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镜湖医学 2023年第1期23卷 36-38页

作者：李濤羅英浛廖婧潘慧王美冰曹麗勤澳門鏡湖醫院麻醉科中國澳門

目的探討硬膜外分娩鎮痛(LEA)與不同孕期增重(GWG)初產婦分娩結局的關係。方法回顧分析經陰道分娩的共801位產婦分娩記錄。以GWG正常、孕期超重及是否接受LEA將其分為四組。Ⅰ組:GWG正常不接受LEA。Ⅱ組:GWG正常接受LEA。Ⅲ組:孕期超重... 详细信息

目的探討硬膜外分娩鎮痛(LEA)與不同孕期增重(GWG)初產婦分娩結局的關係。方法回顧分析經陰道分娩的共801位產婦分娩記錄。以GWG正常、孕期超重及是否接受LEA將其分為四組。Ⅰ組:GWG正常不接受LEA。Ⅱ組:GWG正常接受LEA。Ⅲ組:孕期超重不接受LEA。Ⅳ組:孕期超重接受LEA。分別記錄孕婦分娩方式、產程時間、出血量、新生兒體重、新生兒Apgar評分、產婦的鎮痛時間和順產率等。結果GWG正常產婦中,接受LEA組產婦的第一、二產程時間均長於無LEA產婦;GWG超重產婦中,接受LEA的產婦第二產程時間明顯長於無LEA產婦,其順產率顯著高於無LEA組。GWG正常且接受LEA組產婦所產新生兒的5min Apgar評分顯著低其他三組。結論產婦順產率與GWG無關。雖然接受LEA產婦的產程延長,但其順產率明顯升高。所以,對於所有初產婦,尤其對於GWG超重初產婦,值得推廣LEA。

关键词：孕期增重分娩鎮痛順產率

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CEPC Technical Design Report

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Radiation Detection Technology and Methods 2024年第1期8卷 I0003-I0016,1-1091页

作者： Waleed Abdallah Tiago Carlos Adorno de Freitas Konstantin Afanaciev Shakeel Ahmad Ijaz Ahmed Xiaocong Ai Abid Aleem Wolfgang Altmannshofer Fabio Alves Weiming An Rui An Daniele Paolo Anderle Stefan Antusch Yasuo Arai Andrej Arbuzov Abdesslam Arhrib Mustafa Ashry Sha Bai Yu Bai Yang Bai Vipul Bairathi Csaba Balazs Philip Bambade Yong Ban Tripamo Bandyopadhyay Shou-Shan Bao Desmond P.Barber Ayse Bat Varvara Batozskaya Subash Chandra Behera Alexander Belyaev Michele Bertucci Xiao-Jun Bi Yuanjie Bi Tianjian Bian Fabrizio Bianchi Thomas Biekotter Michela Biglietti Shalva Bilanishvili Deng Binglin Denis Bodrov Anton Bogomyagkov Serge Bondarenko Stewart Boogert Maarten Boonekamp Marcello Borri Angelo Bosotti Vincent Boudry Mohammed Boukidi Igor Boyko Ivanka Bozovic Giuseppe Bozzi Jean-Claude Brient Anastasiia Budzinskaya Masroor Bukhari Vladimir Bytev Giacomo Cacciapaglia Hua Cai Wenyong Cai Wujun Cai Yijian Cai Yizhou Cai Yuchen Cai Haiying Cai Huacheng Cai Lorenzo Calibbi Junsong Cang Guofu Cao Jianshe Cao Antoine Chance Xuejun Chang Yue Chang Zhe Chang Xinyuan Chang Wei Chao Auttakit Chatrabhuti Yimin Che Yuzhi Che Bin Chen Danping Chen Fuqing Chen Fusan Chen Gang Chen Guoming Chen Hua-Xing Chen Huirun Chen Jinhui Chen Ji-Yuan Chen Kai Chen Mali Chen mingjun Chen mingshui Chen Ning Chen Shanhong Chen Shanzhen Chen Shao-Long Chen Shaomin Chen Shiqiang Chen Tianlu Chen Wei Chen Xiang Chen Xiaoyu Chen Xin Chen Xun Chen Xurong Chen Ye Chen Ying Chen Yukai Chen Zelin Chen Zilin Chen Gang Chen Boping Chen Chunhui Chen Hok Chuen Cheng Huajie Cheng Shan Cheng Tongguang Cheng Yunlong Chi Pietro Chimenti Wen Han Chiu Guk cho ming-Chung Chu Xiaotong Chu Ziliang Chu Guglielmo Coloretti Andreas Crivellin Hanhua Cui Xiaohao Cui Zhaoyuan Cui Brunella D'Anzi Ling-Yun Dai Xinchen Dai Xuwen Dai Antonio De Maria Nicola De Filippis Christophe De La Taille Francesca De Mori Chiara De Sio Elisa Del Core Shuangxue Deng Wei-Tian Deng Zhi Deng Ziyan Deng Bhupal Dev Tang Dewen Biagio Di Micco Ran Ding Siqin Dingl Yadong Ding Haiyi Dong Jianin AGH University of Science and Technology Faculty of Physics and Applied Computer ScienceKrakow Anhui University HefeiAnhui Applied Physics Department Federal Urdu University of ArtsScience and TechnologyIslamabad Banaras Hindu University Institute of ScienceVaranasi Bandirma Onyedi Eylul University Bandirma Beihang University Beijing Beijing Computational Science Research Center Beijing Beijing Conveyi LTD Beijing Beijing Glass Research Institute Co. LtdBeijing Beijing Institute of Technology Beijing Beijing Normal University Beijing Brown University ProvidenceRI Budker Institute of Nuclear Physics Novosibirsk Cadi Ayyad University Laboratory of Fundamental and Applied PhysicsPolydisciplinary FacultyMarrakech Cairo University Giza Center for Theory and Computation National Tsing Hua UniversityHsinchu Central China Normal University WuhanHubei Central South University ChangshaHunan Centro de Fisica Teorica de Particulas Universidade Tecnica de LisboaLisboa Chengdu KaitengSifang Digital Radio&TV Equipment Co. LtdChengduSichuan China academy of engineering physics MianyangSichuan China building materials academy Beijing China Center of Advanced Science and Technology Beijing China Institute of Atomic Energy Beijing China Jiliang University HangzhouZhejiang China Nuclear Instrument CO. LTDBeijing China University of Geosciences Beijing China University of Geosciences WuhanHubei China University of mining and Technology XuzhouJiangsu China West Normal University NanchongSichuan chongqing University Department of PhysicsChongqing Chulalongkorn University Bangkok City University of Hong Kong Department of PhysicsHong Kong Cockcroft Institute Daresbury Cornell University IthacaNY CPPM(AMU/IPhU&CNRS/INP) Marseille Dalian minzu University DalianLiaoning Dalian University of Technology Department of PhysicsDalian Deutsches Elektronen-Synchrotron DESY Hamburg Dzhelepov Laboratory of Nuclear Problems of Joint Institute for Nuclear Research(DLNP JINR) Dubna East China University Of Science And Technol

The Circular Electron Positron Collider(CEPC)is a large scientific project initiated and hosted by China,fostered through extensive collaboration with international *** complex comprises four accelerators:a 30 GeV Linac,a 1.1 GeV Damping Ring,a Booster capable of achieving energies up to 180 GeV,and a Collider operating at varying energy modes(Z,W,H,and tt).The Linac and Damping Ring are situated on the surface,while the subterranean Booster and Collider are housed in a 100 km circumference underground tunnel,strategically accommodating future expansion with provisions for a potential Super Proton Proton Collider(SPPC).The CEPC primarily serves as a Higgs *** its baseline design with synchrotron radiation(SR)power of 30 MW per beam,it can achieve a luminosity of 5×10^(34)cm^(-2)s^(-1)per interaction point(IP),resulting in an integrated luminosity of 13 ab^(-1)for two IPs over a decade,producing 2.6 million Higgs *** the SR power to 50 MW per beam expands the CEPC's capability to generate 4.3 million Higgs bosons,facilitating precise measurements of Higgs coupling at sub-percent levels,exceeding the precision expected from the HL-LHC by an order of *** Technical Design Report(TDR)follows the Preliminary Conceptual Design Report(Pre-CDR,2015)and the Conceptual Design Report(CDR,2018),comprehensively detailing the machine's layout,performance metrics,physical design and analysis,technical systems design,R&D and prototyping efforts,and associated civil engineering ***,it includes a cost estimate and a preliminary construction timeline,establishing a framework for forthcoming engineering design phase and site selection *** is anticipated to begin around 2027-2028,pending government approval,with an estimated duration of 8 *** commencement of experiments and data collection could potentially be initiated in the mid-2030s.

关键词： initiated exceeding precise

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Abstracts from the 15th International Myopia Conference

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Eye and Vision 2016年第1期3卷 211-221页

作者： Alexandra Benavente-Perez Ann Nour Tobin Ansel Kathleen Abarr Luying Yan Keisha Roden David Troilo Chanyi Lu Miaozhen Pan min Zheng Jia Qu Xiangtian Zhou Christine F. Wildsoet Fan Lu Jie Chen Jinhua Bao Liang Hu Qinmei Wang Zibing Jin Frances Rucker Stephanie Britton Stephan Hanowsky Molly Spatcher Hui-Ying Kuo Ching-Hsiu Ke I-Hsin Kuo Chien-Chun Peng Han-Yin Sun Ian G. Morgan Jeremy A. Guggenheim Rupal L. Shah Cathy Williams Jinglei Yang Peter S. Reinach Sen Zhang Wenfeng Sun Bo Liu Fen Li Xiaoqing Li Aihua Zhao Tianlu Chen Wei Jia Jun Jiang Haoran Wu Kazuo Tsubota Hiroko Ozawa Hidemasa Torii Shigemasa Takamizawa Toshihide Kurihara Kazuno Negishi Klaus Graef Daniel Rathbun Frank Schaeffel Ladan Ghodsi William K. Stell Machelle T. Pardue Ranjay Chakraborty Han na Park Curran S. Sidhu P. Michael Iuvone Michael J Collins Nethrajeith Srinvasalu Sally A. McFadden Paul N. Baird Pablo Artal Pauline cho SW Cheung Pei-Chang Wu Quan V. Hoang Duk C. Lee Erica G. Landis Michael A. Bergen Curran Sidhu Samer Hattar Richard A. Stone Ravi Metlapally Ruiqin Li Qinglin Xu Hong Zhong Chenglin Pan Weizhong Lan Xiaoning Li Ling Chen Zhikuan Yang Scott A. Read Seang-Mei Saw Shi-Jun Weng Xiao-Hua Wu Kang-Wei Qian Yun-Yun Li Guo-Zhong Xu Furong Huang Xiong-Li Yang Yong-Mei Zhong Earl L Smith, III Baskar Arumugam Li-Fang Hung Lisa A. Ostrin Klaus Trier Monica Jong Brien A. Holden Thomas Chuen Lam Samantha Shan Bing Zuo Dennis Yan-yin Tse Jingfang Bian King-Kit Li Quan Liu Chi-ho To Timothy J. Gawne John T. Siegwart, Jr. Alexander H. Ward Thomas T. Norton Yan Zhang Yue Liu Carol Ho Eileen Phan Abraham Hang Emily Eng Christine Wildsoet Department of Biological Sciences SUNY College of Optometry New York NY 10036 USA School of Optometry and Ophthalmology and Eye Hospital Wenzhou Medical University Wenzhou Zhejiang 325027 China Center for Eye Disease & Development School of Optometry & Vision Science Program University of California Berkeley Berkeley CA 94720-2020 USA Wenzhou Medical University Wenzhou Zhejiang 325027 China Biomedical Science and Disease New England College of Optom Boston MA USA School of Optometry Chung Shan Medical University Taichung City 402 Taiwan Institute of Medicine Chung Shan Medical University Taichung City 402 Taiwan Division of Biochemistry and Molecular Biology Research School of Biology Australian National University Canberra Australia State Key Laboratory of Ophthalmology and Division of Preventive Ophthalmology Zhongshan Ophthalmic Center Sun Yat-Sen University Guangzhou China School of Optometry & Vision Sciences Cardiff University Cardiff UK School of Social and Community Medicine University of Bristol Bristol UK School of and Eye Hospital Wenzhou Medical University Wenzhou Zhejiang 325027 China State Key Laboratory Cultivation Base and Key Laboratory of Vision Science Ministry of Health and Zhejiang Provincial Key Laboratory of Ophthalmology and Optometry Wenzhou Zhejiang 325027 People’s Republic of China Shanghai Key Laboratory of Diabetes Mellitus and Center for Translational Medicine Shanghai Jiao Tong University Affiliated Sixth People’s Hospital Shanghai 200233 China Eye Hospital of Wenzhou Medical University Wenzhou Zhejiang 325027 China Department of Ophthalmology Keio University School of Medicine Shinjuku-ku Tokyo 160-8582 Japan General Medicine Ichikawa Medical Center Urayasu City Chiba 279-0001 Japan Ophthalmic Research Institute University of Tuebingen 72076 Tuebingen Germany Bernstein Center for Computational Neuroscience Tuebingen 72076 Tuebingen Germany Werner Reichardt Centre for Integrative Neuroscience Otfried-Mueller-Straße 25 Tueb

To assess the peripheral refractive changes that occur when eye growth decelerates in *** We measured peripheral refraction and on-axis vitreous chamber depth on a total of 53 marmosets;36 treated monocularly for 12 weeks 9 hrs/day(26 with-5 D contact lenses,10 with+5 D)and 17 untreated *** the 26 marmosets treated with-5 D,10 wore contact lenses 9 hrs/day without interruptions and were mea-sured at the end of 10 weeks of treatment(T10)and after 4 weeks of recovery(R14).Eight had both contact lenses removed for 30 mins twice/day(mid-morning and mid-afternoon)during the first four weeks of treatment(early interruption group)and eight had the lenses removed during the second four weeks of treatment(late interruption group).The two interruption groups were measured after 4,8 and 12 weeks of treatment only(T4,T8,T12).

关键词： removed treatment untreated

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三种小鼠血液生理生化正常值的测定

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实验动物科学与管理 2000年第2期17卷 24-28页

作者：王冬平李善如张敏李升团郑亚萍耿志贤李润芳军事医学科学院实验动物中心北京100071 军事医学科学院微生物流行病学研究所北京100071

本文通过对三种小鼠—BALB/c、C57BL/6J近交系小鼠和昆明远交群小鼠的血液学和血液生化指标进行测定。其结果 :(1 )血液学指标 :BALB/c近交系小鼠的嗜中性白细胞、淋巴细胞雌雄间差异显著 ;C57BL/6J近交系小鼠、昆明小鼠雌雄间差异不显... 详细信息

本文通过对三种小鼠—BALB/c、C57BL/6J近交系小鼠和昆明远交群小鼠的血液学和血液生化指标进行测定。其结果 :(1 )血液学指标 :BALB/c近交系小鼠的嗜中性白细胞、淋巴细胞雌雄间差异显著 ;C57BL/6J近交系小鼠、昆明小鼠雌雄间差异不显著 ;昆明小鼠的白细胞比BALB/c、C57BL/6J近交系小鼠的低 ;BALB/c近交系小鼠的单核细胞、嗜酸性白细胞、嗜碱性白细胞记数比C57BL/6J近交系小鼠和昆明小鼠的低。 (2 )血液生化指标 :C57BL/6J近交系小鼠的cho ,Tbili,ALT ,AST值高于BALB/c和昆明小鼠 ,而昆明小鼠的C1值低于BALB/c和C57BL/6J近交系小鼠。BALB/c近交系小鼠的CK值高于C57BJ/6J近交系小鼠。

关键词：小鼠血液学血液生化值

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蛋白酶体抑制剂可增加足叶乙甙对白血病细胞系M-07e和TF-1的凋亡诱导效应

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中国实验血液学杂志 2003年第5期11卷 485-489页

作者：兰雨张学敏杨平地沈倍奋海军总医院血液科军事医学科学院国家生物医学分析中心北京100850 军事医学科学院基础医学研究所分子免疫研究室北京100850

近年来的研究显示泛素蛋白酶体通路在细胞凋亡调控中发挥了重要的作用。本实验就蛋白酶体抑制剂Z LLL cho与经典的凋亡诱导剂足叶乙甙 (VP16)对白血病细胞系M 0 7e及TF 1的联合效应进行了初步研究。应用MTT法及台盼蓝拒染法显示Z LLL ... 详细信息

近年来的研究显示泛素蛋白酶体通路在细胞凋亡调控中发挥了重要的作用。本实验就蛋白酶体抑制剂Z LLL cho与经典的凋亡诱导剂足叶乙甙 (VP16)对白血病细胞系M 0 7e及TF 1的联合效应进行了初步研究。应用MTT法及台盼蓝拒染法显示Z LLL cho及VP16联合作用于M 0 7e及TF 1细胞 ,可增强两种药物单独的细胞杀伤效应。流式细胞术检测提示单独应用Z LLL cho及VP16均可使S +G2 /M期细胞比例增加 ,两者联合应用导致细胞凋亡峰比例的显著增高。通过对M 0 7e细胞裂解物做免疫印迹检测 ,发现在Z LLL cho及VP16单独作用中均导致Bcl 2蛋白被酶解为 2 2kD的片段 ,而联合作用时Bcl 2的酶解现象具有叠加效应。结论 :Z LLL cho与VP16联合作用较单独作用有更强的细胞杀伤及诱导细胞凋亡活性 ,细胞周期S +G2 /M期比例的增加及Bcl 2酶解片段的增加是导致蛋白酶体抑制剂Z LLL cho及VP16对白血病细胞系联合效应的可能机制。

关键词：蛋白酶体抑制剂足叶乙甙细胞凋亡白血病细胞系 M—07e TF-1

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