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Cytogenetic and molecular aberrations of multiple myeloma patients： a single-center study in Singapore

Chinese Medical Journal 2013年第10期126卷 1872-1877页

作者： lim Alvin Soon Tiong lim Tse hui SEE Karen Hsu Shien NG Yit Jun TAN Yu Min CHO0 Natasha Swee Lian lim Sherry Xin Er YEE Yenny LAU Lai Ching TIEN Sim Leng Kumar Sathish TAN Daryl Chen Lung Cytogenetics Laboratory Department of Pathology SingaporeGeneral Hospital Singapore School of Biological Sciences Nanyang Technological UniversitySingapore Temasek Applied Science School Temasek Polytechnic Singapore Department of Haematology Singapore General HospitalSingapore

Background Much is known about the cytogenetic lesions that characterize multiple myeloma （MM） patients from the USA, Europe, and East Asia. However, little has been published about the disease among Southeast Asians. The aim of this study was to determine the chromosomal abnormalities of MM patients in our Singapore population. Methods Forty-five newly-diagnosed, morphologically confirmed patients comprising 18 males and 27 females, aged 46-84 years （median 65 years） were investigated by karyotyping and fluorescence in situ hybridization （FISH）. FISH employing standard panel probes and lp36/lq21 and 6q21/15q22 probes was performed on diagnostic bone marrow samples. Results Thirty-four cases （75.6%） had karyotypic abnormalities. Including FISH, a total detection rate of 91.1% was at- tained. Numerical and complex structural aberrations were common to both hyperdiploid and non-hyperdiploid patients. Numerical gains of several recurring chromosomes were frequent among hyperdiploid patients while structural rear- rangements of several chromosomes including 8q24.1 and 14q32 characterized non-hyperdiploid patients. With FISH, immunoglobulin heavy chain （IGH） gene rearrangements, especially fibroblast growth factor receptor 3 （FGFR3）/IGH and RB1 deletion/monosomy 13 were the most common abnormalities （43.4%）. Amplification lq21 was 10 times more frequent （42.5%） than del（1p36） and del（6q21）. Conclusions We have successfully reported the comprehensive cytogenetic profiling of a cohort of newly-diagnosed myeloma patients in our population. This study indicates that the genetic and cytogenetic abnormalities, and their frequencies, in our study group are generally similar to other populations.

关键词： amp(l q21), del(13q) fluorescence in situ hybridization, immunoglobulin heavy chain, Southeast Asia

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Removal of Methylene Blue Using Chemically Modified Sugarcane Bagasse

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Natural Resources 2015年第4期6卷 209-220页

作者： Handojo Djati Utomo Ru Yi Natalie Phoon Zhonghuan Shen Li hui Ng Zheng Bang lim Division of Civil Engineering School of Architecture and the Built Environment Singapore Polytechnic Singapore City Singapore Advanced Material Technology Centre Technology Development Office Singapore Polytechnic Singapore City Singapore

Methylene Blue (MB) has been found to be one of the most common dyes used in the industries. Adsorption process using Activated Carbon (AC) has been proven to be able to remove MB effectively but the treatment cost using the adsorbent is considered expensive due to its high energy cost. Sugarcane Bagasse (SGB) is an agricultural by-product and abundantly available material in many developing countries. FTIR and XRD were used to confirm the existence of ligno-cellulose content of SGB after experiencing various chemical treatments. SGB had 5 - 40 folds higher MB removal capability than commercial activated carbon, depending on the pH of water medium and the type of SGB. SGB showed a much better performance in adsorbing MB in alkaline environment than in acidic environment. Langmuir adsorption isotherm model was able to estimate the removal capacity of non-chemical treated SGB (NSGB) and CaCl2 treated SGB (CSGB) at 84.7458 mg/g and 35.2113 mg/g respectively. An extremely higher MB removal capacity was found for BSGB due to the complexity of the surface site after chemical treatment. NaOH treated SGB (BSGB) with low lignin residue content was the most favourable adsorbent for MB adsorption.

关键词： Adsorbent Methylene Blue Ligno-Cellulose Sugarcane Bagasse

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Review of imaging and endovascular intervention of iliocaval venous compression syndrome

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World Journal of Radiology 2020年第3期12卷 18-28页

作者： Ming Ren Toh Tjun Yip Tang Han hui Mervin Nathan lim Nanda Venkatanarasimha Karthikeyan Damodharan Duke-NUS Medical School Singapore 544886Singapore Department of Vascular surgery Singapore General HospitalSingapore 169608Singapore Yong Yoo Ling School of Medicine Singapore 117597Singapore Department of Radiology Singapore General HospitalSingapore 169608Singapore Department of Radiology SengKang General HospitalSingapore 544886Singapore

Iliocaval venous compression syndrome(ICS)is the extrinsic compression of the common iliac vein by the overlying iliac artery against the *** compression can lead to venous stenosis and stasis,which manifests as chronic venous disease and treatment ***,early recognition of ICS and prompt treatment are *** presentations of ICS can be ambiguous and diagnosis requires a high index of suspicion with the relevant imaging *** initial imaging test is typically a Duplex ultrasound for vessel assessment and pelvic ultrasound to exclude a compressive mass,which is followed by computed tomography(CT)or magnetic resonance(MR)*** and MRI can identify the anatomical causes for venous *** patients with high clinical suspicion for ICS,negative findings on CT and MR venography would still warrant further *** diagnosis can be established using catheter-based venography complemented with intravascular ultrasonography but the nature of their invasiveness limits its utility as a routine imaging *** this review paper,we will discuss the evidence,utility and limitations of the existing imaging modalities and endovascular intervention used in the management of ICS.

关键词： Iliocaval venous compression syndrome Duplex ultrasound Intravascular ultrasound Computed tomography venography Magnetic resonance venography Endovascular stent

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A Class Effect Network Meta-analysis of Lipid Modulation in Non-alcoholic Steatohepatitis for Dyslipidemia

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Journal of Clinical and Translational Hepatology 2022年第6期10卷 1042-1049页

作者： Jieling Xiao Cheng-Han Ng Yip-Han Chin Darren Jun Hao Tan Wen-hui lim Grace lim Jingxuan Quek Ansel Shao Pin Tang Kai-En Chan Rou-Yi Soong Nicholas Chew Benjamin Tay Daniel Q.Huang Nobuharu Tamaki Roger Foo Mark Y.Chan Mazen Noureddin Mohammad Shadab Siddiqui Arun J.Sanyaland Mark D.Muthiah Yong Loo Lin School of Medicine National University of SingaporeSingapore Lee Kong Chian School of Medicine Nan-yang Technological UniversitySingapore Department of Cardiology National University Heart CenterNational University HospitalSingapore Division of Gastroenterology and Hepatology Department of MedicineNational University HospitalSingaporeSingapore National University Center for Organ Transplantation National University Health SystemSingapore NAFLD Research Center Division of Gastroenterology and HepatologyDepartment of MedicineUniversity of California at San DiegoLa JollaCAUSA Department of Gastroenterology and Hepatology Musashino Red Cross HospitalTokyoJapan Cedars-Sinai Fatty Liver Program Division of Digestive and Liver DiseasesDepartment of MedicineComprehen-sive Transplant CenterCedars-Sinai Medical CenterLos AngelesCAUSA Division of Gastroenterology Hepatology and NutritionDepartment of Internal MedicineVirginia Commonwealth UniversityRichmondVAUSA

Background and Aims:Pharmaceutical therapy for NASH is associated with lipid modulation,but the consensus on drug treatment is limited and lacks comparative analysis of effectiveness.A network meta-analysis was conducted to compare NASH drug classes in lipid ***:Online databases were searched for randomized controlled trails(RCTs)evaluating NASH treatments in biopsy-proven NASH *** were classified into four groups:(1)inflammation,(2)energy,(3)bile acids,and(4)fibro-sis based on the mechanism of action.A Bayesian network analysis was conducted with outcome measured by mean difference(MD)with credible intervals(Crl)and surface un-der the cumulative ranking curve(SUCRA).Results:Forty-four RCTs were included in the *** acid modulat-ing treatments(MD:0.05,Crl:0.03-0.07)were the best treatment for improvement in high-density lipid(HDL)cho-lesterol,followed by treatments modulating energy(MD:0.03,Crl:0.02-0.04)and fibrosis(MD:0.01,Crl:−0.12 to 0.14)compared with *** top three treatments for reduction in triglycerides were treatments modulating energy(MD:−0.46,Crl:−0.49 to−0.43),bile acids(MD:−0.22,Crl:−0.35 to−0.09),and inflammation(MD:−0.08,Crl:−0.13 to−0.03)compared with *** found treatment modulating fibrosis(MD:−1.27,Crl:−1.76 to−0.79)was the best treatment for reduction in low-density lipid(LDL)cholesterol followed by treatment modulating in-flammation(MD:−1.03,Crl:−1.09 to−0.97)and energy(MD:−0.37,Crl:−0.39 to−0.34)compared with placebo,but LDL cholesterol was worsened by treatments modulat-ing bile ***:Network analysis comparing the class effects of dyslipidemia modulation in NASH found that treatment targets can include optimization of athero-genic *** studies are required to evaluate the cardiovascular outcomes.

关键词： Lipid modulation NASH Dyslipidemia

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宫颈HPV持续感染临床特征及宫颈脱落细胞中miR-148a-3p、Pax 1、LMX 1A表达的诊断价值

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中华医院感染学杂志 2024年第14期34卷 2183-2187页

作者：拓明花孙兴文赵文慧马鸿云中卫市中医医院妇产科宁夏回族自治区中卫755099 中卫市妇幼保健院妇产科宁夏回族自治区中卫755000 中卫市中医医院放射科宁夏回族自治区中卫755099

目的探究宫颈人乳头瘤病毒(HPV)持续感染临床特征及脱落细胞中微小RNA-148a-3p(miR-148a-3p)、配对盒基因1(Pax1)、lim同源盒转录因子1α(LMX 1A)表达的诊断价值.方法选取中卫市中医医院2019年12月-2022年12月收治的289例宫颈HPV阳性患... 详细信息

目的探究宫颈人乳头瘤病毒(HPV)持续感染临床特征及脱落细胞中微小RNA-148a-3p(miR-148a-3p)、配对盒基因1(Pax1)、lim同源盒转录因子1α(LMX 1A)表达的诊断价值.方法选取中卫市中医医院2019年12月-2022年12月收治的289例宫颈HPV阳性患者,随访6个月,根据是否发生HPV持续感染分为HPV持续感染组107例和HPV非持续感染组182例.分析宫颈HPV阳性患者HPV持续感染发生的临床特征,比较两组脱落细胞中miR-148a-3p、Pax1、LMX 1A表达水平,采用受试者工作特征(ROC)曲线分析其对宫颈HPV持续感染的诊断价值.结果289例宫颈HPV阳性患者HPV持续感染发生107例,HPV持续感染发生率为37.02%.两组生殖道炎症、人流次数比较差异有统计学意义(P<0.05);HPV持续感染组脱落细胞中miR-148a-3p、Pax 1、LMX 1A表达水平低于HPV非持续感染组(P<0.05).脱落细胞中miR-148a-3p、Pax 1、LMX 1A联合检测诊断宫颈HPV阳性患者HPV持续感染的曲线下面积(AUC)高于各指标单一检测(P<0.05),且联合检测敏感度、特异度为88.79%、80.22%.结论宫颈HPV阳性患者HPV持续感染发生率高,其脱落细胞中miR-148a-3p、Pax1、LMX1A水平呈低表达,且三者联合检测可提高宫颈HPV阳性患者HPV持续感染的诊断价值.

关键词：宫颈人乳头瘤病毒宫颈人乳头瘤病毒持续感染 miR-148a-3p 配对盒基因1 lim同源盒转录因子1α 受试者工作特征曲线

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Monkeypox claims new victims: the outbreak in men who have sex with men

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Infectious Diseases of Poverty 2022年第4期11卷 91-93页

作者： Xiaoning Liu Zheng Zhu Yun He Jia Wen lim Bethany Lane hui Wang Qiaoli Peng Liqin Sun Hongzhou Lu Department of Infectious Diseases National Clinical Research Center for Infectious DiseasesThe Third People's Hospital of ShenzhenShenzhen 518112GuangdongChina National Heart&Lung Institute Faculty of MedicineImperial College LondonLondonUK School of Nursing Fudan UniversityShanghaiChina Fudan University Centre for Evidence-Based Nursing:A Joanna Briggs Institute Centre of Excellence ShanghaiChina NYU Rory Meyers College of Nursing New York UniversityNew YorkNYUSA St Bartholomew's Hospital LondonUK

Monkeypox has a very prominent regional *** has been confined to Western and Central African *** cases found in countries outside Africa generally have a history of sojourn in endemic ***,the recent multinational outbreak of monkeypox cases in Europe in early May 2022 has revealed a changing epidemiological trend,those confirmed cases had no sojourn history in endemic areas and with a high proportion of cases involving men who have sex with men(MSM).Among the MSM cases,many of them presented atypical clinical manifestations of monkeypox and with other sexually transmitted diseases *** with the high social interactivity in this community,there is likely a higher risk of monkeypox transmission in this *** an infectious disease surveillance system,maintaining highly vigilant regarding the transmission of monkeypox in MSM,and responding promptly are necessary and effective measures to contain the outbreak.

关键词： Monkeypox Men have sex with men Public health Infectious diseases

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呼出气体中部分可挥发性有机物用于诊断肺癌的预测模型

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肿瘤 2015年第4期35卷 404-413页

作者：陈璐刘畅康涛 Teong lim 唐永明徐萌惠宏襄南方医科大学生物技术学院国际代谢病中心广东广州510518 东莞南方医大代谢医学研发有限公司广东东莞523000 暨南大学附属第一医院肿瘤科广东广州510630 美国加州大学洛杉矶大卫格芬医学院胰腺病中心加利福尼亚州洛杉矶90095

目的 :通过比较病理确诊的肺癌患者与健康人呼出气体中可挥发性有机物(volatile organic compounds,VOCs)的差异,寻找可作为肺癌诊断的特异性生物学标志物。方法:收集63例病理确诊的肺癌患者(研究组)和72例健康人(对照组)的呼出气体,应... 详细信息

目的 :通过比较病理确诊的肺癌患者与健康人呼出气体中可挥发性有机物(volatile organic compounds,VOCs)的差异,寻找可作为肺癌诊断的特异性生物学标志物。方法:收集63例病理确诊的肺癌患者(研究组)和72例健康人(对照组)的呼出气体,应用电子鼻对呼出气体中的VOCs进行检测。采用MannWhitney U检验对2组的VOCs进行比较,二分类logistic回归及逐步法筛选变量,建立预测模型,并应用受试者工作特征(receiver operating characteristic,ROC)曲线评价预测模型的诊断能力。结果:研究组与对照组的二甲基甲烷、乙醇、甲烷、己烷、2,2,4,6,6-五甲基庚烷、篙属酮、侧柏醇、十二烷和1,2,6-三甲基萘这9种VOCs成分浓度的差异有统计学意义,结合临床其他相关信息建立的预测模型的方程式为P=1/[1+e(-9.006+0.101×X 1+0.01×X 2+0.02×X 3-0.518×X 4)](其中X 1、X 2、X 3和X 4分别为年龄、己烷浓度、2,2,4,6,6-五甲基庚烷浓度和1,2,6-三甲基萘浓度)。此预测模型对研究组和对照组的判对率分别为80.6%和83.9%,敏感度和特异度分别为74.0%和93.0%。结论:呼出气体中VOCs的组成和浓度可以反映机体的代谢状态和特定的疾病状态。建立和开发呼出气体中VOCs的数据库,对肺癌诊断具有重要的理论和实践意义。

关键词：肺肿瘤可挥发性有机物生物学标志物诊断

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Stenting as a bridge to surgery in obstructing colon cancer:Longterm recurrence pattern and competing risk of mortality

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World Journal of Gastrointestinal Endoscopy 2023年第2期15卷 64-76页

作者： Aik Yong Chok Yun Zhao hui Jun lim Yvonne Ying Ru Ng Emile John Kwong Wei Tan Department of Colorectal Surgery Singapore General HospitalSingapore 169608Singapore Department of Group Analytics Singapore Health ServicesSingapore 168582Singapore

BACKGROUND Stenting as a bridge to curative surgery(SBTS)for obstructing colon cancer(OCC)has been associated with possibly worse oncological *** To evaluate the recurrence patterns,survival outcomes,and colorectal cancer(CRC)-specific death in patients undergoing SBTS for *** Data from 62 patients undergoing SBTS at a single tertiary centre over ten years between 2007 and 2016 were retrospectively *** outcomes were recurrence patterns,overall survival(OS),cancer-specific survival(CSS),and CRC-specific *** and CSS were estimated using the Kaplan-Meier *** risk analysis with cumulative incidence function(CIF)was used to estimate CRC-specific mortality with other cause-specific death as a competing ***-Gray regressions were performed to determine prognostic factors of CRC-specific *** and multivariate subdistribution hazard ratios and their corresponding Wald test P values were *** 28 patients(45.2%)developed metastases after a median period of 16 *** the 18 patients with single-site metastases:Four had lung-only metastases(14.3%),four had liver-only metastases(14.3%),and 10 had peritoneum-only metastases(35.7%),while 10 patients had two or more sites of metastatic disease(35.7%).The peritoneum was the most prevalent(60.7%)site of metastatic involvement(17/28).The median follow-up duration was 46 mo.26(41.9%)of the 62 patients died,of which 16(61.5%)were CRC-specific deaths and 10(38.5%)were deaths owing to other causes. The 1-, 3-, and 5-year OS probabilities were 88%, 74%, and 59%;1-, 3-, and5-year CSS probabilities were 97%, 83%, and 67%. The highest CIF for CRC-specific death at 60 mowas liver-only recurrence (0.69). Liver-only recurrence, peritoneum-only recurrence, and two ormore recurrence sites were predictive of CRC-specific *** peritoneum was the most common metastatic site among patients undergoing SBTS. Liveronlyrecurrence, peritoneum-only recurrence, an

关键词： Obstructing colon cancer Colorectal cancer Endoscopic stenting Competing risk analysis Survival Recurrence Peritoneal metastasis

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Toll-like receptor 9 is correlated to disease activity in Chinese systemic lupus erythematosus population

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Chinese Medical Journal 2012年第16期125卷 2873-2877页

作者： MU Rong SUN Xiao-yun Lik Thai lim XU Chuan-hui DAI Chen-xian SU Yin JIA Ru-lin LI Zhan-guo Department of Rheumatology Peking University People's Hospital Beijing 100044 China Pfizer Investment Co. Ltd Beijing 100010 China

Methods mRNA level of TLR9 and interferon （IFN） regulatory factor 5 （IRF5） in peripheral blood mononuclear cells （PBMCs） were determined by real-time polymerase chain reaction （PCR）. IFN-a expression was measured in the serum of the SLE patients by enzyme-linked immunosorbent assay （ELISA）. Results TLR9 expression was significantly higher in SLE patients than that in health controls （P=0.011）. SLE patients with positive anti-dsDNA antibody had significantly higher expression of TLR9 than that with negative anti-dsDNA antibody （P=0.001）. TLR9 expression was positively correlated with fever （P=0.017）, alopecia （P=0.046）, safety of estrogens in lupus erythematosus national assessment SLE disease activity index （SELENA-SLEDAI） score （rs=0.385, P=0.003）, and the level of IRF5 （rs=0.35, P=0.027） and IFN-a （rs=0.627, P=0.001） in SLE patients. Conclusion TLR9 is associated with SLE disease activity and might be involved in the IFN-a pathway of SLE.

关键词： Toll-like receptor 9 " interferon regulatory factor 5 " interferon alpha " systemic lupus erythematosus

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Mitochondrial DNA sequence analyses in Bornean sucker fishes (Balitoridae: Teleostei: Gastromyzontinae)

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Integrative Zoology 2006年第1期1卷 12-14页

作者： Zohrah Haji SULAIMAN Tan Heok hui Kelvin K.P.lim Peter K.L.NG Department of Biology Faculty of ScienceUniversiti Brunei DarussalamBrunei Darussalam Department of Biological Science National University of SingaporeSingapore

Phylogenetic relationships among Bornean sucker fishes(Teleostei:Balitoridae:Gastromyzontinae)were investigated by comparing cytochrome b gene sequences from eight *** results were in general agreement with previous morphology-based *** was found that the genera Gastromyzon and Neogastromyzon are both monophyletic and that the Chinese homalopterid Crossostoma lacustre(Homalopterinae)is not related to the Bornean *** molecular-level study of cytochrome b gene variation in Bornean gastromyzontins will undoubtedly help to shed light on the molecular systematics of this unique freshwater fish.

关键词： Borneo gastromyzontins sucker fishes mitochondrial DNA phylogenetic relationship

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