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Effects of core/shell volumetric ratio on the dielectric-temperature behavior of BaTiO_(3)

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Journal of Advanced Ceramics 2014年第1期3卷 76-82页

作者： Sang-Chae JEON Byung-Kwon YOON kwan-Hyeong KIM suk-Joong L.KANG Materials Interface Laboratory Department of Materials Science and EngineeringKorea Advanced Institute of Science and Technology291 Daehak-roYuseong-gu Daejeon 305-701Korea LCR Division Samsung Electro-MechanicsSuwon 443-743Korea

Two sets of(Mg,Y)-doped BaTiO_(3)samples were prepared to investigate the effects of the core/shell volumetric ratio on the dielectric-temperature behavior of BaTiO3:one set with samples of the same grain size but different core sizes and the other with samples of the same core size but different shell *** microstructural variation of the samples was characterized and their dielectric properties were *** both sets of samples,the temperature stability of the dielectric properties was generally improved with a reduction of the volumetric shell ratio regardless of the grain and core *** existed,however,a limit of the reduction;for the studied range,shell thickness of one third of the core radius appeared to be an optimum thickness for the given amounts of *** was concluded that the volumetric shell ratio should be optimized so as not to exceed a specific limit,for our case two thirds of the grain volume,to secure temperature stability of the dielectric properties of BaTiO_(3).

关键词： barium titanate core/shell structure dielectric properties temperature stability

Berberine inhibits inflammatory activation of rat brain microglia

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Neural Regeneration Research 2010年第18期5卷 1384-1390页

作者： Kyong Nyon Nam Jae-Hong Kim Hoon-Ji Jung Jung-Mi Park Sang-kwan Moon Young-suk Kim Sun Yeou Kim Eunjoo H. lee Department of Medical Science Graduate School of East-West Medical ScienceKyung Hee University Department of Cardiovascular & Neurologic Diseases (Stroke Center) Hospital of Oriental MedicineKyung Hee University

Chronic activation of microglial cells endangers neuronal survival through the release of various proinflammatory and neurotoxic factors. Berberine, the effective ingredient of Coptidis Rhizoma and Cortex Phellodendti, has a wide range of pharmacological functions, including anti-inflammatory, anti-atherosclerotic and anti-cancer effects. The neuroprotective potential of berberine has previously been demonstrated. The present study aimed to examine whether berberine could repress microglial activation and can be considered a potential therapeutic candidate to target neurodegenerative diseases. Primary microglial cells and BV2 microglial cells were cultured and stimulated with bacterial lipopolysaccharide （LPS）. Berberine chloride was treated prior to LPS or simultaneously with LPS stimulation. Results revealed that berberine was effective at inhibiting nitric oxide release from primary microglial cells when cells were exposed to the compound prior to LPS or simultaneously with LPS. It also reduced the LPS-stimulated production of tumor necrosis factor-α, interleukin-1β, prostaglandin E2, and intracellular reactive oxygen species and nuclear factor-kappa activation. Additionally, berberine reduced nitric oxide release from microglia stimulated with interferon-γ and amyloid β. These results suggest that berberine provides neuroprotection by reducing the production of various neurotoxic molecules from activated microglia.

关键词： brain inflammation berberine interleukin-1β microglia nuclear factor-kappa nitric oxide prostaglandin tumor necrosis factor-a

Characteristics of Algal Succession Following Rock Scraping at Imwon Area in the East Coast of Korea

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Journal of Ocean University of China 2016年第6期15卷 1087-1093页

作者： Young Dae Kim Jung kwan Alan Myung Mo Nam Chu lee Hyun Il Yoo Su Yeoung Yeon Young Hwan Kim Jang Kyun Kim Jae suk Choi East Sea Fisheries Research Institute National Fisheries Research & Development Institute Gangneung 210-860Republic of Korea Korea National Park Service National Park Research Institute Yeosu 550-833 Republic of Korea Seaweed Research Center 1rational Fisheries Research & Development lnstituie Mokpo 530-831 Republic of Korea Department of Biology Chungbuk National University Chongju 361-763 Republic Of Korea Department of Marine Science School of Natural Sciences Incheon National University 22012 Yeonsu-gu Incheon Korea Department of Marine Sciences University of Connecticut 06901 Stamford Connecticut USA Division of Bioindustry Silla University Sasang-gu Busan 617-736 Republic of Korea

Abstract This study was conducted to clarify the characteristics high-pressure water sprayer in the period from June 2010 to April 2011 of algal succession following rock scraping using hoe or We divided the research area off the eastern coast of Korean near Imwon into 3 categories depending upon the severity of the barren ground, i.e., the urchin barren-affected, urchin bar- ren-ongoing and urchin barren-free areas. In April 2011, in the urchin barren-affected area with 25 seaweed species, the cover per- centage and importance value （IV） of erustose coralline algae were higher than those of other species. In the urchin barren-ongoing area with 33 seaweed species, crustose coralline algae （mean IV=62%） as well as Sargassum sp. （mean IV=28%）, and Gelidium amansii （mean IV= 19%） were observed following rock scraping. In the urchin barren-free area where seaweed communities were relatively abundant with 42 species, a variety of algal species including G. amansii （mean IV = 32%） underwent algal succession. Overall, it was observed that, as an aspect of algal succession, the weaker the barren ground severity was, the more frequent and di- verse the seaweeds were, and the more complex the succession pattern was in the study. As an aspect of recovering algal community, rock scraping using hoe was shown to be superior to the method using high-pressure water spraying. Therefore, we conclude that rock scraping using hoe is a very effective strategy for recovering the algal community in urchin barren-ongoing area.

关键词： algal succession sea-urchin barren ground rock scraping subtidal zone

Pig Chromosome 6（SSC6） Differentially Expressed Genes between Korean Native Pig and Yorkshire breeds

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Pig Chromosome 6（SSC6） Differentially Expressed Genes betw...

Risk factors for postoperative recurrence after primary bowel resection in patients with Crohn's disease

第十五次全国动物遗传育种学术讨论会

作者： Cheol-Koo lee kwan-suk Kim College of Life and Environmental Sciences Korea UniversitySeoulKorea Department of Animal Science Chungbuk National UniversityCheongjuKorea

＜正＞Introduction Loin muscle intramuscular fat（IMF） content is one of the most important parameters for determining the meat *** researches indicated that porcine chromosome 6（SSC6） probably hosts genes related ... 详细信息

关键词： SSC6 IMF Differentially Expressed Gene comparative map

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World Journal of Gastroenterology 2017年第38期23卷 7016-7024页

作者： kwan Mo Yang Chang Sik Yu Jong Lyul lee Chan Wook Kim Yong Sik Yoon In Ja Park Seok-Byung Lim Sang Hyoung Park Byong Duk Ye suk-Kyun Yang Jin Cheon Kim Division of Colon and Rectal Surgery Department of Surgery University of Ulsan College of Medicine Asan Medical Center De-partment of Gastroenterology University of Ulsan College of Medicine Asan Medical Center

AIM To evaluate the risk factors for postoperative recurrence after primary bowel resection in a cohort of Korean Crohn's disease(CD) *** This study included 260 patients with no history of previous bowel surgery who underwent primary surgery for CD between January 2000 and December 2010 at Asan Medical Center(Seoul, South Korea). The median follow-up period was 101 *** During the follow-up period, 66 patients(25.4%) underwent a second operation for disease *** 1, 5 and 10 years after the first operation, the cumulative rate of surgical recurrence was 1.1%, 8.3% and 35.9% and clinical recurrence occurred in 1.2%, 23.6% and 68.1%, respectively. In multivariate analysis, undergoing an emergency operation was a significant risk factor for surgical recurrence-free survival(SRFS) [HR = 2.431, 95%CI: 1.394-4.240, P = 0.002], as were the presence of perianal disease after the first operation(HR = 1.715, 95%CI: 1.005-2.926, P = 0.048) and history of smoking(HR = 1.798, 95%CI: 1.088-2.969, P = 0.022). The postoperative use of antitumor necrosis factor(TNF) agents reduced SRFS risk(HR = 0.521, 95%CI: 0.300-0.904, P = 0.02).CONCLUSION History of smoking, postoperative perianal disease and undergoing an emergency operation were independent risk factors for surgical recurrence. Using anti-TNF agents may reduce surgical recurrence.

关键词： Crohn’s disease Recurrence Risk factor

Superior gallstone dissolubility and safety of tert-amyl ethyl ether over methyl-tertiary butyl ether

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World Journal of Gastroenterology 2019年第39期25卷 5936-5952页

作者： Dong Do You suk Joon Cho Ok-Hee Kim Jin Sook Song Kyu-Seok Hwang Sang Chul lee Kee-Hwan Kim Ho Joong Choi Ha-Eun Hong Haeyeon Seo Tae Ho Hong Jung Hyun Park Tae Yoon lee Joseph Ahn Jae-Kyung Jung kwan-Young Jung Say-June Kim Department of Surgery St.Vincent's HospitalCollege of MedicineThe Catholic University of KoreaSeoul 16247South Korea College of Pharmacy Chungbuk National UniversityCheongju 28644South Korea Department of Surgery Seoul St.Mary’s HospitalCollege of Medicinethe Catholic University of KoreaSeoul 06591South Korea Catholic Central Laboratory of Surgery Institute of Biomedical IndustryCollege of Medicinethe Catholic University of KoreaSeoul 06591South Korea Bio and Drug Discovery Division Korea Research Institute of Chemical TechnologyDaejeon 34114South Korea Department of Surgery Daejeon St.Mary's HospitalCollege of Medicinethe Catholic University of KoreaSeoul 34943South Korea Department of Surgery Uijeongbu St.Mary's HospitalCollege of Medicinethe Catholic University of KoreaSeoul 11765South Korea Department of Biomedicine and Health Science College of Medicinethe Catholic University of KoreaSeoul 06591South Korea Department of Surgery Eunpyeong St.Mary’s HospitalCollege of Medicinethe Catholic University of KoreaSeoul 03312South Korea Department of Medicinal Chemistry and Pharmacology University of Science and TechnologyDaejeon 34113South Korea

BACKGROUND The use of methyl-tertiary butyl ether(MTBE)to dissolve gallstones has been limited due to concerns over its toxicity and the widespread recognition of the safety of laparoscopic *** adverse effects of MTBE are largely attributed to its low boiling point,resulting in a tendency to ***,if there is a material with a higher boiling point and similar or higher dissolubility than MTBE,it is expected to be an attractive alternative to *** To determine whether tert-amyl ethyl ether(TAEE),an MTBE analogue with a relatively higher boiling point(102°C),could be used as an alternative to MTBE in terms of gallstone dissolubility and *** The in vitro dissolubility of MTBE and TAEE was determined by measuring the dry weights of human gallstones at predetermined time intervals after placing them in glass containers with either of the two *** in vivo dissolubility was determined by comparing the weights of solvent-treated gallstones and control(dimethyl sulfoxide)-treated gallstones,after the direct infusion of each solvent into the gallbladder in both hamster models with cholesterol and pigmented *** The in vitro results demonstrated a 24 h TAEE-dissolubility of 76.7%,56.5%and 38.75%for cholesterol,mixed,and pigmented gallstones,respectively,which represented a 1.2-,1.4-,and 1.3-fold increase in dissolubility compared to that of *** the in vitro experiment,the 24 h-dissolubility of TAEE was 71.7%and 63.0%for cholesterol and pigmented gallstones,respectively,which represented a 1.4-and 1.9-fold increase in dissolubility compared to that of *** addition,the results of the cell viability assay and western blot analysis indicated that TAEE had a lower toxicity towards gallbladder epithelial cells than *** We demonstrated that TAEE has higher gallstone dissolubility properties and safety than those of *** such,TAEE could present an attractive alternative to MTBE if our findings

关键词： Tert-amyl ethyl ether Gallstones Methyl-tert-butyl ether Contact litholytic agent

Mechanistic study on the effect of cytokine-induced cardiogenesis in embryonic stem cells

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Mechanistic study on the effect of cytokine-induced cardioge...

Cho Min-suk 未来建筑的Mass Studies

第八届海峡两岸心血管科学研讨会

作者： Sau kwan Law Cecilia Sze-lee Leung Chi Lok Tse Ka Long Yau Christina Fung-Ping Leung suk Ying Tsang School of Life Sciences the Chinese University of Hong Kong School of Biomedical Sciences the Chinese University of Hong Kong

＜正＞Embryonic stem cells（ESCs） can self - renew and are pluripotent,meaning that they can proliferate indefinitely in culture while maintaining the ability to differentiate into all cell types,including the cardiomyocytes. During myocardial infarction,significant number of cardiomyocytes is *** can be a potential source of cardiomyocytes for cell replacement *** myocardial infarction,proinflammatory cytokines, including interleukin 1 -beta（IL-1 β ）,interleukin 6（IL-6）,interleukin 10（IL - 10） and interleukin 18（IL- 18） are *** aims of the present study were to investigate the effects of these cytokines on the cardiac differentiation of ESCs,and the mechanisms underlying their effects on cardiac differentiation. The changes of intracellular reactive oxygen species（ROS） level upon cytokine treatment in differentiating embryoid bodies（EBs） were examined by confocal ***-1 β ,IL - 10 and IL - 18 were found to increase the intracellular ROS level in differentiating *** western blotting,ROS were found to enhance cardiac differentiation by increasing the expression of cardiac transcription factors（TFs）,consistent with previous *** addition,ROS was also found to post-translationally modify and activate the cardiac TFs. ROS was found to increase the expression of active phosphorylated TFs while decrease the expression of inactive phosphorylated *** present results showed that some proinflammatory cytokines increased ROS generation in differentiating EBs while ROS increased cardiac differentiation by both increasing the expression and activity of cardiac *** studies would be required to investigate if these cytokines increase cardiac differentiation through increasing ROS.

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缤纷 2007年第5期 132-133页

作者： Vivi Ying Kim Yong kwan

Cho Min-suk之于韩国建筑界,就好像马岩松之于中国建筑界:一样的毕业于名校——获哥伦比亚大学建筑学硕士,一样的师从于大师——曾经在OMA和Rem Koolhass共事,他是OMA在韩国两个项目的顾问,也是Rem Koolhass在韩国最好的朋友。目前他在... 详细信息

Cho Min-suk之于韩国建筑界,就好像马岩松之于中国建筑界:一样的毕业于名校——获哥伦比亚大学建筑学硕士,一样的师从于大师——曾经在OMA和Rem Koolhass共事,他是OMA在韩国两个项目的顾问,也是Rem Koolhass在韩国最好的朋友。目前他在韩国被认为是新锐建筑师的代表,并两次获得进步建筑奖(Progressive architecture)。其设计具有梦幻感和现代感。

关键词：未来建筑韩国建筑物像素房子设计经营项目理想与现实社会文化建筑学硕士