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YPED: An Integrated Bioinformatics Suite and Database for Mass Spectrometry-based Proteomics Research

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Genomics, Proteomics & Bioinformatics 2015年第1期13卷 25-35页

作者： Christopher M.Colangelo Mark Shifman Kei-hoi Cheung Kathryn L.Stone Nicholas J.Carriero Erol E.Gulcicek TuKiet T.Lam Terence Wu Robert D.Bjornson Can Bruce Angus C.Nairn Jesse Rinehart Perry L.Miller Kenneth R.Williams W.M.Keck Foundation Biotechnology Resource Laboratory School of Medicine Yale University Department of Molecular Biophysics & Biochemistry Yale University Yale Center for Medical Informatics School of Medicine Yale University Department of Anesthesiology School of Medicine Yale University Department of Emergency Medicine School of Medicine Yale University VA Connecticut Healthcare System W.M. Keck Foundation Biotechnology Resource Laboratory School of Medicine Yale University Department of Computer Science Yale University Yale Center for Genome Analysis West Campus Yale University Yale West Campus Analytical Core West Campus Yale University Yale Bioinformatics Resource School of Medicine Yale University Department of Psychiatry School of Medicine Yale University Department of Cellular & Molecular Physiology School of Medicine Yale University Systems Biology Institute Yale University

We report a significantly-enhanced bioinformatics suite and database for proteomics research called Yale Protein Expression Database（YPED） that is used by investigators at more than 300 institutions worldwide. YPED meets the data management, archival, and analysis needs of a high-throughput mass spectrometry-based proteomics research ranging from a singlelaboratory, group of laboratories within and beyond an institution, to the entire proteomics community. The current version is a significant improvement over the first version in that it contains new modules for liquid chromatography–tandem mass spectrometry（LC–MS/MS） database search results, label and label-free quantitative proteomic analysis, and several scoring outputs for phosphopeptide site localization. In addition, we have added both peptide and protein comparative analysis tools to enable pairwise analysis of distinct peptides/proteins in each sample and of overlapping peptides/proteins between all samples in multiple datasets. We have also implemented a targeted proteomics module for automated multiple reaction monitoring（MRM）/selective reaction monitoring（SRM） assay development. We have linked YPED＇s database search results and both label-based and label-free fold-change analysis to the Skyline Panorama repository for online spectra visualization. In addition, we have built enhanced functionality to curate peptide identifications into an MS/MS peptide spectral library for all of our protein database search identification results.

关键词： Proteomics Database Bioinformatics Mass spectrometry Repository Spectral library

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促进专校学生全人健康工作坊的评估

中国健康心理学杂志 2016年第1期24卷 97-102页

作者：吴海雅梅锦荣中国.香港明爱専上学院香港大学

目的：评估身心灵工作坊提高专校学生全人健康的效用。工作坊为期两天,为参与者做好应对未来负面事件的准备,通过增进内在能量、正念觉醒、爱、宽恕等素质,提升学生的全人健康。方法：参与工作坊的是香港某专校学生（n=42,女生占60%）... 详细信息

目的：评估身心灵工作坊提高专校学生全人健康的效用。工作坊为期两天,为参与者做好应对未来负面事件的准备,通过增进内在能量、正念觉醒、爱、宽恕等素质,提升学生的全人健康。方法：参与工作坊的是香港某专校学生（n=42,女生占60%）。本研究采用实验前后测试的对照组设计,以全人健康的标准化量表为评估指标。结果：参与工作坊后,学生的沉着平静（安然无住、正念觉醒、活力充沛、灵性自理）显著提升[F（1,91）=15.51-21.64,P〈0.001];而苦恼情绪（情绪脆弱、烦燥易怒、灵性失向）则明显减少[F（1,91）=4.49-38.64,P〈0.05-0.001]。结论：整合身心灵的工作坊,提升了处于成人初显期专校学生的全人健康,学生可望有更强大的韧力,应对未来的生活压力。

关键词：全人健康身心灵工作坊专校学生评估研究

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急性播散性腦脊髓炎1例報告

镜湖医学 2022年第2期22卷 58-58,49页

作者：何志納曾揚海澳門鏡湖醫院急診科中国澳门

急性播散性腦脊髓炎(ADEM)是一種由免疫介導,進展迅速的中樞神經系統炎性脫髓鞘疾病,主要以多灶性或彌漫性脫髓鞘病理改變為特徵[1],多見於冬春季節發病[2],與先前感染和疫苗接種有關,與疫苗相關的ADEM佔不到總量的5%[3],其中在6歲~17... 详细信息

急性播散性腦脊髓炎(ADEM)是一種由免疫介導,進展迅速的中樞神經系統炎性脫髓鞘疾病,主要以多灶性或彌漫性脫髓鞘病理改變為特徵[1],多見於冬春季節發病[2],與先前感染和疫苗接種有關,與疫苗相關的ADEM佔不到總量的5%[3],其中在6歲~17歲年齡段以接種HPV疫苗後出現ADEM的佔比最多見[4]。

关键词： HPV疫苗多灶性脊髓炎髓鞘急性播散性 ADEM

Neuroglobin promotes neurite outgrowth via differential binding to PTEN and Akt

维普期刊数据库评论

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维普期刊数据库

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Neuroglobin promotes neurite outgrowth via differential bind...

中国神经科学学会第十届全国学术会议

作者： Li Li Qian-Rong Liu Xiri-Xin Xiong Ju-Mei Liu Xiao-Jing Lai Yong Chen Feng Pan Shang-Bin Yu Albert Cheung hoi Yu Xiao-Qian Chen School of Basic Medicine Tongji Medical College Key Laboratory of Neurological Diseases Ministry of EducationHubei Provincial Key Laboratory of Neurological Diseases Huazhong University of Science and Technology School of Basic Medical Sciences Health Science Center Neuroscience Research Institute Key Laboratory for Neuroscience Ministry of Education KeyLaboratory for Neuroscience Ministry of Public Health Peking University

Neuroglobin,the third mammalian globin with a hexa-coordinated heme,exists predominantly in neurons of *** plays an important role in neuronal death upon ischemia and oxidative *** physiological function of neuroglobin remains ***,we report a novel function of neuroglobin in neurite ***-down neuroglobin exhibited a prominent neurite-deficient phenotype in mouse neuroblastoma N2a *** neuroglobin prevented neurite outgrowth while ectopic expression of neuroglobin but not homologous cytoglobin promoted neurite outgrowth of N2a cells upon serum *** primary cultured rat cerebral cortical neurons,neuroglobin was up-regulated and preferentially distributed in neurites during neuronal *** of neuroglobin but not cytoglobin in cultured cortical neurons promoted axonal outgrowth while knocking-down of neuroglobin retarded axonal *** overexpression suppressed phosphatase and tensin homolog（PTEN） but increased Akt phosphorylation during neurite *** fluorescence complementation and glutathione S-transferase pull-down assays revealed mat neuroglobin and various mutants（E53Q,E118Q,K119N,H64A,H64L,Y44D） bound with Akt and PTEN *** E53Q mutant showed a prominent reduced PTEN-binding but increased Akt-binding,resulting in decreased p-PTEN,increased p-Akt and increased neurite *** together,we demonstrate a critical role of neuroglobin in neuritogenesis or development via interacting with PTEN and Akt differentially to activate PI3K/Akt pathway,providing potential therapeutic applications of neuroglobin for axonopathy in neurological diseases.

关键词： Ngb neuron axon regeneration PI3K/Akt

来源： cnki会议评论

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马来西亚客属地缘会馆之统计与分析

赣南师范大学学报 2020年第2期41卷 44-49页

作者：廖文辉黄义斌马来西亚新纪元大学学院中国语言文学系马来西亚雪兰莪州加影43000

马来西亚客属地缘会馆为华社三宝之一,遍布全马,在各方言群中,客家人的比重较少,但在早期的各华人地缘性社团中,客家人是最早建立社团的族群之一,且数量居第二位。然而准确的数据是多少,目前仍无明确的统计。使用现有的文献资料,收集整... 详细信息

马来西亚客属地缘会馆为华社三宝之一,遍布全马,在各方言群中,客家人的比重较少,但在早期的各华人地缘性社团中,客家人是最早建立社团的族群之一,且数量居第二位。然而准确的数据是多少,目前仍无明确的统计。使用现有的文献资料,收集整理客家地缘会馆的名称、创办年份,进而以计量方式针对其在全马和各州的分布情况,以及创办年代,并加以统计分析,以见客家公会近200年来在马来西亚发展的情况。

关键词：马来西亚客家地缘会馆客家会馆

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妇女性健康相关因素的探讨

中国性科学 2017年第4期26卷 148-153页

作者：吴海雅梅锦荣明爱専上学院人文及语言学院爱婚姻及家庭研究组香港大学社会工作学系

目的:妇女性健康是医疗专业人员所关注的课题,因为性健康若受损害,对生活满足感和生活质量都有不良影响。本研究探讨与性健康相关的因素,调查香港妇女性健康的一般状况。方法:采用橫向研究法,通过问卷调查搜集数据,参与者人口特征广泛... 详细信息

目的:妇女性健康是医疗专业人员所关注的课题,因为性健康若受损害,对生活满足感和生活质量都有不良影响。本研究探讨与性健康相关的因素,调查香港妇女性健康的一般状况。方法:采用橫向研究法,通过问卷调查搜集数据,参与者人口特征广泛多样。结果:香港妇女性功能尚属健康,仅性欲方面稍为偏低。不利性健康的因素包括高龄、受教育程度低、离婚、停经、曾接受盆腔手术等。性健康较差的妇女,性活动较少,意味性生活质量较差。结论:医疗专业人员可根据掌握的风险因素,针对性的推广性健康咨询和教育讲座,提高妇女的性健康。

关键词：性功能性健康生活质量问卷調查香港妇女

Genomic,transcriptomic,and metabolomic analysis of Oldenlandia corymbosa reveals the biosynthesis and mode of action of anti-cancer metabolites

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Journal of Integrative Plant Biology 2023年第6期65卷 1442-1466页

作者： Irene Julca Daniela Mutwil-Anderwald Vaishnervi Manoj Zahra Khan Soak Kuan Lai Lay K.Yang Ing T.Beh Jerzy Dziekan Yoon P.Lim Shen K.Lim Yee W.Low Yuen I.Lam Seth Tjia Yuguang Mu Qiao W.Tan Przemyslaw Nuc Le M.Choo Gillian Khew Loo Shining Antony Kam James P.Tam Zbynek Bozdech Maximilian Schmidt Bjoern Usadel Yoganathan Kanagasundaram Saleh Alseekh Alisdair Fernie hoi Y.Li Marek Mutwil School of Biological Sciences Nanyang Technological UniversitySingapore 639798Singapore Shared Analytics Singapore Institute of Food and Biotechnology Innovation(SIFBI)Agency for ScienceTechnology and Research(A*STAR)Singapore 138671Singapore Department of Biochemistry National University of SingaporeSingapore 117596Singapore singapore Botanic Gardens Singapore 259569Singapore Department of Gene Expression Faculty of BiologyInstitute of Molecular Biology and BiotechnologyAdam Mickiewicz UniversityPoznan 61-614Poland IBG-4 Bioinformatics Forschungszentrum JülichJülich 52428Germany Max-Planck-Institut für Molekulare Pflanzenphysiologie Potsdam-Golm 14476Germany Center of Plant Systems Biology and Biotechnology Plovdiv 4000Bulgaria

Plants accumulate a vast array of secondary metabolites,which constitute a natural resource for *** corymbosa belongs to the Rubiaceae family,and has been used in traditional medicine to treat different diseases,including ***,the active metabolites of the plant,their biosynthetic pathway and mode of action in cancer are *** fill these gaps,we exposed this plant to eight different stress conditions and combined different omics data capturing gene expression,metabolic profiles,and anti-cancer *** results show that *** extracts are active against breast cancer cell lines and that ursolic acid is responsible for this ***,we assembled a high-quality genome and uncovered two genes involved in the biosynthesis of ursolic ***,we also revealed that ursolic acid causes mitotic catastrophe in cancer cells and identified three high-confidence protein binding targets by Cellular Thermal Shift Assay(CETSA)and reverse ***,these results constitute a valuable resource to further characterize the biosynthesis of active metabolites in the Oldenlandia group,while the mode of action of ursolic acid will allow us to further develop this valuable compound.

关键词： genome medicinal metabolomics mode of action transcriptome

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大规模高利害考试后效研究综述

中国考试 2014年第1期 16-22页

作者：陈为峰孙开键云南师范大学高教院美国宾夕法尼亚州立大学

考试结果被用来进行各种决策,比如教师依据学业考试成绩对考生的学习掌握情况进行评估,高校依据统一高考成绩录取新生等。由于相关决策往往涉及利害关系,考试结果的应用就会产生正面作用或者负面作用,对这一问题的关注就导致了"考试后效... 详细信息

考试结果被用来进行各种决策,比如教师依据学业考试成绩对考生的学习掌握情况进行评估,高校依据统一高考成绩录取新生等。由于相关决策往往涉及利害关系,考试结果的应用就会产生正面作用或者负面作用,对这一问题的关注就导致了"考试后效"概念的形成和发展。本论文对考试后效的研究概况进行梳理。考试后效的研究有助于我们从学生的角度审视高考,对高考的改革步骤进行更好的判断和规划。

关键词：大规模高利害考试考试后效综述

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空芯光子带隙光纤及其传感技术

光电工程 2018年第9期45卷 26-40页

作者：汪超黄贺勇孟冬辉张景川何海律靳伟武汉大学电气工程学院湖北武汉430072 香港理工大学电机工程学系香港999077 北京卫星环境工程研究所北京100094

本文综述了空芯光子带隙光纤的独特性质,并介绍了近年来这类光纤在传感领域应用的新进展。光波在空气纤芯中低损耗传输是空芯光子带隙光纤的重要特性,它带来了长距离、大能量密度的光与物质相互作用通道,降低了光纤材料属性对传输光的影... 详细信息

本文综述了空芯光子带隙光纤的独特性质,并介绍了近年来这类光纤在传感领域应用的新进展。光波在空气纤芯中低损耗传输是空芯光子带隙光纤的重要特性,它带来了长距离、大能量密度的光与物质相互作用通道,降低了光纤材料属性对传输光的影响(如中红外吸收、热光效应),为诸如痕量气体/液体探测、高精度光纤陀螺仪等传感应用提供了高效的新平台。空芯光子带隙光纤内部精细的微结构具有新颖的机械性能和热性能,有利于诸如声波、振动探测等传感应用;还可结合光纤后期热处理、选择性填充等技术,对多孔包层进行结构修改或材料填充,获得进一步的性能和功能扩展。这些灵活性已用于开发具有新特性的光纤器件,例如光栅、起偏器和偏振干涉仪。目前,空芯光子带隙光纤传感技术的发展已大大扩展了光纤的环境感知能力和应用范围,是全光器件和光集成技术发展的重要方向。

关键词：空芯光纤光子带隙光纤光纤传感器气体传感器分布式气体传感