及放弃治疗或转至... 详细信息

目的分析2022年中国新生儿协作网(CHNN)各单位极早产儿(出生胎龄<32周)红细胞输注治疗的状况。方法基于CHNN极早产儿队列的横断面研究, 纳入2022年生后24 h内收入CHNN 89家单位的6 985例极早产儿。排除合并严重先天畸形及放弃治疗或转至非CHNN单位接受治疗的极早产儿。根据是否接受红细胞输注、出生胎龄、接受红细胞输注时应用的呼吸支持方式分组, 根据红细胞输注前血红蛋白水平是否高于阈值分组, 比较各组极早产儿的一般情况、红细胞输注率、输注次数、首次输注时间、输注前血红蛋白水平等以及阈值上输血组与阈值下输血组间极早产儿的不良结局发生率。采用χ2检验、Kruskal-WallisH检验及Mann-WhitneyU检验等进行组间比较, 采用Cochran-Armitage和Jonckheere-Terpstra趋势检验进行不同出生胎龄及不同呼吸支持水平间的趋势检验。结果 6 985例极早产儿中男3 865例(55.3%), 出生胎龄为30.0(28.6, 31.0)周, 出生体重为(1 302±321)g。红细胞输注组3 617例(51.8%), 未输注组3 368例(48.2%)。出生胎龄<28、28～31周的极早产儿红细胞输注率分别为77.7%(893/1 150)、46.7%(2 724/5 835)。红细胞输注组极早产儿共接受9 616次红细胞输注, 输注时需有创呼吸支持的有2 459次(25.6%), 无创呼吸支持4 934次(51.3%), 无呼吸支持的有2 223次(23.1%)。因632次红细胞输注输血前血红蛋白未记录, 8 984次红细胞输注纳入分析。红细胞输注组母亲合并妊娠期高血压比例高于未输注组(χ2=10.73, P=0.001), 剖宫产出生、母亲产前激素应用比例均低于未输注组(χ2=12.00、12.93, 均P<0.001);与未输注组相比, 红细胞输注组患儿出生胎龄更小、出生体重更低, 小于胎龄、多胎以及第5分钟Apgar评分≤3分比例均更高, 女性、本院出生以及延迟脐带结扎比例均更低, 入院时生理稳定性转运风险指数评分更高(均P<0.05)。红细胞输注组极早产儿红细胞输注次数为2(1, 3)次, 首次红细胞输注时为18(8, 29)日龄, 首次红细胞输注前血红蛋白为97(86, 109)g/L。红细胞输注时≤7日龄的极早产儿有创呼吸支持、无创呼吸支持和无呼吸支持组接受红细胞输注前的血红蛋白水平差异无统计学意义(H=5.59, P=0.061);8～21以及≥22日龄的极早产儿不同呼吸支持状况下接受红细胞输注前的血红蛋白水平差异均有统计学意义(H=10.91、39.19, 均P<0.01)。8～21日龄、≥22日龄无呼吸支持的极早产儿阈值上红细胞输注分别为90.1%(264/293)、91.1%(1 578/1 732)。阈值上输血组极早产儿相比阈值下输血组发生坏死性小肠结肠炎的比例更高(χ2=10.59, P=0.001), 住院时间更长(Z=4.67, P<0.001)。结论 2022年CHNN纳入的极早产儿红细胞输注率较高, 接受红细胞输注前的血红蛋白水平普遍高于现有证据推荐的输注阈值。

关键词：婴儿, 早产红细胞输注重症监护病房, 新生儿

Separator Dependency on Cycling Stability of Lithium Metal Batteries Under Practical Conditions

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Energy & Environmental Materials 2023年第5期6卷 307-316页

作者： Hyeongguk An Youngjoon Roh Youngseong Jo Hyuntae lee Minhong Lim Mingyu lee Yong Min lee Hongkyung lee Department of Energy Science and Engineering Daegu Gyeongbuk Institute of Science and Technology DGIST333 Techno Jungang-daeroDaegu 42988Korea Energy Science and Engineering Research Center Daegu Gyeongbuk Institute of Science and Technology(DGIST)333 Techno Jungang-daeroDaegu 42988Korea

Development of practical lithium(Li)metal batteries(LMBs)remains challenging despite promises of Li metal anodes(LMAs),owing to Li dendrite formation and highly reactive surface *** separators used in LMBs may undergo severe mechanical and chemical deterioration when contacting with *** identify the best polyolefin separator for LMBs,this study investigated the separator-deterministic cycling stability of LMBs under practical conditions,and redefined the key influencing factors,including pore structure,mechanical stability,and chemical affinity,using 12 different commercial separators,including polyethylene(PE),polypropylene(PP),and coated *** extreme compression triggered by LMA swelling,isotropic stress release by balancing the machine direction and transverse direction tensile strengths was found to be crucial for mitigating cell *** of PP separators,a PE separator that possesses a high elastic modulus and a highly connected pore structure can uniformly regulate LMA *** ceramic coating reinforced short-circuiting resistance,while the cycling efficiency degraded rapidly owing to the detrimental interactions between ceramics and *** study identified the design principle of separators for practical LMBs with respect to mechanical stability and chemical affinity toward LMAs by elucidating the impacts of separator modification on the cycling performance.

关键词： chemical inertness lithium metal batteries mechanical strength polyolefin separators short-circuiting

SUBic:A Scalable Unsupervised Framework for Discovering High Quality Biclusters

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Journal of Computer Science & Technology 2013年第4期28卷 636-646页

作者： Jooil lee Yanhua Jin Won Suk lee Department of Computer Science Yonsei University

A biclustering algorithm extends conventional clustering techniques to extract all of the meaningful subgroups of genes and conditions in the expression matrix of a microarray dataset. However, such algorithms are very sensitive to input parameters and show poor scalability. This paper proposes a scalable unsupervised biclustering framework, SUBic, to find high quality constant-row biclusters in an expression matrix effectively. A one-dimensional clustering algorithm is proposed to partition the attributes, that is, columns of an expression matrix into disjoint groups based on the similarity of expression values. These groups form a set of short transactions and are used to discover a set of frequent itemsets each of which corresponds to a bicluster. However, a bicluster may include any attribute whose expression value is not similar enough to others, so a bicluster refinement is used to enhance the quality of a bicluster by removing those attributes based on its distribution of expression values. The performance of the proposed method is comparatively analyzed through a series of experiments on synthetic and real datasets.

关键词： biclustering clustering expression matrix frequent itemset sub-matrix

Advanced operation of heated fluidic resonators via mechanical and thermal loss reduction in vacuum

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Microsystems & Nanoengineering 2023年第5期9卷 255-262页

作者： Juhee Ko Bong Jae lee Jungchul lee Department of Mechanical Engineering Center for Extreme Thermal Physics and ManufacturingKorea Advanced Institute of Science and Technology(KAIST)34141 DaejeonKorea

For simultaneous and quantitative thermophysical measurements of ultrasmall liquid volumes,we have recently developed and reported heated fluidic resonators(HFRs).In this paper,we improve the precision of HFRs in a vacuum by significantly reducing the thermal loss around the sensing element.A vacuum chamber with optical,electrical,and microfluidic access is custom-built to decrease the convection loss by two orders of magnitude under 10-4 mbar *** a result,the measurement sensitivities for thermal conductivity and specific heat capacity are increased by 4.1 and 1.6 times,*** differentiating between deionized water(H2O)and heavy water(D2O)with similar thermophysical properties and~10%different mass densities,the signal-to-noise ratio(property differences over standard error)for H2O and D2O is increased by 9 and 5 times for thermal conductivity and specific heat capacity,respectively.

关键词： fluid operation vacuum

New lumped-mass-stick model based on modal characteristics of structures: development and application to a nuclear containment building

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Earthquake Engineering and Engineering Vibration 2013年第2期12卷 307-317页

作者： Hwasung Roh Huseok lee Jong Seh lee Department of Civil Engineering Chonbuk National University Department of Civil and Environmental Engineering Hanyang University

In this study, a new lumped-mass-stick model （LMSM） is developed based on the modal characteristics of a structure such as eigenvalues and eigenvectors. The simplified model, named the ＂frequency adaptive lumped-massstick model,＂ hasonly a small number of stick elements and nodes to provide the same natural frequencies of the structure and is applied to a nuclear containment building. To investigate the numerical performance of the LMSM, a time history analysis is carried out on both the LMSM and the finite element model （FEM） for a nuclear containment building. A comparison of the results shows that the dynamic responses of the LMSM in terms of displacement and acceleration are almost identical to those of the FEM. In addition, the results in terms of floor response spectra at certain elevations are also in good agreement.

关键词： new lumped-mass-stick model frequency adaptive nuclear containment buildings seismic response floor response spectrum

Dynamic Behavior and Deformation Analysis of the Fish Cage System Using Mass-Spring Model

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China Ocean Engineering 2015年第3期29卷 311-324页

作者： Chun Woo lee Jihoon lee Subong PARK Division of Marine Production System Management Pukyong National University Division of Marine Technology Chonnam National University Department of Fisheries Physics Pukyong National University

Fish cage systems are influenced by various oceanic conditions, and the movements and deformation of the system by the external forces can affect the safety of the system itself, as well as the species of fish being cultivated. Structural durability of the system against environmental factors has been major concern for the marine aquaculture system. In this research, a mathematical model and a simulation method were presented for analyzing the performance of the large-scale fish cage system influenced by current and waves. The cage system consisted of netting, mooring ropes, floats, sinkers and floating collar. All the elements were modeled by use of the mass-spring model. The structures were divided into finite elements and mass points were placed at the mid-point of each element, and mass points were connected by springs without mass. Each mass point was applied to external and internal forces, and total force was calculated in every integration step. The computation method was applied to the dynamic simulation of the actual fish cage systems rigged with synthetic fiber and copper wire simultaneously influenced by current and waves. Here, we also tried to find a relevant ratio between buoyancy and sinking force of the fish cages. The simulation results provide improved understanding of the behavior of the structure and valuable information concerning optimum ratio of the buoyancy to sinking force according to current speeds.

关键词： fish cage mathematical model aquaculture computer simulation mass-spring model

Femtosecond Tm-Ho co-doped fiber laser using a bulk-structured Bi2Se3 topological insulator

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Chinese Physics B 2018年第9期27卷 137-143页

作者： Jinho lee Ju Han lee School of Electrical and Computer Engineering University of SeoulSeoul 02504Republic of Kore

We experimentally demonstrate a femtosecond mode-locked thulium-holmium（Tm-Ho） co-doped fiber laser incorporating a saturable absorber（SA） based on a bulk-structured bismuth selenide（Bi2Se3） topological insulator（TI）. The SA was prepared by depositing a mechanically exfoliated Bi2Se3 TI layer onto a side-polished optical fiber platform. Unlike high-quality nano-structured Bi2Se3 TI-based SA, bulk-structured Bi2Se3 with non-negligible oxidation was used as a saturable absorption material for this experimental demonstration due to its easy fabrication process. The saturation power and modulation depth of the prepared SA were measured to be -28.6 W and -13.4%, respectively. By incorporating the prepared SA into a Tm-Ho co-doped fiber ring cavity, stable soliton pulses with a temporal width of - 853 fs could be generated at 1912.12 nm. The 3-dB bandwidth of the mode-locked pulse was measured to be -4.87 nm. This experimental demonstration reaffirms that Bi2Se3 is a superb base material for mid-infrared passive mode-locking even under oxidation.

关键词： topological insulator mode-locked lasers femtosecond pulse fiber lasers