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The World of Chinese 2013年第4期 80-83,5页

作者： Wai Ka-Fai Yau Nai-hoi Ryker Chan Yu Xi

Staff writer Terence Hsieh critiques Johnnie To’s latest blockbuster,a world of crooked cops and crafty criminals

关键词：古天乐

Multiomics approaches to uncover endometrial receptivity in embryo implantation:a mini-review

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Reproductive and Developmental Medicine 2024年第3期8卷 178-185页

作者： Sudini R.Fernando Yang Yan Manish Kumar hoi-Lam Lai Yin-Lau Lee Ernest H.Y.Ng William S.B.Yeung Kai-Fai Lee Department of Obstetrics and Gynaecology Li Ka Shing Faculty of MedicineThe University of Hong KongPokfulamHong Kong SAR 999077China Department of Animal Science Faculty of Animal Science and Export AgricultureUva Wellassa UniversityBadullaSri Lanka Shenzhen Key Laboratory of Fertility Regulation The University of Hong Kong-Shenzhen HospitalFutian DistrictShenzhen 518053China

Successful implantation requires concerted interactions during the apposition,adhesion,and invasion of the embryo into a receptive ***,the embryo implantation rate for assisted reproduction remains low despite the transfer of good quality *** in endometrial transcriptomics,proteomics,lipidomics,and even microbiota all play important roles in embryo ***,the expression of steroid hormone-regulated adhesive and anti-adhesive molecules during the embryo implantation window is becoming an area of increasingly intense *** review(a)summarizes the different molecules expressed in the receptive endometrium and(b)proposes the use of surface protein markers to predict pregnancy outcomes from assisted reproduction.

关键词： Cell surface proteins Steroid regulation Endometrial receptivity Receptivity marker Infertility

Therapeutic efficacy of novel memantine nitrate MN-08 in animal models of Alzheimer disease

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中国药理学与毒理学杂志 2021年第9期35卷 646-647页

作者： WU Liang-miao ZHOU Xin-hua CAO Yi-wan Shing Hung MAK ZHA Ling LI Ning SU Zhi-yang HAN Yi-fan WANG Yu-qiang Maggie Pui Man hoi SUN Ye-wei ZHANG Gao-xiao YANG Xi-fei ZHANG Zai-jun Institute of New Drug Research Jinan University College of PharmacyGuangzhou 510632China

OBJECTIVE Alzheimer disease(AD)is a leading cause of dementia in elderly individuals and therapeutic options for AD are very ***-activation of N-methyl-D-aspar⁃tate(NMDA)receptors,amyloidβ(Aβ)aggrega⁃tion,a decrease in cerebral blood flow(CBF),and downstream pathological events play impor⁃tant roles in the disease progression of *** study seeks to explore the efficacy and mecha⁃nism of action of MN-08,a novel memantine ni⁃trate,in established animal models of *** MN-08′s effectiveness as a preventative and therapeutic agent was tested in 2-to 8-month-old APP/PS1 transgenic mice and 9-to 12-month-old 3×Tg-AD mice,*** neuroprotective mechanism of MN-08 was tested in the glutamate cell *** pharmacokinet⁃ics and safety of MN-08 in vivo were determined in normal rats and beagle *** the behavioral test,Western blotting analysis,pathology,ELISA test and in vitro cell tests,investigators were blinded to the experimental grouping and drug *** MN-08,a novel meman⁃tine nitrate,was found to inhibit Aβaccumulation,prevent neuronal and dendritic spine loss,and consequently attenuate cognitive deficits in 2-month-old APP/PS1 transgenic mice(for a 6-month preventative course)and in the 8-month-old triple-transgenic(3×Tg-AD)mice(for a 4-month therapeutic course).In vitro,MN-08 could bind to and antagonize NMDA receptors,inhibit the calcium influx,and reverse the dysregula⁃tions of ERK and PI3K/Akt/GSK3βpathway,sub⁃sequently preventing glutamate-induced neuro⁃nal *** addition,MN-08 had favorable phar⁃macokinetics,blood-brain barrier penetration,and safety profiles in rats and beagle ***⁃CLUSION The novel memantine nitrate MN-08 may be a useful therapeutic agent for AD.

关键词： Alzheimer disease MN-08 meman⁃tine nitrate

A Universal Strategy to Utilize Polymeric Semiconductor for Perovskite Solar Cells with Enhanced Efficiency and Longevity

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A Universal Strategy to Utilize Polymeric Semiconductor for ...

第五届新型太阳能电池学术研讨会

作者： Fangchao Li Jianyu Yuan Xufeng Ling Yannan Zhuang Yingguo Yang Sin Hang Cheung Carr hoi Yi Ho Xingyu Gao Wanli Ma Soochow University

In this contribution, we successfully report a facile and universal method to fabricate perovskite solar cells(PSCs) with enhanced efficiency and stability. Through dissolving functional conjugated polymers in antisolvent chlorobenzene to treat the spinning CHNHPbI perovskite film, the resultant devices exhibit significantly enhanced efficiency and longevity simultaneously. In-depth characterizations demonstrate that thin polymer layer well covers the top surface of perovskite film, resulting in certain surface passivation and morphology modification. More importantly, we have shown that through rational chemical modification, namely molecular fluorination, the air-stability and photo-stability of the perovskite solar cells are remarkably enhanced. Considering the vast selection of conjugated polymer materials and easy functional design, we expect promising new results in further enhancement of device performance. We believe our findings provide exciting insights into the role of conjugated polymer in improving the current perovskite-based solar cells.

关键词： conjugated polymer perovskite solar cells fluorination and stability

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极紫外光刻光源

半导体技术 2006年第6期31卷 406-408,417页

作者：邱孟通 P.Choi 西北核技术研究所西安710024 EPPRA SAS.Courtaboeuf France

分析了极紫外光刻技术作为下一代光刻技术的首选技术目前飞速发展阶段的状况,表明欧、美、日、俄等国家和地区在该领域集中了大量的人力、物力的目标是将光刻精度提高到50nm。指出了极紫外光源是极紫外光刻的核心设备,目前的主要研究方... 详细信息

分析了极紫外光刻技术作为下一代光刻技术的首选技术目前飞速发展阶段的状况,表明欧、美、日、俄等国家和地区在该领域集中了大量的人力、物力的目标是将光刻精度提高到50nm。指出了极紫外光源是极紫外光刻的核心设备,目前的主要研究方向是提高能量转换效率和输出功率,提高系统各部分的寿命,降低成本等。

关键词：极紫外光刻极紫外光刻下一代光刻

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自發性孤立性腸系膜上動脈夾層2例

镜湖医学 2014年第2期14卷 78-78,83页

作者：張海瑞林萬雙朱偉國李嘉亮澳門鏡湖醫院心胸血管外科中國

患者1男性,57歲,因“腹部持續性絞痛18小時”入院,疼痛以臍上明顯,無他處放射痛,伴嘔吐1次,腹部CT提示:腸系膜上動脈(superior mesenteric artery,SMA)近段壁可疑血管內膜撕裂,SMA近段腔內未見造影劑充盈,累及範圍約7cm,考慮動脈夾層或... 详细信息

患者1男性,57歲,因“腹部持續性絞痛18小時”入院,疼痛以臍上明顯,無他處放射痛,伴嘔吐1次,腹部CT提示:腸系膜上動脈(superior mesenteric artery,SMA)近段壁可疑血管內膜撕裂,SMA近段腔內未見造影劑充盈,累及範圍約7cm,考慮動脈夾層或壁內血腫所致,SNA遠端造影劑充盈可。次日行血管造影檢查:SMA距起始部開口1cm右上壁半球狀突起,內似見一透亮條帶狀影,SMA中遠段及部份空腸動脈關閉可見淺弧形切跡,管腔略窄,中結腸動脈近段閉塞。

关键词：腹部CT 血管造影系膜 artery 放射痛孤立性起始部

星形胶质细胞调节性容积减小(RVD)的关键膜蛋白研究进展

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生物化学与生物物理进展 2022年第11期49卷 2165-2171页

作者：周佐邑高嘉琪高凯龚艳君于常海北京大学第一医院心血管内科北京100034 北京大学第一医院儿科北京100034 北京大学基础医学院神经科学研究所北京100191 北京大学第三医院消化内科北京100191

星形胶质细胞承担着维持脑部内环境稳态的重要功能,包括维持脑的水电解质平衡。然而,在缺血性脑卒中等多种疾病中,星形胶质细胞会首先出现明显的细胞水肿,进而促进脑水肿的发生,加重脑损伤。调节性容积减小(RVD)是星形胶质细胞面对水肿... 详细信息

星形胶质细胞承担着维持脑部内环境稳态的重要功能,包括维持脑的水电解质平衡。然而,在缺血性脑卒中等多种疾病中,星形胶质细胞会首先出现明显的细胞水肿,进而促进脑水肿的发生,加重脑损伤。调节性容积减小(RVD)是星形胶质细胞面对水肿时快速减小自身部分容积的代偿反应。最新研究进展发现,水通道蛋白(AQP)和体积调节性阴离子通道(VRAC)是RVD过程的关键参与者。VRAC是LRRC8家族成员构成的异多聚体,星形胶质细胞水肿时,VRAC激活,介导阴离子和有机渗透性物质快速向细胞外转运,是RVD的主要驱动力。AQP是一种6次跨膜蛋白,具有选择性的双向水通道,是星形胶质细胞快速水肿的结构基础,同时也是RVD过程中水转移至胞外的“快速通道”。进一步了解VRAC和AQP的结构、功能及其在RVD中发挥的作用,有助于最终解析星形胶质细胞RVD的发生机制并为脑水肿的治疗提供潜在靶点。

关键词：水通道蛋白体积调节性阴离子通道调节性容积减小星形胶质细胞脑水肿

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Upregulation of 14-3-3γ is induced by a synergistic effect of multiple factors during ischemia in astrocytes

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Upregulation of 14-3-3γ is induced by a synergistic effect ...

中国神经科学学会第十届全国学术会议

作者： Ymg PANG Yan DONG Hua-Dong LIU Ann Yuen Kwan WONG Greg VATCHER Xiao-Qian CHEN Jian-Guo CHEN Albert Cheung hoi YU Neuroscience Research Institute Department of Neurobiology Key Laboratory for Neuroscience (Peking University) Ministry of Education Key Laboratory for Neuroscience (Peking University) Ministry of Public Health Department of Neurobiology School of Basic Medical Sciences Peking University Health Science Center Department of Pathophysiology the Key Laboratory of Neurological Diseases the Ministry of Education and Department of Pharmacology Tongji Medical College Huazhong University of Science and Technology Department of Cell Biology and Genetics College of Life Sciences Peking University Key Laboratory for Cell Proliferation and Differentiation Ministry of Education State Key Laboratory for Bio-membrane and Membrane Bio-engineering Laboratory ofTranslattonal Medicine Institute of Systems Biomedicine Peking University

14-3-3γ is a multifunctional acidic protein that is induced by ischemia in neural cells,including astrocytes,and has a neuroprotective *** ischemia,a lack of oxygen（hypoxia） and glucose,and an accumulation of toxins,*** order to elucidate which ischemia components caused the damage to astrocytes and the induction of the protective protein 14-3-3γ,we examined the effects of hypoxia,glucose deprivation,and the accumulation of toxins,separately,and compared the degree of damage to ischemia *** caused a rapid upregulation of 14-3-3γthat occurred within 1 to 4 *** alone elevated 14-3-3γ expression,while glucose deprivation did not cause a detectable change in the 14-3-3γ mRNA and protein *** changes of toxic metabolites barely affected14-3-3γ gene and protein expression in the time course *** addition,comparing the activation of the ERK1/2,Akt,P38 and JNK signaling pathways under ischemia and hypoxia in astrocytes revealed mat ischemia activated all four pathways,while hypoxia had little effect on any of *** also observed how glutamate（Glu） and arachidonic acid（AA）,the main toxic substances released by neural cells during ischemia injury,affected the expression of the14-3-3 protein *** all members of the 14-3-3 family,β and γ were up-regulated rapidly after 3 hr of treatment with G1u or AA,while η and ε increased until 6 hr and ζ increased after *** results demonstrated that the three components of ischemia played diverse roles in the regulation of 14-3-3Y) that different isoforms of the 14-3-3family showed disparate responses to Glu and AA treatments,and that the JNK/c-Jun/AP-1 signaling pathway was involved in 14-3-3γ up-regulation.

关键词： 14-3-3γ hypoxia ischemia glutamate arachidonic acid

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微纳结构光纤光谱学

光学学报 2021年第1期41卷 395-412页

作者：靳伟鲍海泓齐云赵焱赵鹏程高寿飞何海律香港理工大学电机工程学系中国香港香港理工大学深圳研究院光子研究中心广东深圳518057

微纳结构光纤光谱学是指以空芯微结构或微纳光纤为样品池,光和物质在纤芯内部或表面进行相互作用的光谱学技术。本文回顾空芯和微纳光纤导光的基本原理,介绍气体、液体样品池构建的理论和方法,综述基于光谱吸收、光热、光声、荧光、拉... 详细信息

微纳结构光纤光谱学是指以空芯微结构或微纳光纤为样品池,光和物质在纤芯内部或表面进行相互作用的光谱学技术。本文回顾空芯和微纳光纤导光的基本原理,介绍气体、液体样品池构建的理论和方法,综述基于光谱吸收、光热、光声、荧光、拉曼等效应的微纳结构光纤光谱学的最新进展及今后可能的发展方向。微纳结构光纤对光场的束缚能力强、模场能量在空气中的比例高,可实现光和物质在其中的高效、长距离相互作用。微纳结构光纤样品池的采用,可提升传统光谱学系统的性能或构建新型的光谱学系统;应用传输光纤与其他光学元器件进行柔性连接,可促进光谱学仪器和传感器的小型化和实用化。

关键词：光谱学激光光谱微结构光纤空芯光纤光纤传感器纳米光波导拉曼光谱学