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microstructure and Properties of the Cr–Si–N Coatings Deposited by Combining High-Power Impulse magnetron Sputtering(HiPImS) and Pulsed DC magnetron Sputtering

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Acta metallurgica Sinica(English Letters) 2017年第7期30卷 688-696页

作者： Tie-Gang Wang Yu Dong Belachew Abera Gebrekidan Yan-mei Liu Qi-Xiang Fan kwang Ho Kim Tianjin Key Laboratory of High Speed Cutting and Precision manufacturing Tianjin University of Technology and Education Global Frontier R&D Center for Hybrid Interface materials Pusan National University

The Cr–Si–N coatings were prepared by combining system of high-power impulse magnetron sputtering and pulsed DC magnetron sputtering. The Si content in the coating was adjusted by changing the sputtering power of the Si *** virtue of electron-probe microanalysis, X-ray diffraction analysis and scanning electron microscopy, the influence of the Si content on the coating composition, phase constituents, deposition rate, surface morphology and microstructure was investigated systematically. In addition, the change rules of micro-hardness, internal stress, adhesion, friction coefficient and wear rate with increasing Si content were also obtained. In this work, the precipitation of silicon in the coating was *** increasing Si content, the coating microstructure gradually evolved from continuous columnar to discontinuous columnar and quasi-equiaxed crystals; accordingly, the coating inner stress first declined sharply and then kept almost constant. Both the coating hardness and the friction coefficient have the same change tendency with the increase of the Si content, namely increasing at first and then decreasing. The Cr–Si–N coating presented the highest hardness and average friction coefficient for an Si content of about 9.7 at.%, but the wear resistance decreased slightly due to the high *** above phenomenon was attributed to a microstructural evolution of the Cr–Si–N coatings induced by the silicon addition.

关键词： Cr–Si–N coating High-power impulse magnetron sputtering(HiPImS) Pulsed DC magnetron sputtering mechanical property Friction coefficient

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Physicochemical and in-vitro release characteristics of vitamin C-loaded antioxidant orally disintegrating films with different catechin levels

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FOOD BIOSCIENCE 2023年第3期53卷 2211-2219页

作者： Shin, Hye-Jung Chang, Jin-hee Han, Jung-Ah Sangmyung Univ Dept Food & Nutr Seoul 03016 South Korea

To develop a convenient food formulation for supplying antioxidants, hyaluronic acid (HA)-based orally dis-integrating film (ODF) containing vitamin C (Vit C) and catechin (CAT) with various molar ratios (Vit C:CAT, 1:0, 1:0.2, 1:0.4, 1:0.6, 1:0.8 and 1:1.0, by name of CAT0, CAT0.2, CAT0.4, CAT0.6, CAT0.8 and CAT1.0, respec-tively) were prepared, and the physico-chemical, and sensory properties of the films were analyzed. In addition, the release properties of the Vit C and CAT in the films were also evaluated. In the results, there was no sig-nificant difference in the moisture content among the films, but the thickness significantly increased with the CAT amount. The water vapor permeability (WVP) started decreasing at CAT0.4. For texture, the addition of CAT decreased tensile strength, and showed inverse relationship with film thickness. Also higher the CAT content was, the more brittle and fragile the texture obtained film. The vitamin C content in the film significantly decreased as the CAT content increased, whereas the antioxidant effects continued to increase with CAT content. In a sensory evaluation, CAT0.2 was the most preferred, followed by CAT0 and CAT0.4, and for those samples containing over 0.6 m ratio CAT, the acceptability dramatically decreased. Based on the above results, the most suitable molar ratio of Vit C:CAT was 1:0.4. As a result of the analysis of the release pattern of the optimized ODF (CAT0.4), both Vit C and CAT exhibited rapid release of over 70% within 30 and 20 min, respectively, in all simulated body fluids. So the prepared ODF can be considered as a suitable delivery formulation for convenient and fast-acting antioxidant.

关键词： Orally disintegrating film Vitamin C Catechin Antioxidant effects Sensory evaluation

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Evaluation of the mrp2-mediated flavonoid-drug interaction potential of quercetin in rats and in vitro models

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Asian Journal of Pharmaceutical Sciences 2019年第6期14卷 621-630页

作者： Ju-hee Oh Joo Hyun Lee Young-Joo Lee Division of Biopharmaceutics College of PharmacyKyung Hee UniversitySeoul 02447Republic of Korea Department of Life and Nanopharmaceutical Sciences College of PharmacyKyung Hee UniversitySeoul 02447Republic of Korea

Quercetin is a biologically active flavonoid that has been used as a popular health *** is reported that quercetin may cause flavonoid-drug interaction mediated by P-glycoprotein,the most predominant efflux *** this study,we comprehensively evaluated the potential of the pharmacokinetic interaction of quercetin mediated by multidrug resistance-associated protein 2(mRP2),another major efflux ***2-transfected mDCKII cells and LS174T cells were used to evaluate the potential inhibition and induction of mRP2 by quercetin in *** evaluate the induction effect of quercetin on mrp2 in vivo,mrp2 mRNA expression in rat liver,kidney,and small intestinal tissues was determined after the oral administration of quercetin(50,100,or 250 mg/kg)for seven ***2-mediated interaction potential was also evaluated by the pharmacokinetic study of phenolsulfonphthalein in rats after single or multiple doses of ***,the effect of quercetin on absorption of docetaxel,a P-glycoprotein and CYP3A4 substrate,was also *** inhibited the function of mRP2 at 10μm and induced the mRNA expression of mRP2 at 50μm in ***,at 100 mg/kg,quercetin markedly increased mrp2 expression in the small intestine of ***,there was no significant change in phenolsulfonphthalein pharmacokinetics due to single-(50,100,or 250 mg/kg)or multiple-dose(50,100,or 250 mg/kg for seven days)quercetin *** contrast,a significant interaction caused by quercetin(100 mg/kg)was observed in the absorption of *** results suggested that although quercetin modulates the function and expression of mRP2 in vitro,it may have a low potential of mrp2-mediated interaction and present negligible safety concerns related to the interaction.

关键词： Quercetin P-glycoprotein multidrug resistance-associated protein 2 Pharmacokinetics Flavonoid-drug interaction

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Design of 1 kbit antifuse one time programmable memory IP using dual program voltage

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Journal of Central South University 2011年第1期18卷 125-132页

作者：金丽妍 JANG Ji-Hye KIm Du-Hwi KIm Young-hee Department of Electronic Engineering Changwon National University9 Sarim-DongChangwon 641-773Korea

A 1 kbit antifuse one time programmable(OTP) memory IP,which is one of the non-volatile memory IPs,was designed and used for power management integrated circuits(ICs).A conventional antifuse OTP cell using a single positive program voltage(VPP) has a problem when applying a higher voltage than the breakdown voltage of the thin gate oxides and at the same time,securing the reliability of medium voltage(Vm) devices that are thick gate transistors.A new antifuse OTP cell using a dual program voltage was proposed to prevent the possibility for failures in a qualification test or the yield *** the newly proposed cell,a stable sensing is secured from the post-program resistances of several ten thousand ohms or below due to the voltage higher than the hard breakdown voltage applied to the terminals of the *** layout size of the designed 1 kbit antifuse OTP memory IP with Dongbu HiTek's 0.18 μm Bipolar-CmOS-DmOS(BCD) process is 567.9 μm×205.135 μm and the post-program resistance of an antifuse is predicted to be several ten thousand ohms.

关键词： one time programmable memory IP antifuse hard breakdown dual program voltage post-program resistance

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Simulation of Solid Particle Interactions Including Segregated Lamination by Using mPS method

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Computer modeling in Engineering & Sciences 2018年第7期116卷 11-29页

作者： Kyung Sung Kim moo-Hyun Kim Hakun Jang hee Chen Cho Tongm.ong University BusanRepublic of Korea Texas A&m University College StationTXU.S.A mississippi State University MSU.S.A

A new mPS(moving Particle Semi-implicit)method is developed to simulate the behaviors and interactions of multiple fine solid particles as a *** fluid particles are affected by viscosity,so solid particles are affected by *** solid particle dynamics for landslides,dumping,and gravity sorting *** can be difficult to simulate using conventional mPS methods,are modeled in this paper using the developed multi-solid-particle mPS method that benefits from drawing comparisons with the corresponding fluid particle *** present mPS results for dumping solid particles are verified against the corresponding DEm(Discrete Element method)*** shape and angle of repose for solid particles are shown to be highly dependent on the friction coefficient between *** peculiar phenomenon of segregated lamination(gravity sorting)among grains of different densities has been successfully reproduced using the multi-solid-particle mPS *** quality is found to be dependent on the densities and frictional coefficients of the constituent *** behavior of heterogeneous mixtures of multiple solid and liquid particles are also compared and *** newly developed tool offers a window into the physical dynamics of sedimentology that the broader geoscience community might benefit from.

关键词： Fine solid particle mPS(moving Particle Semi-implicit) friction force land sliding dumping segregated lamination heterogeneous multiple particles gravity sorting

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Ultrasonic Plasma Engineering Toward Facile Synthesis of Single-Atom m-N4/N-Doped Carbon(m=Fe,Co) as Superior Oxygen Electrocatalyst in Rechargeable Zinc-Air Batteries

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Nano-micro Letters 2021年第4期13卷 76-95页

作者： Kai Chen Seonghee Kim minyeong Je heechae Choi Zhicong Shi Nikola Vladimir kwang Ho Kim Oi Lun Li Department of materials Science and Engineering Pusan National University30 Jangjeon‑dongGeumjeong‑guBusan 609‑735Republic of Korea Theoretical materials and Chemistry Group Institute of Inorganic ChemistryUniversity of CologneGreinstr.650939 CologneGermany School of materials and Energy Guangdong University of TechnologyGuangzhou 510006People’s Republic of China Faculty of mechanical Engineering and Naval Architecture University of ZagrebIvana Lucica 510002 ZagrebCroatia Global Frontier R&D Center for Hybrid Interface materials 30 Jangjeon‑dongGeumjeong‑guBusan 46241Republic of Korea

As bifunctional oxygen evolution/reduction electrocatalysts,transition-metal-based single-atom-doped nitrogen-carbon(NC)matrices are promising successors of the corresponding noblemetal-based catalysts,offering the advantages of ultrahigh atom utilization effciency and surface active ***,the fabrication of such matrices(e.g.,well-dispersed single-atom-doped m-N4/NCs)often requires numerous steps and tedious ***,ultrasonic plasma engineering allows direct carbonization in a precursor solution containing metal phthalocyanine and *** combining with the dispersion effect of ultrasonic waves,we successfully fabricated uniform single-atom m-N4(m=Fe,Co)carbon catalysts with a production rate as high as 10 mg *** Co-N4/NC presented a bifunctional potential drop ofΔE=0.79 V,outperforming the benchmark Pt/C-Ru/C catalyst(ΔE=0.88 V)at the same catalyst *** calculations revealed that Co-N4 was the major active site with superior O2 adsorption-desorption *** a practical Zn-air battery test,the air electrode coated with Co-N4/NC exhibited a specific capacity(762.8 mAh g(-1))and power density(101.62 mW cm^(-2)),exceeding those of Pt/C-Ru/C(700.8 mAh g^(-1) and 89.16 mW cm^(-2),respectively)at the same catalyst ***,for Co-N4/NC,the potential difference increased from 1.16 to 1.47 V after 100 charge-discharge *** proposed innovative and scalable strategy was concluded to be well suited for the fabrication of single-atom-doped carbons as promising bifunctional oxygen evolution/reduction electrocatalysts for metal-air batteries.

关键词： Single-atom-doped m-N4/NC catalyst Plasma engineering ORR/OER bifunctional activity DFT calculation Rechargeable Zn-air battery

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Kinetic insight into perovskite La_(0.8)Sr_(0.2)VO_(3) nanofibers as an efficient electrocatalytic cathode for high-rate Li-O_(2) batteries

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Infomat 2021年第11期3卷 1295-1310页

作者： myeong-Chang Sung Gwang-hee Lee Dong-Wan Kim School of Civil Environmental and Architectural EngineeringKorea UniversitySeoulSouth Korea

Efficient electrocatalysis at the cathode is essential for overcoming the limitations of Li-O_(2) batteries such as poor stability and low rate ***,we systematically studied the kinetic behavior of a Li-O_(2) battery comprising perovskite La_(0.8)Sr_(0.2)VO_(3) nanofibers formed by partial Sr-cation doping and V cations with multiple oxidation *** with undoped LaVO_(3) and La_(0.8)Sr_(0.2)VO_(4) nanofibers,perovskite La_(0.8)Sr_(0.2)VO_(3) nanofibers exhibited an improved capacity of 2000 mA g^(-1),and a 20-times-longer cycle life in Li-O_(2) batteries.X-ray photoelectron spectroscopy,electron paramagnetic resonance spectroscopy,and photoluminescence analyses revealed that the performance variations mainly originated from crystal defects,which modulate oxygen reduction/evolution *** in situ Raman analysis,we showed that these structural defects are closely related to the oxygen reduction/evolution behavior of La_(0.8)Sr_(0.2)VO_(3) nanofibers and result in fewer parasitic *** study offers insights into the potential rate capability of Li-O_(2) batteries and related devices.

关键词： electrocatalysts La_(0.8)Sr_(0.2)VO_(3) Li-O_(2)battery nanofiber perovskite structure

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Evaluation of the safety of hair essence containing 0.05% purified bee venom.on the skin and eyes of rabbits

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Journal of Traditional Chinese medicine 2020年第1期40卷 67-72页

作者： mi Kyung Lim Eun Hye Han Sang Ho Lee Jee hee Kim R&D Center KoreaeundanGyeonggi-do 13207Republic of Korea

OBJECTIVE:To investigate the safety of hair essence containing 0.05%purified bee venom(HE-PBV)on the skin and eyes of New Zealand White ***:HE-PBV which contained 0.05%PBV,purified water,and glycerin,was used as the test *** skin-irritation test(SIT)and eye-irritation test(EIT)were conducted according to the Draize *** the SIT,HE-PBV(0.5 m L)dropped gauze was attached both intact and abraded skin for 24 *** other side of the skin was used as *** 24 and 72 h,the treatment site was observed and scored according to evaluation criteria for skin *** the EIT,the rabbits were divided into two groups:eye-washed(three rabbits)and non-eye-washed(six rabbits).HE-PBV(0.1 m L)was squirted into the right eye of *** left eye was untreated and used as a ***,20-30-s later,the eyes of rabbits in the eye-washed group were washed with^50 m L of physiologic(0.9%)salt ***,1,2,3,4 and 7 d after the start of the EIT,the eyes and behavior of the rabbits were *** degree of eye irritation elicited by HE-PBV was determined in three steps and then the criteria of the classification of eye-irritation ***:The SIT revealed erythema and edema at the site of HE-PBV *** 72 h,the body weight of rabbits was reduced slightly,but other symptoms(except erythema and edema)were not *** Primary Irritation Index score was0.6,and HE-PBV was deemed to be a slight *** EIT did not show mortality or body-weight fluctuation,but hyperemic conjunctiva and eyelid closure were noted after HE-PBV *** for these results,the score for the ophthalmic response on days 1,2,3,4 and 7 was 0,and HE-PBV was deemed to be a ***:These data suggest that HE-PBV did not elicit eye irritation,but was a slight irritant to the skin of rabbits;the latter slight would have been due to the excipients used in manufacture of the hair essence because PBV has been shown to be safe.

关键词： Alopecia Bee Venoms Hair essence Skin irritancy tests Eye irritancy tests Complementary therapies

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Bioinspired urease-powered micromotor as an active oral drug delivery carrier in stomach

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Bioactive materials 2022年第3期7卷 54-62页

作者： Hyunsik Choi Sang Hoon Jeong Tae Yeon Kim Jeeyoon Yi Sei kwang Hahn Department of materials Science and Engineering Pohang University of Science and Technology(POSTECH)77 Cheongam-roNam-guPohangGyeongbuk37673South Korea

Self-propelling micro-and nano-motors(mNms)have been extensively investigated as an emerging oral drug delivery carrier for gastrointestinal(GI)tract ***,the propulsion of current mNms reported so far is mostly based on the redox reaction of metals(such as Zn and mg)with severe propulsion gas generation,remaining non-degradable residue in the GI ***,we develop a bioinspired enzyme-powered biopolymer micromotor mimicking the mucin penetrating behavior of Helicobacter pylori in the *** converts urea to am.onia and the subsequent increase of pH induces local gel-sol transition of the mucin layer facilitating the penetration into the stomach tissue *** successful fabrication of micromotors is confirmed by high-resolution transmission electron microscopy,electron energy loss spectroscopy,dynamic light scattering analysis,zeta-potential *** acidic condition,the immobilized urease can efficiently converted urea to am.onia,comparable with that of neutral condition because of the increase of surrounding pH during *** administration into the stomach,the micromotors show enhanced penetration and prolonged retention in the stomach for 24 ***,histological analysis shows that the micromotors are cleared within 3 days without causing any toxicity in the GI *** enhanced penetration and retention of the micromotors as an active oral delivery carrier in the stomach would be successfully harnessed for the treatment of various GI tract diseases.

关键词： micro-and nanomotors Polydopamine Urease Oral delivery Stomach diseases

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Brillouin expanded time-domain analysis based on dual optical frequency combs

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Light(Science & Applications) 2024年第8期13卷 1534-1544页

作者： Jae Hyeong Youn kwang Yong Song Sonia martin-Lopez miguel Gonzalez-Herraez maría R.Fernández-Ruiz Dept.of Physics Chung-Ang UniversitySeoulKorea Dept.of Electronics Universidad de AlcaláMadridSpain

Brillouin Optical Time-Domain Analysis(BOTDA)is a widely-used distributed optical fiber sensing technology employing pulse-modulated pump waves for local information retrieval of the Brillouin gain or loss *** spatial resolution of BOTDA systems is intrinsically linked to pulse duration,so high-resolution measurements demand high electronic bandwidths inversely proportional to the *** paper introduces Brillouin Expanded Time-Domain Analysis(BETDA)as a modified BOTDA system,simultaneously achieving high spatial resolution and low detection *** two optical frequency combs(OFCs)with different frequency intervals as pump and probe,local Brillouin gain spectra are recorded by their spectral beating traces in an expanded time domain.A 2-cm-long hotspot located in a 230m single-mode fiber is successfully measured in the time domain with a detection bandwidth of less than 100 kHz using dual OFCs with tailored spectral phase,line spacing,and bandwidth.

关键词： pump optical fiber

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