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Thyroid dysfunction and developmental anomalies in first degree relatives of children with thyroid dysgenesis

World Journal of Pediatrics 2016年第2期12卷 215-218页

作者： Lakshminarasimhan Sindhuja Devi Dayal kushaljit singh sodhi Naresh Sachdeva Anish Bhattacharya Pediatric Endocrinology Unit Department of PediatricsPostgraduate Institute of Medical Education and ResearchChandigarh Department of Radiodiagnosis Postgraduate Institute of Medical Education and ResearchChandigarh Department of Endocrinology Postgraduate Institute of Medical Education and ResearchChandigarh Department of Nuclear Medicine Postgraduate Institute of Medical Education and ResearchChandigarh

Background: Familial clustering in patients withpermanent congenital hypothyroidism (CH) caused bythyroid dysgenesis (TD) has been reported in developedcountries. There is no information on familial TD fromdeveloping ***: A total of 312 first degree relativesbelonging to 80 families of children with TD (group 1)and 40 families of age-matched normal children (group2) were screened by thyroid ultrasonography, serum totalthyroxine (T4) and thyroid stimulating hormone (TSH).Results: Thyroid scintigraphy revealed agenesis in78.7% of the patients, ectopic gland in 15%, and hypoplasiain 6.2%. The mean thyroid volumes were similar in parentsand siblings of both groups. Eight (10.6%) mothers in group1 were identified to have thyroid hypoplasia as comparedwith none in group 2 (P=0.03). Serum TSH was signifi cantlyhigher in group 1 than in group 2 (P=0.004). Sixteen (7.8%)subjects (6 mothers, 5 fathers, and 5 siblings) in group 1were found to have subclinical hypothyroidism as comparedto none in group 2 (P<0.05). Four families were identifiedto have thyroid developmental anomalies and abnormalthyroid functions accounting for 5% of cases of familial TDin our ***: Thyroid developmental anomalies andthyroid function abnormalities are more frequent in firstdegree relatives of children with TD as compared with acontrol population. These findings suggest that possiblythere is a genetic component of TD in Indian patients.

关键词： congenital hypothyroidism familial occurrence first degree relatives thyroid developmental anomalies thyroid dysgenesis

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Bleeding per rectum in pediatric population: A pictorial review

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World Journal of Clinical Pediatrics 2022年第3期11卷 270-288页

作者： Karamvir Chandel Rishabh Jain Anmol Bhatia Akshay Kumar Saxena kushaljit singh sodhi Department of Radio Diagnosis and Imaging Post Graduate Institute of Medical Education and ResearchChandigarh 160012India

Bleeding per rectum in children can be seen in congenital as well as acquired conditions that may require medical or surgical *** present review article is aimed to discuss the imaging findings of some common and unco... 详细信息

关键词： Bleeding Per rectum Children Imaging Congenital

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