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Porcine vesical acellular matrix graft of tunica albuginea for penile reconstruction

Asian Journal of Andrology 2006年第5期8卷 543-548页

作者： kwan-joong joo Byung-Soo Kim Jeong-Ho Han Chang-Ju Kim Chil-HunKwon Heung-JaePark Department of Urology Kangbuk Samsung HospitalSungkyunkwan University School of Medicine108 Pyung-DongJongro-KuSeoul 110-746Korea Department of Chemical Engineering Hanyang University College of Engineering 17 Hangdang-DongSeongdong-KuSeoul 133-791Korea Department of Pathology Samsung Medical CenterSungkyunkwan University School of Medicine50 Ilwon-DongGangnam-KuSeoul 135-710Korea Department of Physiology Kyung Hee University College of Medicine1 Hoegi-DongDongdaemun-Ku Seoul 130-701Korea

Aim： To characterize the feasibility of the surgical replacement of the penile tunica albuginea （TA） and to evaluate the value of a porcine bladder acellular matrix （BAM） graft. Methods： Acellular matrices were constructed from pigs＇ bladders by cell lysis, and then examined by scanning electron microscopy （SEM）. Expression levels of the mRNA of the vascular endothelial growth factor （VEGF） receptor, fibroblast growth factor （FGF）-1 receptor, neuregulin, and brain-derived neurotrophic factor （BDNF） in the acellular matrix and submucosa of the pigs＇ bladders were determined through the reverse transcription-polymerase chain reaction （PCR）. A 5 mm× 5 mm square was excised from the penile TA of nine rabbits. The defective TA was then covered in porcine BAM. Equal numbers of animals were sacrificed and histochemically examined at 2, 4 and 6 months after implantation. Results： SEM of the BAM showed collagen fibers with many pores. VEGF receptor, FGF-1 receptor and neuregulin mRNA were expressed in the porcine BAM; BDNF mRNA was not detected. Two months after implantation, the graft sites exhibited excellent healing without contracture, and the fusion between the graft and the neighboring normal TA appeared to be well established. There were no significant histological differences between the implanted tunica and the normal control tunica at 6 months after implantation. Conclusion： The porcine BAM graft resulted in a structure which was sufficiently like that of the normal TA. This implantation might be considered applicable to the reconstruction of the TA in conditions such as trauma or Peyronie＇s disease.

关键词： tissue engineering extracellular matrix penis reconstructive surgical procedure graft survival

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The current status of hormone treatment for prostate cancer patients in Korean real-world practice:a multi-institutional observational study

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Asian Journal of Andrology 2019年第2期21卷 115-120页

作者： Jung Kwon Kim Jung Jun Kim Taek Won Gang Tae Kyun Kwon Hong Sup Kim Seung Chui Park Jae-Shin Park Jong-Yeon Park Seok joong Yoon Youn-Soo Jeon Jin Seon Cho Kwan Joong Joo Sung-Hoo Hong Seok-Soo Byun the Korean Urological Oncology Society Department of Urology Seoul National University Bundang HospitalSeongnam 13620Korea Department of Urology Hallym University Sacred Heart HospitalAnyang 14068Korea Department of Urology Kangbuk Samsung HospitalSeoul 03181Korea Department of Urology Seoul St.Mary HospitalSeoul 06591Korea 不详 Department of Urology Chonnam National University HospitalGwangju 61469Korea School of Medicine Kyungpook National University Medical CenterDaegu 41404Korea Department of Urology Konkuk University Medical CenterSeoul 05080Korea Department of Urology Wonkwang University HospitalIksan 54538Korea Department of Urology Daegu Catholic University Medical CenterDaegu 41911Korea Department of Urology Ulsan UniversityGangneung Asan HospitalGangneung 25440Korea Department of Urology Chungbuk National University HospitalCheongju 28644Korea Department of Urology Soonchunhyang University HospitalCheonan 31151Korea

We aimed to evaluate the current nationwide trend,efficacy,safety,and quality of life(QoL)profiles of hormone treatment in real-world practice settings for prostate cancer(PCa)patients in Korea.A total of 292 men with any biopsy-proven PCa(TanyNanyMany)from 12 institutions in Korea were included in this multi-institutional,observational study of prospectively collected data.All luteinizing hormone-releasing hormone(LHRH)agonists were allowed to be investigational drugs.Efficacy was defined as(1)the rate of castration(serum testosterone≤50 ng dl^-1)at 4-week visit and(2)breakthrough(serum testosterone>50 ng dl^-1 after castration).Safety assessments included routine examinations for potential adverse events,laboratory tests,blood pressure,body weight,and bone min era I density(BMD,at baseli ne and at the last follow-up visit).QoL was assessed using the Expa nded Prostate Cancer Index Composite-26(EPIC-26).The most comm on initial therapeutic regimen was LHRH agonist with an ti-androge n(78.0%),and the most commonly used LHRH agonist for combination and mono therapy was leuprolide(64.0%for combi natio n and 58.0%for monotherapy).The castration and breakthrough rates were 78.4%and 6.6%,respectively.The laboratory results related to dyslipidemia worsened after 4 weeks of hormone treatment.In addition,the mean BMD T-score was significantly lower at the last follow-up(mean:-1.950)compared to baseline(mean:-0.195).The mean total EPIC-26 score decreased from 84.8(standard deviation[s.d.]:12.2)to 78.3(s.d.:8.1),with significant deterioration only in the urinary domain(mean:23.5 at baseli ne and 21.9 at the 4-week visit).These findi ngs dem on strate the n ationwide trend of current practice setti ngs in hormone treatment for PCa in Korea.

关键词： efficacy hormonal treatment Korean population prostate cancer safety trend

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Activation of non-basal ＜c + a> slip in multicomponent Mg alloys

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Journal of Magnesium and Alloys 2022年第2期10卷 585-597页

作者： Hyo-Sun Jang Jong-kwan Lee Antonio Jo?o Seco Ferreira Tapia Nack joon Kim Byeong-joo Lee Department of Materials Science and Engineering Pohang University of Science and Technology (POSTECH) Graduate Institute of Ferrous Technology Pohang University of Science and Technology (POSTECH)

Activating non-basal slip is a key method to improve room temperature ductility and formability of Mg alloys. However, the detailed criterion for activation of the slip in multicomponent Mg alloys, which can be utilized in commercial Mg alloys, requires further understanding. The present authors investigated the mechanism and criterion using a molecular statics simulation on dislocation behaviors in multicomponent Mg alloys. We found that if multicomponent Mg alloys have an equivalent dislocation binding intensity to associated binary Mg alloys that are optimized to minimize the critical resolved shear stress anisotropy and thus activate the slip,then the critical resolved shear stress anisotropy between slip systems of the multicomponent Mg alloys can also be minimized, resulting in activation of the slip. The activation is maximized in multicomponent Mg alloys when alloying a large amount of weak dislocation binding elements. It was confirmed through experiments that the multicomponent Mg alloys satisfying the above criterion show higher room-temperature tensile elongation and formability than other alloys.

关键词： Mg–Zn–Ca alloy Molecular statics simulation Ductility Formability

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Electrochemical characteristics of phosphorus doped Si-C composite for anode active material of lithium secondary batteries

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中国有色金属学会会刊：英文版 2009年第4期19卷 1018-1022页

作者： Jae-Hyun NOH kwan-Yo ung LEE joong-Kee LEE Battery Research Center Korea Institute of Science and Technology Department of Chemical and Biological Engineering Korea University

Phosphorus doped silicon-carbon composite particles were synthesized through a DC arc plasma torch.Silane(SiH4) and methane(CH4) were introduced into the reaction chamber as the precursor of silicon and carbon,respectively.Phosphine(PH3) was used as a phosphorus dopant gas.Characterization of synthesized particles were carried out by scanning electron microscopy(SEM),X-ray diffractometry(XRD),X-ray photoelectron spectroscopy(XPS) and bulk resistivity measurement.Electrochemical properties were investigated by cyclic test and electrochemical voltage spectroscopy(EVS).In the experimental range,phosphorus doped silicon-carbon composite electrode exhibits enhanced cycle performance than intrinsic silicon and phosphorus doped silicon.It can be explained that incorporation of carbon into silicon acts as a buffer matrix and phosphorus doping plays an important role to enhance the conductivity of the electrode,which leads to the improvement of the cycle performance of the cell.

关键词：电化学特性磷掺杂负极活性材料磷硅电池材料锂离子 X射线光电子能谱扫描电子显微镜

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Periodic Tail Motion Linked to Wing Motion Affects the Longitudinal Stability of Ornithopter Flight

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Journal of Bionic Engineering 2012年第1期9卷 18-28页

作者： Jun-seong Lee joong-kwan Kim Jae-hung Han Charles P. Ellington Department of Aerospace Engineering KAIST Daejeon 305701 South Korea Department of Zoology University of Cambridge Downing Street Cambridge CB2 3EJ UK

During slow level flight of a pigeon, a caudal muscle involved in tail movement, the levator caudae pars vertebralis, is activated at a particular phase with the pectoralis wing muscle. Inspired by mechanisms for the control of stability in flying animals, especially the role of the tail in avian flight, we investigated how periodic tail motion linked to motion of the wings affects the longitudinal stability of ornithopter flight. This was achieved by using an integrative ornithopter flight simulator that included aeroelastic behaviour of the flexible wings and tail. Trim flight trajectories of the simulated omithopter model were calculated by time integration of the nonlinear equations of a flexible multi-body dynamics coupled with a semi-empirical flapping-wing and tail aerodynamic models. The unique trim flight characteristics of ornithopter, Limit-Cycle Oscillation, were found under the sets of wingbeat frequency and tail elevation angle, and the appropriate phase angle of tail motion was determined by parameter studies minimizing the amplitude of the oscillations. The numerical simulation results show that tail actuation synchronized with wing motion suppresses the oscillation of body pitch angle over a wide range of wingbeat frequencies.

关键词： omithopter flapping flight periodic tail motion longitudinal flight stability aeroelasticity

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Risk of sedation for diagnostic esophagogastroduodenoscopy in obstructive sleep apnea patients

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World Journal of Gastroenterology 2013年第29期19卷 4745-4751页

作者： Jae Myung Cha Jung Won Jeun kwan Mi Pack Joung Il Lee kwang Ro joo Hyun Phil Shin Won-Chul Shin Department of Internal Medicine Kyung Hee University Hospital at Gang Dong Seoul 134-727 South Korea Department of Neurology Kyung Hee University Hospital at Gang Dong Seoul 134-727 South Korea

AIM: To investigate whether patients with obstructive sleep apnea (OSA) are at risk of sedation-related complications during diagnostic esophagogastroduodenoscopy (EGD). METHODS: A prospective study was performed in consecutive patients with OSA, who were confirmed with full-night polysomnography between July 2010 and April 2011. The occurrence of cardiopulmonary complications related to sedation during diagnostic EGD was compared between OSA and control groups. RESULTS: During the study period, 31 patients with OSA and 65 controls were enrolled. Compared with the control group, a higher dosage of midazolam was administered (P = 0.000) and a higher proportion of deep sedation was performed (P = 0.024) in the OSA group. However, all adverse events, including sedation fail-ure, paradoxical responses, snoring or apnea, hypoxia, hypotension, oxygen or flumazenil administration, and other adverse events were not different between the two groups (all P > 0.1). Patients with OSA were not predisposed to hypoxia with multivariate logistic regression analysis (P = 0.068). CONCLUSION: In patients with OSA, this limited sized study did not disclose an increased risk of cardiopulmonary complications during diagnostic EGD under sedation.

关键词： Conscious sedation Obstructive sleep apnea Endoscopy Complications Safety

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Effects of core/shell volumetric ratio on the dielectric-temperature behavior of BaTiO_(3)

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Journal of Advanced Ceramics 2014年第1期3卷 76-82页

作者： Sang-Chae JEON Byung-Kwon YOON kwan-Hyeong KIM Suk-joong L.KANG Materials Interface Laboratory Department of Materials Science and EngineeringKorea Advanced Institute of Science and Technology291 Daehak-roYuseong-gu Daejeon 305-701Korea LCR Division Samsung Electro-MechanicsSuwon 443-743Korea

Two sets of(Mg,Y)-doped BaTiO_(3)samples were prepared to investigate the effects of the core/shell volumetric ratio on the dielectric-temperature behavior of BaTiO3:one set with samples of the same grain size but different core sizes and the other with samples of the same core size but different shell thicknesses.The microstructural variation of the samples was characterized and their dielectric properties were measured.For both sets of samples,the temperature stability of the dielectric properties was generally improved with a reduction of the volumetric shell ratio regardless of the grain and core sizes.There existed,however,a limit of the reduction;for the studied range,shell thickness of one third of the core radius appeared to be an optimum thickness for the given amounts of dopants.It was concluded that the volumetric shell ratio should be optimized so as not to exceed a specific limit,for our case two thirds of the grain volume,to secure temperature stability of the dielectric properties of BaTiO_(3).

关键词： barium titanate core/shell structure dielectric properties temperature stability

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Effects of tissue-cultured mountain ginseng （Panax ginseng CA Meyer） extract on male patients with erectile dysfunction

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Asian Journal of Andrology 2009年第3期11卷 356-361页

作者： Tae-Hwan Kim Seung Hyun Jeon Eun-joo Hahn Kee-Yoeup Paek Jong kwan Park Nae Young Youn Hyung-Lae Lee Department of Urology School of Medicine Kyung Hee University Seoul 134-727 Korea Research Center for the Development of Advanced Horticultural Technology Chungbuk National University Cheongju 361-711 Korea Department of Urology Chonbuk National University Medical School Jeonju 561-712 Korea Infertility Clinic Sanbornjeil Women＇s Hospital Kunpo 435-042 Korea

Korean ginseng and mountain ginseng （Panax ginseng CA Meyer） are important traditional herbal plants whose ginsenosides are generally accepted as serving to improve sexual functions, such as penile erection. We investigated the effects of tissue-cultured mountain ginseng extract （TMGE） on male patients with erectile dysfunction （ED）. A double-blind, placebo-controlled study was conducted with 143 patients experiencing ED. Over the course of 8 weeks, one group took 1 000 mg of TMGE twice a day, and the other group took 1 000 mg of placebo twice a day. The effects of the TMGE and the placebo were analyzed using the Korean version of the International Index of Erectile Function （IIEF） questionnaire. A total of 86 patients completed 8 weeks of treatment. The scores on the five domains of the IIEF after medication were significantly higher than the baseline scores in the group treated with TMGE （P 〈 0.05）, whereas no significant improvement was observed in the placebo group （P 〉 0.05）. Erectile function and overall satisfaction scores after medication were significantly higher in the TMGE group than in the placebo group （P 〈 0.05）. Erectile function of patients in the TMGE-treated group significantly improved, suggesting that TMGE could be utilized for improving erectile function in male patients.

关键词： erectile dysfunction Panax ginseng tissue-cultured mountain ginseng extract

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Metachronous bile duct cancer nine years after resection of gallbladder cancer

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World Journal of Gastroenterology 2009年第27期15卷 3440-3444页

作者： Hye Jin joo Gi Hyun Kim Won joong Jeon Hee Bok Chae Seon Mee Par Sei Jin Youn Jae Woon Choi Rohyun Sung Department of Internal Medicine College of Medicine Chungbuk National UniversityGaeshindong 62 Heungdukgu Cheongju 361-711 South Korea Department of General Surgery Chungbuk National UniversityGaeshindong 62 Heungdukgu Cheongju 361-711 South Korea Department of Pathology College of Medicine Chungbuk National UniversityGaeshindong 62 Heungdukgu Cheongju 361-711 South Korea

We report a rare case of a 74-year-old man with metachronous gallbladder cancer and bile duct cancer who underwent curative resection twice, with the operations nine years apart. At the age of 65 years, the patient underwent a cholecystectomy and resection of the liver bed for gallbladder cancer. This was a well-differentiated adenocarcinoma, with negative resection margins (T2N0M0, stageB). Nine years later,during a follow-up examination, abdominal computed tomography and MRCP showed an enhanced 1.7 cm mass in the hilum that extended to the second branch of the right intrahepatic bile duct. We diagnosed thislesion as a perihilar bile duct cancer, Bismuth type.

关键词：腺癌胆囊胆道异时性断层扫描医学文献切除术胆管

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Hepatolithiasis and intrahepatic cholangiocarcinoma: A review

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World Journal of Gastroenterology 2015年第48期21卷 13418-13431页

作者： Hyo Jung Kim Jae Seon Kim Moon Kyung joo Beom Jae Lee Ji Hoon Kim Jong Eun Yeon Jong-Jae Park kwan Soo Byun Young-Tae Bak Department of Internal Medicine Korea University college of MedicineGuro Hospital

Although the incidence of hepatolithiasis is decreasing as the pattern of gallstone disease changes in Asia, the prevalence of hepatolithiasis is persistently high, especially in Far Eastern countries. Hepatolithiasis is an established risk factor for cholangiocarcinoma(CCA), and chronic proliferative inflammation may be involved in biliary carcinogenesis and in inducing the upregulation of cell-proliferating factors. With the use of advanced imaging modalities, there has been much improvement in the management of hepatolithiasis and the diagnosis of hepatolithiasis-associated CCA(HLCCA). However, there are many problems in managing the strictures in hepatolithiasis and differentiating them from infiltrating types of CCA. Surgical resection is recommended in cases of single lobe hepatolithiasis with atrophy, uncontrolled stricture, symptom duration of more than 10 years, and long history of biliaryenteric anastomosis. Even after resection, patients should be followed with caution for development of HL-CCA, because HL-CCA is an independent prognostic factor for survival. It is not yet clear whether hepatic resection can reduce the occurrence of subsequent HL-CCA. Furthermore, there are no consistent findings regarding prediction of subsequent HL-CCA in patients with hepatolithiasis. In the management of hepatolithiasis, important factors are the reduction of recurrence of cholangitis and suspicion of unrecognized HL-CCA.

关键词： Cholangiocarcinoma Hepatolithiasis Intrahepatic Management

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