检索结果-南通市图书馆

Apolipoprotein A-I binding protein-mediated neuroprotection in glaucomatous neuroinflammation and neurodegeneration

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第5期20卷 1414-1415页

作者： Sinwoo hwang Seunghwan Choi Soo-Ho Choi Keun-Young kim Yury I.Miller Won-Kyu Ju Hamilton Glaucoma Center and Shiley Eye Institute The Viterbi Family Department of OphthalmologyUniversity of California San DiegoLa JollaCAUSA Department of Medicine University of California San DiegoLa JollaCAUSA National Center for Microscopy and Imaging Research Department of NeurosciencesUniversity of California San DiegoLa JollaCAUSA

Glaucoma is a multifactorial eye disorder that can cause vision loss and irreversible blindness,affecting individ uals aged 40 to 80 yea rs *** to the aging population,it is expected that the number of people affected by glaucoma will surpass 111 million by 2040 as the disease becomes more *** primarily contributes to optic nerve axon loss and the progressive degeneration of retinal ganglion cells (RGCs),subsequently leading to vision impairment.

关键词： irreversible pass primarily

Myostatin gene role in regulating traits of poultry species for potential industrial applications

在线全文

学校读者我要写书评

暂无评论

Journal of Animal Science and Biotechnology 2024年第5期15卷 1793-1801页

作者： Joonbum Lee Dong‑hwan kim Kichoon Lee Department of Animal Sciences The Ohio State UniversityColumbusOH 43210USA

The myostatin(MSTN)gene is considered a potential genetic marker to improve economically important traits in live-stock,since the discovery of its function using the MSTN knockout *** anti-myogenic function of the MSTN gene was further demonstrated in farm animal species with natural or induced *** poultry species,myo-genesis in cell culture was regulated by modulation of the MSTN ***,different expression levels of the MSTN gene in poultry models with different muscle mass have been reported,indicating the conserved myogenic function of the MSTN gene between mammalian and avian *** advances of CRISPR/Cas9-mediated genome edit-ing techniques have led to development of genome-edited poultry species targeting the MSTN gene to clearly dem-onstrate its anti-myogenic function and further investigate other potential functions in poultry *** review summarizes research conducted to understand the function of the MSTN gene in various poultry models from cells to whole ***,the genome-edited poultry models targeting the MSTN gene are reviewed to inte-grate diverse effects of the MSTN gene on different traits of poultry species.

关键词： Chicken Economic traits Myostatin Quail

Influence of Vanadium Content on Bainitic Transformation of a Low-Carbon Boron Steel During Continuous Cooling

在线全文

学校读者我要写书评

暂无评论

Acta Metallurgica Sinica(English Letters) 2015年第6期28卷 692-698页

作者： kwang-Su kim Lin-Xiu Du Cai-Ru Gao State Key Laboratory of Rolling and Automation Northeastern University Department of Materials Kim Chaek University of Technology

The phase transformation behaviors during continuous cooling of low-carbon boron steels with different vanadium contents were studied by means of dilatometric measurement and microstructure observation. The bainite transformation behavior is not noticeably altered when the vanadium content is 0.042 and 0.086 wt%, and these steels exhibit full bainitic microstructure even at a cooling rate of 5 ℃/s. When vanadium content is increased to 0.18 wt%, ferrite is still present in the microstructure even at a cooling rate of 40 ℃/s. Vickers hardness of the steels with 0.042 and 0.086 wt% V is remarkably higher than that of the steel with 0.18 wt% V at a cooling rate higher than 10 ℃/s, and the difference is increased with the increase in cooling rate. Moreover, the amount of coarse vanadium precipitates formed in austenite is increased with the increase in vanadium content. The optimum content of vanadium to obtain bainitic microstructure is 0.086 wt% in this experimental low-carbon boron steels.

关键词： Microalloyed steel Vanadium Bainitic transformation Boron Microstructure

High-efficiency design of a mixed-flow pump

在线全文

学校读者我要写书评

暂无评论

Science China(Technological Sciences) 2010年第1期53卷 24-27页

作者： kim Jin-Hyuk AHN Hyung-Jin kim kwang-Yong Department of Mechanical Engineering Inha University253Yonghyun-DongIncheon402-751Republic of Korea Industrial Machinery Division Iljin Electric Co.Ltd5-5Hwasu-DongIncheon401-020Republic of Korea

High-efficiency design of a mixed-flow pump has been carried out based on numerical analysis of a three-dimensional viscous *** analysis,the Reynolds-averaged Navier-Stokes equations with a shear stress transport turbulence model were discretized by finite-volume *** grid system was constructed in the computational domain,which has O-type grids near the blade surfaces and H/J-type grids in other *** numerical results were validated with experimental data for the heads and hydraulic efficiencies at different flow *** hydraulic efficiency at the design flow coefficient was evaluated with variation of the geometric variables,i.e.,the area of the discharge and length of the vane in the *** result has shown that the hydraulic efficiency of a mixed-flow pump at the design condition is improved by the modification of the geometry.

关键词： mixed-flow pump numerical analysis impeller vane diffuser head hydraulic efficiency

Effect of In Composition on Two-Dimensional Electron Gas in Wurtzite AlGaN/InGaN Heterostructures

在线全文

学校读者我要写书评

暂无评论

Chinese Physics Letters 2010年第11期27卷 188-190页

作者： kim Bong-hwan PARK Seoung-hwan LEE Jung-Hee MOON Yong-Tae Department of Electronics Engineering Catholic University of Daegu Hayang Kyeongsan Kyeongbuk 712-702 R. Korea School of Electrical Engineering and Computer Science Kyungpook National University Daegu 702-701 R. Korea LG Corporate Institute of Technology 16 Woomyeon-dong Seocho-gu Seoul 137-14-0 R. Korea

The effect of In composition on two-dimensional electron gas in wurtzite AlGaN/InGaN heterostructures is theoretically investigated. The sheet carrier density is shown to increase nearly linearly with In mole fraction x, due to the increase in the polarization charge at the AlGaN/InGaN interface. The electron sheet density is enhanced with the doping in the AlGaN layer. The sheet carrier density is as high as 3.7×1013 cm^-2 at the donor density of 10×1018 cm^-3 for the HEMT structure with x=0.3. The contribution of additional donor density on the electron sheet density is nearly independent of the In mole fraction.

关键词： Condensed matter: electrical magnetic and optical Electronics and devices Semiconductors Surfaces interfaces and thin films Condensed matter: structural mechanical & thermal Nanoscale science and low-D systems

A provable-secure and practical two-party distributed signing protocol for SM2 signature algorithm

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Frontiers of Computer Science 2020年第3期14卷 203-215页

作者： Yudi ZHANG Debiao HE Mingwu ZHANG kim-kwang Raymond CHOO Key Laboratory of Aerospace Information Security and Trusted Computing of Ministry of Education School of Cyber Science and EngineeringWuhan UniversityWuhan 430072China School of Computer Sciences Hubei University of TechnologyWuhan 430068China Department of Information Systems and Cyber Security and Department of Electrical and Computer Engineering University of Texas at San AntonioSan AntonioTX 78249USA

Mobile devices are widely used for data access,communications and ***,storing a private key for signature and other cryptographic usage on a single mobile device can be challenging,due to its computational ***,a number of(t,n)threshold secret sharing schemes designed to minimize private key from leakage have been proposed in the ***,existing schemes generally suffer from key reconstruction *** this paper,we propose an efficient and secure two-party distributed signing protocol for the SM2 signature *** latter has been mandated by the Chinese government for all electronic commerce *** proposed protocol separates the private key to storage on two devices and can generate a valid signature without the need to reconstruct the entire private *** prove that our protocol is secure under nonstandard ***,we implement our protocol using MIRACL Cryptographic SDK to demonstrate that the protocol can be deployed in practice to prevent key disclosure.

关键词： SM2 signature two-party signing wireless environment provable security threshold secret sharing

Analysis of optical emission spectroscopy data during silicon etching in SF_(6)/O_(2)/Ar plasma

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Plasma Science and Technology 2021年第12期23卷 117-127页

作者： Dong hwan kim Jeong Eun CHOI Sang Jeen HONG Department of Electronics Engineering Myongji University116 Myongji-roYongin-siGyeonggi-doRepublic of Korea

Silicon etching is an essential process in various applications,and a major challenge for etching process is anisotropic high aspect ratio etching *** etch profile is determined by the plasma parameters and process *** this study,the plasma state with each process parameters were analyzed through the optical emission spectroscopy(OES)plasma diagnostic sensor by both chemical and physical *** temperature and electron density were additionally acquired using the corona model with OES data that provides chemical species information,and the etch profile was evaluated through scanning electron microscope measurement *** results include changes in profile with gas ratio,bias power,and *** figure out that factors like ion energy and ion angular distribution as well as chemical reaction affect the anisotropic profile.

关键词： silicon etching profile optical emission spectroscopy plasma in-formation corona model

Network-based identification of feedback modules that control RhoA activity and cell migration

在线全文

学校读者我要写书评

暂无评论

Journal of Molecular Cell Biology 2015年第3期7卷 242-252页

作者： Tae-hwan kim Naser Monsefi Je-Hoon Song Alex von Kriegsheim Drieke Vandamme Olivier Pertz Boris NKholodenko Walter Kolch kwang-Hyun Cho Department of Bio and Brain Engineering Korea Advanced Institute of Science and Technology(KAIST)Daejeon 305-701Republic of Korea Systems Biology Ireland University College DublinBelfieldDublin 4Ireland Department of Biomedicine University of BaselBaselSwitzerland School of Medicine and Medical Science University College DublinBelfieldDublin 4Ireland Conway Institute of Biomolecular&Biomedical Research University College DublinBelfieldDublin 4Ireland

Cancer cell migration enables metastatic spread causing most cancer ***-family GTPases control cell migration,but being embedded in a highly interconnected feedback network,the control of their dynamical behavior during cell migration remains *** address this question,wereconstructed the Rho-family GTPases signaling network involved in cell migration,and developed a Boolean network model to analyze the different states and emergent rewiring of the Rho-family GTPases signaling network at protrusions and during extracellular matrix-dependent cell *** simulations and experimental validations revealed that the bursts of RhoA activity induced at protrusions by EGFare regulated by a negative-feedback module composed of Src,FAK,and ***,perturbing this module interfered with cyclic Rho activation and extracellular matrix-dependent migration,suggesting that CSK inhibition can be a novel and effective intervention strategy for blocking extracellular matrix-dependent cancer cell migration,while Src inhibition might fail,depending on the genetic background of ***,this study provides new insights into the mechanisms that regulate the intricate activation states of Rho-family GTPases during extracellular matrix-dependent migration,revealing potential new targets for interfering with extracellular matrix-dependent cancer cell migration.

关键词： cell migration Rho-family GTPases signaling network Boolean network model cyclical RhoA bursts

Bird-mimetic Wing System of Flapping-wing Micro Air Vehicle with Autonomous Flight Control Capability

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Bionic Engineering 2016年第3期13卷 458-467页

作者： Sriyulianti Widhiarini Ji hwan Park Bum Soo Yoon kwang Joon Yoon ll-Hyun Paik Jong Heon kim Chan Yik Park Seung Moon Jun Changho Nam Department of Aerospace Engineering Konkuk University Gwangjin-gu Seoul South Korea Deptartment of PGM Technology Hanwha Corp. R&D Center Daejeon South Korea Agency for Defense Development Daejeon South Korea Department of Engineering Technology Arizona State University Mesa Arizona

A micro air vehicle with a bird-mimetic up-down and twisting wing drive system was developed in this study. The Flap- ping-wing Micro Air Vehicle （FMAV）, with a 50 cm wingspan and a double-crank drive system, performed successful flights of up to 23 min. The performance and capabilities of the FMAV were enhanced by adapting a number of unique features, such as a bird-mimetic wing shape with a span-wise camber and an up-down and twisting wing drive mechanism with double-crank linkages, This lift-enhancing design by mimicking the flapping mechanism of a bird＇s wing enabled the 210 g FMAV to fly autonomously in an outdoor field under wind speeds of less than 5 m.s-1. Autonomous flight was enabled by installing a flight control computer with a micro-electro-mechanical gyroscope and accelerometers, along with a micro video camera and an ultralight wireless communication system inside the fuselage. A comprehensive wind tunnel test shows that the FMAV with a high-camber wing and double-crank mechanism generates more lift and less net thrust than the FMAV with a flat wing and single-crank mechanism, which confirms the improved performance of the developed FMAV, as well as the superior slow flying or hovering capabilities of the FMAV with a high-camber wing and double-crank wing drive system.

关键词： flapping-wing MAV autonomous flight biomimetic wing double crank wing